Details for: TIMM9

Gene ID: 26520

Symbol: TIMM9

Ensembl ID: ENSG00000100575

Description: translocase of inner mitochondrial membrane 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 183.3550
    Cell Significance Index: -28.5200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 80.3986
    Cell Significance Index: -33.1200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 75.2347
    Cell Significance Index: -35.5200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 69.1325
    Cell Significance Index: -17.5400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 66.5066
    Cell Significance Index: -34.2100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 53.1838
    Cell Significance Index: -35.6900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.5297
    Cell Significance Index: -32.7100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.9935
    Cell Significance Index: -29.4500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.6061
    Cell Significance Index: -33.9600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.7427
    Cell Significance Index: -20.7100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.9712
    Cell Significance Index: -10.8800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.6012
    Cell Significance Index: 303.1400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.0763
    Cell Significance Index: 337.7000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.3586
    Cell Significance Index: 14.7700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2315
    Cell Significance Index: 1111.9100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0856
    Cell Significance Index: 140.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0259
    Cell Significance Index: 140.8900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0092
    Cell Significance Index: 27.4700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9780
    Cell Significance Index: 69.1700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.9521
    Cell Significance Index: 19.9300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.8341
    Cell Significance Index: 239.9900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8028
    Cell Significance Index: 55.5200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7302
    Cell Significance Index: 322.8500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7256
    Cell Significance Index: 9.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6895
    Cell Significance Index: 376.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6356
    Cell Significance Index: 127.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6279
    Cell Significance Index: 124.6000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6258
    Cell Significance Index: 46.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5364
    Cell Significance Index: 25.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5351
    Cell Significance Index: 34.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5268
    Cell Significance Index: 64.7800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5209
    Cell Significance Index: 13.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4979
    Cell Significance Index: 23.4000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4945
    Cell Significance Index: 25.6900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.4847
    Cell Significance Index: 3.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4185
    Cell Significance Index: 75.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3698
    Cell Significance Index: 43.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3306
    Cell Significance Index: 118.5700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.3113
    Cell Significance Index: 2.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2574
    Cell Significance Index: 16.2200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2282
    Cell Significance Index: 6.0000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2267
    Cell Significance Index: 29.0600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2059
    Cell Significance Index: 4.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1926
    Cell Significance Index: 8.7300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1867
    Cell Significance Index: 35.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1853
    Cell Significance Index: 5.3400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1715
    Cell Significance Index: 5.9600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1417
    Cell Significance Index: 7.4400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1394
    Cell Significance Index: 3.2200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1316
    Cell Significance Index: 91.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1014
    Cell Significance Index: 17.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0946
    Cell Significance Index: 9.3600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0603
    Cell Significance Index: 1.0700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0408
    Cell Significance Index: 1.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0188
    Cell Significance Index: 0.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0177
    Cell Significance Index: 13.4300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0168
    Cell Significance Index: 31.6800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0018
    Cell Significance Index: 0.0300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0034
    Cell Significance Index: -0.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0113
    Cell Significance Index: -20.7600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0127
    Cell Significance Index: -9.3400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0132
    Cell Significance Index: -20.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0181
    Cell Significance Index: -11.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0234
    Cell Significance Index: -31.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0301
    Cell Significance Index: -3.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0309
    Cell Significance Index: -22.9100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0321
    Cell Significance Index: -0.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0453
    Cell Significance Index: -20.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0470
    Cell Significance Index: -3.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0475
    Cell Significance Index: -1.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0492
    Cell Significance Index: -27.7400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0563
    Cell Significance Index: -0.6400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0607
    Cell Significance Index: -37.8900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1256
    Cell Significance Index: -3.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1370
    Cell Significance Index: -19.9100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1376
    Cell Significance Index: -4.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1572
    Cell Significance Index: -8.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1775
    Cell Significance Index: -37.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1777
    Cell Significance Index: -20.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2524
    Cell Significance Index: -16.9700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2772
    Cell Significance Index: -3.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2821
    Cell Significance Index: -12.4800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3021
    Cell Significance Index: -31.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3295
    Cell Significance Index: -26.1000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3462
    Cell Significance Index: -13.1100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3928
    Cell Significance Index: -11.2600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4194
    Cell Significance Index: -5.0000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4528
    Cell Significance Index: -11.3200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4680
    Cell Significance Index: -8.0200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4734
    Cell Significance Index: -23.9300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5619
    Cell Significance Index: -15.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5723
    Cell Significance Index: -35.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5824
    Cell Significance Index: -35.8000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6372
    Cell Significance Index: -3.8500
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.6419
    Cell Significance Index: -6.8200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6524
    Cell Significance Index: -23.9500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6556
    Cell Significance Index: -19.3100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7032
    Cell Significance Index: -18.0800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7485
    Cell Significance Index: -26.2200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.7491
    Cell Significance Index: -10.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mitochondrial Import Inner Membrane Translocase**: TIMM9 is a subunit of the mitochondrial import inner membrane translocase complex, which is responsible for the translocation of proteins across the inner mitochondrial membrane. 2. **Widespread Expression**: TIMM9 is expressed in various cell types, including pancreatic A cells, erythroid progenitor cells, pro-T cells, and neural crest cells. 3. **Zinc Ion Binding**: TIMM9 possesses a zinc ion binding motif, which is essential for its function as a mitochondrial import translocase. 4. **Protein Homodimerization Activity**: TIMM9 exhibits homodimerization activity, which is necessary for its oligomeric structure and function. **Pathways and Functions:** 1. **Mitochondrial Protein Import**: TIMM9 plays a crucial role in the import of proteins into the mitochondria, including mitochondrial chaperones and enzymes. 2. **Protein Degradation**: TIMM9 is involved in the degradation of mitochondrial proteins, which is essential for maintaining mitochondrial homeostasis. 3. **Metabolism of Proteins**: TIMM9 is involved in the metabolism of proteins, including the regulation of protein synthesis and degradation. 4. **Sensory Perception of Sound**: TIMM9 has been implicated in the sensory perception of sound, particularly in the auditory system. **Clinical Significance:** 1. **Diabetes**: Abnormalities in TIMM9 expression have been linked to diabetes, particularly type 2 diabetes. 2. **Neurological Disorders**: TIMM9 has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. 3. **Cancer**: Abnormalities in TIMM9 expression have been observed in various types of cancer, including breast cancer and colon cancer. 4. **Hearing Loss**: TIMM9 has been implicated in hearing loss, particularly in the auditory system. In conclusion, TIMM9 is a crucial gene involved in various cellular processes, including protein import, degradation, and metabolism. Its expression is widespread across different cell types, and abnormalities in TIMM9 expression have been linked to various diseases, including diabetes, neurological disorders, and cancer. Further research is necessary to fully understand the functions and clinical significance of TIMM9.

Genular Protein ID: 829137143

Symbol: TIM9_HUMAN

Name: Mitochondrial import inner membrane translocase subunit Tim9

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10611480

Title: The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom.

PubMed ID: 10611480

DOI: 10.1016/s0014-5793(99)01665-8

PubMed ID: 10552927

Title: The human family of deafness/dystonia peptide (DDP) related mitochondrial import proteins.

PubMed ID: 10552927

DOI: 10.1006/geno.1999.5966

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11489896

Title: Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria.

PubMed ID: 11489896

DOI: 10.1074/jbc.m105313200

PubMed ID: 14726512

Title: Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria.

PubMed ID: 14726512

DOI: 10.1074/jbc.m312485200

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 16387659

Title: Crystal structure of the mitochondrial chaperone TIM9.10 reveals a six-bladed alpha-propeller.

PubMed ID: 16387659

DOI: 10.1016/j.molcel.2005.11.010

Sequence Information:

  • Length: 89
  • Mass: 10378
  • Checksum: 00F17CF6332ABF48
  • Sequence:
  • MAAQIPESDQ IKQFKEFLGT YNKLTETCFL DCVKDFTTRE VKPEETTCSE HCLQKYLKMT 
    QRISMRFQEY HIQQNEALAA KAGLLGQPR

Genular Protein ID: 3589518927

Symbol: A0A1W2PQS5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 61
  • Mass: 6892
  • Checksum: 94058242BF4626E5
  • Sequence:
  • MAAQIPESDQ IKQFKEFLGT YNKLTETCFL DCVKDFTTRE VKPEEQNEAL AAKAGLLGQP 
    R

Genular Protein ID: 1661895255

Symbol: A0A1W2PRH9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 60
  • Mass: 6764
  • Checksum: 0C41E2676A344FA7
  • Sequence:
  • MAAQIPESDQ IKQFKEFLGT YNKLTETCFL DCVKDFTTRE VKPEENEALA AKAGLLGQPR

Genular Protein ID: 3794533899

Symbol: G3V502_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 66
  • Mass: 7563
  • Checksum: 766D1BCE2830406E
  • Sequence:
  • MAAQIPESDQ IKQFKEFLGT YNKLTETCFL DCVKDFTTRE VKPEEEYHIQ QNEALAAKAG 
    LLGQPR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.