Details for: CHIC2

Gene ID: 26511

Symbol: CHIC2

Ensembl ID: ENSG00000109220

Description: cysteine rich hydrophobic domain 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 276.3183
    Cell Significance Index: -42.9800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 172.5651
    Cell Significance Index: -43.7700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 110.6209
    Cell Significance Index: -45.5700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 101.7744
    Cell Significance Index: -48.0500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 99.2721
    Cell Significance Index: -40.3300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 90.7685
    Cell Significance Index: -46.6900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 71.7562
    Cell Significance Index: -48.1500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 42.2836
    Cell Significance Index: -40.3700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.8667
    Cell Significance Index: -45.4600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.7115
    Cell Significance Index: -39.4100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.9005
    Cell Significance Index: -46.9600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.3697
    Cell Significance Index: -31.8500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.7871
    Cell Significance Index: -21.4200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 7.3174
    Cell Significance Index: 120.5800
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 6.3097
    Cell Significance Index: 18.7700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.8016
    Cell Significance Index: 80.3100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6636
    Cell Significance Index: 270.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.5790
    Cell Significance Index: 454.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.5551
    Cell Significance Index: 181.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.4532
    Cell Significance Index: 68.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4368
    Cell Significance Index: 288.2200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.0570
    Cell Significance Index: 20.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0423
    Cell Significance Index: 206.8400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.9967
    Cell Significance Index: 14.3400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.9842
    Cell Significance Index: 25.8800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8877
    Cell Significance Index: 104.6900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8638
    Cell Significance Index: 93.9600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7689
    Cell Significance Index: 10.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7552
    Cell Significance Index: 97.5600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.7422
    Cell Significance Index: 13.1200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6963
    Cell Significance Index: 41.8000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6640
    Cell Significance Index: 238.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5715
    Cell Significance Index: 32.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5713
    Cell Significance Index: 1075.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5072
    Cell Significance Index: 69.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4645
    Cell Significance Index: 57.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4557
    Cell Significance Index: 28.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4285
    Cell Significance Index: 234.0200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3858
    Cell Significance Index: 266.8400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3733
    Cell Significance Index: 25.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3559
    Cell Significance Index: 64.1500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3553
    Cell Significance Index: 9.6700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3502
    Cell Significance Index: 26.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2662
    Cell Significance Index: 7.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2148
    Cell Significance Index: 136.4200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2022
    Cell Significance Index: 25.9200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1708
    Cell Significance Index: 75.5300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1705
    Cell Significance Index: 314.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1553
    Cell Significance Index: 7.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1539
    Cell Significance Index: 236.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1128
    Cell Significance Index: 5.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1105
    Cell Significance Index: 3.1900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0906
    Cell Significance Index: 8.9600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0855
    Cell Significance Index: 5.7500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0853
    Cell Significance Index: 16.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0817
    Cell Significance Index: 6.0900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0539
    Cell Significance Index: 1.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0269
    Cell Significance Index: 12.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0186
    Cell Significance Index: 25.3100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0109
    Cell Significance Index: 0.2900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0063
    Cell Significance Index: 0.0900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0311
    Cell Significance Index: -0.7500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0311
    Cell Significance Index: -1.5700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0316
    Cell Significance Index: -4.6000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0320
    Cell Significance Index: -1.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0384
    Cell Significance Index: -2.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0457
    Cell Significance Index: -33.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0501
    Cell Significance Index: -36.7500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0507
    Cell Significance Index: -38.4000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0629
    Cell Significance Index: -0.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0729
    Cell Significance Index: -41.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0820
    Cell Significance Index: -51.2000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0971
    Cell Significance Index: -4.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1027
    Cell Significance Index: -10.4900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1250
    Cell Significance Index: -21.3500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1584
    Cell Significance Index: -6.0000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1610
    Cell Significance Index: -2.7000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2016
    Cell Significance Index: -14.2600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2330
    Cell Significance Index: -49.0700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2381
    Cell Significance Index: -3.3900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2723
    Cell Significance Index: -5.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3175
    Cell Significance Index: -36.3700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3725
    Cell Significance Index: -38.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3824
    Cell Significance Index: -8.1500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4046
    Cell Significance Index: -6.8200
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.4094
    Cell Significance Index: -2.9400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.5353
    Cell Significance Index: -18.8100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5419
    Cell Significance Index: -42.9200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5509
    Cell Significance Index: -16.1800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5544
    Cell Significance Index: -29.1100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5694
    Cell Significance Index: -35.8900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6230
    Cell Significance Index: -11.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6377
    Cell Significance Index: -39.1000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6531
    Cell Significance Index: -9.6400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6699
    Cell Significance Index: -23.2800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6897
    Cell Significance Index: -11.8200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6986
    Cell Significance Index: -15.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7170
    Cell Significance Index: -37.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7450
    Cell Significance Index: -23.8600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7901
    Cell Significance Index: -19.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CHIC2 is a member of the CHIC family of proteins, which are characterized by the presence of cysteine-rich hydrophobic domains. These domains are thought to play a crucial role in protein-protein interactions and cell signaling. CHIC2 is a large protein, with a molecular weight of approximately 140 kDa, and is composed of multiple domains, including the characteristic cysteine-rich hydrophobic domain. One of the key characteristics of CHIC2 is its ability to interact with other proteins and lipids, which is thought to be mediated by its hydrophobic domains. This interaction is essential for the regulation of various cellular processes, including cell adhesion, migration, and differentiation. CHIC2 is also known to be involved in the regulation of cell growth and survival, and its expression is often altered in response to changes in the cellular environment. **Pathways and Functions** CHIC2 is involved in several cellular pathways, including: 1. **Cell signaling**: CHIC2 interacts with other proteins and lipids to regulate cell signaling pathways, including the PI3K/AKT and MAPK/ERK pathways. 2. **Cell adhesion**: CHIC2 is involved in the regulation of cell adhesion, including the interaction between cells and the extracellular matrix. 3. **Cell migration**: CHIC2 is involved in the regulation of cell migration, including the migration of stem cells and cancer cells. 4. **Cell differentiation**: CHIC2 is involved in the regulation of cell differentiation, including the differentiation of stem cells into specific cell types. **Clinical Significance** CHIC2 has been implicated in several diseases, including: 1. **Cancer**: CHIC2 is overexpressed in several types of cancer, including breast cancer, prostate cancer, and ovarian cancer. Its expression is often associated with poor prognosis and reduced survival rates. 2. **Eye diseases**: CHIC2 is involved in the regulation of cell adhesion and migration in the eye, and its expression is altered in diseases such as age-related macular degeneration and uveitis. 3. **Reproductive diseases**: CHIC2 is involved in the regulation of cell differentiation and migration in the reproductive tract, and its expression is altered in diseases such as infertility and miscarriage. In conclusion, CHIC2 is a protein that plays a critical role in various cellular processes, including cell signaling, adhesion, and differentiation. Its expression is altered in several diseases, including cancer, eye diseases, and reproductive diseases. Further research is needed to fully understand the role of CHIC2 in human disease and to develop therapeutic strategies to target this protein.

Genular Protein ID: 489736864

Symbol: CHIC2_HUMAN

Name: Cysteine-rich hydrophobic domain-containing protein 2

UniProtKB Accession Codes:

Q9UKJ5 B2R639

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10477709

Title: Fusion of a novel gene, BTL, to ETV6 in acute myeloid leukemias with a t(4;12)(q11-q12;p13).

PubMed ID: 10477709

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11257495

Title: A new family of small, palmitoylated, membrane-associated proteins, characterized by the presence of a cysteine-rich hydrophobic motif.

PubMed ID: 11257495

DOI: 10.1016/s0014-5793(01)02240-2

Sequence Information:

  • Length: 165
  • Mass: 19254
  • Checksum: DC32A9C58524B55E
  • Sequence:
    • MADFDEIYEE EEDEERALEE QLLKYSPDPV VVRGSGHVTV FGLSNKFESE FPSSLTGKVA 
PEEFKASINR VNSCLKKNLP VNVRWLLCGC LCCCCTLGCS MWPVICLSKR TRRSIEKLLE 
WENNRLYHKL CLHWRLSKRK CETNNMMEYV ILIEFLPKTP IFRPD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.