Details for: APOBEC3C

Gene ID: 27350

Symbol: APOBEC3C

Ensembl ID: ENSG00000244509

Description: apolipoprotein B mRNA editing enzyme catalytic subunit 3C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 67.3759
    Cell Significance Index: -10.4800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 52.9484
    Cell Significance Index: -13.4300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 43.7386
    Cell Significance Index: -20.6500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 41.5642
    Cell Significance Index: -21.3800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 30.7888
    Cell Significance Index: -20.6600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.7369
    Cell Significance Index: -18.1700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.0720
    Cell Significance Index: -18.6500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.1520
    Cell Significance Index: -20.3300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.8711
    Cell Significance Index: -10.3700
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 3.4716
    Cell Significance Index: 9.3000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.9031
    Cell Significance Index: 51.0000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.2683
    Cell Significance Index: 37.2500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1200
    Cell Significance Index: 1011.2600
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 1.1199
    Cell Significance Index: 0.5100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1022
    Cell Significance Index: 30.0000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.0646
    Cell Significance Index: 124.0700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9610
    Cell Significance Index: 104.5300
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.9376
    Cell Significance Index: 6.2200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.9044
    Cell Significance Index: 23.7800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8726
    Cell Significance Index: 45.3300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8545
    Cell Significance Index: 138.9700
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.8318
    Cell Significance Index: 5.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8315
    Cell Significance Index: 53.6500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.7211
    Cell Significance Index: 6.6400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.6938
    Cell Significance Index: 16.0300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6708
    Cell Significance Index: 82.4800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5582
    Cell Significance Index: 65.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5501
    Cell Significance Index: 75.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5018
    Cell Significance Index: 90.4700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4770
    Cell Significance Index: 32.9900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4214
    Cell Significance Index: 186.2900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3695
    Cell Significance Index: 47.3700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.2902
    Cell Significance Index: 2.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2889
    Cell Significance Index: 54.9800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2873
    Cell Significance Index: 5.3100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2514
    Cell Significance Index: 17.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2402
    Cell Significance Index: 11.2000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2073
    Cell Significance Index: 15.4500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1634
    Cell Significance Index: 4.3700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1110
    Cell Significance Index: 14.3400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0973
    Cell Significance Index: 4.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0946
    Cell Significance Index: 2.0500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0745
    Cell Significance Index: 7.3700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0643
    Cell Significance Index: 35.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0146
    Cell Significance Index: 0.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0135
    Cell Significance Index: 0.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0106
    Cell Significance Index: -19.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0111
    Cell Significance Index: -8.4300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0116
    Cell Significance Index: -0.1800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0279
    Cell Significance Index: -20.4600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0294
    Cell Significance Index: -21.8100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0325
    Cell Significance Index: -20.6600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0368
    Cell Significance Index: -20.7700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0485
    Cell Significance Index: -2.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0491
    Cell Significance Index: -22.2800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0556
    Cell Significance Index: -1.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0575
    Cell Significance Index: -20.6300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0596
    Cell Significance Index: -1.2700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0633
    Cell Significance Index: -2.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0671
    Cell Significance Index: -19.3100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0765
    Cell Significance Index: -1.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0781
    Cell Significance Index: -7.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0805
    Cell Significance Index: -9.2200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0986
    Cell Significance Index: -1.3500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0991
    Cell Significance Index: -19.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1013
    Cell Significance Index: -20.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1080
    Cell Significance Index: -18.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1157
    Cell Significance Index: -24.3600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1430
    Cell Significance Index: -20.7900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1889
    Cell Significance Index: -2.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1920
    Cell Significance Index: -19.9900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2122
    Cell Significance Index: -16.2900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2523
    Cell Significance Index: -4.3500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2620
    Cell Significance Index: -20.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2682
    Cell Significance Index: -16.4400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2743
    Cell Significance Index: -4.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2888
    Cell Significance Index: -9.2500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3210
    Cell Significance Index: -20.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3552
    Cell Significance Index: -19.9300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3574
    Cell Significance Index: -21.9700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3727
    Cell Significance Index: -12.9500
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.3745
    Cell Significance Index: -2.2000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3977
    Cell Significance Index: -6.3100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4001
    Cell Significance Index: -21.0100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4144
    Cell Significance Index: -4.2900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4429
    Cell Significance Index: -13.0500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4606
    Cell Significance Index: -16.9100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.4679
    Cell Significance Index: -6.7100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4763
    Cell Significance Index: -9.8800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4883
    Cell Significance Index: -9.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4949
    Cell Significance Index: -21.8900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.5122
    Cell Significance Index: -6.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5173
    Cell Significance Index: -14.8300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.5247
    Cell Significance Index: -4.4600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.5282
    Cell Significance Index: -2.8800
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.5698
    Cell Significance Index: -3.7200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.5726
    Cell Significance Index: -24.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5778
    Cell Significance Index: -21.8800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5929
    Cell Significance Index: -20.7700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Cytidine Deaminase Activity**: APOBEC3C possesses potent cytidine deaminase activity, which allows it to convert cytidine to uridine in single-stranded RNA. This activity is essential for preventing viral replication and mutagenesis. 2. **RNA Editing**: The APOBEC3C protein has been shown to exhibit RNA-binding capabilities, suggesting its involvement in the editing of RNA molecules. 3. **Zinc Binding**: The protein exhibits zinc-binding properties, which may be essential for its function in the formation of the editosome. 4. **Expression in Immune Cells**: APOBEC3C is expressed in various immune cells, including natural killer cells, T cells, and monocytes, indicating its role in the innate immune response. **Pathways and Functions** 1. **Clearance of Foreign Intracellular DNA**: APOBEC3C plays a crucial role in the clearance of foreign intracellular DNA, which is essential for preventing viral replication and mutagenesis. 2. **Negative Regulation of Viral Genome Replication**: The APOBEC3C protein has been shown to inhibit viral genome replication by converting cytidine to uridine in viral RNA, thereby preventing viral replication. 3. **Innate Immune Response**: APOBEC3C is involved in the innate immune response against viral infections, with its expression and activity being critical for the clearance of foreign DNA and the prevention of viral replication. 4. **Metabolism of RNA**: The APOBEC3C protein has been shown to exhibit RNA-binding capabilities, suggesting its involvement in the metabolism of RNA molecules. **Clinical Significance** 1. **Viral Infections**: APOBEC3C has been shown to play a critical role in the clearance of viral infections, including HIV, herpesvirus, and influenza virus. 2. **Cancer**: The APOBEC3C protein has been implicated in the regulation of cancer cell proliferation and apoptosis, with its expression being altered in various types of cancer. 3. **Immunodeficiency**: Mutations in the APOBEC3C gene have been associated with immunodeficiency, highlighting the importance of this gene in the innate immune response. 4. **Gene Therapy**: APOBEC3C has been explored as a potential target for gene therapy, with its ability to edit DNA and RNA making it an attractive candidate for the treatment of genetic diseases. In conclusion, APOBEC3C is a critical component of the innate immune response, with its ability to edit DNA and RNA making it an essential player in the clearance of foreign intracellular DNA and the prevention of viral replication. Its expression and activity are critical for the innate immune response, and its dysregulation has been implicated in various diseases, including viral infections, cancer, and immunodeficiency.

Genular Protein ID: 3423805467

Symbol: ABC3C_HUMAN

Name: DNA dC->dU-editing enzyme APOBEC-3C

UniProtKB Accession Codes:

Q9NRW3 B2R884 Q5JZ92 Q7Z2N7 Q96F12

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 9 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 7 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11863358

Title: An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22.

PubMed ID: 11863358

DOI: 10.1006/geno.2002.6718

PubMed ID: 12859895

Title: Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif.

PubMed ID: 12859895

DOI: 10.1016/s0092-8674(03)00515-4

PubMed ID: 15466872

Title: APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication.

PubMed ID: 15466872

DOI: 10.1074/jbc.m408802200

PubMed ID: 16527742

Title: APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons.

PubMed ID: 16527742

DOI: 10.1016/j.cub.2006.01.031

PubMed ID: 18304004

Title: The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements.

PubMed ID: 18304004

DOI: 10.1146/annurev.immunol.26.021607.090350

PubMed ID: 18448976

Title: Hepatitis B: modern concepts in pathogenesis--APOBEC3 cytidine deaminases as effectors in innate immunity against the hepatitis B virus.

PubMed ID: 18448976

DOI: 10.1097/qco.0b013e3282fe1bb2

PubMed ID: 19074429

Title: Species-specific inhibition of APOBEC3C by the prototype foamy virus protein bet.

PubMed ID: 19074429

DOI: 10.1074/jbc.m808853200

PubMed ID: 20062055

Title: APOBEC3 proteins mediate the clearance of foreign DNA from human cells.

PubMed ID: 20062055

DOI: 10.1038/nsmb.1744

PubMed ID: 20308164

Title: Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction.

PubMed ID: 20308164

DOI: 10.1093/nar/gkq174

PubMed ID: 21496894

Title: Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain.

PubMed ID: 21496894

DOI: 10.1016/j.cell.2011.03.022

PubMed ID: 21632763

Title: Genetic editing of herpes simplex virus 1 and Epstein-Barr herpesvirus genomes by human APOBEC3 cytidine deaminases in culture and in vivo.

PubMed ID: 21632763

DOI: 10.1128/jvi.00290-11

PubMed ID: 21835787

Title: Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1.

PubMed ID: 21835787

DOI: 10.1128/jvi.05238-11

PubMed ID: 22912627

Title: Retroelements versus APOBEC3 family members: No great escape from the magnificent seven.

PubMed ID: 22912627

DOI: 10.3389/fmicb.2012.00275

PubMed ID: 22977230

Title: Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A.

PubMed ID: 22977230

DOI: 10.1074/jbc.m112.372722

PubMed ID: 22915799

Title: HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies.

PubMed ID: 22915799

DOI: 10.1128/jvi.00595-12

PubMed ID: 22001110

Title: Functions and regulation of the APOBEC family of proteins.

PubMed ID: 22001110

DOI: 10.1016/j.semcdb.2011.10.004

PubMed ID: 23001005

Title: The APOBEC3C crystal structure and the interface for HIV-1 Vif binding.

PubMed ID: 23001005

DOI: 10.1038/nsmb.2378

Sequence Information:

  • Length: 190
  • Mass: 22826
  • Checksum: BE49E80F95C71214
  • Sequence:
    • MNPQIRNPMK AMYPGTFYFQ FKNLWEANDR NETWLCFTVE GIKRRSVVSW KTGVFRNQVD 
SETHCHAERC FLSWFCDDIL SPNTKYQVTW YTSWSPCPDC AGEVAEFLAR HSNVNLTIFT 
ARLYYFQYPC YQEGLRSLSQ EGVAVEIMDY EDFKYCWENF VYNDNEPFKP WKGLKTNFRL 
LKRRLRESLQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.