Details for: DYNC1H1

Gene ID: 1778

Symbol: DYNC1H1

Ensembl ID: ENSG00000197102

Description: dynein cytoplasmic 1 heavy chain 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 572.5023
    Cell Significance Index: -89.0500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 344.4797
    Cell Significance Index: -87.3800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 207.5749
    Cell Significance Index: -85.5100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 198.7195
    Cell Significance Index: -93.8200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 188.0829
    Cell Significance Index: -76.4100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 171.0683
    Cell Significance Index: -88.0000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 139.8911
    Cell Significance Index: -93.8700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 80.2729
    Cell Significance Index: -76.6400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 75.4001
    Cell Significance Index: -92.9700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 32.3459
    Cell Significance Index: -86.6500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 24.9817
    Cell Significance Index: -76.7300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 23.7858
    Cell Significance Index: -93.8600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 17.1800
    Cell Significance Index: -37.6000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.7035
    Cell Significance Index: 140.8200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.4520
    Cell Significance Index: 491.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.9585
    Cell Significance Index: 702.4800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.9221
    Cell Significance Index: 312.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.7636
    Cell Significance Index: 317.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.7205
    Cell Significance Index: 211.5600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.6689
    Cell Significance Index: 48.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.5811
    Cell Significance Index: 97.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4033
    Cell Significance Index: 278.4800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2978
    Cell Significance Index: 141.1700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1514
    Cell Significance Index: 52.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1465
    Cell Significance Index: 87.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1402
    Cell Significance Index: 156.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.1031
    Cell Significance Index: 61.9000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.0914
    Cell Significance Index: 754.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0327
    Cell Significance Index: 66.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9537
    Cell Significance Index: 44.8300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9055
    Cell Significance Index: 494.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8395
    Cell Significance Index: 758.0400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.7410
    Cell Significance Index: 17.7700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7171
    Cell Significance Index: 317.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5770
    Cell Significance Index: 38.8000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5301
    Cell Significance Index: 36.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5240
    Cell Significance Index: 27.2200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5154
    Cell Significance Index: 14.7800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4896
    Cell Significance Index: 62.7700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4565
    Cell Significance Index: 16.0400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4478
    Cell Significance Index: 12.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4450
    Cell Significance Index: 20.7500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.4091
    Cell Significance Index: 7.0100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3143
    Cell Significance Index: 59.8100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2996
    Cell Significance Index: 13.2500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2577
    Cell Significance Index: 30.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1896
    Cell Significance Index: 32.3800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1886
    Cell Significance Index: 7.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1600
    Cell Significance Index: 217.6200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1415
    Cell Significance Index: 266.4300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1366
    Cell Significance Index: 13.5100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1301
    Cell Significance Index: 3.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1201
    Cell Significance Index: 184.9300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1077
    Cell Significance Index: 3.0100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0915
    Cell Significance Index: 6.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0884
    Cell Significance Index: 4.6400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0876
    Cell Significance Index: 1.7100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0732
    Cell Significance Index: 135.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0442
    Cell Significance Index: 28.0600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0216
    Cell Significance Index: 0.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0063
    Cell Significance Index: 0.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0037
    Cell Significance Index: 0.1000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0127
    Cell Significance Index: -9.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0332
    Cell Significance Index: -15.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0466
    Cell Significance Index: -34.5200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0725
    Cell Significance Index: -54.9000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0849
    Cell Significance Index: -53.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1262
    Cell Significance Index: -71.1500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1551
    Cell Significance Index: -10.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1904
    Cell Significance Index: -19.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1937
    Cell Significance Index: -12.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2152
    Cell Significance Index: -45.3200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2647
    Cell Significance Index: -6.9600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2759
    Cell Significance Index: -5.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2854
    Cell Significance Index: -82.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3291
    Cell Significance Index: -47.8400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4061
    Cell Significance Index: -3.7400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4888
    Cell Significance Index: -55.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5421
    Cell Significance Index: -63.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5489
    Cell Significance Index: -62.8800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6748
    Cell Significance Index: -14.6200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.7558
    Cell Significance Index: -16.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7766
    Cell Significance Index: -80.8700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.8160
    Cell Significance Index: -17.0800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.8738
    Cell Significance Index: -22.4600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.9022
    Cell Significance Index: -31.3500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.9354
    Cell Significance Index: -15.6600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9457
    Cell Significance Index: -74.9000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.9956
    Cell Significance Index: -59.7700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.0129
    Cell Significance Index: -25.3200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.0234
    Cell Significance Index: -21.8000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.0626
    Cell Significance Index: -13.2500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.0848
    Cell Significance Index: -14.8000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -1.2856
    Cell Significance Index: -18.4900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.3222
    Cell Significance Index: -35.3700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.3921
    Cell Significance Index: -10.7300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.3962
    Cell Significance Index: -85.6000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.4201
    Cell Significance Index: -30.3600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.4848
    Cell Significance Index: -18.7400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.4887
    Cell Significance Index: -43.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Microtubule Motor Protein:** DYNC1H1 is a heavy chain subunit of the cytoplasmic dynein complex, which is a microtubule motor protein responsible for minus-end-directed movement along microtubules. 2. **Cellular Localization:** DYNC1H1 is primarily localized to the cytoplasm, where it interacts with other dynein complex subunits to regulate microtubule dynamics and transport. 3. **Expression Pattern:** DYNC1H1 is highly expressed in neurons, immune cells, and epithelial cells, suggesting its involvement in various cellular processes, including neuronal function, immune response, and epithelial homeostasis. 4. **Regulatory Interactions:** DYNC1H1 interacts with other proteins to regulate the function and localization of the dynein complex, including the microtubule-associated proteins, dynactin, and the microtubule-binding protein, dynein-binding protein 1. **Pathways and Functions:** 1. **Microtubule Dynamics:** DYNC1H1 regulates microtubule dynamics by interacting with microtubules and other dynein complex subunits to modulate microtubule assembly, disassembly, and transport. 2. **Cell Division:** DYNC1H1 plays a crucial role in regulating the spindle checkpoint, ensuring proper chromosome segregation and mitotic progression. 3. **Intracellular Signaling:** DYNC1H1 is involved in various signaling pathways, including the regulation of the mitotic spindle checkpoint, the G2/M transition, and the regulation of Plk1 activity. 4. **Autophagy and Stress Response:** DYNC1H1 is involved in the regulation of autophagy and the stress response, highlighting its role in maintaining cellular homeostasis under adverse conditions. **Clinical Significance:** 1. **Cancer:** Alterations in DYNC1H1 expression and function have been implicated in various cancers, including glioblastoma, where it is associated with poor prognosis and aggressive disease. 2. **Neurodegenerative Diseases:** DYNC1H1 mutations have been linked to neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), highlighting its role in maintaining neuronal function and integrity. 3. **Immunological Disorders:** DYNC1H1 is involved in the regulation of immune responses, and alterations in its expression and function have been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. In conclusion, DYNC1H1 is a crucial component of the cytoplasmic dynein complex, playing a pivotal role in regulating microtubule dynamics, cell division, and intracellular signaling. Its widespread expression in various cell types and its involvement in various diseases highlight its importance in maintaining cellular homeostasis and responding to environmental cues. Further research is needed to elucidate the mechanisms underlying DYNC1H1 function and its role in disease pathology.

Genular Protein ID: 2796938496

Symbol: DYHC1_HUMAN

Name: Cytoplasmic dynein 1 heavy chain 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9205841

Title: Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9205841

DOI: 10.1093/dnares/4.2.141

PubMed ID: 8666668

Title: Mammalian cells express three distinct dynein heavy chains that are localized to different cytoplasmic organelles.

PubMed ID: 8666668

DOI: 10.1083/jcb.133.4.831

PubMed ID: 8227145

Title: Cytoplasmic dynein plays a role in mammalian mitotic spindle formation.

PubMed ID: 8227145

DOI: 10.1083/jcb.123.4.849

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27462074

Title: Nuclear mitotic apparatus (NuMA) interacts with and regulates astrin at the mitotic spindle.

PubMed ID: 27462074

DOI: 10.1074/jbc.m116.724831

PubMed ID: 31092558

Title: Rab46 integrates Ca2+ and histamine signaling to regulate selective cargo release from Weibel-Palade bodies.

PubMed ID: 31092558

DOI: 10.1083/jcb.201810118

PubMed ID: 29420470

Title: Cryo-EM shows how dynactin recruits two dyneins for faster movement.

PubMed ID: 29420470

DOI: 10.1038/nature25462

PubMed ID: 36071160

Title: Structure of dynein-dynactin on microtubules shows tandem adaptor binding.

PubMed ID: 36071160

DOI: 10.1038/s41586-022-05186-y

PubMed ID: 21076407

Title: A de novo paradigm for mental retardation.

PubMed ID: 21076407

DOI: 10.1038/ng.712

PubMed ID: 21820100

Title: Exome sequencing identifies a DYNC1H1 mutation in a large pedigree with dominant axonal Charcot-Marie-Tooth disease.

PubMed ID: 21820100

DOI: 10.1016/j.ajhg.2011.07.002

PubMed ID: 22368300

Title: Mutations in DYNC1H1 cause severe intellectual disability with neuronal migration defects.

PubMed ID: 22368300

DOI: 10.1136/jmedgenet-2011-100542

PubMed ID: 22847149

Title: A DYNC1H1 mutation causes a dominant spinal muscular atrophy with lower extremity predominance.

PubMed ID: 22847149

DOI: 10.1007/s10048-012-0337-6

PubMed ID: 22459677

Title: Mutations in the tail domain of DYNC1H1 cause dominant spinal muscular atrophy.

PubMed ID: 22459677

DOI: 10.1212/wnl.0b013e3182556c05

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

PubMed ID: 23603762

Title: Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly.

PubMed ID: 23603762

DOI: 10.1038/ng.2613

PubMed ID: 25512093

Title: Novel mutations in the DYNC1H1 tail domain refine the genetic and clinical spectrum of dyneinopathies.

PubMed ID: 25512093

DOI: 10.1002/humu.22744

PubMed ID: 24307404

Title: Novel dynein DYNC1H1 neck and motor domain mutations link distal spinal muscular atrophy and abnormal cortical development.

PubMed ID: 24307404

DOI: 10.1002/humu.22491

PubMed ID: 25484024

Title: Exome Sequencing Identifies DYNC1H1 Variant Associated With Vertebral Abnormality and Spinal Muscular Atrophy With Lower Extremity Predominance.

PubMed ID: 25484024

DOI: 10.1016/j.pediatrneurol.2014.09.003

PubMed ID: 26846447

Title: Identification of a de novo DYNC1H1 mutation via WES according to published guidelines.

PubMed ID: 26846447

DOI: 10.1038/srep20423

PubMed ID: 28193117

Title: Exome Sequencing Identifies De Novo DYNC1H1 Mutations Associated With Distal Spinal Muscular Atrophy and Malformations of Cortical Development.

PubMed ID: 28193117

DOI: 10.1177/0883073816683083

Sequence Information:

  • Length: 4646
  • Mass: 532408
  • Checksum: D4D4E15DFBDE4797
  • Sequence:
  • MSEPGGGGGE DGSAGLEVSA VQNVADVSVL QKHLRKLVPL LLEDGGEAPA ALEAALEEKS 
    ALEQMRKFLS DPQVHTVLVE RSTLKEDVGD EGEEEKEFIS YNINIDIHYG VKSNSLAFIK 
    RTPVIDADKP VSSQLRVLTL SEDSPYETLH SFISNAVAPF FKSYIRESGK ADRDGDKMAP 
    SVEKKIAELE MGLLHLQQNI EIPEISLPIH PMITNVAKQC YERGEKPKVT DFGDKVEDPT 
    FLNQLQSGVN RWIREIQKVT KLDRDPASGT ALQEISFWLN LERALYRIQE KRESPEVLLT 
    LDILKHGKRF HATVSFDTDT GLKQALETVN DYNPLMKDFP LNDLLSATEL DKIRQALVAI 
    FTHLRKIRNT KYPIQRALRL VEAISRDLSS QLLKVLGTRK LMHVAYEEFE KVMVACFEVF 
    QTWDDEYEKL QVLLRDIVKR KREENLKMVW RINPAHRKLQ ARLDQMRKFR RQHEQLRAVI 
    VRVLRPQVTA VAQQNQGEVP EPQDMKVAEV LFDAADANAI EEVNLAYENV KEVDGLDVSK 
    EGTEAWEAAM KRYDERIDRV ETRITARLRD QLGTAKNANE MFRIFSRFNA LFVRPHIRGA 
    IREYQTQLIQ RVKDDIESLH DKFKVQYPQS QACKMSHVRD LPPVSGSIIW AKQIDRQLTA 
    YMKRVEDVLG KGWENHVEGQ KLKQDGDSFR MKLNTQEIFD DWARKVQQRN LGVSGRIFTI 
    ESTRVRGRTG NVLKLKVNFL PEIITLSKEV RNLKWLGFRV PLAIVNKAHQ ANQLYPFAIS 
    LIESVRTYER TCEKVEERNT ISLLVAGLKK EVQALIAEGI ALVWESYKLD PYVQRLAETV 
    FNFQEKVDDL LIIEEKIDLE VRSLETCMYD HKTFSEILNR VQKAVDDLNL HSYSNLPIWV 
    NKLDMEIERI LGVRLQAGLR AWTQVLLGQA EDKAEVDMDT DAPQVSHKPG GEPKIKNVVH 
    ELRITNQVIY LNPPIEECRY KLYQEMFAWK MVVLSLPRIQ SQRYQVGVHY ELTEEEKFYR 
    NALTRMPDGP VALEESYSAV MGIVSEVEQY VKVWLQYQCL WDMQAENIYN RLGEDLNKWQ 
    ALLVQIRKAR GTFDNAETKK EFGPVVIDYG KVQSKVNLKY DSWHKEVLSK FGQMLGSNMT 
    EFHSQISKSR QELEQHSVDT ASTSDAVTFI TYVQSLKRKI KQFEKQVELY RNGQRLLEKQ 
    RFQFPPSWLY IDNIEGEWGA FNDIMRRKDS AIQQQVANLQ MKIVQEDRAV ESRTTDLLTD 
    WEKTKPVTGN LRPEEALQAL TIYEGKFGRL KDDREKCAKA KEALELTDTG LLSGSEERVQ 
    VALEELQDLK GVWSELSKVW EQIDQMKEQP WVSVQPRKLR QNLDALLNQL KSFPARLRQY 
    ASYEFVQRLL KGYMKINMLV IELKSEALKD RHWKQLMKRL HVNWVVSELT LGQIWDVDLQ 
    KNEAIVKDVL LVAQGEMALE EFLKQIREVW NTYELDLVNY QNKCRLIRGW DDLFNKVKEH 
    INSVSAMKLS PYYKVFEEDA LSWEDKLNRI MALFDVWIDV QRRWVYLEGI FTGSADIKHL 
    LPVETQRFQS ISTEFLALMK KVSKSPLVMD VLNIQGVQRS LERLADLLGK IQKALGEYLE 
    RERSSFPRFY FVGDEDLLEI IGNSKNVAKL QKHFKKMFAG VSSIILNEDN SVVLGISSRE 
    GEEVMFKTPV SITEHPKINE WLTLVEKEMR VTLAKLLAES VTEVEIFGKA TSIDPNTYIT 
    WIDKYQAQLV VLSAQIAWSE NVETALSSMG GGGDAAPLHS VLSNVEVTLN VLADSVLMEQ 
    PPLRRRKLEH LITELVHQRD VTRSLIKSKI DNAKSFEWLS QMRFYFDPKQ TDVLQQLSIQ 
    MANAKFNYGF EYLGVQDKLV QTPLTDRCYL TMTQALEARL GGSPFGPAGT GKTESVKALG 
    HQLGRFVLVF NCDETFDFQA MGRIFVGLCQ VGAWGCFDEF NRLEERMLSA VSQQVQCIQE 
    ALREHSNPNY DKTSAPITCE LLNKQVKVSP DMAIFITMNP GYAGRSNLPD NLKKLFRSLA 
    MTKPDRQLIA QVMLYSQGFR TAEVLANKIV PFFKLCDEQL SSQSHYDFGL RALKSVLVSA 
    GNVKRERIQK IKREKEERGE AVDEGEIAEN LPEQEILIQS VCETMVPKLV AEDIPLLFSL 
    LSDVFPGVQY HRGEMTALRE ELKKVCQEMY LTYGDGEEVG GMWVEKVLQL YQITQINHGL 
    MMVGPSGSGK SMAWRVLLKA LERLEGVEGV AHIIDPKAIS KDHLYGTLDP NTREWTDGLF 
    THVLRKIIDS VRGELQKRQW IVFDGDVDPE WVENLNSVLD DNKLLTLPNG ERLSLPPNVR 
    IMFEVQDLKY ATLATVSRCG MVWFSEDVLS TDMIFNNFLA RLRSIPLDEG EDEAQRRRKG 
    KEDEGEEAAS PMLQIQRDAA TIMQPYFTSN GLVTKALEHA FQLEHIMDLT RLRCLGSLFS 
    MLHQACRNVA QYNANHPDFP MQIEQLERYI QRYLVYAILW SLSGDSRLKM RAELGEYIRR 
    ITTVPLPTAP NIPIIDYEVS ISGEWSPWQA KVPQIEVETH KVAAPDVVVP TLDTVRHEAL 
    LYTWLAEHKP LVLCGPPGSG KTMTLFSALR ALPDMEVVGL NFSSATTPEL LLKTFDHYCE 
    YRRTPNGVVL APVQLGKWLV LFCDEINLPD MDKYGTQRVI SFIRQMVEHG GFYRTSDQTW 
    VKLERIQFVG ACNPPTDPGR KPLSHRFLRH VPVVYVDYPG PASLTQIYGT FNRAMLRLIP 
    SLRTYAEPLT AAMVEFYTMS QERFTQDTQP HYIYSPREMT RWVRGIFEAL RPLETLPVEG 
    LIRIWAHEAL RLFQDRLVED EERRWTDENI DTVALKHFPN IDREKAMSRP ILYSNWLSKD 
    YIPVDQEELR DYVKARLKVF YEEELDVPLV LFNEVLDHVL RIDRIFRQPQ GHLLLIGVSG 
    AGKTTLSRFV AWMNGLSVYQ IKVHRKYTGE DFDEDLRTVL RRSGCKNEKI AFIMDESNVL 
    DSGFLERMNT LLANGEVPGL FEGDEYATLM TQCKEGAQKE GLMLDSHEEL YKWFTSQVIR 
    NLHVVFTMNP SSEGLKDRAA TSPALFNRCV LNWFGDWSTE ALYQVGKEFT SKMDLEKPNY 
    IVPDYMPVVY DKLPQPPSHR EAIVNSCVFV HQTLHQANAR LAKRGGRTMA ITPRHYLDFI 
    NHYANLFHEK RSELEEQQMH LNVGLRKIKE TVDQVEELRR DLRIKSQELE VKNAAANDKL 
    KKMVKDQQEA EKKKVMSQEI QEQLHKQQEV IADKQMSVKE DLDKVEPAVI EAQNAVKSIK 
    KQHLVEVRSM ANPPAAVKLA LESICLLLGE STTDWKQIRS IIMRENFIPT IVNFSAEEIS 
    DAIREKMKKN YMSNPSYNYE IVNRASLACG PMVKWAIAQL NYADMLKRVE PLRNELQKLE 
    DDAKDNQQKA NEVEQMIRDL EASIARYKEE YAVLISEAQA IKADLAAVEA KVNRSTALLK 
    SLSAERERWE KTSETFKNQM STIAGDCLLS AAFIAYAGYF DQQMRQNLFT TWSHHLQQAN 
    IQFRTDIART EYLSNADERL RWQASSLPAD DLCTENAIML KRFNRYPLII DPSGQATEFI 
    MNEYKDRKIT RTSFLDDAFR KNLESALRFG NPLLVQDVES YDPVLNPVLN REVRRTGGRV 
    LITLGDQDID LSPSFVIFLS TRDPTVEFPP DLCSRVTFVN FTVTRSSLQS QCLNEVLKAE 
    RPDVDEKRSD LLKLQGEFQL RLRQLEKSLL QALNEVKGRI LDDDTIITTL ENLKREAAEV 
    TRKVEETDIV MQEVETVSQQ YLPLSTACSS IYFTMESLKQ IHFLYQYSLQ FFLDIYHNVL 
    YENPNLKGVT DHTQRLSIIT KDLFQVAFNR VARGMLHQDH ITFAMLLARI KLKGTVGEPT 
    YDAEFQHFLR GNEIVLSAGS TPRIQGLTVE QAEAVVRLSC LPAFKDLIAK VQADEQFGIW 
    LDSSSPEQTV PYLWSEETPA TPIGQAIHRL LLIQAFRPDR LLAMAHMFVS TNLGESFMSI 
    MEQPLDLTHI VGTEVKPNTP VLMCSVPGYD ASGHVEDLAA EQNTQITSIA IGSAEGFNQA 
    DKAINTAVKS GRWVMLKNVH LAPGWLMQLE KKLHSLQPHA CFRLFLTMEI NPKVPVNLLR 
    AGRIFVFEPP PGVKANMLRT FSSIPVSRIC KSPNERARLY FLLAWFHAII QERLRYAPLG 
    WSKKYEFGES DLRSACDTVD TWLDDTAKGR QNISPDKIPW SALKTLMAQS IYGGRVDNEF 
    DQRLLNTFLE RLFTTRSFDS EFKLACKVDG HKDIQMPDGI RREEFVQWVE LLPDTQTPSW 
    LGLPNNAERV LLTTQGVDMI SKMLKMQMLE DEDDLAYAET EKKTRTDSTS DGRPAWMRTL 
    HTTASNWLHL IPQTLSHLKR TVENIKDPLF RFFEREVKMG AKLLQDVRQD LADVVQVCEG 
    KKKQTNYLRT LINELVKGIL PRSWSHYTVP AGMTVIQWVS DFSERIKQLQ NISLAAASGG 
    AKELKNIHVC LGGLFVPEAY ITATRQYVAQ ANSWSLEELC LEVNVTTSQG ATLDACSFGV 
    TGLKLQGATC NNNKLSLSNA ISTALPLTQL RWVKQTNTEK KASVVTLPVY LNFTRADLIF 
    TVDFEIATKE DPRSFYERGV AVLCTE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.