Details for: MCTS1

Gene ID: 28985

Symbol: MCTS1

Ensembl ID: ENSG00000232119

Description: MCTS1 re-initiation and release factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 242.1161
    Cell Significance Index: -37.6600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 124.1901
    Cell Significance Index: -31.5000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 101.6877
    Cell Significance Index: -41.8900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 97.8198
    Cell Significance Index: -39.7400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 93.3020
    Cell Significance Index: -44.0500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 84.2559
    Cell Significance Index: -43.3400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 65.9106
    Cell Significance Index: -44.2300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 42.0846
    Cell Significance Index: -40.1800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 33.6914
    Cell Significance Index: -41.5400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.6551
    Cell Significance Index: -36.5800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.3855
    Cell Significance Index: -34.9700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.8438
    Cell Significance Index: -42.7900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.2565
    Cell Significance Index: -18.0700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 6.6138
    Cell Significance Index: 164.9300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 4.9150
    Cell Significance Index: 572.7900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.3017
    Cell Significance Index: 138.1800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6066
    Cell Significance Index: 21.9200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.1295
    Cell Significance Index: 133.2000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1259
    Cell Significance Index: 614.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0663
    Cell Significance Index: 68.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0634
    Cell Significance Index: 55.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0361
    Cell Significance Index: 186.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9986
    Cell Significance Index: 46.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9927
    Cell Significance Index: 122.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9900
    Cell Significance Index: 198.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8332
    Cell Significance Index: 39.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8154
    Cell Significance Index: 111.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8093
    Cell Significance Index: 16.9400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.6804
    Cell Significance Index: 15.7200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6637
    Cell Significance Index: 18.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6103
    Cell Significance Index: 269.8200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6000
    Cell Significance Index: 5.5300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5960
    Cell Significance Index: 42.1500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5571
    Cell Significance Index: 16.3600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5553
    Cell Significance Index: 12.0300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5202
    Cell Significance Index: 469.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5047
    Cell Significance Index: 65.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4796
    Cell Significance Index: 12.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4523
    Cell Significance Index: 77.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4411
    Cell Significance Index: 87.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4352
    Cell Significance Index: 156.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4262
    Cell Significance Index: 11.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4205
    Cell Significance Index: 31.3400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3755
    Cell Significance Index: 37.1500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.3395
    Cell Significance Index: 212.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3287
    Cell Significance Index: 9.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3085
    Cell Significance Index: 39.5500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3056
    Cell Significance Index: 58.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2944
    Cell Significance Index: 47.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2507
    Cell Significance Index: 15.8000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2012
    Cell Significance Index: 6.9900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0997
    Cell Significance Index: 4.4100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0976
    Cell Significance Index: 0.8200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0947
    Cell Significance Index: 1.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0918
    Cell Significance Index: 10.5200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0378
    Cell Significance Index: 28.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0353
    Cell Significance Index: 2.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0303
    Cell Significance Index: 55.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0285
    Cell Significance Index: 43.8900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0281
    Cell Significance Index: 53.0000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0207
    Cell Significance Index: 0.3100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0190
    Cell Significance Index: 0.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0095
    Cell Significance Index: 0.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0055
    Cell Significance Index: 0.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0009
    Cell Significance Index: -0.6000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0027
    Cell Significance Index: -3.6700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0033
    Cell Significance Index: -2.3100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0080
    Cell Significance Index: -5.9300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0096
    Cell Significance Index: -7.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0364
    Cell Significance Index: -3.7200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0434
    Cell Significance Index: -24.4700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0615
    Cell Significance Index: -27.9000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0733
    Cell Significance Index: -10.6600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0890
    Cell Significance Index: -2.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0920
    Cell Significance Index: -4.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0995
    Cell Significance Index: -20.9600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1160
    Cell Significance Index: -6.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1188
    Cell Significance Index: -34.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1557
    Cell Significance Index: -4.3500
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1572
    Cell Significance Index: -1.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1878
    Cell Significance Index: -10.5400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2048
    Cell Significance Index: -3.5100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2067
    Cell Significance Index: -5.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2107
    Cell Significance Index: -9.5500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2461
    Cell Significance Index: -28.0900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3350
    Cell Significance Index: -4.2900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3415
    Cell Significance Index: -9.1400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3503
    Cell Significance Index: -3.9800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.3720
    Cell Significance Index: -2.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3885
    Cell Significance Index: -40.4500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3942
    Cell Significance Index: -31.2200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4261
    Cell Significance Index: -7.8800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4350
    Cell Significance Index: -7.2800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5887
    Cell Significance Index: -17.3400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6074
    Cell Significance Index: -16.2800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6492
    Cell Significance Index: -14.2200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6829
    Cell Significance Index: -17.0700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6851
    Cell Significance Index: -17.6100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.7042
    Cell Significance Index: -7.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Function:** MCTS1 is a re-initiation and release factor that regulates the release of mRNA from the ribosome during translation initiation. 2. **Cell Type Specificity:** MCTS1 is highly expressed in various cell types, including erythroid progenitor cells, malignant cells, plasmablasts, epithelial cells of the esophagus, and pro-T cells. 3. **Pathway Involvement:** MCTS1 is involved in cell cycle regulation, DNA damage response, and translation initiation, among other cellular processes. 4. **Protein Binding:** MCTS1 interacts with various proteins, including translation initiation factors and ribosomal subunits. **Pathways and Functions:** 1. **Cell Cycle Regulation:** MCTS1 regulates the cell cycle by controlling the release of mRNA from the ribosome, thereby influencing cell proliferation and division. 2. **DNA Damage Response:** MCTS1 is involved in the DNA damage response pathway, which helps to maintain genome stability and prevent cancer. 3. **Translation Initiation:** MCTS1 regulates translation initiation by controlling the release of mRNA from the ribosome, thereby influencing protein synthesis and cell growth. 4. **Ires-dependent Viral Translational Initiation:** MCTS1 is involved in the regulation of Ires-dependent viral translational initiation, which is a mechanism used by some viruses to hijack host cell translation machinery. **Clinical Significance:** 1. **Cancer Development:** MCTS1 overexpression has been associated with various types of cancer, including leukemia, lymphoma, and solid tumors. 2. **Immune Cell Development:** MCTS1 plays a crucial role in the development and function of immune cells, including T cells and B cells. 3. **Regenerative Medicine:** MCTS1 may have therapeutic potential in regenerative medicine, particularly in the context of tissue repair and regeneration. 4. **Viral Infections:** MCTS1 may be involved in the regulation of viral infections, particularly those that utilize Ires-dependent translational initiation. In conclusion, MCTS1 is a multifunctional gene that plays a critical role in various cellular processes, including cell cycle regulation, DNA damage response, and translation initiation. Its overexpression has been associated with various types of cancer, and its involvement in immune cell development and viral infections highlights its potential as a therapeutic target. Further research is needed to fully elucidate the mechanisms by which MCTS1 regulates cellular processes and to explore its therapeutic potential.

Genular Protein ID: 1341550215

Symbol: MCTS1_HUMAN

Name: Malignant T-cell-amplified sequence 1

UniProtKB Accession Codes:

Q9ULC4 B4DGY2 Q502X6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 EvolutionaryTrace 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9766643

Title: A novel candidate oncogene, MCT-1, is involved in cell cycle progression.

PubMed ID: 9766643

PubMed ID: 16533400

Title: NovelFam3000 -- uncharacterized human protein domains conserved across model organisms.

PubMed ID: 16533400

DOI: 10.1186/1471-2164-7-48

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10440924

Title: Increased G1 cyclin/cdk activity in cells overexpressing the candidate oncogene, MCT-1.

PubMed ID: 10440924

DOI: 10.1002/(sici)1097-4644(19990915)74:4<544::aid-jcb4>3.3.co;2-w

PubMed ID: 11709712

Title: Expression and stabilization of the MCT-1 protein by DNA damaging agents.

PubMed ID: 11709712

DOI: 10.1038/sj.onc.1204881

PubMed ID: 12637315

Title: Expression of the candidate MCT-1 oncogene in B- and T-cell lymphoid malignancies.

PubMed ID: 12637315

DOI: 10.1182/blood-2002-11-3486

PubMed ID: 16322206

Title: MCT-1 oncogene contributes to increased in vivo tumorigenicity of MCF7 cells by promotion of angiogenesis and inhibition of apoptosis.

PubMed ID: 16322206

DOI: 10.1158/0008-5472.can-05-0845

PubMed ID: 15897892

Title: The MCT-1 oncogene product impairs cell cycle checkpoint control and transforms human mammary epithelial cells.

PubMed ID: 15897892

DOI: 10.1038/sj.onc.1208680

PubMed ID: 16982740

Title: MCT-1 protein interacts with the cap complex and modulates messenger RNA translational profiles.

PubMed ID: 16982740

DOI: 10.1158/0008-5472.can-06-1999

PubMed ID: 17416211

Title: MCT-1 oncogene downregulates p53 and destabilizes genome structure in the response to DNA double-strand damage.

PubMed ID: 17416211

DOI: 10.1016/j.dnarep.2007.02.028

PubMed ID: 17016429

Title: Phosphorylation of MCT-1 by p44/42 MAPK is required for its stabilization in response to DNA damage.

PubMed ID: 17016429

DOI: 10.1038/sj.onc.1210030

PubMed ID: 20713520

Title: Activities of ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling.

PubMed ID: 20713520

DOI: 10.1101/gad.1957510

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 37875108

Title: Human MCTS1-dependent translation of JAK2 is essential for IFN-gamma immunity to mycobacteria.

PubMed ID: 37875108

DOI: 10.1016/j.cell.2023.09.024

Sequence Information:

  • Length: 181
  • Mass: 20555
  • Checksum: 2FC00C7A992E24EB
  • Sequence:
    • MFKKFDEKEN VSNCIQLKTS VIKGIKNQLI EQFPGIEPWL NQIMPKKDPV KIVRCHEHIE 
ILTVNGELLF FRQREGPFYP TLRLLHKYPF ILPHQQVDKG AIKFVLSGAN IMCPGLTSPG 
AKLYPAAVDT IVAIMAEGKQ HALCVGVMKM SAEDIEKVNK GIGIENIHYL NDGLWHMKTY 
K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.