Details for: EEF1A1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 2037.5424
Cell Significance Index: -316.9300 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 1222.0307
Cell Significance Index: -309.9600 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 980.3188
Cell Significance Index: -403.8400 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 937.1036
Cell Significance Index: -380.7100 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 840.8408
Cell Significance Index: -396.9800 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 800.0230
Cell Significance Index: -411.5200 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 594.4066
Cell Significance Index: -398.8600 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 405.1929
Cell Significance Index: -386.8600 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 290.0428
Cell Significance Index: -357.6100 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 100.9161
Cell Significance Index: -398.2200 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 95.1243
Cell Significance Index: -292.1700 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 54.5237
Cell Significance Index: -119.3300 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 50.9694
Cell Significance Index: -136.5400 - Cell Name: hepatic pit cell (CL2000054)
Fold Change: 25.7477
Cell Significance Index: 68.9800 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 16.4358
Cell Significance Index: 210.4900 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 16.0949
Cell Significance Index: 559.2900 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 15.6259
Cell Significance Index: 734.4000 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 13.9110
Cell Significance Index: 158.0400 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 13.2849
Cell Significance Index: 278.0800 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 13.2381
Cell Significance Index: 1048.4600 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 13.2127
Cell Significance Index: 378.7500 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 12.8502
Cell Significance Index: 237.5100 - Cell Name: granulosa cell (CL0000501)
Fold Change: 12.5275
Cell Significance Index: 329.4100 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 12.1270
Cell Significance Index: 214.3000 - Cell Name: lactocyte (CL0002325)
Fold Change: 11.6049
Cell Significance Index: 1499.2800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 11.3600
Cell Significance Index: 1396.8200 - Cell Name: peg cell (CL4033014)
Fold Change: 11.2059
Cell Significance Index: 258.9000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 11.1855
Cell Significance Index: 2016.4000 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 10.7344
Cell Significance Index: 500.4900 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 10.2458
Cell Significance Index: 763.6100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 9.8845
Cell Significance Index: 1165.6800 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 9.8707
Cell Significance Index: 4364.0700 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 9.7706
Cell Significance Index: 691.0200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 9.7211
Cell Significance Index: 1334.9800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 9.3864
Cell Significance Index: 7104.7300 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 8.9205
Cell Significance Index: 1018.2700 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 8.6751
Cell Significance Index: 451.8800 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 8.5590
Cell Significance Index: 552.1800 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 8.1791
Cell Significance Index: 240.2100 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 8.1663
Cell Significance Index: 222.2800 - Cell Name: odontoblast (CL0000060)
Fold Change: 8.1555
Cell Significance Index: 1045.4900 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 7.9751
Cell Significance Index: 86.7000 - Cell Name: cell in vitro (CL0001034)
Fold Change: 7.6910
Cell Significance Index: 4200.2400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 7.5085
Cell Significance Index: 394.2300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 6.3997
Cell Significance Index: 1092.7800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 5.0484
Cell Significance Index: 3701.4700 - Cell Name: seromucus secreting cell (CL0000159)
Fold Change: 4.9075
Cell Significance Index: 102.3500 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 4.1378
Cell Significance Index: 232.1900 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 3.9560
Cell Significance Index: 105.6300 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 3.9202
Cell Significance Index: 36.1000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 3.2727
Cell Significance Index: 2954.9900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 3.0996
Cell Significance Index: 615.1300 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 3.0000
Cell Significance Index: 18.4600 - Cell Name: kidney cell (CL1000497)
Fold Change: 1.9889
Cell Significance Index: 15.8800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.3185
Cell Significance Index: 250.9200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.9160
Cell Significance Index: 328.5400 - Cell Name: theca cell (CL0000503)
Fold Change: 0.7991
Cell Significance Index: 4.6900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.7824
Cell Significance Index: 156.9500 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.5023
Cell Significance Index: 12.5600 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.2695
Cell Significance Index: 4.5100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.2690
Cell Significance Index: 16.5400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0139
Cell Significance Index: 26.1400 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0604
Cell Significance Index: -6.1700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.1335
Cell Significance Index: -246.2400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.1608
Cell Significance Index: -119.1000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.2080
Cell Significance Index: -320.2600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.2716
Cell Significance Index: -369.2600 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2888
Cell Significance Index: -15.0000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.3303
Cell Significance Index: -206.2800 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.3811
Cell Significance Index: -242.0600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.4971
Cell Significance Index: -280.3700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.6858
Cell Significance Index: -311.2700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.7990
Cell Significance Index: -79.0400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.7992
Cell Significance Index: -168.3300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -1.2773
Cell Significance Index: -367.5300 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -1.7773
Cell Significance Index: -289.0700 - Cell Name: pro-T cell (CL0000827)
Fold Change: -1.8707
Cell Significance Index: -47.7900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -2.1782
Cell Significance Index: -316.6300 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -2.2032
Cell Significance Index: -37.9800 - Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: -2.2216
Cell Significance Index: -19.0900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -2.2325
Cell Significance Index: -255.7700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -2.2765
Cell Significance Index: -63.6200 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -2.3202
Cell Significance Index: -270.4000 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -2.3311
Cell Significance Index: -146.9200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -3.1022
Cell Significance Index: -99.3600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -3.6256
Cell Significance Index: -377.5100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -4.0043
Cell Significance Index: -181.5000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -4.6869
Cell Significance Index: -315.1500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -4.7576
Cell Significance Index: -167.1800 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -5.0098
Cell Significance Index: -346.4600 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -5.1656
Cell Significance Index: -396.4000 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: -5.3872
Cell Significance Index: -38.6900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -5.6239
Cell Significance Index: -76.7300 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -5.6321
Cell Significance Index: -345.3000 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -6.1452
Cell Significance Index: -133.1400 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -7.1179
Cell Significance Index: -190.4000 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -7.7958
Cell Significance Index: -229.6200 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -8.1320
Cell Significance Index: -121.8500 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: -8.1444
Cell Significance Index: -44.4100 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -8.3369
Cell Significance Index: -50.3700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3442682903
Symbol: EF1A1_HUMAN
Name: Elongation factor 1-alpha 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3512269
Title: The primary structure of the alpha subunit of human elongation factor 1. Structural aspects of guanine-nucleotide-binding sites.
PubMed ID: 3512269
PubMed ID: 2564392
Title: Isolation and characterization of the human chromosomal gene for polypeptide chain elongation factor-1 alpha.
PubMed ID: 2564392
PubMed ID: 2183196
Title: Retropseudogenes constitute the major part of the human elongation factor 1 alpha gene family.
PubMed ID: 2183196
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 3960725
Title: Structure of the amino-terminal end of mammalian elongation factor Tu.
PubMed ID: 3960725
PubMed ID: 17177976
Title: Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells.
PubMed ID: 17177976
PubMed ID: 3346208
Title: Retinol-regulated gene expression in human tracheobronchial epithelial cells. Enhanced expression of elongation factor EF-1 alpha.
PubMed ID: 3346208
PubMed ID: 2569467
Title: Murine elongation factor 1 alpha (EF-1 alpha) is posttranslationally modified by novel amide-linked ethanolamine-phosphoglycerol moieties. Addition of ethanolamine-phosphoglycerol to specific glutamic acid residues on EF-1 alpha.
PubMed ID: 2569467
PubMed ID: 8650580
Title: Binding of zinc finger protein ZPR1 to the epidermal growth factor receptor.
PubMed ID: 8650580
PubMed ID: 9677419
Title: Induction of acute translational response genes by homocysteine. Elongation factors-1alpha, -beta, and -delta.
PubMed ID: 9677419
PubMed ID: 12426392
Title: Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm.
PubMed ID: 12426392
DOI: 10.1093/emboj/cdf613
PubMed ID: 12426393
Title: Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA.
PubMed ID: 12426393
DOI: 10.1093/emboj/cdf620
PubMed ID: 16139798
Title: Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.
PubMed ID: 16139798
PubMed ID: 17595531
Title: Male germ cell expression of the PAS domain kinase PASKIN and its novel target eukaryotic translation elongation factor eEF1A1.
PubMed ID: 17595531
DOI: 10.1159/000104169
PubMed ID: 18029264
Title: Lysyl-tRNA synthetase interacts with EF1alpha, aspartyl-tRNA synthetase and p38 in vitro.
PubMed ID: 18029264
PubMed ID: 17980171
Title: The possible interaction of CDA14 and protein elongation factor 1alpha.
PubMed ID: 17980171
PubMed ID: 18263879
Title: Eukaryotic elongation factor 1A interacts with sphingosine kinase and directly enhances its catalytic activity.
PubMed ID: 18263879
PubMed ID: 19158340
Title: The SAM domain of the RhoGAP DLC1 binds EF1A1 to regulate cell migration.
PubMed ID: 19158340
DOI: 10.1242/jcs.027482
PubMed ID: 20832312
Title: Phosphorylation of eEF1A1 at Ser300 by TbetaR-I results in inhibition of mRNA translation.
PubMed ID: 20832312
PubMed ID: 25144183
Title: Selenium-based S-adenosylmethionine analog reveals the mammalian seven-beta-strand methyltransferase METTL10 to be an EF1A1 lysine methyltransferase.
PubMed ID: 25144183
PubMed ID: 26651998
Title: Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex.
PubMed ID: 26651998
DOI: 10.7554/elife.10222
PubMed ID: 26497934
Title: Elongation factor-1A1 is a novel substrate of the protein phosphatase 1-TIMAP complex.
PubMed ID: 26497934
PubMed ID: 26593721
Title: Functional dynamics within the human ribosome regulate the rate of active protein synthesis.
PubMed ID: 26593721
PubMed ID: 26545399
Title: Novel N-terminal and lysine methyltransferases that target translation elongation factor 1A in yeast and human.
PubMed ID: 26545399
PubMed ID: 28108655
Title: The novel lysine specific methyltransferase METTL21B affects mRNA translation through inducible and dynamic methylation of Lys-165 in human eukaryotic elongation factor 1 alpha (eEF1A).
PubMed ID: 28108655
DOI: 10.1093/nar/gkx002
PubMed ID: 28520920
Title: Methylation of human eukaryotic elongation factor alpha (eEF1A) by a member of a novel protein lysine methyltransferase family modulates mRNA translation.
PubMed ID: 28520920
DOI: 10.1093/nar/gkx432
PubMed ID: 30612740
Title: METTL13 methylation of eEF1A increases translational output to promote tumorigenesis.
PubMed ID: 30612740
PubMed ID: 30143613
Title: The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates.
PubMed ID: 30143613
PubMed ID: 33495306
Title: Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A.
PubMed ID: 33495306
PubMed ID: 36264623
Title: Didemnin B and ternatin-4 differentially inhibit conformational changes in eEF1A required for aminoacyl-tRNA accommodation into mammalian ribosomes.
PubMed ID: 36264623
DOI: 10.7554/elife.81608
PubMed ID: 36123449
Title: Synthesis and single-molecule imaging reveal stereospecific enhancement of binding kinetics by the antitumour eEF1A antagonist SR-A3.
PubMed ID: 36123449
PubMed ID: 36638793
Title: An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes.
PubMed ID: 36638793
Sequence Information:
- Length: 462
- Mass: 50141
- Checksum: D465615545AF686A
- Sequence:
MGKEKTHINI VVIGHVDSGK STTTGHLIYK CGGIDKRTIE KFEKEAAEMG KGSFKYAWVL DKLKAERERG ITIDISLWKF ETSKYYVTII DAPGHRDFIK NMITGTSQAD CAVLIVAAGV GEFEAGISKN GQTREHALLA YTLGVKQLIV GVNKMDSTEP PYSQKRYEEI VKEVSTYIKK IGYNPDTVAF VPISGWNGDN MLEPSANMPW FKGWKVTRKD GNASGTTLLE ALDCILPPTR PTDKPLRLPL QDVYKIGGIG TVPVGRVETG VLKPGMVVTF APVNVTTEVK SVEMHHEALS EALPGDNVGF NVKNVSVKDV RRGNVAGDSK NDPPMEAAGF TAQVIILNHP GQISAGYAPV LDCHTAHIAC KFAELKEKID RRSGKKLEDG PKFLKSGDAA IVDMVPGKPM CVESFSDYPP LGRFAVRDMR QTVAVGVIKA VDKKAAGAGK VTKSAQKAQK AK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.