Details for: TRAJ54

Gene ID: 28701

Symbol: TRAJ54

Ensembl ID: ENSG00000211836

Description: T cell receptor alpha joining 54

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 5.8342
    Cell Significance Index: 114.0700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.8839
    Cell Significance Index: 21.4100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.1633
    Cell Significance Index: 2.3800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.0777
    Cell Significance Index: 1.0200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0014
    Cell Significance Index: 0.0200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0005
    Cell Significance Index: 0.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0121
    Cell Significance Index: -4.3300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0123
    Cell Significance Index: -0.2100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0129
    Cell Significance Index: -0.1800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0185
    Cell Significance Index: -0.3000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0322
    Cell Significance Index: -0.4200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0968
    Cell Significance Index: -2.1200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1169
    Cell Significance Index: -1.3800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1296
    Cell Significance Index: -1.4600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1345
    Cell Significance Index: -2.3200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1737
    Cell Significance Index: -4.3300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2139
    Cell Significance Index: -4.2600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2205
    Cell Significance Index: -4.3400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2609
    Cell Significance Index: -3.1100
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.2723
    Cell Significance Index: -3.4100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.2733
    Cell Significance Index: -3.1700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2739
    Cell Significance Index: -3.6400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2773
    Cell Significance Index: -3.4100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2805
    Cell Significance Index: -3.5400
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.2814
    Cell Significance Index: -3.1000
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.2875
    Cell Significance Index: -3.1500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2919
    Cell Significance Index: -3.1800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.2989
    Cell Significance Index: -3.3400
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.2992
    Cell Significance Index: -3.6400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.3097
    Cell Significance Index: -3.6600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.3161
    Cell Significance Index: -4.2600
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.3185
    Cell Significance Index: -3.4700
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.3240
    Cell Significance Index: -2.7600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.3250
    Cell Significance Index: -3.6000
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.3269
    Cell Significance Index: -3.3200
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.3315
    Cell Significance Index: -3.8200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.3322
    Cell Significance Index: -4.2600
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.3332
    Cell Significance Index: -4.4400
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.3460
    Cell Significance Index: -3.5000
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.3561
    Cell Significance Index: -3.1700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.3565
    Cell Significance Index: -3.6400
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.3677
    Cell Significance Index: -3.4000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.3688
    Cell Significance Index: -3.4500
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.3787
    Cell Significance Index: -3.6400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.3787
    Cell Significance Index: -3.5900
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.3791
    Cell Significance Index: -3.8200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.3821
    Cell Significance Index: -4.4900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.3966
    Cell Significance Index: -3.7600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.3967
    Cell Significance Index: -3.4700
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.4207
    Cell Significance Index: -3.6300
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.4289
    Cell Significance Index: -3.5200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.4294
    Cell Significance Index: -4.5300
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.4515
    Cell Significance Index: -3.8100
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.4533
    Cell Significance Index: -3.7500
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.4591
    Cell Significance Index: -4.9500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.4612
    Cell Significance Index: -4.3300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.4678
    Cell Significance Index: -4.1200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.4897
    Cell Significance Index: -3.8100
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.5139
    Cell Significance Index: -4.6300
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.5959
    Cell Significance Index: -4.5600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.6354
    Cell Significance Index: -3.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TRAJ54 is a member of the TRAJ family of genes, which are known to be involved in the assembly and regulation of the TCR complex. The TRAJ54 gene encodes a protein that is specifically expressed in alpha-beta T cells, a subset of T cells that play a central role in the adaptive immune response. The TRAJ54 protein is thought to play a crucial role in the assembly and regulation of the TCR complex, which is composed of the TCR alpha chain, beta chain, and gamma chain. The TRAJ54 gene is also highly expressed in natural killer cells and B cells, suggesting that it may play a broader role in the regulation of the immune response. **Pathways and Functions** The TRAJ54 gene is involved in several key pathways that are essential for the proper functioning of the immune system. The TRAJ54 protein is thought to play a crucial role in the assembly and regulation of the TCR complex, which is essential for the recognition of antigens by T cells. The TCR complex is composed of the TCR alpha chain, beta chain, and gamma chain, and is assembled through a process that is mediated by the TRAJ54 gene. The TRAJ54 protein is also thought to interact with other proteins that are involved in the regulation of the TCR complex, including the TCR alpha chain and beta chain. In addition to its role in the assembly and regulation of the TCR complex, the TRAJ54 gene is also involved in several other pathways that are essential for the proper functioning of the immune system. For example, the TRAJ54 gene is thought to play a role in the regulation of the expression of genes that are involved in the activation and proliferation of T cells. The TRAJ54 gene is also involved in the regulation of the expression of genes that are involved in the production of cytokines, which are signaling molecules that are produced by T cells and play a crucial role in the regulation of the immune response. **Clinical Significance** The TRAJ54 gene has several clinical significance, particularly in the context of immune-related disorders. For example, mutations in the TRAJ54 gene have been associated with several autoimmune diseases, including multiple sclerosis and type 1 diabetes. These mutations are thought to disrupt the assembly and regulation of the TCR complex, leading to an abnormal immune response that is characterized by inflammation and tissue damage. In addition to its role in autoimmune diseases, the TRAJ54 gene is also involved in the regulation of the immune response in the context of cancer. The TRAJ54 gene is thought to play a role in the regulation of the expression of genes that are involved in the activation and proliferation of T cells, which are essential for the recognition and destruction of cancer cells. Mutations in the TRAJ54 gene have been associated with several types of cancer, including breast cancer and lung cancer. In conclusion, the TRAJ54 gene plays a crucial role in the development and function of various immune cells, and is involved in several key pathways that are essential for the proper functioning of the immune system. Its clinical significance is particularly relevant in the context of immune-related disorders, including autoimmune diseases and cancer. Further research is needed to fully understand the role of the TRAJ54 gene in the regulation of the immune response, and to explore its potential as a therapeutic target for the treatment of immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.