Details for: EIF5A

Gene ID: 1984

Symbol: EIF5A

Ensembl ID: ENSG00000132507

Description: eukaryotic translation initiation factor 5A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 335.4651
    Cell Significance Index: -52.1800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 235.4093
    Cell Significance Index: -59.7100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 203.2297
    Cell Significance Index: -83.7200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 185.0798
    Cell Significance Index: -75.1900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 180.5039
    Cell Significance Index: -85.2200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 166.6650
    Cell Significance Index: -85.7300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 127.5219
    Cell Significance Index: -85.5700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 80.0844
    Cell Significance Index: -76.4600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 59.8237
    Cell Significance Index: -73.7600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 21.1199
    Cell Significance Index: -83.3400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.0039
    Cell Significance Index: -48.2300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.5031
    Cell Significance Index: -53.7600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.5156
    Cell Significance Index: -29.5800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 7.7210
    Cell Significance Index: 64.8600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 4.5386
    Cell Significance Index: 39.0000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.1767
    Cell Significance Index: 122.6700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.9388
    Cell Significance Index: 24.2400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.7919
    Cell Significance Index: 178.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.3796
    Cell Significance Index: 251.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.2778
    Cell Significance Index: 211.4700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.1145
    Cell Significance Index: 89.2800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 3.0988
    Cell Significance Index: 219.1600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.9961
    Cell Significance Index: 52.9500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.5792
    Cell Significance Index: 333.2100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.5425
    Cell Significance Index: 1124.1000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.3782
    Cell Significance Index: 21.9000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.2380
    Cell Significance Index: 24.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.0141
    Cell Significance Index: 247.6500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.9993
    Cell Significance Index: 1091.8800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.9894
    Cell Significance Index: 234.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.9672
    Cell Significance Index: 91.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.9009
    Cell Significance Index: 342.6700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.8670
    Cell Significance Index: 21.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.7005
    Cell Significance Index: 233.5200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4514
    Cell Significance Index: 39.5100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.4476
    Cell Significance Index: 30.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2670
    Cell Significance Index: 65.8200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.2052
    Cell Significance Index: 41.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0317
    Cell Significance Index: 29.7300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.6946
    Cell Significance Index: 8.9000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6788
    Cell Significance Index: 35.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.6492
    Cell Significance Index: 186.8000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6284
    Cell Significance Index: 16.7800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.5611
    Cell Significance Index: 10.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5539
    Cell Significance Index: 109.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5289
    Cell Significance Index: 90.3200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5067
    Cell Significance Index: 64.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4694
    Cell Significance Index: 46.4300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4559
    Cell Significance Index: 411.6600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4493
    Cell Significance Index: 12.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.4073
    Cell Significance Index: 308.2900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3839
    Cell Significance Index: 73.0600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3750
    Cell Significance Index: 12.0100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3108
    Cell Significance Index: 16.1900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2354
    Cell Significance Index: 6.1900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1893
    Cell Significance Index: 30.7900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.1460
    Cell Significance Index: 1.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1390
    Cell Significance Index: 27.8900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0278
    Cell Significance Index: 9.9700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0131
    Cell Significance Index: 0.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0104
    Cell Significance Index: 0.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0243
    Cell Significance Index: -17.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0276
    Cell Significance Index: -2.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0301
    Cell Significance Index: -0.8400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0315
    Cell Significance Index: -59.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0371
    Cell Significance Index: -27.1900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0387
    Cell Significance Index: -1.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0474
    Cell Significance Index: -29.5900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0552
    Cell Significance Index: -101.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0653
    Cell Significance Index: -100.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0741
    Cell Significance Index: -100.8000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1039
    Cell Significance Index: -58.5800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1145
    Cell Significance Index: -72.7300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1256
    Cell Significance Index: -5.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1768
    Cell Significance Index: -11.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1829
    Cell Significance Index: -82.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2029
    Cell Significance Index: -23.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2075
    Cell Significance Index: -43.7100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2493
    Cell Significance Index: -6.3700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2781
    Cell Significance Index: -1.6800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2790
    Cell Significance Index: -4.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4311
    Cell Significance Index: -9.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4473
    Cell Significance Index: -52.1300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4722
    Cell Significance Index: -10.9100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5270
    Cell Significance Index: -76.6100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6340
    Cell Significance Index: -8.6500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6951
    Cell Significance Index: -79.3500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7932
    Cell Significance Index: -62.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.8087
    Cell Significance Index: -84.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.1210
    Cell Significance Index: -86.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.1272
    Cell Significance Index: -63.2500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -1.2900
    Cell Significance Index: -10.3000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.3389
    Cell Significance Index: -33.4700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.3833
    Cell Significance Index: -84.8100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.4247
    Cell Significance Index: -24.5600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.5904
    Cell Significance Index: -46.8500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.6915
    Cell Significance Index: -36.0300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.7517
    Cell Significance Index: -64.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.8009
    Cell Significance Index: -79.6600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.9876
    Cell Significance Index: -51.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** EIF5A is a multifunctional protein that belongs to the eukaryotic translation initiation factor family. It is characterized by its ability to bind to ribosomes, RNA, and other proteins, influencing translation elongation, transcription, and post-translational modifications. EIF5A's structure consists of three domains: the N-terminal domain, the C-terminal domain, and a central domain that mediates protein-protein interactions. The gene is highly conserved across species, suggesting its essential role in eukaryotic cells. **Pathways and Functions** EIF5A is involved in various signaling pathways, including: 1. **Translation elongation**: EIF5A regulates the elongation phase of translation, ensuring accurate protein synthesis and preventing aberrant translation. 2. **Transcription regulation**: EIF5A interacts with RNA polymerase II, influencing the regulation of transcriptional programs. 3. **Post-translational modifications**: EIF5A is involved in the regulation of post-translational modifications, including hypusination, hydroxylation, and gamma-carboxylation. 4. **Apoptosis regulation**: EIF5A interacts with p53 class mediators, influencing the intrinsic apoptotic signaling pathway. 5. **Immune responses**: EIF5A is expressed in immune cells, such as T-helper 22 cells and mature alpha-beta T cells, suggesting its role in immune regulation. **Clinical Significance** EIF5A's involvement in various cellular processes and its expression in multiple cell types make it an attractive target for therapeutic intervention in diseases characterized by aberrant protein synthesis or transcriptional dysregulation. Some potential clinical applications of EIF5A include: 1. **Cancer therapy**: EIF5A's role in regulation of transcription and translation elongation makes it a potential target for cancer therapy. 2. **Immunotherapy**: EIF5A's expression in immune cells suggests its potential as a therapeutic target for immunotherapeutic approaches. 3. **Neurological disorders**: EIF5A's involvement in post-translational modifications and regulation of transcriptional programs may make it a potential target for the treatment of neurological disorders, such as Alzheimer's disease or Parkinson's disease. In conclusion, EIF5A is a multifunctional protein that plays a crucial role in various cellular processes, including translation elongation, transcription regulation, and post-translational modifications. Its expression in multiple cell types and involvement in various signaling pathways make it an attractive target for therapeutic intervention in diseases characterized by aberrant protein synthesis or transcriptional dysregulation.

Genular Protein ID: 4064949804

Symbol: IF5A1_HUMAN

Name: Eukaryotic initiation factor 5A isoform 1

UniProtKB Accession Codes:

P63241 A8K9A0 D3DTP2 P10159 Q16182 Q7L7L3 Q7Z4L1 Q9D0G2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 18 EMDB 4 Ensembl 14 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PIRSF 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2492279

Title: Sequence determination and cDNA cloning of eukaryotic initiation factor 4D, the hypusine-containing protein.

PubMed ID: 2492279

DOI: 10.1016/s0021-9258(18)94226-2

PubMed ID: 8253832

Title: Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type 1 Rev activation domain mediating trans-activation.

PubMed ID: 8253832

DOI: 10.1083/jcb.123.6.1309

PubMed ID: 7545941

Title: The genomic structure encoding human initiation factor eIF-5A.

PubMed ID: 7545941

DOI: 10.1016/0378-1119(94)90385-9

PubMed ID: 7622067

Title: Identification of a new member of the human eIF-5A gene family.

PubMed ID: 7622067

DOI: 10.1016/0378-1119(95)00136-t

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10229683

Title: Complex formation between deoxyhypusine synthase and its protein substrate, the eukaryotic translation initiation factor 5A (eIF5A) precursor.

PubMed ID: 10229683

DOI: 10.1042/bj3400273

PubMed ID: 3095320

Title: Eukaryotic initiation factor 4D. Purification from human red blood cells and the sequence of amino acids around its single hypusine residue.

PubMed ID: 3095320

DOI: 10.1016/s0021-9258(18)66899-1

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 8660923

Title: The subcellular distribution of eukaryotic translation initiation factor, eIF-5A, in cultured cells.

PubMed ID: 8660923

DOI: 10.1006/excr.1996.0185

PubMed ID: 10944119

Title: Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes.

PubMed ID: 10944119

DOI: 10.1093/emboj/19.16.4362

PubMed ID: 15303967

Title: Identification of mRNA that binds to eukaryotic initiation factor 5A by affinity co-purification and differential display.

PubMed ID: 15303967

DOI: 10.1042/bj20041232

PubMed ID: 15262146

Title: Eukaryotic initiation factor 5A-1 (eIF5A-1) as a diagnostic marker for aberrant proliferation in intraepithelial neoplasia of the vulva.

PubMed ID: 15262146

DOI: 10.1016/j.ygyno.2004.03.018

PubMed ID: 15371445

Title: A novel eIF5A complex functions as a regulator of p53 and p53-dependent apoptosis.

PubMed ID: 15371445

DOI: 10.1074/jbc.m407165200

PubMed ID: 15452064

Title: Role of eIF5A in TNF-alpha-mediated apoptosis of lamina cribrosa cells.

PubMed ID: 15452064

DOI: 10.1167/iovs.03-1367

PubMed ID: 16519677

Title: Differential expression of eIF5A-1 and eIF5A-2 in human cancer cells.

PubMed ID: 16519677

DOI: 10.1111/j.1742-4658.2006.05135.x

PubMed ID: 16987817

Title: Temperature-sensitive eIF5A mutant accumulates transcripts targeted to the nonsense-mediated decay pathway.

PubMed ID: 16987817

DOI: 10.1074/jbc.m601460200

PubMed ID: 17187778

Title: Eukaryotic translation initiation factor 5A induces apoptosis in colon cancer cells and associates with the nucleus in response to tumour necrosis factor alpha signalling.

PubMed ID: 17187778

DOI: 10.1016/j.yexcr.2006.09.030

PubMed ID: 17213197

Title: Specificity of the deoxyhypusine hydroxylase-eukaryotic translation initiation factor (eIF5A) interaction: identification of amino acid residues of the enzyme required for binding of its substrate, deoxyhypusine-containing eIF5A.

PubMed ID: 17213197

DOI: 10.1074/jbc.m607495200

PubMed ID: 17360499

Title: Neuronal growth and survival mediated by eIF5A, a polyamine-modified translation initiation factor.

PubMed ID: 17360499

DOI: 10.1073/pnas.0611609104

PubMed ID: 18067580

Title: Mutational analyses of human eIF5A-1: identification of amino acid residues critical for eIF5A activity and hypusine modification.

PubMed ID: 18067580

DOI: 10.1111/j.1742-4658.2007.06172.x

PubMed ID: 19379712

Title: The effect of hypusine modification on the intracellular localization of eIF5A.

PubMed ID: 19379712

DOI: 10.1016/j.bbrc.2009.04.049

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22771473

Title: Acetylation regulates subcellular localization of eukaryotic translation initiation factor 5A (eIF5A).

PubMed ID: 22771473

DOI: 10.1016/j.febslet.2012.06.042

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27115996

Title: Evidence for a negative cooperativity between eIF5A and eEF2 on binding to the ribosome.

PubMed ID: 27115996

DOI: 10.1371/journal.pone.0154205

PubMed ID: 29712776

Title: eIF5A is required for autophagy by mediating ATG3 translation.

PubMed ID: 29712776

DOI: 10.15252/embr.201846072

PubMed ID: 11742107

Title: Homology modelling of the human eukaryotic initiation factor 5A (eIF-5A).

PubMed ID: 11742107

DOI: 10.1093/protein/14.11.881

PubMed ID: 19280598

Title: Crystal structure of human eIF5A1: insight into functional similarity of human eIF5A1 and eIF5A2.

PubMed ID: 19280598

DOI: 10.1002/prot.22378

PubMed ID: 27306458

Title: Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A.

PubMed ID: 27306458

DOI: 10.1038/ncomms11952

PubMed ID: 33547280

Title: Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine.

PubMed ID: 33547280

DOI: 10.1038/s41467-021-21053-2

Sequence Information:

  • Length: 154
  • Mass: 16832
  • Checksum: 07EF043C7DEA3091
  • Sequence:
    • MADDLDFETG DAGASATFPM QCSALRKNGF VVLKGRPCKI VEMSTSKTGK HGHAKVHLVG 
IDIFTGKKYE DICPSTHNMD VPNIKRNDFQ LIGIQDGYLS LLQDSGEVRE DLRLPEGDLG 
KEIEQKYDCG EEILITVLSA MTEEAAVAIK AMAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.