Details for: FHL3

Gene ID: 2275

Symbol: FHL3

Ensembl ID: ENSG00000183386

Description: four and a half LIM domains 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.91
    Marker Score: 3332
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.56
    Marker Score: 1132
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.43
    Marker Score: 3370.5
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.42
    Marker Score: 536
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.31
    Marker Score: 5639
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.27
    Marker Score: 8275
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.17
    Marker Score: 15407
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.16
    Marker Score: 2888
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.09
    Marker Score: 1365
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71763
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47988
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30402
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.97
    Marker Score: 10905
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.95
    Marker Score: 1009
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 487
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.94
    Marker Score: 270
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 442
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.92
    Marker Score: 578
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2717
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.89
    Marker Score: 356
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.89
    Marker Score: 710
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.88
    Marker Score: 249
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.87
    Marker Score: 631
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4970
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5259
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310.5
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.85
    Marker Score: 5147
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.84
    Marker Score: 239
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.83
    Marker Score: 786
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.82
    Marker Score: 1542
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.8
    Marker Score: 277
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.79
    Marker Score: 953
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.77
    Marker Score: 952
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1245
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.75
    Marker Score: 1429.5
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.75
    Marker Score: 3061
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.74
    Marker Score: 424
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 563
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 671
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.73
    Marker Score: 41008
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 378
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.73
    Marker Score: 3578.5
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.73
    Marker Score: 254
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.72
    Marker Score: 993
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.71
    Marker Score: 923
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.7
    Marker Score: 750
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.7
    Marker Score: 499
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.7
    Marker Score: 1080
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.7
    Marker Score: 2213
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.69
    Marker Score: 987
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.67
    Marker Score: 1470
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.67
    Marker Score: 317
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.67
    Marker Score: 452
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.66
    Marker Score: 212
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2754
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.65
    Marker Score: 1848
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.65
    Marker Score: 3931
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.65
    Marker Score: 232
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.65
    Marker Score: 1270
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.64
    Marker Score: 1880
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.63
    Marker Score: 21555
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.63
    Marker Score: 191
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.63
    Marker Score: 1650
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.63
    Marker Score: 479
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.63
    Marker Score: 413
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.61
    Marker Score: 619
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.6
    Marker Score: 1566
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.6
    Marker Score: 301
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.59
    Marker Score: 565
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.58
    Marker Score: 9048
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.58
    Marker Score: 888
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.58
    Marker Score: 674
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.57
    Marker Score: 145
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.57
    Marker Score: 245
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.56
    Marker Score: 358
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.56
    Marker Score: 1546
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.55
    Marker Score: 262
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.53
    Marker Score: 119
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.53
    Marker Score: 155
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.53
    Marker Score: 255
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.51
    Marker Score: 125
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5
    Marker Score: 338
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5
    Marker Score: 1049
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.49
    Marker Score: 244
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.49
    Marker Score: 1337
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.48
    Marker Score: 554
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.48
    Marker Score: 961
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.48
    Marker Score: 344
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.48
    Marker Score: 157
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.48
    Marker Score: 126
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.47
    Marker Score: 543
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.47
    Marker Score: 205
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.47
    Marker Score: 232
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.47
    Marker Score: 457
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.47
    Marker Score: 385.5
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.47
    Marker Score: 215
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.47
    Marker Score: 318

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Other Information

**Key characteristics:** - FHL3 is a transmembrane protein with four and a half LIM domains. - It is a cytoskeletal protein that is involved in cell adhesion, migration, and differentiation. - It is expressed in a variety of cell types, including germ cells, which are responsible for the development of the embryo. - It is also expressed in cells that are involved in tissue repair and development, such as colon goblet cells, enteric smooth muscle cells, and smooth muscle cells of the large intestine. **Pathways and functions:** - FHL3 is a key regulator of cell migration by binding to the extracellular matrix protein fibronectin and promoting its interaction with integrins. This interaction allows FHL3 to anchor the cell to the extracellular matrix and to migrate in a cell-dependent manner. - FHL3 is also involved in cell adhesion and differentiation. It is expressed in cells that are attached to the extracellular matrix, and it is necessary for these cells to adhere to the matrix and to differentiate into other cell types. - FHL3 is a key regulator of tissue repair and development. It is expressed in cells that are responsible for regenerating tissues, such as the skin, muscles, and organs. FHL3 deficiency mice have a number of developmental defects, including heart defects, skeletal abnormalities, and brain abnormalities. **Clinical significance:** FHL3 is a promising target for cancer therapy. It is expressed in a number of cancer cells, and it is involved in their migration, invasion, and metastasis. Inhibition of FHL3 has been shown to inhibit cancer cell growth and metastasis, suggesting that it could be a promising therapy for cancer.

Genular Protein ID: 336616935

Symbol: FHL3_HUMAN

Name: Four and a half LIM domains protein 3

UniProtKB Accession Codes:

Q13643 D3DPT6 Q6I9T0 Q9BVA2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 3 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10049693

Title: The LIM proteins FHL1 and FHL3 are expressed differently in skeletal muscle.

PubMed ID: 10049693

DOI: 10.1006/bbrc.1999.0179

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8753811

Title: Slim defines a novel family of LIM-proteins expressed in skeletal muscle.

PubMed ID: 8753811

DOI: 10.1006/bbrc.1996.1222

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 280
  • Mass: 31192
  • Checksum: D1A037C260370DFD
  • Sequence:
    • MSESFDCAKC NESLYGRKYI QTDSGPYCVP CYDNTFANTC AECQQLIGHD SRELFYEDRH 
FHEGCFRCCR CQRSLADEPF TCQDSELLCN DCYCSAFSSQ CSACGETVMP GSRKLEYGGQ 
TWHEHCFLCS GCEQPLGSRS FVPDKGAHYC VPCYENKFAP RCARCSKTLT QGGVTYRDQP 
WHRECLVCTG CQTPLAGQQF TSRDEDPYCV ACFGELFAPK CSSCKRPIVG LGGGKYVSFE 
DRHWHHNCFS CARCSTSLVG QGFVPDGDQV LCQGCSQAGP

Genular Protein ID: 3524978181

Symbol: Q96C98_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96C98

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 Genevisible 1 GenomeRNAi 1 IntAct 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 172
  • Mass: 18918
  • Checksum: 5918FF5E8C015BE6
  • Sequence:
    • MPGSRKLEYG GQTWHEHCFL CSGCEQPLGS RSFVPDKGAH YCVPCYENKF APRCARCSKT 
LTQGGVTYRD QPWHRECLVC TGCQTPLAGQ QFTSRDEDPY CVACFGELFA PKCSSCKRPI 
VGLGGGKYVS FEDRHWHHNC FSCARCSTSL VGQGFVPDGD QVLCQGCSQA GP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.