Details for: GPR27

Gene ID: 2850

Symbol: GPR27

Ensembl ID: ENSG00000170837

Description: G protein-coupled receptor 27

Associated with

  • G alpha (s) signalling events
    (R-HSA-418555)
  • Gpcr downstream signalling
    (R-HSA-388396)
  • Signaling by gpcr
    (R-HSA-372790)
  • G protein-coupled receptor activity
    (GO:0004930)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of insulin secretion involved in cellular response to glucose stimulus
    (GO:0035774)
  • Positive regulation of phospholipase c-activating g protein-coupled receptor signaling pathway
    (GO:1900738)
  • Signal transduction
    (GO:0007165)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3
    Marker Score: 1298
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 850
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 1.22
    Marker Score: 1754.5
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4809
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.13
    Marker Score: 824.5
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.07
    Marker Score: 1046
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71820
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48044
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5314
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.9
    Marker Score: 372
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 704
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 586
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.76
    Marker Score: 858
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.67
    Marker Score: 290
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.65
    Marker Score: 318
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.65
    Marker Score: 1595
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.55
    Marker Score: 4741
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.55
    Marker Score: 351.5
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.53
    Marker Score: 2152
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.52
    Marker Score: 904
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.48
    Marker Score: 160
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.45
    Marker Score: 118
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.44
    Marker Score: 100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.41
    Marker Score: 141
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.4
    Marker Score: 101
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.4
    Marker Score: 148
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.38
    Marker Score: 219
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.37
    Marker Score: 790
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.37
    Marker Score: 991.5
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.37
    Marker Score: 106
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.36
    Marker Score: 3467
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.36
    Marker Score: 1780
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.34
    Marker Score: 475
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.34
    Marker Score: 1305
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.34
    Marker Score: 339
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.34
    Marker Score: 518
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.32
    Marker Score: 337
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.31
    Marker Score: 313.5
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3
    Marker Score: 10250
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.3
    Marker Score: 4532
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3
    Marker Score: 4660
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.29
    Marker Score: 290.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.27
    Marker Score: 2541
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.27
    Marker Score: 10250
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.27
    Marker Score: 680
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.27
    Marker Score: 111
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.26
    Marker Score: 16275
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.26
    Marker Score: 135
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.26
    Marker Score: 1964
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.25
    Marker Score: 154
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.25
    Marker Score: 157
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.24
    Marker Score: 1122
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.24
    Marker Score: 457
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.23
    Marker Score: 77
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.23
    Marker Score: 463
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.22
    Marker Score: 323
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.22
    Marker Score: 110
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.22
    Marker Score: 195
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.22
    Marker Score: 320
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.22
    Marker Score: 307
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.21
    Marker Score: 91
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.21
    Marker Score: 872
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.21
    Marker Score: 513
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.21
    Marker Score: 136
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.2
    Marker Score: 208
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.2
    Marker Score: 93
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.2
    Marker Score: 117
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.19
    Marker Score: 1997
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.19
    Marker Score: 1141
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.19
    Marker Score: 3780.5
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.19
    Marker Score: 53
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.19
    Marker Score: 96
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.18
    Marker Score: 2009
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.18
    Marker Score: 183
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.17
    Marker Score: 212
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.17
    Marker Score: 100
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.16
    Marker Score: 86.5
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.16
    Marker Score: 130
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.16
    Marker Score: 74
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.16
    Marker Score: 78
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.16
    Marker Score: 40
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.16
    Marker Score: 82
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.15
    Marker Score: 98
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.15
    Marker Score: 8358
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.15
    Marker Score: 51.5

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Other Information

**Key characteristics** * GPR27 is a single-pass transmembrane protein that belongs to the GPCR family. * It is expressed in high levels in the enterocyte of the large intestine, intestinal crypt stem cell of the small intestine, respiratory basal cell, enterocyte of the small intestine, colon goblet cell, pancreatic A cell, cerebral cortex GABAergic interneuron, forebrain radial glial cell, and absorptive cell. * It is a ligand-gated channel that is activated by various hormones and growth factors. * When activated, it induces the closure of the channel, leading to a decrease in intracellular calcium levels and inhibition of insulin secretion. **Pathways and functions** * GPR27 is primarily a negative regulator of insulin secretion. * It works by binding to its ligand, which is the hormone glucagon. * When bound, it triggers the closure of the GPCR channel, leading to a decrease in intracellular calcium levels and inhibition of insulin secretion. * This helps to maintain blood glucose homeostasis by preventing the release of insulin into the bloodstream. **Clinical significance** * Mutations in GPR27 have been linked to the development of type 2 diabetes, obesity, and other metabolic disorders. * In type 2 diabetes, the mutation in the GPR27 gene leads to the loss of the GPCR's function, resulting in increased insulin secretion and hyperglycemia. * Therefore, GPR27 is a potential target for the treatment of type 2 diabetes.

Genular Protein ID: 4247413349

Symbol: GPR27_HUMAN

Name: Probable G-protein coupled receptor 27

UniProtKB Accession Codes:

Q9NS67

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 1 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 10833454

Title: An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system.

PubMed ID: 10833454

DOI: 10.1006/bbrc.2000.2829

Sequence Information:

  • Length: 375
  • Mass: 39818
  • Checksum: E17AF3D86FD47204
  • Sequence:
    • MANASEPGGS GGGEAAALGL KLATLSLLLC VSLAGNVLFA LLIVRERSLH RAPYYLLLDL 
CLADGLRALA CLPAVMLAAR RAAAAAGAPP GALGCKLLAF LAALFCFHAA FLLLGVGVTR 
YLAIAHHRFY AERLAGWPCA AMLVCAAWAL ALAAAFPPVL DGGGDDEDAP CALEQRPDGA 
PGALGFLLLL AVVVGATHLV YLRLLFFIHD RRKMRPARLV PAVSHDWTFH GPGATGQAAA 
NWTAGFGRGP TPPALVGIRP AGPGRGARRL LVLEEFKTEK RLCKMFYAVT LLFLLLWGPY 
VVASYLRVLV RPGAVPQAYL TASVWLTFAQ AGINPVVCFL FNRELRDCFR AQFPCCQSPR 
TTQATHPCDL KGIGL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.