Details for: FUT8

Gene ID: 2530

Symbol: FUT8

Ensembl ID: ENSG00000033170

Description: fucosyltransferase 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 352.3734
    Cell Significance Index: -54.8100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 214.0012
    Cell Significance Index: -54.2800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 125.4528
    Cell Significance Index: -51.6800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 119.0157
    Cell Significance Index: -56.1900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 114.0411
    Cell Significance Index: -46.3300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 84.0509
    Cell Significance Index: -56.4000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 48.4947
    Cell Significance Index: -46.3000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 45.0300
    Cell Significance Index: -55.5200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.6095
    Cell Significance Index: -55.2100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.7035
    Cell Significance Index: -32.1800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.1420
    Cell Significance Index: -55.8100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.9185
    Cell Significance Index: -42.7500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 6.4362
    Cell Significance Index: 137.5800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.9749
    Cell Significance Index: 65.1400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 2.7035
    Cell Significance Index: 46.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.5113
    Cell Significance Index: 503.7700
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 2.3265
    Cell Significance Index: 23.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.1624
    Cell Significance Index: 775.6000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.9994
    Cell Significance Index: 47.9500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.9898
    Cell Significance Index: 122.3000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.9842
    Cell Significance Index: 322.7200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.8110
    Cell Significance Index: 1252.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.6920
    Cell Significance Index: 74.8400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.6419
    Cell Significance Index: 62.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.3348
    Cell Significance Index: 89.7500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1660
    Cell Significance Index: 126.8200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.1252
    Cell Significance Index: 21.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.1099
    Cell Significance Index: 62.2800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.0656
    Cell Significance Index: 24.6200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9820
    Cell Significance Index: 58.9600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.8946
    Cell Significance Index: 25.5300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7836
    Cell Significance Index: 21.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5858
    Cell Significance Index: 57.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5353
    Cell Significance Index: 106.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4125
    Cell Significance Index: 11.8900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2758
    Cell Significance Index: 52.4900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2623
    Cell Significance Index: 493.8100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2451
    Cell Significance Index: 221.3100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.2153
    Cell Significance Index: 2.6700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.2141
    Cell Significance Index: 3.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1928
    Cell Significance Index: 122.4600
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.1924
    Cell Significance Index: 2.6900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1823
    Cell Significance Index: 4.6900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1808
    Cell Significance Index: 98.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1407
    Cell Significance Index: 63.8500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1267
    Cell Significance Index: 22.8400
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 0.1189
    Cell Significance Index: 1.1900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0815
    Cell Significance Index: 5.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0577
    Cell Significance Index: 88.8000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0379
    Cell Significance Index: 69.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0066
    Cell Significance Index: 0.8100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0026
    Cell Significance Index: 3.4700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0022
    Cell Significance Index: 0.0600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0003
    Cell Significance Index: 0.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0006
    Cell Significance Index: -0.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0057
    Cell Significance Index: -0.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0210
    Cell Significance Index: -0.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0281
    Cell Significance Index: -4.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0580
    Cell Significance Index: -9.9000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0615
    Cell Significance Index: -45.5400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0663
    Cell Significance Index: -48.6400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0714
    Cell Significance Index: -54.0200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0909
    Cell Significance Index: -11.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0990
    Cell Significance Index: -55.8200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1002
    Cell Significance Index: -62.5800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1662
    Cell Significance Index: -47.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1876
    Cell Significance Index: -22.1200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2360
    Cell Significance Index: -6.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2996
    Cell Significance Index: -63.1100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3161
    Cell Significance Index: -6.2500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3531
    Cell Significance Index: -41.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3571
    Cell Significance Index: -16.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3604
    Cell Significance Index: -36.8100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3859
    Cell Significance Index: -49.8600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4227
    Cell Significance Index: -22.0200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4264
    Cell Significance Index: -9.0500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4323
    Cell Significance Index: -45.0100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4777
    Cell Significance Index: -24.8200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4818
    Cell Significance Index: -35.9100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4893
    Cell Significance Index: -56.0600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5567
    Cell Significance Index: -17.8300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5646
    Cell Significance Index: -36.4300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.5698
    Cell Significance Index: -7.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.6010
    Cell Significance Index: -21.1200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6211
    Cell Significance Index: -29.1900
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.6249
    Cell Significance Index: -6.7000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.6402
    Cell Significance Index: -45.2800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6428
    Cell Significance Index: -50.9100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6505
    Cell Significance Index: -39.8800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7553
    Cell Significance Index: -24.7300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.7555
    Cell Significance Index: -10.8200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7786
    Cell Significance Index: -49.0700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7850
    Cell Significance Index: -25.0000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7864
    Cell Significance Index: -41.2900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.8258
    Cell Significance Index: -17.8900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.8830
    Cell Significance Index: -12.6800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.9073
    Cell Significance Index: -18.2200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.9450
    Cell Significance Index: -16.3400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.9607
    Cell Significance Index: -11.9800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -1.0885
    Cell Significance Index: -14.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FUT8 is a type II transmembrane glycosyltransferase enzyme that belongs to the FUT family of enzymes. It is responsible for the transfer of fucose residues to specific carbohydrate structures, resulting in the formation of complex glycoconjugates. The FUT8 enzyme is characterized by its ability to recognize and add fucose residues to specific substrates, including glycoproteins and glycolipids. Its activity is crucial for the proper functioning of various cellular processes, including cell adhesion, migration, and signaling. **Pathways and Functions** FUT8 is involved in several cellular pathways, including: 1. **Asparagine N-linked glycosylation**: FUT8 is responsible for the addition of fucose residues to asparagine-linked glycoproteins, which is essential for their proper functioning and stability. 2. **Golgi apparatus**: FUT8 is localized to the Golgi apparatus, where it plays a crucial role in the processing of glycoproteins and glycolipids. 3. **Integrin-mediated signaling pathway**: FUT8 has been shown to interact with integrins, which are transmembrane receptors involved in cell adhesion and signaling. 4. **Viral protein processing**: FUT8 has been implicated in the processing of viral proteins, particularly those of SARS-CoV-2, suggesting a potential role in modulating the host-virus interaction. **Clinical Significance** The FUT8 gene has been associated with various diseases, including: 1. **Neurological disorders**: FUT8 has been implicated in the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease, due to its involvement in the processing of glycoproteins and glycolipids. 2. **Cancer**: FUT8 has been shown to be overexpressed in certain types of cancer, including glioblastoma and breast cancer, suggesting its potential role in tumorigenesis. 3. **Infectious diseases**: FUT8 has been implicated in the processing of viral proteins, particularly those of SARS-CoV-2, suggesting a potential role in modulating the host-virus interaction. In conclusion, the FUT8 gene is a critical component of the glycosylation machinery that plays a significant role in the post-translational modification of proteins. Its involvement in various cellular pathways, including asparagine N-linked glycosylation, integrin-mediated signaling, and viral protein processing, highlights its importance in maintaining cellular homeostasis and modulating host-virus interactions. Further studies are needed to fully elucidate the clinical significance of FUT8 and its potential role in various diseases.

Genular Protein ID: 1371197739

Symbol: FUT8_HUMAN

Name: Alpha-(1,6)-fucosyltransferase

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9133635

Title: Purification and cDNA cloning of GDP-L-Fuc:N-acetyl-beta-D-glucosaminide:alpha1-6 fucosyltransferase (alpha1-6 FucT) from human gastric cancer MKN45 cells.

PubMed ID: 9133635

DOI: 10.1093/oxfordjournals.jbchem.a021631

PubMed ID: 10814706

Title: Genomic structure and promoter analysis of the human alpha1,6-fucosyltransferase gene (FUT8).

PubMed ID: 10814706

DOI: 10.1093/glycob/10.6.637

PubMed ID: 14514715

Title: Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis.

PubMed ID: 14514715

DOI: 10.1093/glycob/cwh006

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10764839

Title: A sequence motif involved in the donor substrate binding by alpha1,6-fucosyltransferase: the role of the conserved arginine residues.

PubMed ID: 10764839

DOI: 10.1093/glycob/10.5.503

PubMed ID: 25171405

Title: A secreted tyrosine kinase acts in the extracellular environment.

PubMed ID: 25171405

DOI: 10.1016/j.cell.2014.06.048

PubMed ID: 29304374

Title: Biallelic Mutations in FUT8 Cause a Congenital Disorder of Glycosylation with Defective Fucosylation.

PubMed ID: 29304374

DOI: 10.1016/j.ajhg.2017.12.009

PubMed ID: 17172260

Title: Crystal structure of mammalian alpha1,6-fucosyltransferase, FUT8.

PubMed ID: 17172260

DOI: 10.1093/glycob/cwl079

PubMed ID: 30237576

Title: Autozygome and high throughput confirmation of disease genes candidacy.

PubMed ID: 30237576

DOI: 10.1038/s41436-018-0138-x

Sequence Information:

  • Length: 575
  • Mass: 66516
  • Checksum: 5AE24A93881E18D0
  • Sequence:
  • MRPWTGSWRW IMLILFAWGT LLFYIGGHLV RDNDHPDHSS RELSKILAKL ERLKQQNEDL 
    RRMAESLRIP EGPIDQGPAI GRVRVLEEQL VKAKEQIENY KKQTRNGLGK DHEILRRRIE 
    NGAKELWFFL QSELKKLKNL EGNELQRHAD EFLLDLGHHE RSIMTDLYYL SQTDGAGDWR 
    EKEAKDLTEL VQRRITYLQN PKDCSKAKKL VCNINKGCGY GCQLHHVVYC FMIAYGTQRT 
    LILESQNWRY ATGGWETVFR PVSETCTDRS GISTGHWSGE VKDKNVQVVE LPIVDSLHPR 
    PPYLPLAVPE DLADRLVRVH GDPAVWWVSQ FVKYLIRPQP WLEKEIEEAT KKLGFKHPVI 
    GVHVRRTDKV GTEAAFHPIE EYMVHVEEHF QLLARRMQVD KKRVYLATDD PSLLKEAKTK 
    YPNYEFISDN SISWSAGLHN RYTENSLRGV ILDIHFLSQA DFLVCTFSSQ VCRVAYEIMQ 
    TLHPDASANF HSLDDIYYFG GQNAHNQIAI YAHQPRTADE IPMEPGDIIG VAGNHWDGYS 
    KGVNRKLGRT GLYPSYKVRE KIETVKYPTY PEAEK

Genular Protein ID: 443855701

Symbol: A8K8P8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 575
  • Mass: 66516
  • Checksum: C52E5E78CCA05730
  • Sequence:
  • MRPWTGSWRW IMLILFAWGT LLFYIGGHLV RDNDHPDHSS RELSKILAKL ERLKQQNEDL 
    RRMAESLRIP EGPIDQGPAI GRVRVLEEQL VKAKEQIENY KKQTRNGLGE DHEILRRRIE 
    NGAKELWFFL QSELKKLKNL EGNELQRHAD EFLLDLGHHE RSIMTDLYYL SQTDGAGDWR 
    EKEAKDLTEL VQRRITYLQN PKDCSKAKKL VCNINKGCGY GCQLHHVVYC FMIAYGTQRT 
    LILESQNWRY ATGGWETVFR PVSETCTDRS GISTGHWSGE VKDKNVQVVE LPIVDSLHPR 
    PPYLPLAVPE DLADRLVRVH GDPAVWWVSQ FVKYLIRPQP WLEKEIEEAT KKLGFKHPVI 
    GVHVRRTDKV GTEAAFHPIE EYMVHVEEHF QLLARRMQVD KKRVYLATDD PSLLKEAKTK 
    YPNYEFISDN SISWSAGLHN RYTENSLRGV ILDIHFLSQA DFLVCTFSSQ VCRVAYEIMQ 
    TLHPDASANF HSLDDIYYFG GQNAHNQIAI YAHQPRTADE IPMEPGDIIG VAGNHWNGYS 
    KGVNRKLGRT GLYPSYKVRE KIETVKYPTY PEAEK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.