Details for: EIF4A2

Gene ID: 1974

Symbol: EIF4A2

Ensembl ID: ENSG00000156976

Description: eukaryotic translation initiation factor 4A2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 812.1111
    Cell Significance Index: -126.3200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 425.9524
    Cell Significance Index: -108.0400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 357.6668
    Cell Significance Index: -147.3400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 310.8007
    Cell Significance Index: -126.2700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 305.6886
    Cell Significance Index: -144.3200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 275.9994
    Cell Significance Index: -141.9700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 215.7157
    Cell Significance Index: -144.7500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 134.0518
    Cell Significance Index: -127.9900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 111.1719
    Cell Significance Index: -137.0700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 36.3452
    Cell Significance Index: -143.4200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 36.0057
    Cell Significance Index: -110.5900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 32.1200
    Cell Significance Index: -86.0500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 22.6036
    Cell Significance Index: -49.4700
  • Cell Name: theca cell (CL0000503)
    Fold Change: 15.6136
    Cell Significance Index: 91.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 12.3098
    Cell Significance Index: 646.3100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 6.0194
    Cell Significance Index: 209.1700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 6.0118
    Cell Significance Index: 48.0000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.5593
    Cell Significance Index: 159.3600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.1499
    Cell Significance Index: 140.1800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 4.6351
    Cell Significance Index: 121.8800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.4297
    Cell Significance Index: 92.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 4.3482
    Cell Significance Index: 204.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 4.1731
    Cell Significance Index: 573.0800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 4.0061
    Cell Significance Index: 513.5600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.3354
    Cell Significance Index: 42.7200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.1874
    Cell Significance Index: 73.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.1129
    Cell Significance Index: 1700.0200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.9313
    Cell Significance Index: 189.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.8899
    Cell Significance Index: 373.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.3991
    Cell Significance Index: 294.9900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.3957
    Cell Significance Index: 42.3400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.3507
    Cell Significance Index: 122.4500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.2813
    Cell Significance Index: 170.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.2677
    Cell Significance Index: 408.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.0367
    Cell Significance Index: 900.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0082
    Cell Significance Index: 402.8500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.8872
    Cell Significance Index: 222.5600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.8713
    Cell Significance Index: 87.2500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.7917
    Cell Significance Index: 47.8400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.6051
    Cell Significance Index: 17.4500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5651
    Cell Significance Index: 154.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2776
    Cell Significance Index: 253.5500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.2595
    Cell Significance Index: 215.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.1467
    Cell Significance Index: 81.1000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0010
    Cell Significance Index: 359.0300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7677
    Cell Significance Index: 124.8600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7257
    Cell Significance Index: 20.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5814
    Cell Significance Index: 16.7500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4926
    Cell Significance Index: 444.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4644
    Cell Significance Index: 21.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3994
    Cell Significance Index: 20.7500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3697
    Cell Significance Index: 4.2000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2025
    Cell Significance Index: 3.4700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1443
    Cell Significance Index: 2.4200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1018
    Cell Significance Index: 19.3800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0805
    Cell Significance Index: 59.0500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0538
    Cell Significance Index: 6.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0531
    Cell Significance Index: 40.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0039
    Cell Significance Index: 7.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0061
    Cell Significance Index: -11.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0071
    Cell Significance Index: -10.9900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0129
    Cell Significance Index: -0.7900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0432
    Cell Significance Index: -58.7400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0507
    Cell Significance Index: -37.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0567
    Cell Significance Index: -36.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0619
    Cell Significance Index: -2.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1013
    Cell Significance Index: -10.3500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1136
    Cell Significance Index: -70.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1358
    Cell Significance Index: -7.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1426
    Cell Significance Index: -64.7400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.1573
    Cell Significance Index: -108.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1723
    Cell Significance Index: -97.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2632
    Cell Significance Index: -55.4400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3208
    Cell Significance Index: -24.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4078
    Cell Significance Index: -27.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4300
    Cell Significance Index: -123.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4459
    Cell Significance Index: -14.2800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5801
    Cell Significance Index: -84.3200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6013
    Cell Significance Index: -17.6600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6571
    Cell Significance Index: -76.5800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7270
    Cell Significance Index: -45.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.8109
    Cell Significance Index: -92.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9235
    Cell Significance Index: -73.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.0021
    Cell Significance Index: -21.7100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.0729
    Cell Significance Index: -27.4100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -1.1545
    Cell Significance Index: -7.1000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.3028
    Cell Significance Index: -135.6500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.5053
    Cell Significance Index: -11.6000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.7547
    Cell Significance Index: -23.9400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.8474
    Cell Significance Index: -127.7600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.9034
    Cell Significance Index: -84.1900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.9097
    Cell Significance Index: -51.1700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -2.0199
    Cell Significance Index: -34.8200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.1483
    Cell Significance Index: -131.7100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -2.3866
    Cell Significance Index: -90.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -2.4462
    Cell Significance Index: -65.4400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.5622
    Cell Significance Index: -38.3900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.6173
    Cell Significance Index: -77.0900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -2.6302
    Cell Significance Index: -63.0800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -2.6446
    Cell Significance Index: -75.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** EIF4A2 is a 40-kDa protein that belongs to the eukaryotic translation initiation factor 4A (eIF4A) family. It is characterized by its ability to bind to the cap-binding complex and eIF4E, which is essential for the recruitment of the 43S ribosomal subunit to the mRNA. EIF4A2 is also known for its helicase activity, which is required for the unwinding of double-stranded RNA (dsRNA) and the activation of antiviral mechanisms. Additionally, EIF4A2 has been shown to interact with other proteins, including eIF4E-binding protein 1 (4E-BP1) and eIF4G, which are involved in the regulation of translation initiation. **Pathways and Functions** EIF4A2 is involved in several key pathways, including: 1. **Antiviral mechanism**: EIF4A2 is activated by interferons (IFNs) and plays a crucial role in the antiviral response by unwinding dsRNA and activating the JAK/STAT signaling pathway. 2. **Cytokine signaling**: EIF4A2 is involved in the regulation of cytokine signaling, including the activation of immune responses and the production of inflammatory cytokines. 3. **Translation regulation**: EIF4A2 is a key regulator of translation initiation, and its activity is involved in the regulation of protein synthesis in response to various stimuli, including stress and nutrient availability. 4. **RNA helicase activity**: EIF4A2 has been shown to possess RNA helicase activity, which is required for the unwinding of dsRNA and the activation of antiviral mechanisms. **Clinical Significance** EIF4A2 has been implicated in various diseases, including: 1. **Cancer**: EIF4A2 is overexpressed in several types of cancer, including breast cancer, lung cancer, and leukemia, and has been shown to promote tumor growth and metastasis. 2. **Neurological disorders**: EIF4A2 has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, and has been shown to play a role in the regulation of protein synthesis and clearance. 3. **Infectious diseases**: EIF4A2 has been shown to play a role in the antiviral response to viral infections, including influenza and HIV-1, and has been identified as a potential target for the development of antiviral therapies. In conclusion, EIF4A2 is a multifunctional protein that plays a critical role in the regulation of protein synthesis and the antiviral response in eukaryotic cells. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, and infectious diseases, highlighting the importance of further research into the functions and mechanisms of this protein.

Genular Protein ID: 2501863404

Symbol: IF4A2_HUMAN

Name: Eukaryotic initiation factor 4A-II

UniProtKB Accession Codes:

Q14240 D3DNU9 Q53XJ6 Q96B90 Q96EA8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 6 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 9 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRIDE 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 9 RefSeq 1 Rhea 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8521730

Title: Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2.

PubMed ID: 8521730

DOI: 10.1159/000134145

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11408474

Title: Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo.

PubMed ID: 11408474

DOI: 10.1074/jbc.c100284200

PubMed ID: 15715967

Title: Identification of NOM1, a nucleolar, eIF4A binding protein encoded within the chromosome 7q36 breakpoint region targeted in cases of pediatric acute myeloid leukemia.

PubMed ID: 15715967

DOI: 10.1016/j.gene.2004.12.027

PubMed ID: 16014927

Title: mRNA decay during herpes simplex virus (HSV) infections: protein-protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A.

PubMed ID: 16014927

DOI: 10.1128/jvi.79.15.9651-9664.2005

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 20941364

Title: Comparative structural analysis of human DEAD-box RNA helicases.

PubMed ID: 20941364

DOI: 10.1371/journal.pone.0012791

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 36528028

Title: Rare EIF4A2 variants are associated with a neurodevelopmental disorder characterized by intellectual disability, hypotonia, and epilepsy.

PubMed ID: 36528028

DOI: 10.1016/j.ajhg.2022.11.011

PubMed ID: 36868207

Title:

PubMed ID: 36868207

DOI: 10.1016/j.ajhg.2023.02.010

Sequence Information:

  • Length: 407
  • Mass: 46402
  • Checksum: FAA7D3BA9D8C6DA0
  • Sequence:
    • MSGGSADYNR EHGGPEGMDP DGVIESNWNE IVDNFDDMNL KESLLRGIYA YGFEKPSAIQ 
QRAIIPCIKG YDVIAQAQSG TGKTATFAIS ILQQLEIEFK ETQALVLAPT RELAQQIQKV 
ILALGDYMGA TCHACIGGTN VRNEMQKLQA EAPHIVVGTP GRVFDMLNRR YLSPKWIKMF 
VLDEADEMLS RGFKDQIYEI FQKLNTSIQV VLLSATMPTD VLEVTKKFMR DPIRILVKKE 
ELTLEGIKQF YINVEREEWK LDTLCDLYET LTITQAVIFL NTRRKVDWLT EKMHARDFTV 
SALHGDMDQK ERDVIMREFR SGSSRVLITT DLLARGIDVQ QVSLVINYDL PTNRENYIHR 
IGRGGRFGRK GVAINFVTEE DKRILRDIET FYNTTVEEMP MNVADLI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.