Details for: GLRA1
Associated with
Cells (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: retinal cone cell (CL0000573)
Fold Change: 2.52
Marker Score: 7219 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.99
Marker Score: 1980 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.6
Marker Score: 1160 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.58
Marker Score: 3947 - Cell Name: mural cell (CL0008034)
Fold Change: 1.48
Marker Score: 170128 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.25
Marker Score: 849 - Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 1.25
Marker Score: 2591 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.2
Marker Score: 2267 - Cell Name: lens fiber cell (CL0011004)
Fold Change: 1.17
Marker Score: 371 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.17
Marker Score: 486 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.17
Marker Score: 12078 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4792 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 1.13
Marker Score: 3214 - Cell Name: goblet cell (CL0000160)
Fold Change: 1.11
Marker Score: 7367 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.04
Marker Score: 16317 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71798 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48022 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 507 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 461 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5344 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 374 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.93
Marker Score: 426 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.92
Marker Score: 387 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2742 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 327 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5282 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.84
Marker Score: 1701 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.79
Marker Score: 10526 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1266 - Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 706 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 396 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.74
Marker Score: 202 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 461 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.67
Marker Score: 400 - Cell Name: fast muscle cell (CL0000190)
Fold Change: 0.59
Marker Score: 178 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.59
Marker Score: 309 - Cell Name: neuron (CL0000540)
Fold Change: 0.56
Marker Score: 2280 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 175 - Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.55
Marker Score: 247 - Cell Name: hepatocyte (CL0000182)
Fold Change: 0.47
Marker Score: 319 - Cell Name: rod bipolar cell (CL0000751)
Fold Change: 0.46
Marker Score: 241 - Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.46
Marker Score: 258 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.45
Marker Score: 217 - Cell Name: retina horizontal cell (CL0000745)
Fold Change: 0.45
Marker Score: 427 - Cell Name: melanocyte (CL0000148)
Fold Change: 0.44
Marker Score: 178 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.43
Marker Score: 16245 - Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.43
Marker Score: 135 - Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 0.4
Marker Score: 3385 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.4
Marker Score: 190 - Cell Name: interneuron (CL0000099)
Fold Change: 0.39
Marker Score: 179 - Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 0.37
Marker Score: 118 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.37
Marker Score: 367 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.37
Marker Score: 3167 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.36
Marker Score: 1278 - Cell Name: astrocyte (CL0000127)
Fold Change: 0.35
Marker Score: 307.5 - Cell Name: ependymal cell (CL0000065)
Fold Change: 0.34
Marker Score: 119 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.34
Marker Score: 2016 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.34
Marker Score: 790 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.32
Marker Score: 190 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.32
Marker Score: 1345 - Cell Name: endothelial cell (CL0000115)
Fold Change: 0.32
Marker Score: 286 - Cell Name: macrophage (CL0000235)
Fold Change: 0.31
Marker Score: 349 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.31
Marker Score: 184 - Cell Name: mast cell (CL0000097)
Fold Change: 0.3
Marker Score: 174 - Cell Name: CNS interneuron (CL0000402)
Fold Change: 0.3
Marker Score: 144 - Cell Name: B cell (CL0000236)
Fold Change: 0.29
Marker Score: 276.5 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.29
Marker Score: 358 - Cell Name: myeloid cell (CL0000763)
Fold Change: 0.28
Marker Score: 448 - Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.27
Marker Score: 71 - Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.27
Marker Score: 119 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.27
Marker Score: 83 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.26
Marker Score: 95 - Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.26
Marker Score: 76 - Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.26
Marker Score: 52 - Cell Name: PP cell (CL0000696)
Fold Change: 0.24
Marker Score: 53 - Cell Name: pericyte (CL0000669)
Fold Change: 0.23
Marker Score: 137 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 0.23
Marker Score: 5233 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.23
Marker Score: 361 - Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.23
Marker Score: 95 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.23
Marker Score: 66 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 76 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.22
Marker Score: 49 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.22
Marker Score: 72 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.22
Marker Score: 275 - Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.22
Marker Score: 351 - Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.21
Marker Score: 208 - Cell Name: adventitial cell (CL0002503)
Fold Change: 0.2
Marker Score: 50 - Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.19
Marker Score: 50 - Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 0.19
Marker Score: 51 - Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 0.19
Marker Score: 69 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.19
Marker Score: 499 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.18
Marker Score: 45 - Cell Name: mucus secreting cell (CL0000319)
Fold Change: 0.18
Marker Score: 46 - Cell Name: starburst amacrine cell (CL0004232)
Fold Change: 0.18
Marker Score: 51 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.17
Marker Score: 723 - Cell Name: mesothelial fibroblast (CL4023054)
Fold Change: 0.17
Marker Score: 51 - Cell Name: lymphocyte (CL0000542)
Fold Change: 0.17
Marker Score: 86
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Other Information
Genular Protein ID: 1381578589
Symbol: GLRA1_HUMAN
Name: Glycine receptor subunit alpha-1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2155780
Title: Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes.
PubMed ID: 2155780
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7920629
Title: A missense mutation in the gene encoding the alpha 1 subunit of the inhibitory glycine receptor in the spasmodic mouse.
PubMed ID: 7920629
DOI: 10.1038/ng0694-131
PubMed ID: 14551753
Title: Kinetic analysis of recombinant mammalian alpha(1) and alpha(1)beta glycine receptor channels.
PubMed ID: 14551753
PubMed ID: 16144831
Title: Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors.
PubMed ID: 16144831
PubMed ID: 19861413
Title: Mapping of disulfide bonds within the amino-terminal extracellular domain of the inhibitory glycine receptor.
PubMed ID: 19861413
PubMed ID: 22715885
Title: Stoichiometry and subunit arrangement of alpha1beta glycine receptors as determined by atomic force microscopy.
PubMed ID: 22715885
DOI: 10.1021/bi300063m
PubMed ID: 22973015
Title: Stoichiometry of the human glycine receptor revealed by direct subunit counting.
PubMed ID: 22973015
PubMed ID: 25973519
Title: Ethanol modulation is quantitatively determined by the transmembrane domain of human alpha1 glycine receptors.
PubMed ID: 25973519
DOI: 10.1111/acer.12735
PubMed ID: 25445488
Title: Functional reconstitution of glycinergic synapses incorporating defined glycine receptor subunit combinations.
PubMed ID: 25445488
PubMed ID: 35526563
Title: Clinical, genetic, and functional characterization of the glycine receptor beta-subunit A455P variant in a family affected by hyperekplexia syndrome.
PubMed ID: 35526563
PubMed ID: 12667090
Title: NMR structure and backbone dynamics of the extended second transmembrane domain of the human neuronal glycine receptor alpha1 subunit.
PubMed ID: 12667090
DOI: 10.1021/bi026767g
PubMed ID: 15952785
Title: Structure and dynamics of the second and third transmembrane domains of human glycine receptor.
PubMed ID: 15952785
DOI: 10.1021/bi050256n
PubMed ID: 23994010
Title: Open-channel structures of the human glycine receptor alpha1 full-length transmembrane domain.
PubMed ID: 23994010
PubMed ID: 25730860
Title: Allosteric and hyperekplexic mutant phenotypes investigated on an alpha1 glycine receptor transmembrane structure.
PubMed ID: 25730860
PubMed ID: 8298642
Title: Mutations in the alpha 1 subunit of the inhibitory glycine receptor cause the dominant neurologic disorder, hyperekplexia.
PubMed ID: 8298642
DOI: 10.1038/ng1293-351
PubMed ID: 7925268
Title: Decreased agonist affinity and chloride conductance of mutant glycine receptors associated with human hereditary hyperekplexia.
PubMed ID: 7925268
PubMed ID: 7981700
Title: An additional family with Startle disease and a G1192A mutation at the alpha 1 subunit of the inhibitory glycine receptor gene.
PubMed ID: 7981700
DOI: 10.1093/hmg/3.7.1201
PubMed ID: 7881416
Title: Evidence for recessive as well as dominant forms of startle disease (hyperekplexia) caused by mutations in the alpha 1 subunit of the inhibitory glycine receptor.
PubMed ID: 7881416
PubMed ID: 7611730
Title: Mutational analysis of familial and sporadic hyperekplexia.
PubMed ID: 7611730
PubMed ID: 8571969
Title: A novel mutation (Gln266-->His) in the alpha 1 subunit of the inhibitory glycine-receptor gene (GLRA1) in hereditary hyperekplexia.
PubMed ID: 8571969
PubMed ID: 8733061
Title: Analysis of GLRA1 in hereditary and sporadic hyperekplexia: a novel mutation in a family cosegregating for hyperekplexia and spastic paraparesis.
PubMed ID: 8733061
DOI: 10.1136/jmg.33.5.435
PubMed ID: 9009272
Title: Identification of intracellular and extracellular domains mediating signal transduction in the inhibitory glycine receptor chloride channel.
PubMed ID: 9009272
PubMed ID: 9067762
Title: Startle disease in an Italian family by mutation (K276E): the alpha-subunit of the inhibiting glycine receptor.
PubMed ID: 9067762
DOI: 10.1002/(sici)1098-1004(1997)9:2<185::aid-humu14>3.0.co;2-z
PubMed ID: 10514101
Title: Hyperekplexia phenotype due to compound heterozygosity for GLRA1 gene mutations.
PubMed ID: 10514101
DOI: 10.1002/1531-8249(199910)46:4<634::aid-ana12>3.0.co;2-9
PubMed ID: 9920650
Title: Novel GLRA1 missense mutation (P250T) in dominant hyperekplexia defines an intracellular determinant of glycine receptor channel gating.
PubMed ID: 9920650
PubMed ID: 24108130
Title: New hyperekplexia mutations provide insight into glycine receptor assembly, trafficking, and activation mechanisms.
PubMed ID: 24108130
Sequence Information:
- Length: 457
- Mass: 52624
- Checksum: 5ED80AF62B06A3AA
- Sequence:
MYSFNTLRLY LWETIVFFSL AASKEAEAAR SAPKPMSPSD FLDKLMGRTS GYDARIRPNF KGPPVNVSCN IFINSFGSIA ETTMDYRVNI FLRQQWNDPR LAYNEYPDDS LDLDPSMLDS IWKPDLFFAN EKGAHFHEIT TDNKLLRISR NGNVLYSIRI TLTLACPMDL KNFPMDVQTC IMQLESFGYT MNDLIFEWQE QGAVQVADGL TLPQFILKEE KDLRYCTKHY NTGKFTCIEA RFHLERQMGY YLIQMYIPSL LIVILSWISF WINMDAAPAR VGLGITTVLT MTTQSSGSRA SLPKVSYVKA IDIWMAVCLL FVFSALLEYA AVNFVSRQHK ELLRFRRKRR HHKSPMLNLF QEDEAGEGRF NFSAYGMGPA CLQAKDGISV KGANNSNTTN PPPAPSKSPE EMRKLFIQRA KKIDKISRIG FPMAFLIFNM FYWIIYKIVR REDVHNQ
Genular Protein ID: 3167826959
Symbol: Q14C71_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 366
- Mass: 42466
- Checksum: 65C10AFD651B019E
- Sequence:
MDYRVNIFLR QQWNDPRLAY NEYPDDSLDL DPSMLDSIWK PDLFFANEKG AHFHEITTDN KLLRISRNGN VLYSIRITLT LACPMDLKNF PMDVQTCIMQ LESFGYTMND LIFEWQEQGA VQVADGLTLP QFILKEEKDL RYCTKHYNTG KFTCIEARFH LERQMGYYLI QMYIPSLLIV ILSWISFWIN MDAAPARVGL GITTVLTMTT QSSGSRASLP KVSYVKAIDI WMAVCLLFVF SALLEYAAVN FVSRQHKELL RFRRKRRHHK EDEAGEGRFN FSAYGMGPAC LQAKDGISVK GANNSNTTNP PPAPSKSPEE MRKLFIQRAK KIDKISRIGF PMAFLIFNMF YWIIYKIVRR EDVHNQ
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.