Details for: CCDC59

Gene ID: 29080

Symbol: CCDC59

Ensembl ID: ENSG00000133773

Description: coiled-coil domain containing 59

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 236.5871
    Cell Significance Index: -36.8000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 138.2650
    Cell Significance Index: -35.0700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 107.4166
    Cell Significance Index: -44.2500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 98.1101
    Cell Significance Index: -46.3200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 90.0784
    Cell Significance Index: -46.3400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 69.1147
    Cell Significance Index: -46.3800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 35.5325
    Cell Significance Index: -43.8100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.3378
    Cell Significance Index: -35.7300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.8673
    Cell Significance Index: -36.4500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.6990
    Cell Significance Index: -46.1700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.5894
    Cell Significance Index: -16.6100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.0993
    Cell Significance Index: 32.9300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.0416
    Cell Significance Index: 55.5700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.8506
    Cell Significance Index: 53.0500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.7619
    Cell Significance Index: 1590.8500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.4163
    Cell Significance Index: 91.3800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.2342
    Cell Significance Index: 87.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2263
    Cell Significance Index: 168.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1846
    Cell Significance Index: 523.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.1477
    Cell Significance Index: 53.9400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7971
    Cell Significance Index: 94.0000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7961
    Cell Significance Index: 102.8600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7834
    Cell Significance Index: 96.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7679
    Cell Significance Index: 138.4400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7659
    Cell Significance Index: 418.2600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6563
    Cell Significance Index: 84.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6497
    Cell Significance Index: 48.4200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.6335
    Cell Significance Index: 11.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6191
    Cell Significance Index: 16.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6033
    Cell Significance Index: 28.1300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5862
    Cell Significance Index: 20.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5175
    Cell Significance Index: 103.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4745
    Cell Significance Index: 24.6500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4362
    Cell Significance Index: 9.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3966
    Cell Significance Index: 10.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3960
    Cell Significance Index: 78.5800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3851
    Cell Significance Index: 9.6300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3833
    Cell Significance Index: 26.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3716
    Cell Significance Index: 16.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3649
    Cell Significance Index: 130.9000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3294
    Cell Significance Index: 7.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2977
    Cell Significance Index: 6.4500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2381
    Cell Significance Index: 12.5000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2171
    Cell Significance Index: 2.3600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1891
    Cell Significance Index: 3.5000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1857
    Cell Significance Index: 2.1100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1552
    Cell Significance Index: 9.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1456
    Cell Significance Index: 4.2000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1136
    Cell Significance Index: 11.2400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0205
    Cell Significance Index: 1.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0060
    Cell Significance Index: 11.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0014
    Cell Significance Index: 1.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0031
    Cell Significance Index: -0.5900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0064
    Cell Significance Index: -4.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0088
    Cell Significance Index: -1.5100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0115
    Cell Significance Index: -7.9700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0173
    Cell Significance Index: -31.9500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0212
    Cell Significance Index: -32.6600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0240
    Cell Significance Index: -32.6600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0362
    Cell Significance Index: -3.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0366
    Cell Significance Index: -23.2200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0385
    Cell Significance Index: -1.7100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0421
    Cell Significance Index: -1.6000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0439
    Cell Significance Index: -0.9400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0460
    Cell Significance Index: -0.7700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0508
    Cell Significance Index: -37.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0560
    Cell Significance Index: -25.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0726
    Cell Significance Index: -40.9600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0801
    Cell Significance Index: -50.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1162
    Cell Significance Index: -33.4200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1270
    Cell Significance Index: -18.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1694
    Cell Significance Index: -10.4100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2290
    Cell Significance Index: -26.6900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2334
    Cell Significance Index: -49.1700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2528
    Cell Significance Index: -7.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2782
    Cell Significance Index: -31.8700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2979
    Cell Significance Index: -1.8000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3265
    Cell Significance Index: -18.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3334
    Cell Significance Index: -25.5900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3715
    Cell Significance Index: -11.9000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3806
    Cell Significance Index: -10.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3811
    Cell Significance Index: -10.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3905
    Cell Significance Index: -40.6700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4174
    Cell Significance Index: -33.0600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4177
    Cell Significance Index: -10.6700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4346
    Cell Significance Index: -5.9300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4985
    Cell Significance Index: -14.2300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6273
    Cell Significance Index: -38.4600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.6304
    Cell Significance Index: -22.1500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7742
    Cell Significance Index: -19.9000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.8593
    Cell Significance Index: -11.0100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.8613
    Cell Significance Index: -16.8100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.8698
    Cell Significance Index: -8.0100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8923
    Cell Significance Index: -23.9100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.9259
    Cell Significance Index: -33.9900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.9361
    Cell Significance Index: -47.3100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.9431
    Cell Significance Index: -7.5300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.9441
    Cell Significance Index: -16.1800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.0064
    Cell Significance Index: -24.1400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.0486
    Cell Significance Index: -10.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Coiled-Coil Domain**: The CCDC59 protein contains a coiled-coil domain, a structural motif common in many proteins involved in protein-protein interactions and cellular signaling. 2. **Wide Expression Pattern**: CCDC59 is expressed in various cell types, including pancreatic acinar cells, fibroblasts, and B cells, suggesting its involvement in multiple cellular processes. 3. **Protein Binding and RNA Binding**: The gene's products are associated with protein binding and RNA binding activities, indicating potential roles in regulating protein metabolism and RNA processing. 4. **Surfactant Metabolism**: CCDC59's involvement in surfactant metabolism suggests a possible role in maintaining lung homeostasis and regulating surfactant function. **Pathways and Functions:** 1. **Metabolism of Proteins**: CCDC59's protein binding activity may regulate protein degradation, synthesis, or transport, influencing cellular protein homeostasis. 2. **RNA Binding**: The gene's RNA binding activity could modulate RNA processing, splicing, or translation, affecting gene expression and cellular response to environmental cues. 3. **Surfactant Metabolism**: CCDC59's involvement in surfactant metabolism may regulate surfactant function, influencing lung development, homeostasis, and disease susceptibility. 4. **Cell Signaling and Communication**: The coiled-coil domain and protein binding activity of CCDC59 may facilitate cell signaling and communication, influencing cellular behavior and response to environmental stimuli. **Clinical Significance:** 1. **Lung Disease**: CCDC59's involvement in surfactant metabolism suggests a potential link to lung diseases, such as surfactant deficiency or respiratory distress syndrome. 2. **Immunological Disorders**: The gene's expression in B cells and T cells implies a possible role in immune function and regulation, potentially contributing to immunological disorders, such as autoimmune diseases or immunodeficiencies. 3. **Cancer**: CCDC59's expression in various cell types and its involvement in cellular processes may contribute to cancer development or progression, warranting further investigation. 4. **Neurological Disorders**: The gene's expression in oogonial cells and cortical thymic epithelial cells suggests a potential link to neurological disorders, such as neurodevelopmental disorders or synaptic dysfunction. In conclusion, CCDC59 is a multifaceted gene with a wide range of cellular processes and functions. Further research is necessary to elucidate its mechanisms of action, clinical significance, and potential roles in human disease.

Genular Protein ID: 2695922729

Symbol: TAP26_HUMAN

Name: Thyroid transcription factor 1-associated protein 26

UniProtKB Accession Codes:

Q9P031 Q9H2V5 Q9NW62

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11152647

Title: BR22, a novel protein, interacts with thyroid transcription factor-1 and activates the human surfactant protein B promoter.

PubMed ID: 11152647

DOI: 10.1165/ajrcmb.24.1.4050

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12882447

Title: BR22, a 26 kDa thyroid transcription factor-1 associated protein (TAP26), is expressed in human lung cells.

PubMed ID: 12882447

DOI: 10.1183/09031936.03.00117702

PubMed ID: 16630564

Title: The TTF-1/TAP26 complex differentially modulates surfactant protein-B (SFTPB) and -C (SFTPBC) promoters in lung cells.

PubMed ID: 16630564

DOI: 10.1016/j.bbrc.2006.03.158

Sequence Information:

  • Length: 241
  • Mass: 28670
  • Checksum: A9012048D32A87AE
  • Sequence:
    • MAPVRRSAKW RPGGIEARGE GVSTVGYRNK NVRQKTWRPN HPQAFVGSVR EGQGFAFRRK 
LKIQQSYKKL LRKEKKAQTS LESQFTDRYP DNLKHLYLAE EERHRKQARK VDHPLSEQVH 
QPLLEEQCSI DEPLFEDQCS FDQPQPEEQC IKTVNSFTIP KKNKKKTSNQ KAQEEYEQIQ 
AKRAAKKQEF ERRKQEREEA QRQYKKKKME VFKILNKKTK KGQPNLNVQM EYLLQKIQEK 
C

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.