Gene EIF4A2 - ENSG00000156976 | NCBI Gene ID: 1974

Details for: EIF4A2

Gene ID: 1974

Symbol: EIF4A2

Ensembl ID: ENSG00000156976

Description: eukaryotic translation initiation factor 4A2

Associated with

Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
(R-HSA-72662)
Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Cap-dependent translation initiation
(R-HSA-72737)
Cytokine signaling in immune system
(R-HSA-1280215)
Deadenylation-dependent mrna decay
(R-HSA-429914)
Deadenylation of mrna
(R-HSA-429947)
Developmental biology
(R-HSA-1266738)
Eukaryotic translation initiation
(R-HSA-72613)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Immune system
(R-HSA-168256)
Interferon signaling
(R-HSA-913531)
Isg15 antiviral mechanism
(R-HSA-1169408)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
M-decay: degradation of maternal mrnas by maternally stored factors
(R-HSA-9820841)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Ribosomal scanning and start codon recognition
(R-HSA-72702)
Translation
(R-HSA-72766)
Translation initiation complex formation
(R-HSA-72649)
Z-decay: degradation of maternal mrnas by zygotically expressed factors
(R-HSA-9820865)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Cellular response to leukemia inhibitory factor
(GO:1990830)
Cytoplasmic translational initiation
(GO:0002183)
Cytosol
(GO:0005829)
Eukaryotic translation initiation factor 4f complex
(GO:0016281)
Helicase activity
(GO:0004386)
Negative regulation of rna-dependent rna polymerase activity
(GO:1900260)
Perinuclear region of cytoplasm
(GO:0048471)
Protein binding
(GO:0005515)
Regulation of translational initiation
(GO:0006446)
Rna binding
(GO:0003723)
Rna helicase activity
(GO:0003724)
Translational initiation
(GO:0006413)
Translation initiation factor activity
(GO:0003743)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: glycinergic neuron (CL1001509)
Fold Change: 4.47
Marker Score: 5393.5
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.36
Marker Score: 148232
Cell Name: theca cell (CL0000503)
Fold Change: 4.14
Marker Score: 2967
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 4.11
Marker Score: 3215
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 4.1
Marker Score: 3865.5
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 4.02
Marker Score: 6194
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 3.99
Marker Score: 5201
Cell Name: mesodermal cell (CL0000222)
Fold Change: 3.87
Marker Score: 51041
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.69
Marker Score: 9019
Cell Name: supporting cell (CL0000630)
Fold Change: 3.61
Marker Score: 6782
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 3.6
Marker Score: 15003
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 3.47
Marker Score: 9574
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 3.45
Marker Score: 2616
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 3.41
Marker Score: 9555
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 3.39
Marker Score: 809
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 3.39
Marker Score: 2887
Cell Name: naive B cell (CL0000788)
Fold Change: 3.38
Marker Score: 3017
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 3.35
Marker Score: 6802
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 3.32
Marker Score: 1770
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.31
Marker Score: 3538
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.3
Marker Score: 21480
Cell Name: mature T cell (CL0002419)
Fold Change: 3.27
Marker Score: 32381
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 3.24
Marker Score: 1116
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 3.23
Marker Score: 170575
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 3.17
Marker Score: 9245
Cell Name: germinal center B cell (CL0000844)
Fold Change: 3.13
Marker Score: 1905
Cell Name: radial glial cell (CL0000681)
Fold Change: 3.12
Marker Score: 1150
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 3.03
Marker Score: 9553
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 3.03
Marker Score: 2385
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 3.03
Marker Score: 984
Cell Name: chondrocyte (CL0000138)
Fold Change: 3.02
Marker Score: 1360
Cell Name: cell in vitro (CL0001034)
Fold Change: 3.01
Marker Score: 104302.5
Cell Name: late pro-B cell (CL0002048)
Fold Change: 3
Marker Score: 3537.5
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 2.98
Marker Score: 1240
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 2.97
Marker Score: 7966
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 2.94
Marker Score: 1726.5
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 2.93
Marker Score: 5859
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 2.9
Marker Score: 665
Cell Name: malignant cell (CL0001064)
Fold Change: 2.9
Marker Score: 38939.5
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 2.89
Marker Score: 2432
Cell Name: mucous neck cell (CL0000651)
Fold Change: 2.88
Marker Score: 6542
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 2.87
Marker Score: 2446
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 2.87
Marker Score: 1432
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 2.87
Marker Score: 2823
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 2.86
Marker Score: 1798
Cell Name: naive T cell (CL0000898)
Fold Change: 2.85
Marker Score: 1838
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 2.85
Marker Score: 1660
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 2.85
Marker Score: 4671
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 2.85
Marker Score: 12208
Cell Name: basophil (CL0000767)
Fold Change: 2.83
Marker Score: 1345
Cell Name: pro-B cell (CL0000826)
Fold Change: 2.81
Marker Score: 2708
Cell Name: fibroblast (CL0000057)
Fold Change: 2.8
Marker Score: 2709
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 2.8
Marker Score: 13775
Cell Name: motor neuron (CL0000100)
Fold Change: 2.8
Marker Score: 1664
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 2.8
Marker Score: 741
Cell Name: endothelial tip cell (CL0000704)
Fold Change: 2.8
Marker Score: 651
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 2.79
Marker Score: 795
Cell Name: ependymal cell (CL0000065)
Fold Change: 2.78
Marker Score: 971
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 2.77
Marker Score: 1432
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 2.76
Marker Score: 5764
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 2.76
Marker Score: 4667
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 2.76
Marker Score: 2000
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 2.75
Marker Score: 1123
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 2.75
Marker Score: 4712
Cell Name: B-1 B cell (CL0000819)
Fold Change: 2.75
Marker Score: 4787
Cell Name: basal cell (CL0000646)
Fold Change: 2.74
Marker Score: 3543
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 2.74
Marker Score: 2983
Cell Name: starburst amacrine cell (CL0004232)
Fold Change: 2.74
Marker Score: 778
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 2.74
Marker Score: 6906
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 2.74
Marker Score: 3074
Cell Name: decidual cell (CL2000002)
Fold Change: 2.74
Marker Score: 11799
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.73
Marker Score: 10540
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.73
Marker Score: 27650
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 2.72
Marker Score: 922
Cell Name: epidermal cell (CL0000362)
Fold Change: 2.72
Marker Score: 764.5
Cell Name: meningeal macrophage (CL0000879)
Fold Change: 2.72
Marker Score: 765
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 2.72
Marker Score: 4852
Cell Name: connective tissue cell (CL0002320)
Fold Change: 2.71
Marker Score: 704
Cell Name: S cone cell (CL0003050)
Fold Change: 2.7
Marker Score: 812
Cell Name: memory B cell (CL0000787)
Fold Change: 2.7
Marker Score: 2043
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 2.69
Marker Score: 933
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 2.69
Marker Score: 4577
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 2.69
Marker Score: 1771
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 2.69
Marker Score: 4461
Cell Name: immature B cell (CL0000816)
Fold Change: 2.69
Marker Score: 1781
Cell Name: mesothelial fibroblast (CL4023054)
Fold Change: 2.69
Marker Score: 794
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 2.69
Marker Score: 1274
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 2.68
Marker Score: 23539
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 2.68
Marker Score: 7009
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 2.67
Marker Score: 17058
Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 2.67
Marker Score: 707
Cell Name: granulosa cell (CL0000501)
Fold Change: 2.67
Marker Score: 26837
Cell Name: lung neuroendocrine cell (CL1000223)
Fold Change: 2.67
Marker Score: 752
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 2.66
Marker Score: 1257
Cell Name: endothelial cell (CL0000115)
Fold Change: 2.66
Marker Score: 2386
Cell Name: epithelial cell of sweat gland (CL1000448)
Fold Change: 2.66
Marker Score: 814
Cell Name: epithelial cell (CL0000066)
Fold Change: 2.66
Marker Score: 4225
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 2.65
Marker Score: 697
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.65
Marker Score: 29809
Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 2.64
Marker Score: 809

Hover over a box to see details here...

**Key characteristics**: * EIF4A2 is a key regulator of protein synthesis. * It is expressed in a variety of cell types, including glial cells, epithelial cells, and immune cells. * It is a key regulator of the initiation of protein synthesis. * It is a target for antiviral drugs. **Pathways and functions:** * EIF4A2 is involved in the activation of the mrna upon binding of the cap-binding complex and eifs. * It is also involved in the anti-viral mechanism of interferons. * It is involved in the cap-dependent translation initiation pathway. * It is involved in the regulation of cytokine signaling in the immune system. * It is involved in the dedenylation-dependent mrna decay pathway. * It is involved in the degradation of maternal mrnas by maternally stored factors. **Clinical significance:** * EIF4A2 is a potential therapeutic target for a variety of diseases, including cancer and viral infections. * Inhibition of EIF4A2 has been shown to inhibit protein synthesis and inhibit the growth of cancer cells. * EIF4A2 is a promising target for the treatment of viral infections.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Eukaryotic initiation factor 4A-II

Genular Protein ID: 2501863404

Symbol: IF4A2_HUMAN

Name: Eukaryotic initiation factor 4A-II

UniProtKB Accession Codes:

Q14240 D3DNU9 Q53XJ6 Q96B90 Q96EA8

Database IDs:

Citations:

PubMed ID: 8521730

Title: Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2.

PubMed ID: 8521730

DOI: 10.1159/000134145

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11408474

Title: Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo.

PubMed ID: 11408474

DOI: 10.1074/jbc.c100284200

PubMed ID: 15715967

Title: Identification of NOM1, a nucleolar, eIF4A binding protein encoded within the chromosome 7q36 breakpoint region targeted in cases of pediatric acute myeloid leukemia.

PubMed ID: 15715967

DOI: 10.1016/j.gene.2004.12.027

PubMed ID: 16014927

Title: mRNA decay during herpes simplex virus (HSV) infections: protein-protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A.

PubMed ID: 16014927

DOI: 10.1128/jvi.79.15.9651-9664.2005

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 20941364

Title: Comparative structural analysis of human DEAD-box RNA helicases.

PubMed ID: 20941364

DOI: 10.1371/journal.pone.0012791

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

Length: 407
Mass: 46402
Checksum: FAA7D3BA9D8C6DA0
Sequence:

MSGGSADYNR EHGGPEGMDP DGVIESNWNE IVDNFDDMNL KESLLRGIYA YGFEKPSAIQ 
QRAIIPCIKG YDVIAQAQSG TGKTATFAIS ILQQLEIEFK ETQALVLAPT RELAQQIQKV 
ILALGDYMGA TCHACIGGTN VRNEMQKLQA EAPHIVVGTP GRVFDMLNRR YLSPKWIKMF 
VLDEADEMLS RGFKDQIYEI FQKLNTSIQV VLLSATMPTD VLEVTKKFMR DPIRILVKKE 
ELTLEGIKQF YINVEREEWK LDTLCDLYET LTITQAVIFL NTRRKVDWLT EKMHARDFTV 
SALHGDMDQK ERDVIMREFR SGSSRVLITT DLLARGIDVQ QVSLVINYDL PTNRENYIHR 
IGRGGRFGRK GVAINFVTEE DKRILRDIET FYNTTVEEMP MNVADLI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: EIF4A2

Associated with

Cells (max top 100)

Other Information

Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2. PubMed ID: 8521730

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo. PubMed ID: 11408474

Identification of NOM1, a nucleolar, eIF4A binding protein encoded within the chromosome 7q36 breakpoint region targeted in cases of pediatric acute myeloid leukemia. PubMed ID: 15715967

mRNA decay during herpes simplex virus (HSV) infections: protein-protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A. PubMed ID: 16014927

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Comparative structural analysis of human DEAD-box RNA helicases. PubMed ID: 20941364

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974