Details for: GNG5

Gene ID: 2787

Symbol: GNG5

Ensembl ID: ENSG00000174021

Description: G protein subunit gamma 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 446.8154
    Cell Significance Index: -69.5000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 289.8164
    Cell Significance Index: -73.5100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 236.9476
    Cell Significance Index: -97.6100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 211.4917
    Cell Significance Index: -85.9200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 201.1554
    Cell Significance Index: -94.9700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 183.9866
    Cell Significance Index: -94.6400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 141.7390
    Cell Significance Index: -95.1100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 91.7525
    Cell Significance Index: -87.6000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 70.7730
    Cell Significance Index: -87.2600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 26.7886
    Cell Significance Index: -82.2800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 24.4246
    Cell Significance Index: -65.4300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 23.4386
    Cell Significance Index: -92.4900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.7891
    Cell Significance Index: -27.9900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 7.6553
    Cell Significance Index: 141.4900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 4.8049
    Cell Significance Index: 29.5700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 4.5370
    Cell Significance Index: 41.7800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.8293
    Cell Significance Index: 88.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.7456
    Cell Significance Index: 176.0400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.7441
    Cell Significance Index: 78.3700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 3.7366
    Cell Significance Index: 42.4500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.6437
    Cell Significance Index: 429.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.4949
    Cell Significance Index: 260.4700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.2547
    Cell Significance Index: 1777.4600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.1413
    Cell Significance Index: 82.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.0019
    Cell Significance Index: 541.1600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.9910
    Cell Significance Index: 367.7700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.9637
    Cell Significance Index: 87.0400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.6460
    Cell Significance Index: 75.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.5757
    Cell Significance Index: 353.7100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.5053
    Cell Significance Index: 32.0900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.4082
    Cell Significance Index: 26.1800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.3639
    Cell Significance Index: 123.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.3515
    Cell Significance Index: 151.7100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.2279
    Cell Significance Index: 39.3700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.1894
    Cell Significance Index: 282.8600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.9870
    Cell Significance Index: 878.4900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.7785
    Cell Significance Index: 14.2000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.4466
    Cell Significance Index: 102.3100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.2386
    Cell Significance Index: 43.0400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8463
    Cell Significance Index: 83.7200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.7929
    Cell Significance Index: 495.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7794
    Cell Significance Index: 20.8100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7326
    Cell Significance Index: 93.9200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5974
    Cell Significance Index: 539.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.5395
    Cell Significance Index: 408.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3083
    Cell Significance Index: 61.1800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.2672
    Cell Significance Index: 1.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2300
    Cell Significance Index: 10.7300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2191
    Cell Significance Index: 41.7000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1825
    Cell Significance Index: 133.8300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1328
    Cell Significance Index: 22.6700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1201
    Cell Significance Index: 2.0100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0985
    Cell Significance Index: 0.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0171
    Cell Significance Index: 1.7500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0135
    Cell Significance Index: -9.9800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0457
    Cell Significance Index: -86.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0620
    Cell Significance Index: -114.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0738
    Cell Significance Index: -113.6600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0841
    Cell Significance Index: -114.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1111
    Cell Significance Index: -62.6400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1127
    Cell Significance Index: -12.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1381
    Cell Significance Index: -3.7600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1405
    Cell Significance Index: -89.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1957
    Cell Significance Index: -41.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2200
    Cell Significance Index: -99.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.2528
    Cell Significance Index: -90.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2847
    Cell Significance Index: -81.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.3633
    Cell Significance Index: -72.8700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3763
    Cell Significance Index: -43.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3786
    Cell Significance Index: -43.3700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4946
    Cell Significance Index: -15.8400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5163
    Cell Significance Index: -13.1900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5277
    Cell Significance Index: -41.7900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5843
    Cell Significance Index: -16.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6125
    Cell Significance Index: -13.2700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6267
    Cell Significance Index: -9.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6522
    Cell Significance Index: -50.0500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.6587
    Cell Significance Index: -26.9900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.6638
    Cell Significance Index: -96.4900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7086
    Cell Significance Index: -36.8100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.8894
    Cell Significance Index: -44.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.8955
    Cell Significance Index: -93.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.9384
    Cell Significance Index: -52.6600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.0290
    Cell Significance Index: -63.2500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.1022
    Cell Significance Index: -11.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.1210
    Cell Significance Index: -50.8100
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -1.2681
    Cell Significance Index: -5.8600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.3610
    Cell Significance Index: -36.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.3893
    Cell Significance Index: -93.4200
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -1.4704
    Cell Significance Index: -10.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.5194
    Cell Significance Index: -95.7600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.5240
    Cell Significance Index: -40.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.5447
    Cell Significance Index: -94.7100
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -1.5602
    Cell Significance Index: -8.2100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.5896
    Cell Significance Index: -46.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.8418
    Cell Significance Index: -96.7000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.9494
    Cell Significance Index: -48.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.1561
    Cell Significance Index: -95.3700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.1937
    Cell Significance Index: -80.5300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -2.2608
    Cell Significance Index: -18.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **G protein subunit**: GNG5 is a gamma subunit of the G protein complex, which is composed of three subunits: alpha, beta, and gamma. The gamma subunit is involved in the regulation of the G protein's activity and interaction with downstream effectors. 2. **Signal transduction**: GNG5 is involved in the transmission of signals from G protein-coupled receptors (GPCRs) to downstream effectors, such as adenylyl cyclase, protein kinases, and ion channels. 3. **Metabolic regulation**: GNG5 is involved in the regulation of glucose and lipid metabolism, insulin secretion, and energy homeostasis. 4. **Immune response**: GNG5 is expressed on immune cells, such as monocytes and macrophages, and is involved in the regulation of inflammatory responses and the production of anti-inflammatory cytokines. **Pathways and Functions** 1. **Activation of GPCRs**: GNG5 interacts with GPCRs, such as adrenergic receptors, and modulates their signaling. 2. **Activation of ion channels**: GNG5 regulates the activity of potassium channels, including inwardly rectifying potassium channels and G protein-gated potassium channels. 3. **Regulation of insulin secretion**: GNG5 is involved in the regulation of insulin secretion by pancreatic beta cells. 4. **Inflammation and immune response**: GNG5 is expressed on immune cells and is involved in the regulation of inflammatory responses and the production of anti-inflammatory cytokines. 5. **Metabolic regulation**: GNG5 regulates glucose and lipid metabolism, including the regulation of energy homeostasis. **Clinical Significance** 1. **Inflammatory diseases**: Abnormal expression of GNG5 has been linked to inflammatory diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Metabolic disorders**: GNG5 is involved in the regulation of glucose and lipid metabolism, and its dysregulation has been linked to metabolic disorders, such as type 2 diabetes and obesity. 3. **Cancer**: GNG5 is overexpressed in certain types of cancer, including breast and lung cancer, and is involved in the regulation of cell growth and survival. 4. **Neurological disorders**: GNG5 is involved in the regulation of neuronal signaling and is expressed in the brain, where it is involved in the regulation of synaptic plasticity and neuronal development. In conclusion, the GNG5 gene plays a crucial role in various cellular processes, including signal transduction, metabolism, and immune response. Its dysregulation has been linked to various diseases, including inflammatory disorders, metabolic disorders, and cancer. Further research is needed to fully understand the role of GNG5 in human health and disease.

Genular Protein ID: 580165722

Symbol: GBG5_HUMAN

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5

UniProtKB Accession Codes:

P63218 B2R5A0 P30670 Q5VX54 Q61015

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 3 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 28 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9790912

Title: Structure of human G protein Ggamma5 gene GNG5.

PubMed ID: 9790912

DOI: 10.1006/bbrc.1998.9439

PubMed ID: 9653160

Title: Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning.

PubMed ID: 9653160

DOI: 10.1073/pnas.95.14.8175

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 68
  • Mass: 7318
  • Checksum: 9AF7A16558863602
  • Sequence:
    • MSGSSSVAAM KKVVQQLRLE AGLNRVKVSQ AAADLKQFCL QNAQHDPLLT GVSSSTNPFR 
PQKVCSFL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.