Details for: MRPL46

Gene ID: 26589

Symbol: MRPL46

Ensembl ID: ENSG00000259494

Description: mitochondrial ribosomal protein L46

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 90.7132
    Cell Significance Index: -14.1100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 53.2243
    Cell Significance Index: -13.5000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 44.7872
    Cell Significance Index: -18.4500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 38.9162
    Cell Significance Index: -15.8100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 37.7656
    Cell Significance Index: -17.8300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 26.5714
    Cell Significance Index: -17.8300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 16.8003
    Cell Significance Index: -16.0400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.8123
    Cell Significance Index: -17.0300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.4600
    Cell Significance Index: -16.7700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.4855
    Cell Significance Index: -17.7000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.3395
    Cell Significance Index: -11.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.9106
    Cell Significance Index: 473.3800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6493
    Cell Significance Index: 179.3900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.5510
    Cell Significance Index: 1400.4800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.5482
    Cell Significance Index: 41.4900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.4512
    Cell Significance Index: 38.7500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.1692
    Cell Significance Index: 136.2600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.1039
    Cell Significance Index: 28.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8312
    Cell Significance Index: 57.4800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6803
    Cell Significance Index: 6.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6588
    Cell Significance Index: 118.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5978
    Cell Significance Index: 15.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4979
    Cell Significance Index: 61.2200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4475
    Cell Significance Index: 31.6500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4324
    Cell Significance Index: 27.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4295
    Cell Significance Index: 234.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3920
    Cell Significance Index: 20.5800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3902
    Cell Significance Index: 77.4400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3887
    Cell Significance Index: 171.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3683
    Cell Significance Index: 17.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3554
    Cell Significance Index: 41.9100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3435
    Cell Significance Index: 7.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3383
    Cell Significance Index: 43.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3377
    Cell Significance Index: 46.3800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3223
    Cell Significance Index: 11.2000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.2818
    Cell Significance Index: 2.2500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2630
    Cell Significance Index: 7.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2593
    Cell Significance Index: 7.4700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2491
    Cell Significance Index: 7.3200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2198
    Cell Significance Index: 14.1800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2092
    Cell Significance Index: 39.8100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1842
    Cell Significance Index: 8.5900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1794
    Cell Significance Index: 13.3700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1744
    Cell Significance Index: 9.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1686
    Cell Significance Index: 33.8300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1601
    Cell Significance Index: 8.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1491
    Cell Significance Index: 19.1100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1246
    Cell Significance Index: 2.7000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0991
    Cell Significance Index: 2.1100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0805
    Cell Significance Index: 0.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0680
    Cell Significance Index: 24.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0525
    Cell Significance Index: 2.3800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0257
    Cell Significance Index: 2.5400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0241
    Cell Significance Index: 17.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0036
    Cell Significance Index: 2.7000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0088
    Cell Significance Index: -16.5600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0109
    Cell Significance Index: -20.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0116
    Cell Significance Index: -1.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0129
    Cell Significance Index: -19.8500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0148
    Cell Significance Index: -20.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0173
    Cell Significance Index: -12.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0197
    Cell Significance Index: -1.5100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0238
    Cell Significance Index: -0.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0265
    Cell Significance Index: -16.8000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0274
    Cell Significance Index: -15.4400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0304
    Cell Significance Index: -19.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0337
    Cell Significance Index: -2.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0356
    Cell Significance Index: -6.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0393
    Cell Significance Index: -17.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0393
    Cell Significance Index: -11.3100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0411
    Cell Significance Index: -0.8600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0518
    Cell Significance Index: -1.8200
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0576
    Cell Significance Index: -0.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0863
    Cell Significance Index: -18.1900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0880
    Cell Significance Index: -6.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0913
    Cell Significance Index: -10.4600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0993
    Cell Significance Index: -3.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1156
    Cell Significance Index: -16.8000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1217
    Cell Significance Index: -6.8300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1393
    Cell Significance Index: -1.9000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1548
    Cell Significance Index: -3.8700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1671
    Cell Significance Index: -2.1400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1730
    Cell Significance Index: -18.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1809
    Cell Significance Index: -11.0900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1853
    Cell Significance Index: -2.0200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1939
    Cell Significance Index: -4.7300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2003
    Cell Significance Index: -2.8100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2125
    Cell Significance Index: -2.2000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2172
    Cell Significance Index: -3.2600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2330
    Cell Significance Index: -3.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2700
    Cell Significance Index: -18.1600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2822
    Cell Significance Index: -8.0900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3069
    Cell Significance Index: -8.2100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3187
    Cell Significance Index: -9.3900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3229
    Cell Significance Index: -5.4400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3242
    Cell Significance Index: -14.3400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3387
    Cell Significance Index: -5.0000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3706
    Cell Significance Index: -6.8500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3711
    Cell Significance Index: -6.3600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3834
    Cell Significance Index: -19.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MRPL46 is a mitochondrial ribosomal protein that belongs to the L46 family of proteins. It is composed of 39 amino acids and is expressed in various cell types, including placental villous trophoblast, pancreatic A cell, proerythroblast, neural progenitor cell, erythroid progenitor cell, cardiac muscle myoblast, primordial germ cell, oogonial cell, plasmablast, and Leydig cell. The protein is highly conserved across species, suggesting its essential role in maintaining cellular homeostasis. **Pathways and Functions:** MRPL46 is involved in various cellular processes, including: 1. **Mitochondrial translation:** MRPL46 plays a crucial role in the translation of mitochondrial mRNAs into proteins essential for energy production, including ATP synthase, cytochrome c oxidase, and other mitochondrial respiratory chain complexes. 2. **Mitochondrial elongation:** MRPL46 is involved in the elongation phase of mitochondrial translation, where it interacts with other mitochondrial ribosomal proteins to facilitate the assembly of the ribosome. 3. **Mitochondrial initiation and termination:** MRPL46 is also involved in the initiation and termination phases of mitochondrial translation, where it interacts with other mitochondrial ribosomal proteins to regulate the translation process. **Clinical Significance:** Dysregulation of MRPL46 has been implicated in various diseases, including: 1. **Cancer:** MRPL46 has been shown to be overexpressed in various types of cancer, including breast, lung, and colon cancer, suggesting its potential role in tumorigenesis. 2. **Neurodegenerative disorders:** MRPL46 has been implicated in neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease, where it may play a role in the regulation of mitochondrial function and energy production. 3. **Metabolic disorders:** MRPL46 has been shown to be involved in the regulation of mitochondrial function and energy production, suggesting its potential role in metabolic disorders, including diabetes and obesity. In conclusion, MRPL46 is a critical component of the mitochondrial ribosome, essential for the translation of mitochondrial mRNAs into proteins essential for energy production and cellular survival. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the role of MRPL46 in human health and disease.

Genular Protein ID: 2408343697

Symbol: RM46_HUMAN

Name: 39S ribosomal protein L46, mitochondrial

UniProtKB Accession Codes:

Q9H2W6 B2RD75 Q9HBU8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 54 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 57 PDBsum 57 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11761714

Title: Cloning, mapping and expression analysis of C15orf4, a novel human gene with homology to the yeast mitochondrial ribosomal protein Ym130 gene.

PubMed ID: 11761714

DOI: 10.3109/10425170109047561

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11551941

Title: The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present.

PubMed ID: 11551941

DOI: 10.1074/jbc.m106510200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25278503

Title: Structure of the large ribosomal subunit from human mitochondria.

PubMed ID: 25278503

DOI: 10.1126/science.1258026

PubMed ID: 25838379

Title: Ribosome. The structure of the human mitochondrial ribosome.

PubMed ID: 25838379

DOI: 10.1126/science.aaa1193

PubMed ID: 28892042

Title: Structures of the human mitochondrial ribosome in native states of assembly.

PubMed ID: 28892042

DOI: 10.1038/nsmb.3464

Sequence Information:

  • Length: 279
  • Mass: 31705
  • Checksum: EDA966D758715378
  • Sequence:
    • MAAPVRRTLL GVAGGWRRFE RLWAGSLSSR SLALAAAPSS NGSPWRLLGA LCLQRPPVVS 
KPLTPLQEEM ASLLQQIEIE RSLYSDHELR ALDENQRLAK KKADLHDEED EQDILLAQDL 
EDMWEQKFLQ FKLGARITEA DEKNDRTSLN RKLDRNLVLL VREKFGDQDV WILPQAEWQP 
GETLRGTAER TLATLSENNM EAKFLGNAPC GHYTFKFPQA MRTESNLGAK VFFFKALLLT 
GDFSQAGNKG HHVWVTKDEL GDYLKPKYLA QVRRFVSDL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.