Details for: GPR27

Gene ID: 2850

Symbol: GPR27

Ensembl ID: ENSG00000170837

Description: G protein-coupled receptor 27

Associated with

  • G alpha (s) signalling events
    (R-HSA-418555)
  • Gpcr downstream signalling
    (R-HSA-388396)
  • Signaling by gpcr
    (R-HSA-372790)
  • G protein-coupled receptor activity
    (GO:0004930)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of insulin secretion involved in cellular response to glucose stimulus
    (GO:0035774)
  • Positive regulation of phospholipase c-activating g protein-coupled receptor signaling pathway
    (GO:1900738)
  • Signal transduction
    (GO:0007165)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 52.0106
    Cell Significance Index: -8.0900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 30.0028
    Cell Significance Index: -7.6100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.6993
    Cell Significance Index: -8.2600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.1160
    Cell Significance Index: -8.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.2423
    Cell Significance Index: 76.1700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.8714
    Cell Significance Index: 19.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6648
    Cell Significance Index: 126.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6276
    Cell Significance Index: 28.4500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5613
    Cell Significance Index: 33.7000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4379
    Cell Significance Index: 9.3300
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.3337
    Cell Significance Index: 2.1300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3170
    Cell Significance Index: 34.4800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2392
    Cell Significance Index: 23.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2027
    Cell Significance Index: 10.5300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.1916
    Cell Significance Index: 2.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1879
    Cell Significance Index: 11.5500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1798
    Cell Significance Index: 2.8900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1777
    Cell Significance Index: 160.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1592
    Cell Significance Index: 45.8000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1476
    Cell Significance Index: 3.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1472
    Cell Significance Index: 52.8000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1387
    Cell Significance Index: 22.5600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1316
    Cell Significance Index: 9.1000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1035
    Cell Significance Index: 7.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0987
    Cell Significance Index: 13.5600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0983
    Cell Significance Index: 12.6000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0772
    Cell Significance Index: 34.1100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0718
    Cell Significance Index: 1.9600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0675
    Cell Significance Index: 1.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0523
    Cell Significance Index: 3.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0481
    Cell Significance Index: 26.2900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0409
    Cell Significance Index: 0.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0250
    Cell Significance Index: 4.5000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0140
    Cell Significance Index: 0.4000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0091
    Cell Significance Index: 1.1800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0078
    Cell Significance Index: 0.2700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0060
    Cell Significance Index: 0.1300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0023
    Cell Significance Index: 1.7000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0014
    Cell Significance Index: -2.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0032
    Cell Significance Index: -0.4000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0039
    Cell Significance Index: -0.4500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0045
    Cell Significance Index: -0.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0051
    Cell Significance Index: -0.1800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0053
    Cell Significance Index: -3.6700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0056
    Cell Significance Index: -4.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0088
    Cell Significance Index: -4.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0090
    Cell Significance Index: -5.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0094
    Cell Significance Index: -1.8800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0105
    Cell Significance Index: -7.9500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0153
    Cell Significance Index: -6.9500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0203
    Cell Significance Index: -3.4700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0263
    Cell Significance Index: -0.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0309
    Cell Significance Index: -0.9900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0311
    Cell Significance Index: -0.8700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0314
    Cell Significance Index: -2.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0330
    Cell Significance Index: -4.8000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0336
    Cell Significance Index: -0.8400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0340
    Cell Significance Index: -7.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0365
    Cell Significance Index: -7.2500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0439
    Cell Significance Index: -1.9400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0440
    Cell Significance Index: -0.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0520
    Cell Significance Index: -6.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0574
    Cell Significance Index: -5.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0619
    Cell Significance Index: -2.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0656
    Cell Significance Index: -2.4900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0673
    Cell Significance Index: -0.9500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0685
    Cell Significance Index: -1.4200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0716
    Cell Significance Index: -5.6700
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0769
    Cell Significance Index: -0.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0770
    Cell Significance Index: -8.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0789
    Cell Significance Index: -4.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1020
    Cell Significance Index: -7.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1066
    Cell Significance Index: -5.9800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1157
    Cell Significance Index: -1.3500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1158
    Cell Significance Index: -7.4700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1166
    Cell Significance Index: -7.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1181
    Cell Significance Index: -6.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1192
    Cell Significance Index: -3.2000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1287
    Cell Significance Index: -1.9400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1329
    Cell Significance Index: -1.2600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1414
    Cell Significance Index: -2.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1465
    Cell Significance Index: -6.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1498
    Cell Significance Index: -3.9400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1533
    Cell Significance Index: -3.9400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1560
    Cell Significance Index: -1.7000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1628
    Cell Significance Index: -5.3300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1706
    Cell Significance Index: -1.4500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1719
    Cell Significance Index: -1.0200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1721
    Cell Significance Index: -3.1800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1751
    Cell Significance Index: -5.0200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1888
    Cell Significance Index: -6.6200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1931
    Cell Significance Index: -6.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2011
    Cell Significance Index: -5.3700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2055
    Cell Significance Index: -8.9400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2062
    Cell Significance Index: -7.5700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2156
    Cell Significance Index: -6.3500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2180
    Cell Significance Index: -2.3700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2200
    Cell Significance Index: -5.3300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2343
    Cell Significance Index: -6.8800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2388
    Cell Significance Index: -5.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GPR27 exhibits several distinct features that set it apart from other GPCRs. Firstly, its ability to regulate insulin secretion in response to glucose stimuli makes it an attractive target for investigating glucose homeostasis and diabetes. Moreover, its expression in various cell types, including enterocytes and intestinal crypt stem cells, suggests a broader role in maintaining gut homeostasis. Furthermore, GPR27's involvement in signaling pathways, such as Gα(s) signaling events and phospholipase C-activating GPCR signaling pathways, underscores its potential as a key player in mediating cellular responses to glucose and other stimuli. **Pathways and Functions:** GPR27's signaling pathways are intricately linked to various cellular processes, including insulin secretion, glucose homeostasis, and cellular proliferation. The receptor's ability to regulate insulin secretion in response to glucose stimuli is mediated through its interaction with Gα(s) proteins, which activate phospholipase C (PLC) and subsequent signaling cascades. This process is critical for maintaining glucose homeostasis and preventing hyperglycemia. Additionally, GPR27's involvement in signaling pathways related to cellular proliferation and differentiation, such as those mediated by GABAergic interneurons and radial glial cells, highlights its potential role in maintaining tissue homeostasis. **Clinical Significance:** The clinical significance of GPR27 is multifaceted. Firstly, its involvement in regulating insulin secretion and glucose homeostasis makes it an attractive target for investigating the pathogenesis of diabetes and developing novel therapeutic strategies for glucose dysregulation. Secondly, its expression in various cell types, including enterocytes and intestinal crypt stem cells, suggests a broader role in maintaining gut homeostasis and preventing gastrointestinal disorders. Finally, GPR27's involvement in signaling pathways related to cellular proliferation and differentiation highlights its potential role in maintaining tissue homeostasis and preventing various diseases, including cancer and neurodegenerative disorders. In conclusion, GPR27 is a novel GPCR that plays a critical role in regulating insulin secretion, glucose homeostasis, and cellular signaling. Its clinical significance is multifaceted, and further research is needed to fully elucidate its role in various diseases and develop novel therapeutic strategies for glucose dysregulation and tissue homeostasis. **Recommendations for Future Research:** 1. Investigate the molecular mechanisms underlying GPR27's regulation of insulin secretion and glucose homeostasis. 2. Explore the role of GPR27 in maintaining gut homeostasis and preventing gastrointestinal disorders. 3. Investigate the potential therapeutic applications of GPR27 in the treatment of diabetes and other glucose-related disorders. 4. Examine the role of GPR27 in signaling pathways related to cellular proliferation and differentiation.

Genular Protein ID: 4247413349

Symbol: GPR27_HUMAN

Name: Probable G-protein coupled receptor 27

UniProtKB Accession Codes:

Q9NS67

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 1 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 10833454

Title: An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system.

PubMed ID: 10833454

DOI: 10.1006/bbrc.2000.2829

Sequence Information:

  • Length: 375
  • Mass: 39818
  • Checksum: E17AF3D86FD47204
  • Sequence:
    • MANASEPGGS GGGEAAALGL KLATLSLLLC VSLAGNVLFA LLIVRERSLH RAPYYLLLDL 
CLADGLRALA CLPAVMLAAR RAAAAAGAPP GALGCKLLAF LAALFCFHAA FLLLGVGVTR 
YLAIAHHRFY AERLAGWPCA AMLVCAAWAL ALAAAFPPVL DGGGDDEDAP CALEQRPDGA 
PGALGFLLLL AVVVGATHLV YLRLLFFIHD RRKMRPARLV PAVSHDWTFH GPGATGQAAA 
NWTAGFGRGP TPPALVGIRP AGPGRGARRL LVLEEFKTEK RLCKMFYAVT LLFLLLWGPY 
VVASYLRVLV RPGAVPQAYL TASVWLTFAQ AGINPVVCFL FNRELRDCFR AQFPCCQSPR 
TTQATHPCDL KGIGL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.