Details for: FHL3

Gene ID: 2275

Symbol: FHL3

Ensembl ID: ENSG00000183386

Description: four and a half LIM domains 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 83.9627
    Cell Significance Index: -13.0600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 39.5437
    Cell Significance Index: -10.0300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 28.8061
    Cell Significance Index: -13.6000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 28.6201
    Cell Significance Index: -11.7900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 28.5287
    Cell Significance Index: -11.5900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 25.6034
    Cell Significance Index: -13.1700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.7303
    Cell Significance Index: -13.2300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 6.8459
    Cell Significance Index: 110.4600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 5.8616
    Cell Significance Index: 143.0200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.6270
    Cell Significance Index: -12.4000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.5928
    Cell Significance Index: -11.0400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.4110
    Cell Significance Index: -13.4600
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.5865
    Cell Significance Index: 13.6100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.1370
    Cell Significance Index: 17.9500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.0130
    Cell Significance Index: 25.7800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.5536
    Cell Significance Index: 16.8900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.4758
    Cell Significance Index: 30.8900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8105
    Cell Significance Index: 111.3000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6159
    Cell Significance Index: 117.2200
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.5460
    Cell Significance Index: 5.7000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.5189
    Cell Significance Index: 9.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4142
    Cell Significance Index: 40.9700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3890
    Cell Significance Index: 63.2700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3190
    Cell Significance Index: 8.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3167
    Cell Significance Index: 8.6200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3077
    Cell Significance Index: 8.8200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2917
    Cell Significance Index: 37.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2687
    Cell Significance Index: 12.6300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2464
    Cell Significance Index: 14.8000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2402
    Cell Significance Index: 216.9000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2341
    Cell Significance Index: 30.2500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2217
    Cell Significance Index: 24.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2075
    Cell Significance Index: 91.7300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1916
    Cell Significance Index: 9.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1515
    Cell Significance Index: 17.6500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1332
    Cell Significance Index: 9.4200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1150
    Cell Significance Index: 62.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0965
    Cell Significance Index: 4.5000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0685
    Cell Significance Index: 4.7400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0559
    Cell Significance Index: 1.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0534
    Cell Significance Index: 6.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0392
    Cell Significance Index: 7.7700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0369
    Cell Significance Index: 2.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0300
    Cell Significance Index: 5.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0271
    Cell Significance Index: 5.4300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0232
    Cell Significance Index: 0.1400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0226
    Cell Significance Index: 0.6500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0209
    Cell Significance Index: 0.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0180
    Cell Significance Index: 8.1900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.0076
    Cell Significance Index: 0.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0026
    Cell Significance Index: -0.0900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0042
    Cell Significance Index: -2.9200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0057
    Cell Significance Index: -10.6400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0093
    Cell Significance Index: -17.2300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0100
    Cell Significance Index: -0.2500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0103
    Cell Significance Index: -0.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0108
    Cell Significance Index: -16.6000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0110
    Cell Significance Index: -0.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0125
    Cell Significance Index: -9.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0129
    Cell Significance Index: -17.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0136
    Cell Significance Index: -3.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0149
    Cell Significance Index: -9.4800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0154
    Cell Significance Index: -11.2700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0157
    Cell Significance Index: -0.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0213
    Cell Significance Index: -15.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0231
    Cell Significance Index: -3.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0241
    Cell Significance Index: -15.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0255
    Cell Significance Index: -14.3900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0282
    Cell Significance Index: -10.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0322
    Cell Significance Index: -1.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0425
    Cell Significance Index: -4.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0645
    Cell Significance Index: -7.3900
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0671
    Cell Significance Index: -0.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0749
    Cell Significance Index: -4.5900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0761
    Cell Significance Index: -16.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0793
    Cell Significance Index: -11.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0821
    Cell Significance Index: -9.6800
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.0868
    Cell Significance Index: -0.5100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0880
    Cell Significance Index: -1.8800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1128
    Cell Significance Index: -3.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1189
    Cell Significance Index: -12.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1201
    Cell Significance Index: -9.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1305
    Cell Significance Index: -6.7800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1350
    Cell Significance Index: -2.8000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1371
    Cell Significance Index: -1.8700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1374
    Cell Significance Index: -3.8400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1417
    Cell Significance Index: -7.1600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1569
    Cell Significance Index: -12.4300
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.1589
    Cell Significance Index: -1.2000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1668
    Cell Significance Index: -4.9000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1743
    Cell Significance Index: -10.7200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1811
    Cell Significance Index: -5.8000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1997
    Cell Significance Index: -13.4300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2042
    Cell Significance Index: -8.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2087
    Cell Significance Index: -13.1600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2153
    Cell Significance Index: -5.7600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2205
    Cell Significance Index: -3.0600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2244
    Cell Significance Index: -5.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2440
    Cell Significance Index: -13.6900
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.2507
    Cell Significance Index: -3.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FHL3 is a member of the four and a half LIM domains (FHL) protein family, which consists of seven members. FHL3 is characterized by its four and a half LIM domains, which are responsible for its interaction with other proteins and regulation of cellular processes. FHL3 is a relatively small protein, with a molecular weight of approximately 50 kDa. Its expression is widespread, with significant levels detected in germ cells, smooth muscle cells, and immune cells, including CD14-positive monocytes. **Pathways and Functions:** FHL3 is implicated in various cellular processes, including: 1. **Actin cytoskeleton organization**: FHL3 interacts with actin-binding proteins to regulate the organization and dynamics of the actin cytoskeleton, which is crucial for cell shape, movement, and signaling. 2. **Focal adhesion**: FHL3 is involved in the formation and regulation of focal adhesions, which are critical for cell adhesion, migration, and signaling. 3. **Muscle organ development**: FHL3 is essential for the development and maintenance of muscle tissue, particularly in smooth muscle cells. 4. **Stress fiber formation**: FHL3 is involved in the formation of stress fibers, which are dynamic structures that regulate cell shape and movement. 5. **Transcription coregulation**: FHL3 interacts with transcription factors and other regulatory proteins to modulate gene expression. **Clinical Significance:** FHL3 has been implicated in various diseases, including: 1. **Muscular dystrophy**: Mutations in FHL3 have been associated with muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. 2. **Cancer**: FHL3 has been reported to be overexpressed in various types of cancer, including colon and breast cancer, suggesting its potential role in tumorigenesis. 3. **Autoimmune diseases**: FHL3 has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where it may contribute to the regulation of immune responses. 4. **Neurological disorders**: FHL3 has been associated with neurological disorders, including Parkinson's disease and Alzheimer's disease, where it may play a role in the regulation of neuronal function and survival. In conclusion, FHL3 is a multifaceted protein with a wide range of cellular functions, from actin cytoskeleton organization to transcription coregulation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the role of FHL3 in human health and disease.

Genular Protein ID: 336616935

Symbol: FHL3_HUMAN

Name: Four and a half LIM domains protein 3

UniProtKB Accession Codes:

Q13643 D3DPT6 Q6I9T0 Q9BVA2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 EvolutionaryTrace 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10049693

Title: The LIM proteins FHL1 and FHL3 are expressed differently in skeletal muscle.

PubMed ID: 10049693

DOI: 10.1006/bbrc.1999.0179

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8753811

Title: Slim defines a novel family of LIM-proteins expressed in skeletal muscle.

PubMed ID: 8753811

DOI: 10.1006/bbrc.1996.1222

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 280
  • Mass: 31192
  • Checksum: D1A037C260370DFD
  • Sequence:
    • MSESFDCAKC NESLYGRKYI QTDSGPYCVP CYDNTFANTC AECQQLIGHD SRELFYEDRH 
FHEGCFRCCR CQRSLADEPF TCQDSELLCN DCYCSAFSSQ CSACGETVMP GSRKLEYGGQ 
TWHEHCFLCS GCEQPLGSRS FVPDKGAHYC VPCYENKFAP RCARCSKTLT QGGVTYRDQP 
WHRECLVCTG CQTPLAGQQF TSRDEDPYCV ACFGELFAPK CSSCKRPIVG LGGGKYVSFE 
DRHWHHNCFS CARCSTSLVG QGFVPDGDQV LCQGCSQAGP

Genular Protein ID: 3524978181

Symbol: Q96C98_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96C98

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 7 Gene3D 1 IntAct 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 172
  • Mass: 18918
  • Checksum: 5918FF5E8C015BE6
  • Sequence:
    • MPGSRKLEYG GQTWHEHCFL CSGCEQPLGS RSFVPDKGAH YCVPCYENKF APRCARCSKT 
LTQGGVTYRD QPWHRECLVC TGCQTPLAGQ QFTSRDEDPY CVACFGELFA PKCSSCKRPI 
VGLGGGKYVS FEDRHWHHNC FSCARCSTSL VGQGFVPDGD QVLCQGCSQA GP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.