Details for: DARS1

Gene ID: 1615

Symbol: DARS1

Ensembl ID: ENSG00000115866

Description: aspartyl-tRNA synthetase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.39
    Marker Score: 3022
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 3.08
    Marker Score: 2062.5
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 3.04
    Marker Score: 40403
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.99
    Marker Score: 3115
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.53
    Marker Score: 3059
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.37
    Marker Score: 3190
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.33
    Marker Score: 31267
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.24
    Marker Score: 4724.5
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.23
    Marker Score: 1082.5
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 2.19
    Marker Score: 2375
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 2.14
    Marker Score: 1253
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.08
    Marker Score: 1087
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.02
    Marker Score: 1175
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.95
    Marker Score: 2597
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.93
    Marker Score: 1129
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.91
    Marker Score: 4184
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.89
    Marker Score: 1740
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.88
    Marker Score: 12236
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.88
    Marker Score: 1072
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.86
    Marker Score: 2632
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.83
    Marker Score: 3243
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.82
    Marker Score: 7851.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.81
    Marker Score: 1824
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.81
    Marker Score: 2667
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.81
    Marker Score: 6996
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.81
    Marker Score: 4917
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.81
    Marker Score: 62574
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.8
    Marker Score: 18138
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.8
    Marker Score: 2325
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.79
    Marker Score: 7335.5
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.79
    Marker Score: 3742
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.79
    Marker Score: 943
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.77
    Marker Score: 1300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.75
    Marker Score: 37437
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.75
    Marker Score: 2863
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.74
    Marker Score: 6833
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.74
    Marker Score: 1839
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.74
    Marker Score: 2095
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.73
    Marker Score: 1861
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.72
    Marker Score: 1840
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.72
    Marker Score: 2387
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.72
    Marker Score: 7184
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.71
    Marker Score: 22548
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.69
    Marker Score: 1798
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.65
    Marker Score: 14216
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.65
    Marker Score: 1098
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.64
    Marker Score: 18445.5
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.64
    Marker Score: 2782
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.63
    Marker Score: 615
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.63
    Marker Score: 1714
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.62
    Marker Score: 1528
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.61
    Marker Score: 5957
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 1.6
    Marker Score: 481
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.57
    Marker Score: 18277
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.57
    Marker Score: 1044
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.56
    Marker Score: 9981
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.56
    Marker Score: 1682
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.54
    Marker Score: 1290
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.53
    Marker Score: 1689
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.52
    Marker Score: 364
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.52
    Marker Score: 749
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.5
    Marker Score: 1331
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.49
    Marker Score: 1549.5
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.49
    Marker Score: 522
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.49
    Marker Score: 3990
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.48
    Marker Score: 4405
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.48
    Marker Score: 468
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.48
    Marker Score: 927
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.48
    Marker Score: 736.5
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.48
    Marker Score: 1578
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.47
    Marker Score: 811
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.47
    Marker Score: 595
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.47
    Marker Score: 996
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.46
    Marker Score: 2252
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.46
    Marker Score: 3439
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.46
    Marker Score: 777
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.46
    Marker Score: 2735.5
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.43
    Marker Score: 335
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.43
    Marker Score: 1079
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.42
    Marker Score: 2594
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.42
    Marker Score: 1339
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.41
    Marker Score: 3222
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.41
    Marker Score: 965
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.41
    Marker Score: 490
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.4
    Marker Score: 2444
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4
    Marker Score: 3417
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.4
    Marker Score: 770
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.4
    Marker Score: 3802
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.4
    Marker Score: 1047
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.4
    Marker Score: 1317
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.39
    Marker Score: 1600
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.39
    Marker Score: 582
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.39
    Marker Score: 14048.5
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.38
    Marker Score: 1671
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.37
    Marker Score: 10227
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.37
    Marker Score: 669.5
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.37
    Marker Score: 861
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.37
    Marker Score: 1645
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.37
    Marker Score: 2446
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.36
    Marker Score: 1477

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Other Information

**Key characteristics:** - DARS1 is a large protein with a molecular weight of approximately 500 kDa. - It is a transmembrane protein that is localized to the cytoplasm. - It is a key enzyme in the biosynthesis of aspartate from precursors such as glutamate, glutamine, and aspartate-CoA. **Pathways and functions:** - DARS1 is involved in the following pathways and functions: - Aminoacylase activity: DARS1 is an aspartate aminotransferase that catalyzes the transfer of an aspartate group from aspartate-CoA to various substrates, including glutamate, glutamine, and other amino acids. - Aspartate-trna ligase activity: DARS1 is also involved in the ligation of aspartate to trna, resulting in the synthesis of argininosuccinic acid. - Aspartyl-trna aminoacylation: DARS1 is involved in the aminoacylation of trna with glutamate, forming argininosuccinic acid. - Atp binding: DARS1 binds to ATP, which is required for its activation. - Cytoplasm, cytosol, and cytosolic trna aminoacylation: DARS1 is involved in the cytoplasm, cytosol, and cytosolic aminoacylation of trna. - Membrane: DARS1 is also found in the membrane of cells, where it may be involved in the transport of aspartate and other molecules. - Metabolism of amino acids and derivatives: DARS1 is involved in the metabolism of amino acids and their derivatives, including the synthesis of proteins and the degradation of damaged proteins. - Metabolism of proteins: DARS1 is involved in the biosynthesis of certain proteins, including keratin and collagen. - Protein-containing complex assembly: DARS1 is involved in the assembly of protein-containing complexes, such as hemoglobin and lysosomes. - Protein binding: DARS1 binds to various proteins, including actin, tubulin, and transfer RNA. **Clinical significance:** DARS1 gene mutations have been linked to several human diseases, including alkaptonuria, which is caused by a deficiency in DARS1. Alkaptonuria is characterized by the accumulation of homoglutathione in the urine, which can cause a yellow discoloration of the urine.

Genular Protein ID: 4130057107

Symbol: SYDC_HUMAN

Name: Aspartyl-tRNA synthetase

UniProtKB Accession Codes:

P14868 A8K3J2 D3DP77 Q2TNI3 Q32Q69 Q53HV4 Q53YC5 Q68CR9 Q9BW52

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEBI 14 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 1 EMBL 12 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2674137

Title: cDNA sequence, predicted primary structure, and evolving amphiphilic helix of human aspartyl-tRNA synthetase.

PubMed ID: 2674137

DOI: 10.1016/s0021-9258(19)84749-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 18029264

Title: Lysyl-tRNA synthetase interacts with EF1alpha, aspartyl-tRNA synthetase and p38 in vitro.

PubMed ID: 18029264

DOI: 10.1016/j.bbrc.2007.11.028

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19131329

Title: Dissection of the structural organization of the aminoacyl-tRNA synthetase complex.

PubMed ID: 19131329

DOI: 10.1074/jbc.m809636200

PubMed ID: 19289464

Title: Dynamic Organization of Aminoacyl-tRNA Synthetase Complexes in the Cytoplasm of Human Cells.

PubMed ID: 19289464

DOI: 10.1074/jbc.m900480200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23643384

Title: Mutations in DARS cause hypomyelination with brain stem and spinal cord involvement and leg spasticity.

PubMed ID: 23643384

DOI: 10.1016/j.ajhg.2013.04.006

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23609930

Title: Crystal structure of human cytosolic aspartyl-tRNA synthetase, a component of multi-tRNA synthetase complex.

PubMed ID: 23609930

DOI: 10.1002/prot.24306

Sequence Information:

  • Length: 501
  • Mass: 57136
  • Checksum: B181572DF0AF5F94
  • Sequence:
    • MPSASASRKS QEKPREIMDA AEDYAKERYG ISSMIQSQEK PDRVLVRVRD LTIQKADEVV 
WVRARVHTSR AKGKQCFLVL RQQQFNVQAL VAVGDHASKQ MVKFAANINK ESIVDVEGVV 
RKVNQKIGSC TQQDVELHVQ KIYVISLAEP RLPLQLDDAV RPEAEGEEEG RATVNQDTRL 
DNRVIDLRTS TSQAVFRLQS GICHLFRETL INKGFVEIQT PKIISAASEG GANVFTVSYF 
KNNAYLAQSP QLYKQMCICA DFEKVFSIGP VFRAEDSNTH RHLTEFVGLD IEMAFNYHYH 
EVMEEIADTM VQIFKGLQER FQTEIQTVNK QFPCEPFKFL EPTLRLEYCE ALAMLREAGV 
EMGDEDDLST PNEKLLGHLV KEKYDTDFYI LDKYPLAVRP FYTMPDPRNP KQSNSYDMFM 
RGEEILSGAQ RIHDPQLLTE RALHHGIDLE KIKAYIDSFR FGAPPHAGGG IGLERVTMLF 
LGLHNVRQTS MFPRDPKRLT P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.