Details for: TIMM8B

Gene ID: 26521

Symbol: TIMM8B

Ensembl ID: ENSG00000150779

Description: translocase of inner mitochondrial membrane 8 homolog B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 258.4457
    Cell Significance Index: -40.2000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 183.0129
    Cell Significance Index: -46.4200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 138.4642
    Cell Significance Index: -57.0400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 123.1855
    Cell Significance Index: -50.0500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 122.9765
    Cell Significance Index: -58.0600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 108.0222
    Cell Significance Index: -55.5700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 86.7930
    Cell Significance Index: -58.2400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 52.7367
    Cell Significance Index: -50.3500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 45.4355
    Cell Significance Index: -56.0200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.4664
    Cell Significance Index: -46.7900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.1949
    Cell Significance Index: -59.9600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.1171
    Cell Significance Index: -43.3600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 5.1652
    Cell Significance Index: 41.2400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.9916
    Cell Significance Index: 18.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.9314
    Cell Significance Index: 1054.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.7026
    Cell Significance Index: 44.7700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.6649
    Cell Significance Index: 18.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.5276
    Cell Significance Index: 187.8400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.5023
    Cell Significance Index: 106.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.4999
    Cell Significance Index: 270.3900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.4891
    Cell Significance Index: 31.1700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.3765
    Cell Significance Index: 36.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.3653
    Cell Significance Index: 64.1700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.3352
    Cell Significance Index: 590.3300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.3330
    Cell Significance Index: 62.1500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.3114
    Cell Significance Index: 19.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.3071
    Cell Significance Index: 154.1500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.2596
    Cell Significance Index: 14.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2081
    Cell Significance Index: 165.9100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1525
    Cell Significance Index: 52.2400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1173
    Cell Significance Index: 181.7200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.1037
    Cell Significance Index: 25.5000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9240
    Cell Significance Index: 63.9000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8685
    Cell Significance Index: 111.3400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.8684
    Cell Significance Index: 64.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8484
    Cell Significance Index: 44.0700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8040
    Cell Significance Index: 103.8700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7233
    Cell Significance Index: 15.6700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7012
    Cell Significance Index: 45.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6619
    Cell Significance Index: 17.7400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6167
    Cell Significance Index: 21.4300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5819
    Cell Significance Index: 15.8400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5560
    Cell Significance Index: 16.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5086
    Cell Significance Index: 100.9300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5084
    Cell Significance Index: 26.7000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.5016
    Cell Significance Index: 9.2700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4750
    Cell Significance Index: 13.6900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4744
    Cell Significance Index: 90.2900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3590
    Cell Significance Index: 22.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3459
    Cell Significance Index: 34.2200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2130
    Cell Significance Index: 192.3400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1974
    Cell Significance Index: 5.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1701
    Cell Significance Index: 29.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1507
    Cell Significance Index: 30.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1501
    Cell Significance Index: 113.6100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0678
    Cell Significance Index: 1.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0607
    Cell Significance Index: 44.4800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0097
    Cell Significance Index: 0.3100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0042
    Cell Significance Index: -3.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0047
    Cell Significance Index: -0.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0205
    Cell Significance Index: -7.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0246
    Cell Significance Index: -46.3100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0323
    Cell Significance Index: -20.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0351
    Cell Significance Index: -3.5900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0401
    Cell Significance Index: -73.9800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0478
    Cell Significance Index: -73.5400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0553
    Cell Significance Index: -75.2600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0575
    Cell Significance Index: -6.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0608
    Cell Significance Index: -17.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0648
    Cell Significance Index: -36.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0689
    Cell Significance Index: -43.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0956
    Cell Significance Index: -10.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1038
    Cell Significance Index: -21.8600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1132
    Cell Significance Index: -51.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1343
    Cell Significance Index: -4.7200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1875
    Cell Significance Index: -4.7900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2567
    Cell Significance Index: -29.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2968
    Cell Significance Index: -23.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2992
    Cell Significance Index: -18.3900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3106
    Cell Significance Index: -16.1800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.3160
    Cell Significance Index: -4.8000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3348
    Cell Significance Index: -7.1300
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.3561
    Cell Significance Index: -3.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3575
    Cell Significance Index: -51.9700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3786
    Cell Significance Index: -43.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4033
    Cell Significance Index: -30.9500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4255
    Cell Significance Index: -5.8100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4447
    Cell Significance Index: -5.7000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5765
    Cell Significance Index: -60.0300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6104
    Cell Significance Index: -17.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6127
    Cell Significance Index: -34.3800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6722
    Cell Significance Index: -19.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7139
    Cell Significance Index: -48.0000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.8669
    Cell Significance Index: -5.3400
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.8674
    Cell Significance Index: -5.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9452
    Cell Significance Index: -57.9500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.0876
    Cell Significance Index: -12.9700
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -1.2097
    Cell Significance Index: -7.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.3585
    Cell Significance Index: -60.0900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.3615
    Cell Significance Index: -49.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TIMM8B is a mitochondrial inner membrane translocase that facilitates the import of proteins into the mitochondria. This process is essential for maintaining the integrity of the mitochondrial proteome, ensuring the proper functioning of the organelle. The gene exhibits high expression levels in cells with high energy demands, such as erythroid progenitor cells and kidney cells. Additionally, TIMM8B has been linked to the regulation of zinc ion binding, a process that is critical for various cellular functions, including protein function and cell signaling. **Pathways and Functions:** TIMM8B is involved in several key pathways, including: 1. **Protein Insertion into Mitochondrial Inner Membrane:** TIMM8B facilitates the import of proteins into the mitochondrial inner membrane, allowing for the proper functioning of the organelle. 2. **Mitochondrial Protein Import:** This pathway is essential for maintaining the integrity of the mitochondrial proteome, ensuring the proper functioning of the organelle. 3. **Protein Localization:** TIMM8B plays a role in regulating the localization of proteins within the cell, including those destined for the mitochondria. 4. **Sensory Perception of Sound:** Although this pathway may seem unrelated to mitochondrial function, TIMM8B has been linked to the regulation of zinc ion binding, which is critical for various cellular functions, including protein function and cell signaling. **Clinical Significance:** Dysregulation of TIMM8B has been implicated in various diseases, including: 1. **Mitochondrial Diseases:** Mutations in the TIMM8B gene have been associated with mitochondrial diseases, such as mitochondrial myopathies and encephalopathies. 2. **Cancer:** Aberrant expression of TIMM8B has been observed in various types of cancer, including breast cancer and lung cancer. 3. **Neurological Disorders:** TIMM8B has been linked to the regulation of zinc ion binding, which is critical for various cellular functions, including protein function and cell signaling. Dysregulation of TIMM8B may contribute to the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, TIMM8B is a mitochondrial import translocase that plays a crucial role in maintaining cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the function and regulation of this gene.

Genular Protein ID: 764880573

Symbol: TIM8B_HUMAN

Name: Mitochondrial import inner membrane translocase subunit Tim8 B

UniProtKB Accession Codes:

Q9Y5J9 B0YJA5 Q3KQS9 Q9UN04

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10552927

Title: The human family of deafness/dystonia peptide (DDP) related mitochondrial import proteins.

PubMed ID: 10552927

DOI: 10.1006/geno.1999.5966

PubMed ID: 10611480

Title: The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom.

PubMed ID: 10611480

DOI: 10.1016/s0014-5793(99)01665-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 83
  • Mass: 9344
  • Checksum: 9DC47BB475DB8692
  • Sequence:
    • MAELGEADEA ELQRLVAAEQ QKAQFTAQVH HFMELCWDKC VEKPGNRLDS RTENCLSSCV 
DRFIDTTLAI TSRFAQIVQK GGQ

Genular Protein ID: 1346141435

Symbol: G3XAN8_HUMAN

Name: N/A

UniProtKB Accession Codes:

G3XAN8

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 2 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.M111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 98
  • Mass: 11155
  • Checksum: B26EBA42548AFB46
  • Sequence:
    • MRKHSCRKVA SLRRTMAELG EADEAELQRL VAAEQQKAQF TAQVHHFMEL CWDKCVEKPG 
NRLDSRTENC LSSCVDRFID TTLAITSRFA QIVQKGGQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.