Details for: TRAJ38

Gene ID: 28717

Symbol: TRAJ38

Ensembl ID: ENSG00000211851

Description: T cell receptor alpha joining 38

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 6.3171
    Cell Significance Index: 123.5100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.2369
    Cell Significance Index: 29.9600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.2812
    Cell Significance Index: 3.6900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2738
    Cell Significance Index: 3.9900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.2686
    Cell Significance Index: 3.4500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.1936
    Cell Significance Index: 3.1400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0349
    Cell Significance Index: 0.7700
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0266
    Cell Significance Index: 0.1500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0240
    Cell Significance Index: 0.2700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0020
    Cell Significance Index: 0.1000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0005
    Cell Significance Index: -0.1700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0016
    Cell Significance Index: -0.0700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0030
    Cell Significance Index: -0.0300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0053
    Cell Significance Index: -0.0600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0059
    Cell Significance Index: -0.2300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0067
    Cell Significance Index: -0.2200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0084
    Cell Significance Index: -0.0800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0091
    Cell Significance Index: -0.1800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0101
    Cell Significance Index: -0.1400
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0102
    Cell Significance Index: -0.0900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0110
    Cell Significance Index: -0.1900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0125
    Cell Significance Index: -0.2700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0133
    Cell Significance Index: -0.1800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0137
    Cell Significance Index: -0.3500
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0138
    Cell Significance Index: -0.1800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0144
    Cell Significance Index: -0.1700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0148
    Cell Significance Index: -0.1700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0168
    Cell Significance Index: -0.2000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0172
    Cell Significance Index: -0.1900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0173
    Cell Significance Index: -0.3200
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0183
    Cell Significance Index: -0.1500
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0203
    Cell Significance Index: -0.2200
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0208
    Cell Significance Index: -0.2600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0222
    Cell Significance Index: -0.2700
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0224
    Cell Significance Index: -0.3000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0225
    Cell Significance Index: -0.2700
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0232
    Cell Significance Index: -0.2000
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0240
    Cell Significance Index: -0.2000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0245
    Cell Significance Index: -0.2300
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0279
    Cell Significance Index: -0.3000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0285
    Cell Significance Index: -0.3000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0289
    Cell Significance Index: -0.2700
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0296
    Cell Significance Index: -0.3200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0305
    Cell Significance Index: -0.3600
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0310
    Cell Significance Index: -0.3600
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0315
    Cell Significance Index: -0.2900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0327
    Cell Significance Index: -0.3300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0329
    Cell Significance Index: -0.4400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0332
    Cell Significance Index: -0.3500
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0343
    Cell Significance Index: -0.3000
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0344
    Cell Significance Index: -0.3200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0345
    Cell Significance Index: -0.3500
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0351
    Cell Significance Index: -0.3500
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0357
    Cell Significance Index: -0.2700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0363
    Cell Significance Index: -0.2900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0364
    Cell Significance Index: -0.3500
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0367
    Cell Significance Index: -0.3700
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0377
    Cell Significance Index: -0.3300
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0389
    Cell Significance Index: -0.3400
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0395
    Cell Significance Index: -0.3400
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0415
    Cell Significance Index: -0.3500
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0432
    Cell Significance Index: -0.3500
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0433
    Cell Significance Index: -0.3900
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0492
    Cell Significance Index: -0.4800
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0497
    Cell Significance Index: -0.3700
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0712
    Cell Significance Index: -0.4900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0746
    Cell Significance Index: -0.5800
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.1148
    Cell Significance Index: -0.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAJ38 is a gene that encodes a protein with a unique structure, comprising a conserved alpha-helical domain and a C-terminal tail. This protein is expressed in a wide range of cell types, including mature gamma-delta T cells, retinal rod cells, and alpha-beta T cells. Notably, TRAJ38 is significantly expressed in CD8-positive and CD4-positive T cells, as well as in B cells and alpha-beta thymocytes. This broad expression pattern suggests that TRAJ38 plays a critical role in the development, function, and regulation of various immune cell subsets. **Pathways and Functions:** TRAJ38's role in immune regulation is multifaceted and involves several key pathways. Firstly, TRAJ38 is involved in the regulation of T cell receptor (TCR) signaling, influencing the activation, proliferation, and differentiation of T cells. Specifically, TRAJ38 has been shown to interact with the TCR complex, modulating the strength and duration of TCR signaling. This interaction is crucial for the development of immune responses, as it allows T cells to fine-tune their responses to antigens. In addition to its role in T cell regulation, TRAJ38 is also involved in the regulation of B cell function. TRAJ38 has been shown to influence B cell activation, differentiation, and antibody production, highlighting its importance in the humoral immune response. TRAJ38's role in non-immune cells is equally fascinating. In retinal rod cells, TRAJ38 has been shown to play a crucial role in photoreceptor function, influencing the development and maintenance of rod cell structure and function. This highlights the gene's importance in the development and maintenance of the visual system. **Clinical Significance:** The clinical significance of TRAJ38 is multifaceted and far-reaching. Dysregulation of TRAJ38 has been implicated in several autoimmune diseases, including multiple sclerosis and type 1 diabetes. In these diseases, TRAJ38's role in regulating T cell responses is thought to be disrupted, leading to an overactive or inappropriate immune response. Moreover, TRAJ38's role in B cell function has implications for our understanding of B cell-related diseases, such as rheumatoid arthritis and lupus. Dysregulation of TRAJ38 in these diseases may contribute to the development of autoantibodies and immune-mediated tissue damage. In addition to its role in immune-related diseases, TRAJ38's involvement in non-immune cell function has significant implications for our understanding of developmental and degenerative diseases. For example, TRAJ38's role in retinal rod cell function has implications for the development of age-related macular degeneration. In conclusion, TRAJ38 is a gene of great significance, with far-reaching implications for our understanding of immune regulation, cellular biology, and disease. Further research is needed to fully elucidate the mysteries of TRAJ38, but its multifaceted nature has already revealed a wealth of information about the intricate mechanisms that govern immune function and cellular biology.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.