Details for: F10

Gene ID: 2159

Symbol: F10

Ensembl ID: ENSG00000126218

Description: coagulation factor X

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 28.1071
    Cell Significance Index: -13.2700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 3.4608
    Cell Significance Index: 29.0700
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.2865
    Cell Significance Index: 13.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.9272
    Cell Significance Index: 382.4500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.4750
    Cell Significance Index: 23.4000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.1362
    Cell Significance Index: 19.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8467
    Cell Significance Index: 116.2700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5769
    Cell Significance Index: 11.2600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5665
    Cell Significance Index: 72.6200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5657
    Cell Significance Index: 33.9600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.5384
    Cell Significance Index: 6.9000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4551
    Cell Significance Index: 410.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4118
    Cell Significance Index: 40.7400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2780
    Cell Significance Index: 7.9700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2365
    Cell Significance Index: 16.3600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2189
    Cell Significance Index: 35.6100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2128
    Cell Significance Index: 40.5100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1666
    Cell Significance Index: 8.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1654
    Cell Significance Index: 103.2800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1233
    Cell Significance Index: 2.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1173
    Cell Significance Index: 3.3800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0795
    Cell Significance Index: 2.1300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0743
    Cell Significance Index: 1.6100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0606
    Cell Significance Index: 1.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0357
    Cell Significance Index: 48.5800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0355
    Cell Significance Index: 66.9300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0291
    Cell Significance Index: 0.4300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0263
    Cell Significance Index: 3.0600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0186
    Cell Significance Index: 12.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0113
    Cell Significance Index: 17.3900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0107
    Cell Significance Index: 19.7800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0093
    Cell Significance Index: 1.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0086
    Cell Significance Index: 0.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0040
    Cell Significance Index: 0.1400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0021
    Cell Significance Index: 0.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0015
    Cell Significance Index: 1.0800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0045
    Cell Significance Index: -0.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0130
    Cell Significance Index: -8.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0145
    Cell Significance Index: -8.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0177
    Cell Significance Index: -13.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0189
    Cell Significance Index: -13.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0193
    Cell Significance Index: -4.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0209
    Cell Significance Index: -7.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0220
    Cell Significance Index: -12.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0274
    Cell Significance Index: -12.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0332
    Cell Significance Index: -5.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0369
    Cell Significance Index: -10.6200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0427
    Cell Significance Index: -4.8700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0430
    Cell Significance Index: -0.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0436
    Cell Significance Index: -6.3400
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.0485
    Cell Significance Index: -0.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0512
    Cell Significance Index: -2.8800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0553
    Cell Significance Index: -9.9700
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0591
    Cell Significance Index: -0.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0693
    Cell Significance Index: -7.9400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0743
    Cell Significance Index: -4.5600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0909
    Cell Significance Index: -1.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0914
    Cell Significance Index: -11.2400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0963
    Cell Significance Index: -2.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1054
    Cell Significance Index: -8.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1056
    Cell Significance Index: -11.0000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1071
    Cell Significance Index: -10.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1101
    Cell Significance Index: -14.2200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1131
    Cell Significance Index: -1.4100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1151
    Cell Significance Index: -2.8700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1467
    Cell Significance Index: -4.1000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1507
    Cell Significance Index: -7.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1623
    Cell Significance Index: -7.6300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1717
    Cell Significance Index: -7.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1769
    Cell Significance Index: -14.0100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1789
    Cell Significance Index: -12.0300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1899
    Cell Significance Index: -14.1500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1925
    Cell Significance Index: -2.4300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2065
    Cell Significance Index: -12.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2089
    Cell Significance Index: -6.6900
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.2093
    Cell Significance Index: -1.3000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2143
    Cell Significance Index: -2.3300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2322
    Cell Significance Index: -3.9800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2390
    Cell Significance Index: -3.6300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2413
    Cell Significance Index: -12.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2529
    Cell Significance Index: -11.7900
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.2572
    Cell Significance Index: -1.6100
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.2613
    Cell Significance Index: -1.2500
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.2755
    Cell Significance Index: -3.8100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2783
    Cell Significance Index: -12.3100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2901
    Cell Significance Index: -4.7800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2907
    Cell Significance Index: -15.1000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2947
    Cell Significance Index: -12.0700
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.3069
    Cell Significance Index: -1.8800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3232
    Cell Significance Index: -4.5300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3273
    Cell Significance Index: -12.3900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3315
    Cell Significance Index: -11.5200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.3369
    Cell Significance Index: -2.6900
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.3410
    Cell Significance Index: -4.8500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3451
    Cell Significance Index: -5.2000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3497
    Cell Significance Index: -8.4700
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.3513
    Cell Significance Index: -2.9000
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.3535
    Cell Significance Index: -3.4600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3549
    Cell Significance Index: -11.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Coagulation factor X is a serine protease that is activated by the binding of thrombin to factor V, resulting in the formation of the tenase complex. This complex then cleaves factor X, activating it to its active form. Factor X is also involved in the gamma-carboxylation of protein precursors, which is essential for their proper function. Additionally, factor X is a target for various post-translational modifications, including hydroxylation, arylsulfatase activation, and removal of aminoterminal propeptides. **Pathways and Functions:** Coagulation factor X is integral to the coagulation cascade, participating in both the extrinsic and intrinsic pathways of fibrin clot formation. The extrinsic pathway involves the activation of factor X by tissue factor, while the intrinsic pathway involves the activation of factor X by factor VIIa. Once activated, factor X cleaves and activates prothrombin to thrombin, which then converts fibrinogen to fibrin, forming a stable clot. In addition to its role in clot formation, factor X is also involved in the regulation of cell migration, positive regulation of TOR signaling, and protein binding. Its dysregulation can lead to various bleeding disorders, including hemophilia B, and thrombotic conditions, such as thrombophilia. **Clinical Significance:** Dysregulation of coagulation factor X can lead to various clinical conditions, including: 1. **Hemophilia B:** A genetic disorder caused by mutations in the F10 gene, leading to impaired factor X activity and resulting in bleeding disorders. 2. **Thrombophilia:** A condition characterized by an increased risk of thrombosis, often caused by mutations in the F10 gene that lead to impaired factor X activity. 3. **Hemostatic disorders:** Factor X dysregulation can lead to impaired hemostasis, resulting in bleeding disorders, such as hemophilia A and hemophilia C. Furthermore, factor X has been implicated in various diseases, including cancer, cardiovascular disease, and neurodegenerative disorders. Its dysregulation can also contribute to the development of thrombotic complications in patients with cardiovascular disease. **Significantly Expressed Cells:** Coagulation factor X is expressed in various cell types, including enterocytes of the colon, type A enteroendocrine cells, fibroblasts of connective tissue, P/D1 enteroendocrine cells, mural cells, hepatoblasts, stromal cells of the ovary, keratocytes, fibroblasts of the lung, and fibroblasts of the glandular part of the prostate. In conclusion, coagulation factor X is a complex protein with multiple roles in the coagulation cascade, cell migration, and protein binding. Its dysregulation can lead to various bleeding disorders and thrombotic conditions, highlighting the importance of maintaining its proper function in maintaining hemostasis. Further research is necessary to fully understand the mechanisms underlying factor X dysregulation and its implications in disease states.

Genular Protein ID: 3057900335

Symbol: FA10_HUMAN

Name: Coagulation factor X

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1902434

Title: Cloning and expression in COS-1 cells of a full-length cDNA encoding human coagulation factor X.

PubMed ID: 1902434

DOI: 10.1016/0378-1119(91)90141-w

PubMed ID: 3768336

Title: Gene for human factor X: a blood coagulation factor whose gene organization is essentially identical with that of factor IX and protein C.

PubMed ID: 3768336

DOI: 10.1021/bi00366a018

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2582420

Title: Characterization of an almost full-length cDNA coding for human blood coagulation factor X.

PubMed ID: 2582420

DOI: 10.1073/pnas.82.11.3591

PubMed ID: 3011603

Title: Isolation and characterization of human blood-coagulation factor X cDNA.

PubMed ID: 3011603

DOI: 10.1016/0378-1119(86)90112-5

PubMed ID: 6871167

Title: Complete amino acid sequence of the light chain of human blood coagulation factor X: evidence for identification of residue 63 as beta-hydroxyaspartic acid.

PubMed ID: 6871167

DOI: 10.1021/bi00281a016

PubMed ID: 6587384

Title: Characterization of a cDNA coding for human factor X.

PubMed ID: 6587384

DOI: 10.1073/pnas.81.12.3699

PubMed ID: 8243461

Title: Identification of O-linked oligosaccharide chains in the activation peptides of blood coagulation factor X. The role of the carbohydrate moieties in the activation of factor X.

PubMed ID: 8243461

DOI: 10.1111/j.1432-1033.1993.tb18361.x

PubMed ID: 2612918

Title: Cloning and characterization of the 5' end (exon 1) of the gene encoding human factor X.

PubMed ID: 2612918

DOI: 10.1016/0378-1119(89)90529-5

PubMed ID: 6323392

Title: Mechanism of inhibition of activated protein C by protein C inhibitor.

PubMed ID: 6323392

DOI: 10.1093/oxfordjournals.jbchem.a134583

PubMed ID: 8920993

Title: Activation of Mac-1 (CD11b/CD18)-bound factor X by released cathepsin G defines an alternative pathway of leucocyte initiation of coagulation.

PubMed ID: 8920993

DOI: 10.1042/bj3190873

PubMed ID: 9780208

Title: Factor Xa induces cytokine production and expression of adhesion molecules by human umbilical vein endothelial cells.

PubMed ID: 9780208

PubMed ID: 11986214

Title: Ixolaris, a novel recombinant tissue factor pathway inhibitor (TFPI) from the salivary gland of the tick, Ixodes scapularis: identification of factor X and factor Xa as scaffolds for the inhibition of factor VIIa/tissue factor complex.

PubMed ID: 11986214

DOI: 10.1182/blood-2001-12-0237

PubMed ID: 16807644

Title: Antithrombotic properties of Ixolaris, a potent inhibitor of the extrinsic pathway of the coagulation cascade.

PubMed ID: 16807644

DOI: 10.1160/th06-02-0105

PubMed ID: 18042685

Title: Ixolaris binding to factor X reveals a precursor state of factor Xa heparin-binding exosite.

PubMed ID: 18042685

DOI: 10.1110/ps.073016308

PubMed ID: 20427285

Title: Basis for the specificity and activation of the serpin protein Z-dependent proteinase inhibitor (ZPI) as an inhibitor of membrane-associated factor Xa.

PubMed ID: 20427285

DOI: 10.1074/jbc.m110.112748

PubMed ID: 21673107

Title: Alboserpin, a factor Xa inhibitor from the mosquito vector of yellow fever, binds heparin and membrane phospholipids and exhibits antithrombotic activity.

PubMed ID: 21673107

DOI: 10.1074/jbc.m111.247924

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 24041930

Title: Coagulation factor Xa induces an inflammatory signalling by activation of protease-activated receptors in human atrial tissue.

PubMed ID: 24041930

DOI: 10.1016/j.ejphar.2013.09.006

PubMed ID: 30568593

Title: TAK-442, a Direct Factor Xa Inhibitor, Inhibits Monocyte Chemoattractant Protein 1 Production in Endothelial Cells via Involvement of Protease-Activated Receptor 1.

PubMed ID: 30568593

DOI: 10.3389/fphar.2018.01431

PubMed ID: 31133602

Title: NMR structure determination of Ixolaris and factor X(a) interaction reveals a noncanonical mechanism of Kunitz inhibition.

PubMed ID: 31133602

DOI: 10.1182/blood.2018889493

PubMed ID: 34831181

Title: Coagulation Factor Xa Induces Proinflammatory Responses in Cardiac Fibroblasts via Activation of Protease-Activated Receptor-1.

PubMed ID: 34831181

DOI: 10.3390/cells10112958

PubMed ID: 34502392

Title: Ixodes ricinus Salivary Serpin Iripin-8 Inhibits the Intrinsic Pathway of Coagulation and Complement.

PubMed ID: 34502392

DOI: 10.3390/ijms22179480

PubMed ID: 35738824

Title: Alboserpin, the Main Salivary Anticoagulant from the Disease Vector Aedes albopictus, Displays Anti-FXa-PAR Signaling In Vitro and In Vivo.

PubMed ID: 35738824

DOI: 10.4049/immunohorizons.2200045

PubMed ID: 8355279

Title: Structure of human des(1-45) factor Xa at 2.2-A resolution.

PubMed ID: 8355279

DOI: 10.1006/jmbi.1993.1441

PubMed ID: 9618463

Title: Structural basis for chemical inhibition of human blood coagulation factor Xa.

PubMed ID: 9618463

DOI: 10.1073/pnas.95.12.6630

PubMed ID: 17227710

Title: Substituted thiophene-anthranilamides as potent inhibitors of human factor Xa.

PubMed ID: 17227710

DOI: 10.1016/j.bmc.2006.12.019

PubMed ID: 2790181

Title: Molecular characterization of human factor XSan Antonio.

PubMed ID: 2790181

PubMed ID: 1973167

Title: Molecular defect (Gla+14TO: hereditary factor X deficiency (factor X 'Vorarlberg').

PubMed ID: 1973167

DOI: 10.1016/s0021-9258(19)38497-2

PubMed ID: 1985698

Title: Molecular defect in coagulation factor XFriuli results from a substitution of serine for proline at position 343.

PubMed ID: 1985698

PubMed ID: 7669671

Title: Molecular bases of CRM+ factor X deficiency: a frequent mutation (Ser334Pro) in the catalytic domain and a substitution (Glu102Lys) in the second EGF-like domain.

PubMed ID: 7669671

DOI: 10.1111/j.1365-2141.1995.tb05214.x

PubMed ID: 8529633

Title: Functional consequences of the Ser334-->Pro mutation in a human factor X variant (factor XMarseille).

PubMed ID: 8529633

DOI: 10.1111/j.1432-1033.1995.140_c.x

PubMed ID: 7860069

Title: Factor XKetchikan: a variant molecule in which Gly replaces a Gla residue at position 14 in the light chain.

PubMed ID: 7860069

DOI: 10.1007/bf00209404

PubMed ID: 8845463

Title: Factor X Stockton: a mild bleeding diathesis associated with an active site mutation in factor X.

PubMed ID: 8845463

PubMed ID: 8910490

Title: Factor XSt. Louis II. Identification of a glycine substitution at residue 7 and characterization of the recombinant protein.

PubMed ID: 8910490

DOI: 10.1074/jbc.271.45.28601

PubMed ID: 10468877

Title: A family with hereditary factor X deficiency with a point mutation Gla32 to Gln in the Gla domain (factor X Tokyo).

PubMed ID: 10468877

DOI: 10.1046/j.1365-2141.1999.01614.x

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

PubMed ID: 10746568

Title: Molecular analysis of the genotype-phenotype relationship in factor X deficiency.

PubMed ID: 10746568

DOI: 10.1007/s004390051035

PubMed ID: 10739379

Title: The impact of Glu102Lys on the factor X function in a patient with a doubly homozygous factor X deficiency (Gla14Lys and Glu102Lys).

PubMed ID: 10739379

PubMed ID: 11248282

Title: A dysfunctional factor X (factor X San Giovanni Rotondo) present at homozygous and double heterozygous level: identification of a novel microdeletion (delC556) and missense mutation (Lys(408)-->Asn) in the factor X gene. A study of an Italian family.

PubMed ID: 11248282

DOI: 10.1016/s0049-3848(00)00406-0

PubMed ID: 11728527

Title: A new factor X defect (factor X Padua 3): a compound heterozygous between true deficiency (Gly(380)-->Arg) and an abnormality (Ser(334)-->Pro).

PubMed ID: 11728527

DOI: 10.1016/s0049-3848(01)00371-1

PubMed ID: 12945883

Title: A novel type I factor X variant (factor X Cys350Phe) due to loss of a disulfide bond in the catalytic domain.

PubMed ID: 12945883

DOI: 10.1097/00001721-200306000-00012

PubMed ID: 12574802

Title: Impaired prothrombinase activity of factor X Gly381Asp results in severe familial CRM+ FX deficiency.

PubMed ID: 12574802

PubMed ID: 15075089

Title: Molecular characterization of factor X deficiency associated with borderline plasma factor X level.

PubMed ID: 15075089

PubMed ID: 15650540

Title: Genetic analysis of hereditary factor X deficiency in a French patient of Sri Lankan ancestry: in vitro expression study identified Gly366Ser substitution as the molecular basis of the dysfunctional factor X.

PubMed ID: 15650540

DOI: 10.1097/00001721-200501000-00002

PubMed ID: 17393015

Title: Analysis of the novel factor X gene mutation Glu51Lys in two families with factor X-Riyadh anomaly.

PubMed ID: 17393015

DOI: 10.1160/th06-09-0532

PubMed ID: 19135706

Title: Characterization of a homozygous Gly11Val mutation in the Gla domain of coagulation factor X.

PubMed ID: 19135706

DOI: 10.1016/j.thromres.2008.11.018

PubMed ID: 25313940

Title: Molecular dynamics characterization of five pathogenic Factor X mutants associated with decreased catalytic activity.

PubMed ID: 25313940

DOI: 10.1021/bi500770p

PubMed ID: 26222694

Title: Frequency of the p.Gly262Asp mutation in congenital Factor X deficiency.

PubMed ID: 26222694

DOI: 10.1111/eci.12511

Sequence Information:

  • Length: 488
  • Mass: 54732
  • Checksum: F81D5746AF4797AF
  • Sequence:
  • MGRPLHLVLL SASLAGLLLL GESLFIRREQ ANNILARVTR ANSFLEEMKK GHLERECMEE 
    TCSYEEAREV FEDSDKTNEF WNKYKDGDQC ETSPCQNQGK CKDGLGEYTC TCLEGFEGKN 
    CELFTRKLCS LDNGDCDQFC HEEQNSVVCS CARGYTLADN GKACIPTGPY PCGKQTLERR 
    KRSVAQATSS SGEAPDSITW KPYDAADLDP TENPFDLLDF NQTQPERGDN NLTRIVGGQE 
    CKDGECPWQA LLINEENEGF CGGTILSEFY ILTAAHCLYQ AKRFKVRVGD RNTEQEEGGE 
    AVHEVEVVIK HNRFTKETYD FDIAVLRLKT PITFRMNVAP ACLPERDWAE STLMTQKTGI 
    VSGFGRTHEK GRQSTRLKML EVPYVDRNSC KLSSSFIITQ NMFCAGYDTK QEDACQGDSG 
    GPHVTRFKDT YFVTGIVSWG EGCARKGKYG IYTKVTAFLK WIDRSMKTRG LPKAKSHAPE 
    VITSSPLK

Genular Protein ID: 1556262470

Symbol: Q5JVE8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 332
  • Mass: 37094
  • Checksum: 434393FC2A30A8FB
  • Sequence:
  • MGRPLHLVLL SASLAGLLLL GESLFIRREQ ANNILARVTR ANSFLEEMKK GHLERECMEE 
    TCSYEEAREV FEDSDKTNEF WNKYKDGDQC ETSPCQNQGK CKDGLGEYTC TCLEGFEGKN 
    CELFTRKLCS LDNGDCDQFC HEEQNSVVCS CARGYTLADN GKACIPTGPY PCGKQTLERR 
    KRSVAQATSS SGEAPDSITW KPYDAADLDP TENPFDLLDF NQTQPERGDN NLTRIVGGQE 
    CKDGECPWQA LLINEENEGF CGGTILSEFY ILTAAHCLYQ AKRFKGTGTR SRRRAVRRCT 
    RWRWSSSTTG SQRRPMTSTS PCSGSRPPSP SA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.