H2BC1 | ENSG00000146047 | NCBI 255626

Details for: H2BC1

Gene ID: 255626

Symbol: H2BC1

Ensembl ID: ENSG00000146047

Description: H2B clustered histone 1

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna double-strand break repair
(R-HSA-5693532)
Dna double strand break response
(R-HSA-5693606)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
E3 ubiquitin ligases ubiquitinate target proteins
(R-HSA-8866654)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Infectious disease
(R-HSA-5663205)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Nonhomologous end-joining (nhej)
(R-HSA-5693571)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Protein ubiquitination
(R-HSA-8852135)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-HSA-5693565)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by piwi-interacting rnas (pirnas)
(R-HSA-9845323)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Replacement of protamines by nucleosomes in the male pronucleus
(R-HSA-9821993)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Ub-specific processing proteases
(R-HSA-5689880)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: germ cell (CL0000586)
Fold Change: 1.1042
Cell Significance Index: 8.3400
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.5139
Cell Significance Index: 6.0700
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.2864
Cell Significance Index: 3.1700
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.2297
Cell Significance Index: 2.5700
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.1240
Cell Significance Index: 1.8000
Cell Name: B cell (CL0000236)
Fold Change: 0.1089
Cell Significance Index: 1.2900
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.0924
Cell Significance Index: 1.0900
Cell Name: astrocyte (CL0000127)
Fold Change: 0.0785
Cell Significance Index: 0.9000
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.0644
Cell Significance Index: 0.6900
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.0144
Cell Significance Index: 0.1600
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.0130
Cell Significance Index: 0.1400
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.0092
Cell Significance Index: 0.1200
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.0056
Cell Significance Index: 0.0800
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.0025
Cell Significance Index: 0.0700
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.0020
Cell Significance Index: 0.0200
Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
Fold Change: 0.0019
Cell Significance Index: 0.0200
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.0011
Cell Significance Index: 0.0100
Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: 0.0004
Cell Significance Index: 0.0100
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0009
Cell Significance Index: -0.0300
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: -0.0017
Cell Significance Index: -0.0200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0020
Cell Significance Index: -0.4000
Cell Name: secretory cell (CL0000151)
Fold Change: -0.0020
Cell Significance Index: -0.0100
Cell Name: oligodendrocyte (CL0000128)
Fold Change: -0.0021
Cell Significance Index: -0.0200
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: -0.0047
Cell Significance Index: -0.0500
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.0070
Cell Significance Index: -0.0900
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -0.0079
Cell Significance Index: -0.0900
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.0080
Cell Significance Index: -0.1300
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.0080
Cell Significance Index: -0.1000
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0113
Cell Significance Index: -0.3000
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0118
Cell Significance Index: -0.3100
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0130
Cell Significance Index: -0.3300
Cell Name: neuron (CL0000540)
Fold Change: -0.0177
Cell Significance Index: -0.1700
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.0228
Cell Significance Index: -0.3200
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0240
Cell Significance Index: -0.6000
Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.0247
Cell Significance Index: -0.2400
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.0251
Cell Significance Index: -0.3400
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0275
Cell Significance Index: -0.3000
Cell Name: microglial cell (CL0000129)
Fold Change: -0.0289
Cell Significance Index: -0.3400
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0299
Cell Significance Index: -0.6000
Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
Fold Change: -0.0310
Cell Significance Index: -0.3100
Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.0319
Cell Significance Index: -0.4300
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.0325
Cell Significance Index: -0.4300
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.0333
Cell Significance Index: -0.4900
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.0339
Cell Significance Index: -0.4300
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.0348
Cell Significance Index: -0.6000
Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.0349
Cell Significance Index: -0.4400
Cell Name: pericyte (CL0000669)
Fold Change: -0.0372
Cell Significance Index: -0.4500
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.0439
Cell Significance Index: -0.5800
Cell Name: mesothelial cell (CL0000077)
Fold Change: -0.0440
Cell Significance Index: -0.5400
Cell Name: fibroblast (CL0000057)
Fold Change: -0.0490
Cell Significance Index: -0.4600
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: -0.0557
Cell Significance Index: -0.7500
Cell Name: mast cell (CL0000097)
Fold Change: -0.0560
Cell Significance Index: -0.7400
Cell Name: epithelial cell (CL0000066)
Fold Change: -0.0595
Cell Significance Index: -0.6300
Cell Name: adipocyte (CL0000136)
Fold Change: -0.0640
Cell Significance Index: -0.8500
Cell Name: radial glial cell (CL0000681)
Fold Change: -0.0668
Cell Significance Index: -0.4000
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.0688
Cell Significance Index: -0.8100
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.0723
Cell Significance Index: -0.9800
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.0783
Cell Significance Index: -0.4700
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.0788
Cell Significance Index: -1.0100
Cell Name: malignant cell (CL0001064)
Fold Change: -0.0815
Cell Significance Index: -0.4400
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0832
Cell Significance Index: -1.3900
Cell Name: endothelial cell (CL0000115)
Fold Change: -0.0903
Cell Significance Index: -1.1100
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.0934
Cell Significance Index: -1.3100
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: -0.0977
Cell Significance Index: -0.7500
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -0.1025
Cell Significance Index: -0.6400
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: -0.1034
Cell Significance Index: -0.5000
Cell Name: mural cell (CL0008034)
Fold Change: -0.1121
Cell Significance Index: -1.3700
Cell Name: supporting cell (CL0000630)
Fold Change: -0.1121
Cell Significance Index: -0.5200
Cell Name: perivascular cell (CL4033054)
Fold Change: -0.1135
Cell Significance Index: -0.5200
Cell Name: T cell (CL0000084)
Fold Change: -0.1401
Cell Significance Index: -1.6500
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: -0.1594
Cell Significance Index: -1.6900
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: -0.1682
Cell Significance Index: -1.7400
Cell Name: alveolar macrophage (CL0000583)
Fold Change: -0.1974
Cell Significance Index: -1.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** H2BC1 is a member of the histone H2B family, which accounts for approximately 15% of the total histone content in eukaryotic cells. It is characterized by its unique C-terminal tail, which is rich in arginine and lysine residues, essential for protein-protein interactions and histone modifications. H2BC1 is highly conserved across species, suggesting its critical role in maintaining chromatin structure and function. **Pathways and Functions** H2BC1 is involved in various chromatin-related pathways, including: 1. **DNA replication and repair**: H2BC1 is required for the assembly of the pre-replicative complex and the recruitment of DNA repair proteins to damaged DNA. 2. **Transcriptional regulation**: H2BC1 influences chromatin accessibility and gene expression by interacting with transcriptional regulators and modifying histones. 3. **Chromatin remodeling**: H2BC1 is involved in the assembly and disassembly of chromatin structures, such as nucleosome arrays and chromatin loops. 4. **Cell cycle regulation**: H2BC1 plays a role in the regulation of the cell cycle, particularly in the G2/M checkpoint. **Clinical Significance** Dysregulation of H2BC1 has been implicated in various human diseases, including: 1. **Cancer**: Altered histone modifications, including those involving H2BC1, have been observed in cancer cells, suggesting a role in tumorigenesis. 2. **Neurodegenerative diseases**: H2BC1 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's, where chromatin dysfunction contributes to disease progression. 3. **Immunological disorders**: H2BC1 has been linked to immunological disorders, such as multiple sclerosis, where chromatin alterations contribute to immune cell dysfunction. **Conclusion** In conclusion, H2BC1 is a vital component of chromatin structure and function, influencing various cellular processes, including DNA replication, repair, and transcription. Its dysregulation has been implicated in various human diseases, highlighting the importance of H2BC1 in maintaining chromatin homeostasis and overall cellular health. Further research is necessary to fully elucidate the mechanisms underlying H2BC1's role in human disease and to explore potential therapeutic strategies for targeting this protein.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Histone H2B type 1-A

Genular Protein ID: 2744721316

Symbol: H2B1A_HUMAN

Name: Histone H2B type 1-A

UniProtKB Accession Codes:

Q96A08 B2R544 Q6NZ98 Q6NZA0 Q6NZA1

Database IDs:

Citations:

PubMed ID: 12213818

Title: Human testis/sperm-specific histone H2B (hTSH2B). Molecular cloning and characterization.

PubMed ID: 12213818

DOI: 10.1074/jbc.m206065200

PubMed ID: 12408966

Title: The human and mouse replication-dependent histone genes.

PubMed ID: 12408966

DOI: 10.1016/s0888-7543(02)96850-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16307923

Title: Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation.

PubMed ID: 16307923

DOI: 10.1016/j.molcel.2005.09.025

PubMed ID: 16283522

Title: Inhibition of core histones acetylation by carcinogenic nickel(II).

PubMed ID: 16283522

DOI: 10.1007/s11010-005-8285-1

PubMed ID: 16713563

Title: Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II.

PubMed ID: 16713563

DOI: 10.1016/j.cell.2006.04.029

PubMed ID: 21925322

Title: Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification.

PubMed ID: 21925322

DOI: 10.1016/j.cell.2011.08.008

PubMed ID: 21726816

Title: The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation.

PubMed ID: 21726816

DOI: 10.1016/j.molcel.2011.05.015

PubMed ID: 21249133

Title: Histone variants and their post-translational modifications in primary human fat cells.

PubMed ID: 21249133

DOI: 10.1371/journal.pone.0015960

PubMed ID: 31645732

Title: Metabolic regulation of gene expression by histone lactylation.

PubMed ID: 31645732

DOI: 10.1038/s41586-019-1678-1

Sequence Information:

Length: 127
Mass: 14167
Checksum: 3EE4124DA9B3C3E8
Sequence:

MPEVSSKGAT ISKKGFKKAV VKTQKKEGKK RKRTRKESYS IYIYKVLKQV HPDTGISSKA 
MSIMNSFVTD IFERIASEAS RLAHYSKRST ISSREIQTAV RLLLPGELAK HAVSEGTKAV 
TKYTSSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: H2BC1

Associated with

Cells (max top 100)

Other Information

Human testis/sperm-specific histone H2B (hTSH2B). Molecular cloning and characterization. PubMed ID: 12213818

The human and mouse replication-dependent histone genes. PubMed ID: 12408966

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. PubMed ID: 16307923

Inhibition of core histones acetylation by carcinogenic nickel(II). PubMed ID: 16283522

Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. PubMed ID: 16713563

Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. PubMed ID: 21925322

The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation. PubMed ID: 21726816

Histone variants and their post-translational modifications in primary human fat cells. PubMed ID: 21249133

Metabolic regulation of gene expression by histone lactylation. PubMed ID: 31645732