Details for: FANCF

Gene ID: 2188

Symbol: FANCF

Ensembl ID: ENSG00000183161

Description: FA complementation group F

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.14
    Marker Score: 1988
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.08
    Marker Score: 16928
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1
    Marker Score: 801
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71764
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47989
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 483
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 439
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2719
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4984
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5259
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.79
    Marker Score: 1505.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.75
    Marker Score: 412
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.73
    Marker Score: 1524.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 557.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.73
    Marker Score: 6322
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 375
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.71
    Marker Score: 286
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.69
    Marker Score: 727
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 614
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2754
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 168
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.64
    Marker Score: 1088
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.63
    Marker Score: 419
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.63
    Marker Score: 376
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.62
    Marker Score: 620
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.61
    Marker Score: 1671
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.61
    Marker Score: 389
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.59
    Marker Score: 289
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.58
    Marker Score: 837
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.57
    Marker Score: 607
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.56
    Marker Score: 1149
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.56
    Marker Score: 383
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.56
    Marker Score: 586
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.56
    Marker Score: 162
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.56
    Marker Score: 131
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.56
    Marker Score: 1309
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 433
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.52
    Marker Score: 1238
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.52
    Marker Score: 2131
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.52
    Marker Score: 18003
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.52
    Marker Score: 2009
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.51
    Marker Score: 906
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.51
    Marker Score: 636
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.5
    Marker Score: 566
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.5
    Marker Score: 264
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.49
    Marker Score: 1041
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.49
    Marker Score: 688
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.48
    Marker Score: 913
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.47
    Marker Score: 4728
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.47
    Marker Score: 453
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.46
    Marker Score: 1262
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.46
    Marker Score: 220
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.46
    Marker Score: 174
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.45
    Marker Score: 1563
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.45
    Marker Score: 1065
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.45
    Marker Score: 119
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.44
    Marker Score: 232
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.44
    Marker Score: 291
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.44
    Marker Score: 130
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.44
    Marker Score: 400
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.43
    Marker Score: 181
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.43
    Marker Score: 2793
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.43
    Marker Score: 206
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.42
    Marker Score: 184
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.42
    Marker Score: 174
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.42
    Marker Score: 1553
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.42
    Marker Score: 448
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.42
    Marker Score: 135
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.42
    Marker Score: 501
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.41
    Marker Score: 405
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.41
    Marker Score: 364
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.41
    Marker Score: 5404
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.41
    Marker Score: 122
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.4
    Marker Score: 400
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.4
    Marker Score: 182
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.4
    Marker Score: 86
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.39
    Marker Score: 185
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.38
    Marker Score: 1094
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.38
    Marker Score: 412
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.38
    Marker Score: 175
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.38
    Marker Score: 122
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.38
    Marker Score: 2807
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.38
    Marker Score: 132
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.38
    Marker Score: 1477
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.38
    Marker Score: 261.5
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.37
    Marker Score: 108
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.37
    Marker Score: 117
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.37
    Marker Score: 95
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.37
    Marker Score: 89
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.36
    Marker Score: 593
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.36
    Marker Score: 364.5
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.36
    Marker Score: 336
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.36
    Marker Score: 372
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.35
    Marker Score: 266
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.35
    Marker Score: 1691
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.35
    Marker Score: 252

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - FANCF is a protein of the Fanconi anemia group, which is characterized by severe anemia and bone marrow failure. - It is a secreted protein that is expressed in various cell types. - It is involved in the regulation of cell cycle progression, DNA repair, and apoptosis. **Pathways and functions:** - FANCF is involved in the Fanconi anemia pathway, a group of genetic disorders characterized by severe anemia and bone marrow failure. - It is a key regulator of the pathway, and its expression is often upregulated in Fanconi anemia patients. - It is involved in the repair of DNA damage, including double-strand breaks and single-strand breaks. - It also plays a role in the regulation of cell cycle progression and apoptosis. **Clinical significance:** - Mutations in the FANCF gene are a common cause of Fanconi anemia. - Prenatal testing for FANCF mutations can help diagnose the condition in pregnant women. - Early diagnosis and treatment can help prevent the development of severe anemia and bone marrow failure. - FANCF gene therapy is being investigated as a potential treatment for Fanconi anemia.

Genular Protein ID: 3694424282

Symbol: FANCF_HUMAN

Name: Fanconi anemia group F protein

UniProtKB Accession Codes:

Q9NPI8 Q52LM0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 7 EMDB 6 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 7 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10615118

Title: The Fanconi anaemia gene FANCF encodes a novel protein with homology to ROM.

PubMed ID: 10615118

DOI: 10.1038/71626

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17082180

Title: Structural determinants of human FANCF protein that function in the assembly of a DNA damage signaling complex.

PubMed ID: 17082180

DOI: 10.1074/jbc.m608356200

PubMed ID: 11063725

Title: The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG.

PubMed ID: 11063725

DOI: 10.1093/hmg/9.18.2665

PubMed ID: 12724401

Title: A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome.

PubMed ID: 12724401

DOI: 10.1128/mcb.23.10.3417-3426.2003

PubMed ID: 15502827

Title: X-linked inheritance of Fanconi anemia complementation group B.

PubMed ID: 15502827

DOI: 10.1038/ng1458

PubMed ID: 16116422

Title: A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M.

PubMed ID: 16116422

DOI: 10.1038/ng1626

PubMed ID: 18550849

Title: HES1 is a novel interactor of the Fanconi anemia core complex.

PubMed ID: 18550849

DOI: 10.1182/blood-2008-04-152710

Sequence Information:

  • Length: 374
  • Mass: 42254
  • Checksum: 1F295CD1FBE6ED7D
  • Sequence:
    • MESLLQHLDR FSELLAVSST TYVSTWDPAT VRRALQWARY LRHIHRRFGR HGPIRTALER 
RLHNQWRQEG GFGRGPVPGL ANFQALGHCD VLLSLRLLEN RALGDAARYH LVQQLFPGPG 
VRDADEETLQ ESLARLARRR SAVHMLRFNG YRENPNLQED SLMKTQAELL LERLQEVGKA 
EAERPARFLS SLWERLPQNN FLKVIAVALL QPPLSRRPQE ELEPGIHKSP GEGSQVLVHW 
LLGNSEVFAA FCRALPAGLL TLVTSRHPAL SPVYLGLLTD WGQRLHYDLQ KGIWVGTESQ 
DVPWEELHNR FQSLCQAPPP LKDKVLTALE TCKAQDGDFE VPGLSIWTDL LLALRSGAFR 
KRQVLGLSAG LSSV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.