Details for: DARS1

Gene ID: 1615

Symbol: DARS1

Ensembl ID: ENSG00000115866

Description: aspartyl-tRNA synthetase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 347.6159
    Cell Significance Index: -54.0700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 163.6155
    Cell Significance Index: -41.5000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 146.9847
    Cell Significance Index: -60.5500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 137.6714
    Cell Significance Index: -55.9300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 134.3295
    Cell Significance Index: -63.4200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 120.0851
    Cell Significance Index: -61.7700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 95.0937
    Cell Significance Index: -63.8100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 58.9792
    Cell Significance Index: -56.3100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 47.5686
    Cell Significance Index: -58.6500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.1544
    Cell Significance Index: -59.8000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.1257
    Cell Significance Index: -40.3200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.6337
    Cell Significance Index: -27.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6782
    Cell Significance Index: 333.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.5440
    Cell Significance Index: 212.0400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4776
    Cell Significance Index: 160.7200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4054
    Cell Significance Index: 38.2600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.3831
    Cell Significance Index: 36.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2552
    Cell Significance Index: 154.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2444
    Cell Significance Index: 679.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.2178
    Cell Significance Index: 219.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1887
    Cell Significance Index: 238.4500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.1314
    Cell Significance Index: 26.1400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.0458
    Cell Significance Index: 73.9600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0058
    Cell Significance Index: 28.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.9969
    Cell Significance Index: 55.9400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9872
    Cell Significance Index: 436.4800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.9808
    Cell Significance Index: 14.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9614
    Cell Significance Index: 113.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9571
    Cell Significance Index: 49.7200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8912
    Cell Significance Index: 114.2500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8357
    Cell Significance Index: 29.0400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8266
    Cell Significance Index: 106.7900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.8028
    Cell Significance Index: 21.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7906
    Cell Significance Index: 51.0100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7643
    Cell Significance Index: 39.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7436
    Cell Significance Index: 57.0600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6602
    Cell Significance Index: 19.3900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6248
    Cell Significance Index: 43.2100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5952
    Cell Significance Index: 537.4100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.5703
    Cell Significance Index: 6.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5397
    Cell Significance Index: 193.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5335
    Cell Significance Index: 25.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4613
    Cell Significance Index: 21.5100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4561
    Cell Significance Index: 315.4900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4228
    Cell Significance Index: 68.7700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3663
    Cell Significance Index: 19.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3580
    Cell Significance Index: 26.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3396
    Cell Significance Index: 9.7900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3200
    Cell Significance Index: 492.7000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2369
    Cell Significance Index: 11.9700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2356
    Cell Significance Index: 434.4300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2313
    Cell Significance Index: 44.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2281
    Cell Significance Index: 429.4800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1825
    Cell Significance Index: 3.8200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1498
    Cell Significance Index: 203.7300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.1347
    Cell Significance Index: 1.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1202
    Cell Significance Index: 54.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1098
    Cell Significance Index: 18.7600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0951
    Cell Significance Index: 60.3900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0911
    Cell Significance Index: 4.1300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0430
    Cell Significance Index: 0.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0060
    Cell Significance Index: 4.3700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0054
    Cell Significance Index: 0.1400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0120
    Cell Significance Index: -1.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0291
    Cell Significance Index: -22.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0352
    Cell Significance Index: -3.6000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0435
    Cell Significance Index: -1.5300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0558
    Cell Significance Index: -0.6700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0558
    Cell Significance Index: -2.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0760
    Cell Significance Index: -56.2600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0968
    Cell Significance Index: -1.6200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1045
    Cell Significance Index: -58.9400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1074
    Cell Significance Index: -67.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1191
    Cell Significance Index: -4.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1485
    Cell Significance Index: -21.5900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1724
    Cell Significance Index: -10.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1812
    Cell Significance Index: -20.7600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1913
    Cell Significance Index: -55.0500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2929
    Cell Significance Index: -2.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3177
    Cell Significance Index: -66.9100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3243
    Cell Significance Index: -6.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3670
    Cell Significance Index: -38.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3693
    Cell Significance Index: -24.8300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4122
    Cell Significance Index: -10.5300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.4761
    Cell Significance Index: -3.6700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4827
    Cell Significance Index: -4.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5086
    Cell Significance Index: -16.2900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5344
    Cell Significance Index: -7.8900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.5367
    Cell Significance Index: -3.3400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5675
    Cell Significance Index: -15.1800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5761
    Cell Significance Index: -7.8600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6076
    Cell Significance Index: -48.1300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.7991
    Cell Significance Index: -6.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8069
    Cell Significance Index: -49.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.8133
    Cell Significance Index: -17.6200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.8397
    Cell Significance Index: -14.3900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.9318
    Cell Significance Index: -5.6300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.9435
    Cell Significance Index: -13.5700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9672
    Cell Significance Index: -27.7300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.0109
    Cell Significance Index: -14.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** DARS1 is a cytoplasmic enzyme that catalyzes the aminoacylation of aspartic acid to its corresponding tRNA. This reaction involves the formation of a high-energy phosphoanhydride bond between the aspartic acid and the tRNA, which is then hydrolyzed to release the amino acid. DARS1 is a member of the aminoacyl-tRNA synthetase family, which is characterized by its ability to recognize and bind specific amino acids and tRNAs. The enzyme's activity is essential for the proper functioning of protein synthesis, as incorrect amino acid incorporation can lead to the production of aberrant proteins. **Pathways and Functions** DARS1 is involved in several cellular pathways, including: 1. **Aminoacyl-tRNA Synthetase Multienzyme Complex**: This pathway involves the coordinated action of multiple aminoacyl-tRNA synthetases to ensure the accurate incorporation of amino acids into proteins. 2. **Aminoacylase Activity**: This pathway involves the hydrolysis of the high-energy phosphoanhydride bond formed during aminoacylation, releasing the amino acid from the tRNA. 3. **Aspartate-tRNA Ligase Activity**: This pathway involves the formation of the high-energy phosphoanhydride bond between aspartic acid and its corresponding tRNA. 4. **Selenoamino Acid Metabolism**: This pathway involves the incorporation of selenium into selenocysteine, a rare amino acid that plays a crucial role in various cellular processes. **Clinical Significance** DARS1 has been implicated in several diseases, including: 1. **Cancer**: Mutations in DARS1 have been associated with various types of cancer, including leukemia and lymphoma. 2. **Neurodegenerative Diseases**: Abnormalities in DARS1 have been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's. 3. **Muscle Diseases**: Mutations in DARS1 have been associated with muscle disorders, including muscular dystrophy and myopathy. 4. **Cardiovascular Diseases**: Abnormalities in DARS1 have been linked to cardiovascular diseases, including atherosclerosis and cardiac arrhythmias. In conclusion, DARS1 is a critical enzyme involved in the aminoacylation of aspartic acid to its corresponding tRNA, a process essential for protein synthesis. Its dysregulation has been implicated in various diseases, highlighting the importance of this enzyme in maintaining cellular homeostasis. Further research is needed to fully understand the mechanisms by which DARS1 regulates protein synthesis and to develop therapeutic strategies to target this enzyme in the treatment of diseases associated with its dysfunction.

Genular Protein ID: 4130057107

Symbol: SYDC_HUMAN

Name: Aspartyl-tRNA synthetase

UniProtKB Accession Codes:

P14868 A8K3J2 D3DP77 Q2TNI3 Q32Q69 Q53HV4 Q53YC5 Q68CR9 Q9BW52

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEBI 14 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 1 EMBL 12 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 3 RefSeq 2 Rhea 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2674137

Title: cDNA sequence, predicted primary structure, and evolving amphiphilic helix of human aspartyl-tRNA synthetase.

PubMed ID: 2674137

DOI: 10.1016/s0021-9258(19)84749-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 18029264

Title: Lysyl-tRNA synthetase interacts with EF1alpha, aspartyl-tRNA synthetase and p38 in vitro.

PubMed ID: 18029264

DOI: 10.1016/j.bbrc.2007.11.028

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19131329

Title: Dissection of the structural organization of the aminoacyl-tRNA synthetase complex.

PubMed ID: 19131329

DOI: 10.1074/jbc.m809636200

PubMed ID: 19289464

Title: Dynamic Organization of Aminoacyl-tRNA Synthetase Complexes in the Cytoplasm of Human Cells.

PubMed ID: 19289464

DOI: 10.1074/jbc.m900480200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23643384

Title: Mutations in DARS cause hypomyelination with brain stem and spinal cord involvement and leg spasticity.

PubMed ID: 23643384

DOI: 10.1016/j.ajhg.2013.04.006

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23609930

Title: Crystal structure of human cytosolic aspartyl-tRNA synthetase, a component of multi-tRNA synthetase complex.

PubMed ID: 23609930

DOI: 10.1002/prot.24306

Sequence Information:

  • Length: 501
  • Mass: 57136
  • Checksum: B181572DF0AF5F94
  • Sequence:
    • MPSASASRKS QEKPREIMDA AEDYAKERYG ISSMIQSQEK PDRVLVRVRD LTIQKADEVV 
WVRARVHTSR AKGKQCFLVL RQQQFNVQAL VAVGDHASKQ MVKFAANINK ESIVDVEGVV 
RKVNQKIGSC TQQDVELHVQ KIYVISLAEP RLPLQLDDAV RPEAEGEEEG RATVNQDTRL 
DNRVIDLRTS TSQAVFRLQS GICHLFRETL INKGFVEIQT PKIISAASEG GANVFTVSYF 
KNNAYLAQSP QLYKQMCICA DFEKVFSIGP VFRAEDSNTH RHLTEFVGLD IEMAFNYHYH 
EVMEEIADTM VQIFKGLQER FQTEIQTVNK QFPCEPFKFL EPTLRLEYCE ALAMLREAGV 
EMGDEDDLST PNEKLLGHLV KEKYDTDFYI LDKYPLAVRP FYTMPDPRNP KQSNSYDMFM 
RGEEILSGAQ RIHDPQLLTE RALHHGIDLE KIKAYIDSFR FGAPPHAGGG IGLERVTMLF 
LGLHNVRQTS MFPRDPKRLT P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.