Details for: ESD

Gene ID: 2098

Symbol: ESD

Ensembl ID: ENSG00000139684

Description: esterase D

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.43
    Marker Score: 3574
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.08
    Marker Score: 5784
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3
    Marker Score: 39632
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.76
    Marker Score: 3594
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.51
    Marker Score: 3863
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.51
    Marker Score: 10254
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.49
    Marker Score: 5197
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.45
    Marker Score: 10570
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.44
    Marker Score: 1747.5
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.43
    Marker Score: 15789
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.35
    Marker Score: 2512
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.34
    Marker Score: 1833
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.32
    Marker Score: 5462
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.3
    Marker Score: 3815
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.26
    Marker Score: 2413
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.25
    Marker Score: 2531
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.24
    Marker Score: 2256
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.23
    Marker Score: 2631
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.22
    Marker Score: 22546
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.22
    Marker Score: 841
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.22
    Marker Score: 3773
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.21
    Marker Score: 5781
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.19
    Marker Score: 1462
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.18
    Marker Score: 24558
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.17
    Marker Score: 2041
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.16
    Marker Score: 74990
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.15
    Marker Score: 1349
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.11
    Marker Score: 1389
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.11
    Marker Score: 2227
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.1
    Marker Score: 3341
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.09
    Marker Score: 5268
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.07
    Marker Score: 3321
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 2.06
    Marker Score: 1554
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.05
    Marker Score: 4086
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.04
    Marker Score: 1454
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.04
    Marker Score: 4980.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.02
    Marker Score: 7162
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2
    Marker Score: 12168
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2
    Marker Score: 13048
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.99
    Marker Score: 51022
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.99
    Marker Score: 3266
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.97
    Marker Score: 2428
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.97
    Marker Score: 647
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.96
    Marker Score: 4656
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.95
    Marker Score: 7237
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.95
    Marker Score: 16801.5
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.94
    Marker Score: 550
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.93
    Marker Score: 5255.5
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.93
    Marker Score: 1061
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.93
    Marker Score: 2046
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.9
    Marker Score: 5105
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.9
    Marker Score: 2637.5
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.89
    Marker Score: 7440.5
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.89
    Marker Score: 698
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.89
    Marker Score: 1122
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.88
    Marker Score: 2029
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.88
    Marker Score: 1908
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.88
    Marker Score: 1360
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.87
    Marker Score: 985
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.87
    Marker Score: 628
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.87
    Marker Score: 3307
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.85
    Marker Score: 1789
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.85
    Marker Score: 874
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.85
    Marker Score: 5276
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.85
    Marker Score: 5024
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.85
    Marker Score: 904
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.81
    Marker Score: 1748
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.81
    Marker Score: 2176
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.8
    Marker Score: 929
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.8
    Marker Score: 6931.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.8
    Marker Score: 2104
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.79
    Marker Score: 411
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.77
    Marker Score: 945
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.76
    Marker Score: 565
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.76
    Marker Score: 412
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.75
    Marker Score: 59704
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.74
    Marker Score: 2468
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.73
    Marker Score: 920
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.73
    Marker Score: 417
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.73
    Marker Score: 598
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.72
    Marker Score: 1533
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.71
    Marker Score: 811
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.7
    Marker Score: 17104
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.7
    Marker Score: 692
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.69
    Marker Score: 593
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.69
    Marker Score: 2492
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.68
    Marker Score: 402.5
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.67
    Marker Score: 2295
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.67
    Marker Score: 2361
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.67
    Marker Score: 3782
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.66
    Marker Score: 488
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.66
    Marker Score: 1043
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.66
    Marker Score: 1586
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.66
    Marker Score: 1757
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.65
    Marker Score: 530
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.65
    Marker Score: 407
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.65
    Marker Score: 1116
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.64
    Marker Score: 2781.5
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.64
    Marker Score: 901.5
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.62
    Marker Score: 949

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Other Information

**Key characteristics:** * The ESTD gene is located on chromosome 17q21.1. * It is a single-exon gene that encodes a protein of 534 amino acids. * ESTD is a member of the esterase superfamily of enzymes. * It is involved in the metabolism of various compounds, including fatty acids, cholesterol, and bile acids. **Pathways and functions:** * EstD is involved in the carboxylation of S-formylglutathione to produce glutathione. * It is a key enzyme in the metabolism of carnitine, which is involved in energy metabolism. * EstD is also involved in the detoxification of reactive oxygen species (ROS). * It is involved in the regulation of inflammation and immune responses. **Clinical significance:** * Mutations in the ESTD gene have been linked to several human diseases, including liver disease, cardiovascular disease, and cancer. * EstD is a potential therapeutic target for these diseases. * EstD inhibitors are being investigated as a treatment for cancer and other diseases that are characterized by impaired glutathione metabolism. **Additional notes:** * The ESTD gene is also known as GSTE1. * It is a highly conserved protein, with a similar sequence in mammals and humans. * EstD is a highly active enzyme, with a reported EC50 of less than 10^-5 M.

Genular Protein ID: 1484643917

Symbol: ESTD_HUMAN

Name: S-formylglutathione hydrolase

UniProtKB Accession Codes:

P10768 Q5TBU8 Q5TBV0 Q5TBV2 Q9BVJ2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 2 CTD 1 ChEBI 10 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 1 EC 4 EMBL 6 EPD 1 ESTHER 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3462698

Title: Molecular cloning of the human esterase D gene, a genetic marker of retinoblastoma.

PubMed ID: 3462698

DOI: 10.1073/pnas.83.17.6337

PubMed ID: 3164702

Title: Human esterase D gene: complete cDNA sequence, genomic structure, and application in the genetic diagnosis of human retinoblastoma.

PubMed ID: 3164702

DOI: 10.1007/bf00280552

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3462714

Title: Cloning of the esterase D gene: a polymorphic gene probe closely linked to the retinoblastoma locus on chromosome 13.

PubMed ID: 3462714

DOI: 10.1073/pnas.83.17.6573

PubMed ID: 4768551

Title: Esterase D: a new human polymorphism.

PubMed ID: 4768551

DOI: 10.1111/j.1469-1809.1973.tb01820.x

PubMed ID: 3770744

Title: Identity of the polymorphisms for esterase D and S-formylglutathione hydrolase in red blood cells.

PubMed ID: 3770744

DOI: 10.1007/bf00282085

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 19126594

Title: Crystal structure of human esterase D: a potential genetic marker of retinoblastoma.

PubMed ID: 19126594

DOI: 10.1096/fj.08-125286

PubMed ID: 7907313

Title: Molecular analysis of esterase D polymorphism.

PubMed ID: 7907313

DOI: 10.1007/bf00212018

PubMed ID: 12721789

Title: Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population.

PubMed ID: 12721789

DOI: 10.1007/s10038-003-0021-7

Sequence Information:

  • Length: 282
  • Mass: 31463
  • Checksum: BFC20D5FA2BB0DCE
  • Sequence:
    • MALKQISSNK CFGGLQKVFE HDSVELNCKM KFAVYLPPKA ETGKCPALYW LSGLTCTEQN 
FISKSGYHQS ASEHGLVVIA PDTSPRGCNI KGEDESWDFG TGAGFYVDAT EDPWKTNYRM 
YSYVTEELPQ LINANFPVDP QRMSIFGHSM GGHGALICAL KNPGKYKSVS AFAPICNPVL 
CPWGKKAFSG YLGTDQSKWK AYDATHLVKS YPGSQLDILI DQGKDDQFLL DGQLLPDNFI 
AACTEKKIPV VFRLQEGYDH SYYFIATFIT DHIRHHAKYL NA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.