Details for: EEF1A1

Gene ID: 1915

Symbol: EEF1A1

Ensembl ID: ENSG00000156508

Description: eukaryotic translation elongation factor 1 alpha 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 2037.5424
    Cell Significance Index: -316.9300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 1222.0307
    Cell Significance Index: -309.9600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 980.3188
    Cell Significance Index: -403.8400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 937.1036
    Cell Significance Index: -380.7100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 840.8408
    Cell Significance Index: -396.9800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 800.0230
    Cell Significance Index: -411.5200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 594.4066
    Cell Significance Index: -398.8600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 405.1929
    Cell Significance Index: -386.8600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 290.0428
    Cell Significance Index: -357.6100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 100.9161
    Cell Significance Index: -398.2200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 95.1243
    Cell Significance Index: -292.1700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 54.5237
    Cell Significance Index: -119.3300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 50.9694
    Cell Significance Index: -136.5400
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 25.7477
    Cell Significance Index: 68.9800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 16.4358
    Cell Significance Index: 210.4900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 16.0949
    Cell Significance Index: 559.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 15.6259
    Cell Significance Index: 734.4000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 13.9110
    Cell Significance Index: 158.0400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 13.2849
    Cell Significance Index: 278.0800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 13.2381
    Cell Significance Index: 1048.4600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 13.2127
    Cell Significance Index: 378.7500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 12.8502
    Cell Significance Index: 237.5100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 12.5275
    Cell Significance Index: 329.4100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 12.1270
    Cell Significance Index: 214.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 11.6049
    Cell Significance Index: 1499.2800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 11.3600
    Cell Significance Index: 1396.8200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 11.2059
    Cell Significance Index: 258.9000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 11.1855
    Cell Significance Index: 2016.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 10.7344
    Cell Significance Index: 500.4900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 10.2458
    Cell Significance Index: 763.6100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 9.8845
    Cell Significance Index: 1165.6800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 9.8707
    Cell Significance Index: 4364.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 9.7706
    Cell Significance Index: 691.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 9.7211
    Cell Significance Index: 1334.9800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 9.3864
    Cell Significance Index: 7104.7300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 8.9205
    Cell Significance Index: 1018.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 8.6751
    Cell Significance Index: 451.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 8.5590
    Cell Significance Index: 552.1800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 8.1791
    Cell Significance Index: 240.2100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 8.1663
    Cell Significance Index: 222.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 8.1555
    Cell Significance Index: 1045.4900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 7.9751
    Cell Significance Index: 86.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 7.6910
    Cell Significance Index: 4200.2400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 7.5085
    Cell Significance Index: 394.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 6.3997
    Cell Significance Index: 1092.7800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 5.0484
    Cell Significance Index: 3701.4700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 4.9075
    Cell Significance Index: 102.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 4.1378
    Cell Significance Index: 232.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.9560
    Cell Significance Index: 105.6300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.9202
    Cell Significance Index: 36.1000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 3.2727
    Cell Significance Index: 2954.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.0996
    Cell Significance Index: 615.1300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.0000
    Cell Significance Index: 18.4600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.9889
    Cell Significance Index: 15.8800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3185
    Cell Significance Index: 250.9200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9160
    Cell Significance Index: 328.5400
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.7991
    Cell Significance Index: 4.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7824
    Cell Significance Index: 156.9500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5023
    Cell Significance Index: 12.5600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.2695
    Cell Significance Index: 4.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2690
    Cell Significance Index: 16.5400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0139
    Cell Significance Index: 26.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0604
    Cell Significance Index: -6.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1335
    Cell Significance Index: -246.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1608
    Cell Significance Index: -119.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.2080
    Cell Significance Index: -320.2600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2716
    Cell Significance Index: -369.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2888
    Cell Significance Index: -15.0000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.3303
    Cell Significance Index: -206.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3811
    Cell Significance Index: -242.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.4971
    Cell Significance Index: -280.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.6858
    Cell Significance Index: -311.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.7990
    Cell Significance Index: -79.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.7992
    Cell Significance Index: -168.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -1.2773
    Cell Significance Index: -367.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -1.7773
    Cell Significance Index: -289.0700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.8707
    Cell Significance Index: -47.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -2.1782
    Cell Significance Index: -316.6300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -2.2032
    Cell Significance Index: -37.9800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -2.2216
    Cell Significance Index: -19.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -2.2325
    Cell Significance Index: -255.7700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -2.2765
    Cell Significance Index: -63.6200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -2.3202
    Cell Significance Index: -270.4000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.3311
    Cell Significance Index: -146.9200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -3.1022
    Cell Significance Index: -99.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -3.6256
    Cell Significance Index: -377.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -4.0043
    Cell Significance Index: -181.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -4.6869
    Cell Significance Index: -315.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -4.7576
    Cell Significance Index: -167.1800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -5.0098
    Cell Significance Index: -346.4600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -5.1656
    Cell Significance Index: -396.4000
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -5.3872
    Cell Significance Index: -38.6900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -5.6239
    Cell Significance Index: -76.7300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -5.6321
    Cell Significance Index: -345.3000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -6.1452
    Cell Significance Index: -133.1400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -7.1179
    Cell Significance Index: -190.4000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -7.7958
    Cell Significance Index: -229.6200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -8.1320
    Cell Significance Index: -121.8500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -8.1444
    Cell Significance Index: -44.4100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -8.3369
    Cell Significance Index: -50.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The EEF1A1 gene is a single-copy gene located on chromosome 11q12.2-q13.1. It is highly expressed in various cell types, including secretory cells, immune cells, and cancer cells. The protein product of this gene, eEF1A1, is a 38-kDa protein that belongs to the elongation factor 1 complex (EF1C). It is a GTPase-bound protein that interacts with ribosomes, translation initiation factors, and other proteins to facilitate the translation process. **Pathways and Functions:** EEF1A1 plays a central role in the following cellular processes: 1. **Eukaryotic Translation Elongation:** EEF1A1 is essential for the elongation phase of protein synthesis, where it facilitates the translocation of ribosomes along the mRNA and the assembly of amino acids into polypeptide chains. 2. **Autophagy:** EEF1A1 is involved in the regulation of chaperone-mediated autophagy, a process by which damaged or dysfunctional proteins are degraded by autophagosomes. 3. **Stress Response:** EEF1A1 is activated in response to heat shock, allowing cells to rapidly translate proteins involved in stress response and survival. 4. **Immune System Regulation:** EEF1A1 is expressed in immune cells and is involved in the regulation of neutrophil degranulation, a process that is critical for the clearance of pathogens. 5. **Cellular Response to Viral Infections:** EEF1A1 is modulated by SARS-CoV-1, a coronavirus that causes severe respiratory illness. **Clinical Significance:** Dysregulation of the EEF1A1 gene has been implicated in various diseases, including: 1. **Cancer:** Overexpression of EEF1A1 has been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Infectious Diseases:** EEF1A1 has been shown to be modulated by SARS-CoV-1, suggesting that it plays a role in the regulation of the host translation machinery during viral infections. 3. **Neurodegenerative Disorders:** EEF1A1 has been implicated in the regulation of protein homeostasis in neurons, suggesting that it may play a role in the pathogenesis of neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. In conclusion, the EEF1A1 gene is a critical component of eukaryotic translation elongation and plays a broader role in various cellular processes, including autophagy, stress response, and immune system regulation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and regulation of this gene.

Genular Protein ID: 3442682903

Symbol: EF1A1_HUMAN

Name: Elongation factor 1-alpha 1

UniProtKB Accession Codes:

P68104 P04719 P04720 Q6IQ15

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 EMBL 22 EMDB 3 Ensembl 10 ExpressionAtlas 1 GO 31 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 MoonProt 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 7 RefSeq 2 Rhea 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3512269

Title: The primary structure of the alpha subunit of human elongation factor 1. Structural aspects of guanine-nucleotide-binding sites.

PubMed ID: 3512269

DOI: 10.1111/j.1432-1033.1986.tb09472.x

PubMed ID: 2564392

Title: Isolation and characterization of the human chromosomal gene for polypeptide chain elongation factor-1 alpha.

PubMed ID: 2564392

DOI: 10.1016/s0021-9258(18)83619-5

PubMed ID: 2183196

Title: Retropseudogenes constitute the major part of the human elongation factor 1 alpha gene family.

PubMed ID: 2183196

DOI: 10.1093/nar/18.6.1513

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3960725

Title: Structure of the amino-terminal end of mammalian elongation factor Tu.

PubMed ID: 3960725

DOI: 10.1093/nar/14.5.2409

PubMed ID: 17177976

Title: Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells.

PubMed ID: 17177976

DOI: 10.1111/j.1365-2249.2006.03249.x

PubMed ID: 3346208

Title: Retinol-regulated gene expression in human tracheobronchial epithelial cells. Enhanced expression of elongation factor EF-1 alpha.

PubMed ID: 3346208

DOI: 10.1016/s0021-9258(18)68958-6

PubMed ID: 2569467

Title: Murine elongation factor 1 alpha (EF-1 alpha) is posttranslationally modified by novel amide-linked ethanolamine-phosphoglycerol moieties. Addition of ethanolamine-phosphoglycerol to specific glutamic acid residues on EF-1 alpha.

PubMed ID: 2569467

DOI: 10.1016/s0021-9258(18)71682-7

PubMed ID: 8650580

Title: Binding of zinc finger protein ZPR1 to the epidermal growth factor receptor.

PubMed ID: 8650580

DOI: 10.1126/science.272.5269.1797

PubMed ID: 9677419

Title: Induction of acute translational response genes by homocysteine. Elongation factors-1alpha, -beta, and -delta.

PubMed ID: 9677419

DOI: 10.1074/jbc.273.31.19840

PubMed ID: 12426392

Title: Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm.

PubMed ID: 12426392

DOI: 10.1093/emboj/cdf613

PubMed ID: 12426393

Title: Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA.

PubMed ID: 12426393

DOI: 10.1093/emboj/cdf620

PubMed ID: 16139798

Title: Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.

PubMed ID: 16139798

DOI: 10.1016/j.bbrc.2005.08.132

PubMed ID: 17595531

Title: Male germ cell expression of the PAS domain kinase PASKIN and its novel target eukaryotic translation elongation factor eEF1A1.

PubMed ID: 17595531

DOI: 10.1159/000104169

PubMed ID: 18029264

Title: Lysyl-tRNA synthetase interacts with EF1alpha, aspartyl-tRNA synthetase and p38 in vitro.

PubMed ID: 18029264

DOI: 10.1016/j.bbrc.2007.11.028

PubMed ID: 17980171

Title: The possible interaction of CDA14 and protein elongation factor 1alpha.

PubMed ID: 17980171

DOI: 10.1016/j.bbapap.2007.10.006

PubMed ID: 18263879

Title: Eukaryotic elongation factor 1A interacts with sphingosine kinase and directly enhances its catalytic activity.

PubMed ID: 18263879

DOI: 10.1074/jbc.m708782200

PubMed ID: 19158340

Title: The SAM domain of the RhoGAP DLC1 binds EF1A1 to regulate cell migration.

PubMed ID: 19158340

DOI: 10.1242/jcs.027482

PubMed ID: 20832312

Title: Phosphorylation of eEF1A1 at Ser300 by TbetaR-I results in inhibition of mRNA translation.

PubMed ID: 20832312

DOI: 10.1016/j.cub.2010.08.017

PubMed ID: 25144183

Title: Selenium-based S-adenosylmethionine analog reveals the mammalian seven-beta-strand methyltransferase METTL10 to be an EF1A1 lysine methyltransferase.

PubMed ID: 25144183

DOI: 10.1371/journal.pone.0105394

PubMed ID: 26651998

Title: Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex.

PubMed ID: 26651998

DOI: 10.7554/elife.10222

PubMed ID: 26497934

Title: Elongation factor-1A1 is a novel substrate of the protein phosphatase 1-TIMAP complex.

PubMed ID: 26497934

DOI: 10.1016/j.biocel.2015.10.021

PubMed ID: 26593721

Title: Functional dynamics within the human ribosome regulate the rate of active protein synthesis.

PubMed ID: 26593721

DOI: 10.1016/j.molcel.2015.09.013

PubMed ID: 26545399

Title: Novel N-terminal and lysine methyltransferases that target translation elongation factor 1A in yeast and human.

PubMed ID: 26545399

DOI: 10.1074/mcp.m115.052449

PubMed ID: 28108655

Title: The novel lysine specific methyltransferase METTL21B affects mRNA translation through inducible and dynamic methylation of Lys-165 in human eukaryotic elongation factor 1 alpha (eEF1A).

PubMed ID: 28108655

DOI: 10.1093/nar/gkx002

PubMed ID: 28520920

Title: Methylation of human eukaryotic elongation factor alpha (eEF1A) by a member of a novel protein lysine methyltransferase family modulates mRNA translation.

PubMed ID: 28520920

DOI: 10.1093/nar/gkx432

PubMed ID: 30612740

Title: METTL13 methylation of eEF1A increases translational output to promote tumorigenesis.

PubMed ID: 30612740

DOI: 10.1016/j.cell.2018.11.038

PubMed ID: 30143613

Title: The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates.

PubMed ID: 30143613

DOI: 10.1038/s41467-018-05646-y

PubMed ID: 33495306

Title: Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A.

PubMed ID: 33495306

DOI: 10.1126/science.abf4058

PubMed ID: 36264623

Title: Didemnin B and ternatin-4 differentially inhibit conformational changes in eEF1A required for aminoacyl-tRNA accommodation into mammalian ribosomes.

PubMed ID: 36264623

DOI: 10.7554/elife.81608

PubMed ID: 36123449

Title: Synthesis and single-molecule imaging reveal stereospecific enhancement of binding kinetics by the antitumour eEF1A antagonist SR-A3.

PubMed ID: 36123449

DOI: 10.1038/s41557-022-01039-3

PubMed ID: 36638793

Title: An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes.

PubMed ID: 36638793

DOI: 10.1016/j.cell.2022.12.025

Sequence Information:

  • Length: 462
  • Mass: 50141
  • Checksum: D465615545AF686A
  • Sequence:
    • MGKEKTHINI VVIGHVDSGK STTTGHLIYK CGGIDKRTIE KFEKEAAEMG KGSFKYAWVL 
DKLKAERERG ITIDISLWKF ETSKYYVTII DAPGHRDFIK NMITGTSQAD CAVLIVAAGV 
GEFEAGISKN GQTREHALLA YTLGVKQLIV GVNKMDSTEP PYSQKRYEEI VKEVSTYIKK 
IGYNPDTVAF VPISGWNGDN MLEPSANMPW FKGWKVTRKD GNASGTTLLE ALDCILPPTR 
PTDKPLRLPL QDVYKIGGIG TVPVGRVETG VLKPGMVVTF APVNVTTEVK SVEMHHEALS 
EALPGDNVGF NVKNVSVKDV RRGNVAGDSK NDPPMEAAGF TAQVIILNHP GQISAGYAPV 
LDCHTAHIAC KFAELKEKID RRSGKKLEDG PKFLKSGDAA IVDMVPGKPM CVESFSDYPP 
LGRFAVRDMR QTVAVGVIKA VDKKAAGAGK VTKSAQKAQK AK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.