Details for: GLO1

Gene ID: 2739

Symbol: GLO1

Ensembl ID: ENSG00000124767

Description: glyoxalase I

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.93
    Marker Score: 11354
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.21
    Marker Score: 4500
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.2
    Marker Score: 3184
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.13
    Marker Score: 13588
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.07
    Marker Score: 2497
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.04
    Marker Score: 3277
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.03
    Marker Score: 5124
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.03
    Marker Score: 4241
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.01
    Marker Score: 13054
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.99
    Marker Score: 5430
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.97
    Marker Score: 1857
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.97
    Marker Score: 1145
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.94
    Marker Score: 2088
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.91
    Marker Score: 2020
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.91
    Marker Score: 66098
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.9
    Marker Score: 12374
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.89
    Marker Score: 3210
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.84
    Marker Score: 18523
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.84
    Marker Score: 1920
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.8
    Marker Score: 2981
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.8
    Marker Score: 23678
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.79
    Marker Score: 1685
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.78
    Marker Score: 6848
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.76
    Marker Score: 2799
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.76
    Marker Score: 2440
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.75
    Marker Score: 4749
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.73
    Marker Score: 1838
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.73
    Marker Score: 4070
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.72
    Marker Score: 4383
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.72
    Marker Score: 1839
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.68
    Marker Score: 1123
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.68
    Marker Score: 2969
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.66
    Marker Score: 2562
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.65
    Marker Score: 4435
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.64
    Marker Score: 7082
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.64
    Marker Score: 4000
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.64
    Marker Score: 1647
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.63
    Marker Score: 14039
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.62
    Marker Score: 8496
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.6
    Marker Score: 1336
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.59
    Marker Score: 6256
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.57
    Marker Score: 2229
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.57
    Marker Score: 1664.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.55
    Marker Score: 2279
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.54
    Marker Score: 1216
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.54
    Marker Score: 9111
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.53
    Marker Score: 359
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.52
    Marker Score: 4965
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.51
    Marker Score: 1614
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.48
    Marker Score: 418
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.47
    Marker Score: 925
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.46
    Marker Score: 2752
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.46
    Marker Score: 1483
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.46
    Marker Score: 538
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.46
    Marker Score: 434.5
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.46
    Marker Score: 831
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.45
    Marker Score: 747
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.44
    Marker Score: 165747
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.43
    Marker Score: 5302
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.43
    Marker Score: 342
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.43
    Marker Score: 970
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.42
    Marker Score: 3377
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.42
    Marker Score: 1474
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.42
    Marker Score: 11069
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.42
    Marker Score: 1947
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.39
    Marker Score: 1043
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.39
    Marker Score: 1201
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.39
    Marker Score: 3955.5
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.39
    Marker Score: 15611
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.38
    Marker Score: 5646
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.38
    Marker Score: 6620
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.38
    Marker Score: 270
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.37
    Marker Score: 1538
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.37
    Marker Score: 863
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.37
    Marker Score: 450
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.36
    Marker Score: 6691
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.35
    Marker Score: 742
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.34
    Marker Score: 1786
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.34
    Marker Score: 465
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 1.33
    Marker Score: 873
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.33
    Marker Score: 1429
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.33
    Marker Score: 305
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.32
    Marker Score: 15348
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.32
    Marker Score: 325
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.32
    Marker Score: 943
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.31
    Marker Score: 458
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.31
    Marker Score: 2989
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.31
    Marker Score: 33508
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.29
    Marker Score: 43835
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.29
    Marker Score: 587
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.28
    Marker Score: 3355
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.28
    Marker Score: 1494
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.27
    Marker Score: 622
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.26
    Marker Score: 1087
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.26
    Marker Score: 1188
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 1.26
    Marker Score: 566
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.26
    Marker Score: 363
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.25
    Marker Score: 781
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.25
    Marker Score: 1114
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.24
    Marker Score: 899

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Other Information

**Key characteristics:** * The GLO1 gene is located on chromosome 15q26.1. * It is a highly expressed gene in neural progenitor cell, GABAergic amacrine cell, alveolar capillary type 2 endothelial cell, CD4-positive, alpha-beta memory T cell, CD45RO-positive, glycinergic neuron, pneumocyte, kidney collecting duct principal cell, epithelial cell of nephron, interstitial cell of ovary, and ovarian surface epithelial cell. * The protein encoded by GLO1 is a glyoxalase enzyme that catalyzes the hydrolysis of glyoxal to pyruvate, which can be further metabolized by the citric acid (tca) cycle. **Pathways and functions:** * The GLO1 gene is involved in multiple pathways and functions, including: * Carbohydrate metabolic process * Cytoplasm * Cytosol * Extracellular exosome * Glutathione metabolic process * Lactoylglutathione lyase activity * Metabolism * Methylglyoxal metabolic process * Negative regulation of apoptotic process * Nucleoplasm * Osteoclast differentiation * Plasma membrane * Protein binding * Pyruvate metabolism * Pyruvate metabolism and citric acid (tca) cycle * Regulation of transcription by rna polymerase ii * The citric acid (tca) cycle and respiratory electron transport **Clinical significance:** * Mutations in the GLO1 gene have been linked to several human diseases, including: * Neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease) * Cancer * Cardiovascular diseases **Conclusion:** The GLO1 gene plays a crucial role in maintaining cellular homeostasis and protecting against cellular damage. Its expression is highly concentrated in specific cell types, and its dysfunction can lead to various diseases.

Genular Protein ID: 2629313131

Symbol: LGUL_HUMAN

Name: Lactoylglutathione lyase

UniProtKB Accession Codes:

Q04760 B2R6P7 B4DDV0 P78375 Q59EL0 Q5TZW3 Q96FC0 Q96J41

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 5 CPTC 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 DrugCentral 1 EC 1 EMBL 13 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 2 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 11 PIR 2 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 1 RefSeq 1 Rhea 2 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7684374

Title: Human glyoxalase I. cDNA cloning, expression, and sequence similarity to glyoxalase I from Pseudomonas putida.

PubMed ID: 7684374

DOI: 10.1016/s0021-9258(18)82113-5

PubMed ID: 8449929

Title: Cloning and characterization of human colon glyoxalase-I.

PubMed ID: 8449929

DOI: 10.1016/s0021-9258(18)53370-6

PubMed ID: 8670058

Title: Optimized heterologous expression of the human zinc enzyme glyoxalase I.

PubMed ID: 8670058

DOI: 10.1042/bj3140463

PubMed ID: 10564821

Title: Genomic sequence of human glyoxalase-I: analysis of promoter activity and its regulation.

PubMed ID: 10564821

DOI: 10.1016/s0378-1119(99)00420-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20454679

Title: Posttranslational modification of human glyoxalase 1 indicates redox-dependent regulation.

PubMed ID: 20454679

DOI: 10.1371/journal.pone.0010399

PubMed ID: 17576200

Title: Tumour necrosis factor induces phosphorylation primarily of the nitric-oxide-responsive form of glyoxalase I.

PubMed ID: 17576200

DOI: 10.1042/bj20070379

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19199007

Title: Phosphorylation on Thr-106 and NO-modification of glyoxalase I suppress the TNF-induced transcriptional activity of NF-kappaB.

PubMed ID: 19199007

DOI: 10.1007/s11010-009-0031-7

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 9218781

Title: Crystal structure of human glyoxalase I -- evidence for gene duplication and 3D domain swapping.

PubMed ID: 9218781

DOI: 10.1093/emboj/16.12.3386

PubMed ID: 9705294

Title: Involvement of an active-site Zn2+ ligand in the catalytic mechanism of human glyoxalase I.

PubMed ID: 9705294

DOI: 10.1074/jbc.273.34.21623

PubMed ID: 10521255

Title: Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue.

PubMed ID: 10521255

DOI: 10.1021/bi990696c

PubMed ID: 23122816

Title: Design and evaluation of azaindole-substituted N-hydroxypyridones as glyoxalase I inhibitors.

PubMed ID: 23122816

DOI: 10.1016/j.bmcl.2012.10.045

Sequence Information:

  • Length: 184
  • Mass: 20778
  • Checksum: 46291B7878070028
  • Sequence:
    • MAEPQPPSGG LTDEAALSCC SDADPSTKDF LLQQTMLRVK DPKKSLDFYT RVLGMTLIQK 
CDFPIMKFSL YFLAYEDKND IPKEKDEKIA WALSRKATLE LTHNWGTEDD ETQSYHNGNS 
DPRGFGHIGI AVPDVYSACK RFEELGVKFV KKPDDGKMKG LAFIQDPDGY WIEILNPNKM 
ATLM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.