Details for: EIF5A

Gene ID: 1984

Symbol: EIF5A

Ensembl ID: ENSG00000132507

Description: eukaryotic translation initiation factor 5A

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 3.09
    Marker Score: 6485
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.06
    Marker Score: 104010
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.05
    Marker Score: 3001
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.99
    Marker Score: 3119
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.95
    Marker Score: 3151
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.94
    Marker Score: 22971
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.94
    Marker Score: 12598
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.8
    Marker Score: 148193
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.76
    Marker Score: 3903
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.75
    Marker Score: 10617
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.69
    Marker Score: 8493
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.68
    Marker Score: 13149
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.68
    Marker Score: 1612
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.67
    Marker Score: 4778
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.59
    Marker Score: 16557
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.53
    Marker Score: 3052
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.53
    Marker Score: 2376.5
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.49
    Marker Score: 886
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.49
    Marker Score: 25245
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.49
    Marker Score: 10182
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.46
    Marker Score: 21202
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.46
    Marker Score: 3390
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.45
    Marker Score: 1261
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.41
    Marker Score: 27194
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.41
    Marker Score: 854
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.39
    Marker Score: 3846
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.38
    Marker Score: 765
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.37
    Marker Score: 15416
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.37
    Marker Score: 1716
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.35
    Marker Score: 2476
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.35
    Marker Score: 2750
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 2.35
    Marker Score: 1375
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.34
    Marker Score: 3723
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.34
    Marker Score: 1702
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.32
    Marker Score: 5659
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.31
    Marker Score: 4026
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.29
    Marker Score: 79479
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.29
    Marker Score: 754
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.29
    Marker Score: 2141
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.27
    Marker Score: 6378
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.27
    Marker Score: 127092
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.27
    Marker Score: 26348.5
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.25
    Marker Score: 4390
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.25
    Marker Score: 1894
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 2.25
    Marker Score: 1843
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.25
    Marker Score: 2404
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.25
    Marker Score: 3309
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.24
    Marker Score: 6543
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.22
    Marker Score: 14169
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.21
    Marker Score: 21882
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.21
    Marker Score: 6936
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.2
    Marker Score: 29072
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 2.2
    Marker Score: 1387
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.2
    Marker Score: 9474
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.19
    Marker Score: 3232
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.19
    Marker Score: 7776
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.18
    Marker Score: 1913
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.18
    Marker Score: 4092
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.17
    Marker Score: 4937
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.15
    Marker Score: 2018
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.14
    Marker Score: 5915
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.14
    Marker Score: 1344
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.14
    Marker Score: 2170
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 2.14
    Marker Score: 1566
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 2.13
    Marker Score: 2300
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 2.12
    Marker Score: 739
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.12
    Marker Score: 2135
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.11
    Marker Score: 505
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.1
    Marker Score: 3556
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.1
    Marker Score: 1588
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 2.09
    Marker Score: 672
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 2.09
    Marker Score: 2778
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.08
    Marker Score: 8174
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 2.08
    Marker Score: 3568
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.06
    Marker Score: 4840
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.06
    Marker Score: 3409
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.06
    Marker Score: 1485
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.05
    Marker Score: 2211
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.04
    Marker Score: 2295.5
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 2.04
    Marker Score: 505
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.03
    Marker Score: 2162
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.03
    Marker Score: 3604
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.03
    Marker Score: 4830
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 2.03
    Marker Score: 1378
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.02
    Marker Score: 13193
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.02
    Marker Score: 7487
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.02
    Marker Score: 1687
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 2.02
    Marker Score: 1357
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.01
    Marker Score: 1225
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.01
    Marker Score: 662
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.01
    Marker Score: 5460
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2
    Marker Score: 1141
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2
    Marker Score: 3280
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.99
    Marker Score: 1407
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.99
    Marker Score: 1651
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.99
    Marker Score: 2161
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.99
    Marker Score: 5893
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.98
    Marker Score: 1764
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.97
    Marker Score: 9468
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.97
    Marker Score: 4964

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Other Information

## Summary EIF5A is an eukaryotic translation initiation factor that plays a crucial role in the initiation of protein synthesis in eukaryotic cells. It is a multi-functional protein that has been shown to be involved in various cellular processes, including cell cycle regulation, apoptosis, and immune responses. ## Key characteristics * EIF5A is a highly conserved protein with a conserved structure and function across different species. * It is a key regulator of protein synthesis, and its expression is regulated by various cellular signals. * EIF5A is involved in both constitutive and regulated translation initiation. * It is a key regulator of cell cycle progression and apoptosis. ## Pathways and functions * EIF5A is involved in the initiation of protein synthesis through the binding of its target mRNAs and facilitating the binding of the initiator complex to the 5' cap of the mRNA. * It is also involved in the regulation of translation initiation factors, such as eIF4B and eIF4G, by promoting their phosphorylation and degradation. * EIF5A also plays a role in the regulation of apoptosis by binding to the BH3-only protein Bcl-xL and promoting its degradation, leading to cell survival. * It is also involved in the regulation of cell cycle progression by binding to the p53 tumor suppressor protein and promoting its degradation, leading to cell cycle progression. * EIF5A also plays a role in the regulation of inflammation by binding to the U6 small nuclear RNA (snRNA) and facilitating the binding of the transcription factor NF-κB. ## Clinical significance * Mutations in EIF5A have been linked to various human diseases, including cancer and autoimmune disorders. * Targeting EIF5A has been explored as a therapeutic strategy for cancer and other diseases that are characterized by abnormal protein synthesis. * However, clinical trials of EIF5A inhibitors have shown limited success, likely due to the complex and multifaceted role of EIF5A in cellular processes.

Genular Protein ID: 4064949804

Symbol: IF5A1_HUMAN

Name: Eukaryotic translation initiation factor 5A-1

UniProtKB Accession Codes:

P63241 A8K9A0 D3DTP2 P10159 Q16182 Q7L7L3 Q7Z4L1 Q9D0G2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DisProt 1 EMBL 18 EMDB 3 EPD 1 Ensembl 14 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 2 PIR 1 PIRSF 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 2 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2492279

Title: Sequence determination and cDNA cloning of eukaryotic initiation factor 4D, the hypusine-containing protein.

PubMed ID: 2492279

DOI: 10.1016/s0021-9258(18)94226-2

PubMed ID: 8253832

Title: Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type 1 Rev activation domain mediating trans-activation.

PubMed ID: 8253832

DOI: 10.1083/jcb.123.6.1309

PubMed ID: 7545941

Title: The genomic structure encoding human initiation factor eIF-5A.

PubMed ID: 7545941

DOI: 10.1016/0378-1119(94)90385-9

PubMed ID: 7622067

Title: Identification of a new member of the human eIF-5A gene family.

PubMed ID: 7622067

DOI: 10.1016/0378-1119(95)00136-t

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10229683

Title: Complex formation between deoxyhypusine synthase and its protein substrate, the eukaryotic translation initiation factor 5A (eIF5A) precursor.

PubMed ID: 10229683

DOI: 10.1042/bj3400273

PubMed ID: 3095320

Title: Eukaryotic initiation factor 4D. Purification from human red blood cells and the sequence of amino acids around its single hypusine residue.

PubMed ID: 3095320

DOI: 10.1016/s0021-9258(18)66899-1

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 8660923

Title: The subcellular distribution of eukaryotic translation initiation factor, eIF-5A, in cultured cells.

PubMed ID: 8660923

DOI: 10.1006/excr.1996.0185

PubMed ID: 10944119

Title: Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes.

PubMed ID: 10944119

DOI: 10.1093/emboj/19.16.4362

PubMed ID: 15303967

Title: Identification of mRNA that binds to eukaryotic initiation factor 5A by affinity co-purification and differential display.

PubMed ID: 15303967

DOI: 10.1042/bj20041232

PubMed ID: 15262146

Title: Eukaryotic initiation factor 5A-1 (eIF5A-1) as a diagnostic marker for aberrant proliferation in intraepithelial neoplasia of the vulva.

PubMed ID: 15262146

DOI: 10.1016/j.ygyno.2004.03.018

PubMed ID: 15371445

Title: A novel eIF5A complex functions as a regulator of p53 and p53-dependent apoptosis.

PubMed ID: 15371445

DOI: 10.1074/jbc.m407165200

PubMed ID: 15452064

Title: Role of eIF5A in TNF-alpha-mediated apoptosis of lamina cribrosa cells.

PubMed ID: 15452064

DOI: 10.1167/iovs.03-1367

PubMed ID: 16519677

Title: Differential expression of eIF5A-1 and eIF5A-2 in human cancer cells.

PubMed ID: 16519677

DOI: 10.1111/j.1742-4658.2006.05135.x

PubMed ID: 16987817

Title: Temperature-sensitive eIF5A mutant accumulates transcripts targeted to the nonsense-mediated decay pathway.

PubMed ID: 16987817

DOI: 10.1074/jbc.m601460200

PubMed ID: 17187778

Title: Eukaryotic translation initiation factor 5A induces apoptosis in colon cancer cells and associates with the nucleus in response to tumour necrosis factor alpha signalling.

PubMed ID: 17187778

DOI: 10.1016/j.yexcr.2006.09.030

PubMed ID: 17213197

Title: Specificity of the deoxyhypusine hydroxylase-eukaryotic translation initiation factor (eIF5A) interaction: identification of amino acid residues of the enzyme required for binding of its substrate, deoxyhypusine-containing eIF5A.

PubMed ID: 17213197

DOI: 10.1074/jbc.m607495200

PubMed ID: 17360499

Title: Neuronal growth and survival mediated by eIF5A, a polyamine-modified translation initiation factor.

PubMed ID: 17360499

DOI: 10.1073/pnas.0611609104

PubMed ID: 18067580

Title: Mutational analyses of human eIF5A-1: identification of amino acid residues critical for eIF5A activity and hypusine modification.

PubMed ID: 18067580

DOI: 10.1111/j.1742-4658.2007.06172.x

PubMed ID: 19379712

Title: The effect of hypusine modification on the intracellular localization of eIF5A.

PubMed ID: 19379712

DOI: 10.1016/j.bbrc.2009.04.049

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22771473

Title: Acetylation regulates subcellular localization of eukaryotic translation initiation factor 5A (eIF5A).

PubMed ID: 22771473

DOI: 10.1016/j.febslet.2012.06.042

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27115996

Title: Evidence for a negative cooperativity between eIF5A and eEF2 on binding to the ribosome.

PubMed ID: 27115996

DOI: 10.1371/journal.pone.0154205

PubMed ID: 11742107

Title: Homology modelling of the human eukaryotic initiation factor 5A (eIF-5A).

PubMed ID: 11742107

DOI: 10.1093/protein/14.11.881

PubMed ID: 19280598

Title: Crystal structure of human eIF5A1: insight into functional similarity of human eIF5A1 and eIF5A2.

PubMed ID: 19280598

DOI: 10.1002/prot.22378

PubMed ID: 27306458

Title: Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A.

PubMed ID: 27306458

DOI: 10.1038/ncomms11952

PubMed ID: 33547280

Title: Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine.

PubMed ID: 33547280

DOI: 10.1038/s41467-021-21053-2

Sequence Information:

  • Length: 154
  • Mass: 16832
  • Checksum: 07EF043C7DEA3091
  • Sequence:
    • MADDLDFETG DAGASATFPM QCSALRKNGF VVLKGRPCKI VEMSTSKTGK HGHAKVHLVG 
IDIFTGKKYE DICPSTHNMD VPNIKRNDFQ LIGIQDGYLS LLQDSGEVRE DLRLPEGDLG 
KEIEQKYDCG EEILITVLSA MTEEAAVAIK AMAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.