Details for: FUT8

Gene ID: 2530

Symbol: FUT8

Ensembl ID: ENSG00000033170

Description: fucosyltransferase 8

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.94
    Marker Score: 133077
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 3.79
    Marker Score: 20345
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 3.5
    Marker Score: 11740
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 3.34
    Marker Score: 8007
  • Cell Name: granule cell (CL0000120)
    Fold Change: 3.12
    Marker Score: 23546
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.8
    Marker Score: 59742
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 2.77
    Marker Score: 2273
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.6
    Marker Score: 1285
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.58
    Marker Score: 5919
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.42
    Marker Score: 48111
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.36
    Marker Score: 35251
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.24
    Marker Score: 11772
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.22
    Marker Score: 84453
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.19
    Marker Score: 9089
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.14
    Marker Score: 16424
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.1
    Marker Score: 77520
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.09
    Marker Score: 601
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.05
    Marker Score: 19275
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.04
    Marker Score: 7894
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.99
    Marker Score: 9217
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.99
    Marker Score: 122139
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.95
    Marker Score: 4282
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.91
    Marker Score: 7788.5
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.9
    Marker Score: 3192
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.85
    Marker Score: 5290
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.84
    Marker Score: 1212
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.84
    Marker Score: 884
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.82
    Marker Score: 17298
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.77
    Marker Score: 18265
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.76
    Marker Score: 15119
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.75
    Marker Score: 734
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.72
    Marker Score: 1027
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.68
    Marker Score: 3238
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.67
    Marker Score: 6979
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.58
    Marker Score: 1702
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.56
    Marker Score: 2405
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.49
    Marker Score: 1711
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167292
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.45
    Marker Score: 825
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.44
    Marker Score: 1016
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.42
    Marker Score: 1759
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.41
    Marker Score: 1753
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.4
    Marker Score: 1211
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.4
    Marker Score: 3170
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.39
    Marker Score: 3177
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.39
    Marker Score: 806
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.34
    Marker Score: 391
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.33
    Marker Score: 5544
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.3
    Marker Score: 726
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.25
    Marker Score: 414
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.24
    Marker Score: 7911
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.23
    Marker Score: 514
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.19
    Marker Score: 1352
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.19
    Marker Score: 324
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.18
    Marker Score: 1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.18
    Marker Score: 402
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.16
    Marker Score: 18684
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.16
    Marker Score: 18203
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.16
    Marker Score: 1214
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.15
    Marker Score: 641
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.13
    Marker Score: 1417.5
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.13
    Marker Score: 434
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.12
    Marker Score: 776
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.11
    Marker Score: 402
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.09
    Marker Score: 653
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.09
    Marker Score: 562
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.07
    Marker Score: 2178
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.07
    Marker Score: 1950
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.06
    Marker Score: 6785
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.03
    Marker Score: 4067
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.02
    Marker Score: 322.5
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.01
    Marker Score: 1256
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.01
    Marker Score: 477
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71686
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47911
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.99
    Marker Score: 553.5
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.98
    Marker Score: 1192
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30389
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.96
    Marker Score: 301
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2399
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.94
    Marker Score: 458
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.93
    Marker Score: 3311
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 478
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.93
    Marker Score: 2184
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 436
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.92
    Marker Score: 1494
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.91
    Marker Score: 600
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.91
    Marker Score: 335
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2707
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.9
    Marker Score: 448
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.9
    Marker Score: 229
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.89
    Marker Score: 232
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.89
    Marker Score: 408
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.89
    Marker Score: 236
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.88
    Marker Score: 983
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.87
    Marker Score: 5207
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.86
    Marker Score: 312
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.86
    Marker Score: 1038
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309

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Other Information

**Key characteristics** * The FUT8 gene is located on chromosome 15q26.1. * It is a large gene with a predicted protein length of 2,412 amino acids. * The protein contains a SH3 domain, which is involved in protein-protein interactions. * It is significantly expressed in certain cell types, including those that are involved in the immune response. **Pathways and functions** The FUT8 protein is involved in a variety of pathways, including: * Alpha-(1->6)-fucosyltransferase activity: This activity is essential for the synthesis of glycoproteins, which are proteins that are involved in a variety of cellular processes, including cell adhesion, cell signaling, and immune responses. * Asparagine n-linked glycosylation: This is another type of glycosylation that is carried out by the FUT8 protein. * Disease: The FUT8 gene has been linked to a number of diseases, including sars-cov-2 infection, sars-cov infections, and in utero embryonic development. * Glycoprotein 6-alpha-l-fucosyltransferase activity: This activity is involved in the formation of glycoproteins that are used for cell adhesion and signaling. * Infectious disease: The FUT8 protein is also involved in the response to infectious disease. * Post-translational protein modification: The FUT8 protein is a target for post-translational protein modification, which can alter the protein's function. **Clinical significance** The FUT8 gene is a potential target for the treatment of a variety of diseases. For example, mutations in the FUT8 gene have been linked to sars-cov-2 infection, sars-cov infections, and in utero embryonic development. Therefore, inhibitors of the FUT8 protein could be used to treat these diseases. **Additional information** * The FUT8 protein is a highly conserved protein, with similar proteins found in organisms ranging from yeast to humans. * The FUT8 protein is a multi-domain protein, with a SH3 domain and a variety of other domains. * The FUT8 protein is a relatively new protein, with no known human disease associated with it.

Genular Protein ID: 1371197739

Symbol: FUT8_HUMAN

Name: Alpha-(1,6)-fucosyltransferase

UniProtKB Accession Codes:

Q9BYC5 B4DFS7 G3V5N0 O00235 Q8IUA5 Q9BYC6 Q9P2U5 Q9P2U6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 2 CDD 2 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 19 EPD 1 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 24 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PDB 9 PDBsum 8 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 Rhea 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9133635

Title: Purification and cDNA cloning of GDP-L-Fuc:N-acetyl-beta-D-glucosaminide:alpha1-6 fucosyltransferase (alpha1-6 FucT) from human gastric cancer MKN45 cells.

PubMed ID: 9133635

DOI: 10.1093/oxfordjournals.jbchem.a021631

PubMed ID: 10814706

Title: Genomic structure and promoter analysis of the human alpha1,6-fucosyltransferase gene (FUT8).

PubMed ID: 10814706

DOI: 10.1093/glycob/10.6.637

PubMed ID: 14514715

Title: Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis.

PubMed ID: 14514715

DOI: 10.1093/glycob/cwh006

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10764839

Title: A sequence motif involved in the donor substrate binding by alpha1,6-fucosyltransferase: the role of the conserved arginine residues.

PubMed ID: 10764839

DOI: 10.1093/glycob/10.5.503

PubMed ID: 25171405

Title: A secreted tyrosine kinase acts in the extracellular environment.

PubMed ID: 25171405

DOI: 10.1016/j.cell.2014.06.048

PubMed ID: 29304374

Title: Biallelic Mutations in FUT8 Cause a Congenital Disorder of Glycosylation with Defective Fucosylation.

PubMed ID: 29304374

DOI: 10.1016/j.ajhg.2017.12.009

PubMed ID: 17172260

Title: Crystal structure of mammalian alpha1,6-fucosyltransferase, FUT8.

PubMed ID: 17172260

DOI: 10.1093/glycob/cwl079

PubMed ID: 30237576

Title: Autozygome and high throughput confirmation of disease genes candidacy.

PubMed ID: 30237576

DOI: 10.1038/s41436-018-0138-x

Sequence Information:

  • Length: 575
  • Mass: 66516
  • Checksum: 5AE24A93881E18D0
  • Sequence:
    • MRPWTGSWRW IMLILFAWGT LLFYIGGHLV RDNDHPDHSS RELSKILAKL ERLKQQNEDL 
RRMAESLRIP EGPIDQGPAI GRVRVLEEQL VKAKEQIENY KKQTRNGLGK DHEILRRRIE 
NGAKELWFFL QSELKKLKNL EGNELQRHAD EFLLDLGHHE RSIMTDLYYL SQTDGAGDWR 
EKEAKDLTEL VQRRITYLQN PKDCSKAKKL VCNINKGCGY GCQLHHVVYC FMIAYGTQRT 
LILESQNWRY ATGGWETVFR PVSETCTDRS GISTGHWSGE VKDKNVQVVE LPIVDSLHPR 
PPYLPLAVPE DLADRLVRVH GDPAVWWVSQ FVKYLIRPQP WLEKEIEEAT KKLGFKHPVI 
GVHVRRTDKV GTEAAFHPIE EYMVHVEEHF QLLARRMQVD KKRVYLATDD PSLLKEAKTK 
YPNYEFISDN SISWSAGLHN RYTENSLRGV ILDIHFLSQA DFLVCTFSSQ VCRVAYEIMQ 
TLHPDASANF HSLDDIYYFG GQNAHNQIAI YAHQPRTADE IPMEPGDIIG VAGNHWDGYS 
KGVNRKLGRT GLYPSYKVRE KIETVKYPTY PEAEK

Genular Protein ID: 443855701

Symbol: A8K8P8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K8P8

Database IDs:

ARBA 17 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 5 DNASU 1 EC 1 EMBL 2 GO 4 Gene3D 3 Genevisible 1 GenomeRNAi 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 3 PROSITE 4 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 2 RefSeq 1 Rhea 3 SAM 2 SMART 1 SUPFAM 1 UniPathway 1

Sequence Information:

  • Length: 575
  • Mass: 66516
  • Checksum: C52E5E78CCA05730
  • Sequence:
    • MRPWTGSWRW IMLILFAWGT LLFYIGGHLV RDNDHPDHSS RELSKILAKL ERLKQQNEDL 
RRMAESLRIP EGPIDQGPAI GRVRVLEEQL VKAKEQIENY KKQTRNGLGE DHEILRRRIE 
NGAKELWFFL QSELKKLKNL EGNELQRHAD EFLLDLGHHE RSIMTDLYYL SQTDGAGDWR 
EKEAKDLTEL VQRRITYLQN PKDCSKAKKL VCNINKGCGY GCQLHHVVYC FMIAYGTQRT 
LILESQNWRY ATGGWETVFR PVSETCTDRS GISTGHWSGE VKDKNVQVVE LPIVDSLHPR 
PPYLPLAVPE DLADRLVRVH GDPAVWWVSQ FVKYLIRPQP WLEKEIEEAT KKLGFKHPVI 
GVHVRRTDKV GTEAAFHPIE EYMVHVEEHF QLLARRMQVD KKRVYLATDD PSLLKEAKTK 
YPNYEFISDN SISWSAGLHN RYTENSLRGV ILDIHFLSQA DFLVCTFSSQ VCRVAYEIMQ 
TLHPDASANF HSLDDIYYFG GQNAHNQIAI YAHQPRTADE IPMEPGDIIG VAGNHWNGYS 
KGVNRKLGRT GLYPSYKVRE KIETVKYPTY PEAEK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.