Details for: FKBP1A

Gene ID: 2280

Symbol: FKBP1A

Ensembl ID: ENSG00000088832

Description: FKBP prolyl isomerase 1A

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 5
    Marker Score: 3531
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 4.84
    Marker Score: 12313
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 4.65
    Marker Score: 2820
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 4.01
    Marker Score: 5809
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 3.9
    Marker Score: 16187
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.5
    Marker Score: 195962
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 3.45
    Marker Score: 20973.5
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.38
    Marker Score: 2913
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.18
    Marker Score: 6356
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.14
    Marker Score: 8684
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 3.12
    Marker Score: 3122
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 3.07
    Marker Score: 900
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.04
    Marker Score: 35340.5
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.98
    Marker Score: 5806
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.91
    Marker Score: 3127
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.87
    Marker Score: 2994
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.83
    Marker Score: 6920
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 2.81
    Marker Score: 1568
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.81
    Marker Score: 3311
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.79
    Marker Score: 12050
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.77
    Marker Score: 3920
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.76
    Marker Score: 36398
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.76
    Marker Score: 21520.5
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.74
    Marker Score: 3135
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.71
    Marker Score: 26843
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 2.67
    Marker Score: 2264
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.65
    Marker Score: 1499
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.64
    Marker Score: 4468
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.64
    Marker Score: 6209.5
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.59
    Marker Score: 66407.5
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.59
    Marker Score: 10611
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.58
    Marker Score: 16464
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.57
    Marker Score: 12633
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.55
    Marker Score: 2403
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.54
    Marker Score: 591
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.51
    Marker Score: 21638
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.51
    Marker Score: 85256
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.5
    Marker Score: 4360
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 2.5
    Marker Score: 1079
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.49
    Marker Score: 1516
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.48
    Marker Score: 7360
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.47
    Marker Score: 15770
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.47
    Marker Score: 27792
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.46
    Marker Score: 5144
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.46
    Marker Score: 1936
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.45
    Marker Score: 15921
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.44
    Marker Score: 997
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.44
    Marker Score: 1019
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.42
    Marker Score: 7606
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.42
    Marker Score: 3891
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.42
    Marker Score: 1749
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 2.41
    Marker Score: 1816
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.4
    Marker Score: 83277.5
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.4
    Marker Score: 5985
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.4
    Marker Score: 3126
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.4
    Marker Score: 932
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.4
    Marker Score: 2562
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.38
    Marker Score: 1225
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.37
    Marker Score: 1486.5
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.36
    Marker Score: 813
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.36
    Marker Score: 2645
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.34
    Marker Score: 1151
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.32
    Marker Score: 1663
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.32
    Marker Score: 1221
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.32
    Marker Score: 31140
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.32
    Marker Score: 4350
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.31
    Marker Score: 5246
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.3
    Marker Score: 3912.5
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.28
    Marker Score: 2147
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.27
    Marker Score: 1355
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.27
    Marker Score: 2517
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.26
    Marker Score: 1292
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.26
    Marker Score: 2278
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.24
    Marker Score: 5398
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.24
    Marker Score: 1231
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.23
    Marker Score: 3664
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 2.23
    Marker Score: 2011
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 2.23
    Marker Score: 1489
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.22
    Marker Score: 8566
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.21
    Marker Score: 3944
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.2
    Marker Score: 5708.5
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.2
    Marker Score: 1470
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.2
    Marker Score: 2323
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.18
    Marker Score: 5941
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.17
    Marker Score: 5327.5
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.17
    Marker Score: 1246
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 2.15
    Marker Score: 891
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.14
    Marker Score: 2306
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.14
    Marker Score: 1559
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.14
    Marker Score: 3073
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 2.13
    Marker Score: 1344
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.13
    Marker Score: 3277
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 2.13
    Marker Score: 1898
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.12
    Marker Score: 8343
  • Cell Name: platelet (CL0000233)
    Fold Change: 2.12
    Marker Score: 961
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 2.12
    Marker Score: 972
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.12
    Marker Score: 7838
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 2.12
    Marker Score: 476
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 2.12
    Marker Score: 2042
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.12
    Marker Score: 3748

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Other Information

**Key characteristics:** * FKBP1A is a protein of the FKBP family of prolyl isomerases. * It is expressed in high levels in immune cells, including monocytes, macrophages, and dendritic cells. * It is a key regulator of inflammation and cell growth. * It is involved in the regulation of the adaptive immune system by controlling the activity of the transcription factor NFAT. * It is also involved in the regulation of cell growth by controlling the expression of growth factors. **Pathways and functions:** * FKBP1A is involved in the regulation of inflammation by controlling the activity of the transcription factor NFAT. * NFAT is a key regulator of inflammation. It is responsible for the production of pro-inflammatory cytokines and chemokines, which can lead to the recruitment of immune cells to the site of inflammation. * FKBP1A is also involved in the regulation of cell growth by controlling the expression of growth factors. * It is involved in the regulation of the adaptive immune system by controlling the activity of the transcription factor NFAT. **Clinical significance:** * Mutations in FKBP1A have been linked to a number of human diseases, including autoimmune disorders, cancer, and inflammatory diseases. * FKBP1A inhibitors are being investigated as a treatment for these diseases. * Understanding the role of FKBP1A in the immune system could lead to the development of new treatments for autoimmune disorders and cancer.

Genular Protein ID: 2404836209

Symbol: FKB1A_HUMAN

Name: Peptidyl-prolyl cis-trans isomerase FKBP1A

UniProtKB Accession Codes:

P62942 D3DVW6 P20071 Q4VC47 Q6FGD9 Q6LEU3 Q9H103 Q9H566

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 15 DrugCentral 1 EC 1 EMBL 17 EMDB 1 EPD 1 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 39 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 82 PDBsum 79 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 7 RefSeq 2 Rhea 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1695378

Title: Complementary DNA encoding the human T-cell FK506-binding protein, a peptidylprolyl cis-trans isomerase distinct from cyclophilin.

PubMed ID: 1695378

DOI: 10.1073/pnas.87.14.5440

PubMed ID: 1696686

Title: Molecular cloning and overexpression of the human FK506-binding protein FKBP.

PubMed ID: 1696686

DOI: 10.1038/346671a0

PubMed ID: 1716149

Title: Exon organization of the human FKBP-12 gene: correlation with structural and functional protein domains.

PubMed ID: 1716149

DOI: 10.1021/bi00099a002

PubMed ID: 7529739

Title: Three distinct messenger RNAs can encode the human immunosuppressant-binding protein FKBP12.

PubMed ID: 7529739

DOI: 10.1016/0378-1119(94)90434-0

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1701173

Title: The cytosolic-binding protein for the immunosuppressant FK-506 is both a ubiquitous and highly conserved peptidyl-prolyl cis-trans isomerase.

PubMed ID: 1701173

DOI: 10.1016/s0021-9258(17)45319-1

PubMed ID: 2477715

Title: A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase.

PubMed ID: 2477715

DOI: 10.1038/341758a0

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 8955134

Title: FAP48, a new protein that forms specific complexes with both immunophilins FKBP59 and FKBP12. Prevention by the immunosuppressant drugs FK506 and rapamycin.

PubMed ID: 8955134

DOI: 10.1074/jbc.271.51.32923

PubMed ID: 9233797

Title: Mechanism of TGFbeta receptor inhibition by FKBP12.

PubMed ID: 9233797

DOI: 10.1093/emboj/16.13.3866

PubMed ID: 10358090

Title: Further characterization of the type 3 ryanodine receptor (RyR3) purified from rabbit diaphragm.

PubMed ID: 10358090

DOI: 10.1074/jbc.274.24.17297

PubMed ID: 16720724

Title: FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor.

PubMed ID: 16720724

DOI: 10.1677/jme.1.01966

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22100703

Title: Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels.

PubMed ID: 22100703

DOI: 10.1016/j.abb.2011.11.004

PubMed ID: 1709363

Title: Proton and nitrogen sequential assignments and secondary structure determination of the human FK506 and rapamycin binding protein.

PubMed ID: 1709363

DOI: 10.1021/bi00233a020

PubMed ID: 1709301

Title: Solution structure of FKBP, a rotamase enzyme and receptor for FK506 and rapamycin.

PubMed ID: 1709301

DOI: 10.1126/science.1709301

PubMed ID: 1375171

Title: Solution structure of FK506 bound to FKBP-12.

PubMed ID: 1375171

DOI: 10.1016/0014-5793(92)80292-o

PubMed ID: 7682113

Title: 1H, 13C, and 15N assignments and secondary structure of the FK506 binding protein when bound to ascomycin.

PubMed ID: 7682113

DOI: 10.1002/bip.360330404

PubMed ID: 1709302

Title: Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex.

PubMed ID: 1709302

DOI: 10.1126/science.1709302

PubMed ID: 7678431

Title: Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin.

PubMed ID: 7678431

DOI: 10.1006/jmbi.1993.1012

PubMed ID: 10025408

Title: Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12.

PubMed ID: 10025408

DOI: 10.1016/s0092-8674(00)80555-3

PubMed ID: 10656803

Title: X-ray structures of small ligand-FKBP complexes provide an estimate for hydrophobic interaction energies.

PubMed ID: 10656803

DOI: 10.1006/jmbi.1999.3411

Sequence Information:

  • Length: 108
  • Mass: 11951
  • Checksum: 9CC8493C802540B4
  • Sequence:
    • MGVQVETISP GDGRTFPKRG QTCVVHYTGM LEDGKKFDSS RDRNKPFKFM LGKQEVIRGW 
EEGVAQMSVG QRAKLTISPD YAYGATGHPG IIPPHATLVF DVELLKLE

Genular Protein ID: 1616946723

Symbol: Q0VDC6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q0VDC6

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 2 ChiTaRS 1 DNASU 1 EC 1 EMBL 2 GO 1 Gene3D 1 Genevisible 1 GenomeRNAi 1 IntAct 1 InterPro 2 KEGG 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 Rhea 3 SAM 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 145
  • Mass: 15689
  • Checksum: DFB0CDCB1F74A847
  • Sequence:
    • MGRQRAEGLG RAVEPPPGRC WSTPPVAPPA RSASAAAMGV QVETISPGDG RTFPKRGQTC 
VVHYTGMLED GKKFDSSRDR NKPFKFMLGK QEVIRGWEEG VAQMSVGQRA KLTISPDYAY 
GATGHPGIIP PHATLVFDVE LLKLE

Genular Protein ID: 623162252

Symbol: A0A087WTS4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WTS4

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 Proteomes 2 RefSeq 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

Sequence Information:

  • Length: 97
  • Mass: 10800
  • Checksum: 508EAC10C43E54BA
  • Sequence:
    • MGVQVETISP GDGRTFPKRG QTCVVHYTDE CGSESQTDYI SRLCLWCHWA PRHHPTTCHS 
RLRCGASKTG MTGMASSLSS LFLDLPWRDL VPPDMCT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.