Details for: METTL5

Gene ID: 29081

Symbol: METTL5

Ensembl ID: ENSG00000138382

Description: methyltransferase 5, N6-adenosine

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 209.2639
    Cell Significance Index: -32.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 118.7888
    Cell Significance Index: -30.1300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 104.2851
    Cell Significance Index: -42.9600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 90.7815
    Cell Significance Index: -42.8600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 87.8015
    Cell Significance Index: -35.6700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 80.2511
    Cell Significance Index: -41.2800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 64.2155
    Cell Significance Index: -43.0900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 37.5389
    Cell Significance Index: -35.8400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 33.2534
    Cell Significance Index: -41.0000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.7363
    Cell Significance Index: -31.4400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.9882
    Cell Significance Index: -43.3600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.1916
    Cell Significance Index: -25.1600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 3.0341
    Cell Significance Index: 493.4700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.5317
    Cell Significance Index: 151.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.6646
    Cell Significance Index: 45.3100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6345
    Cell Significance Index: 22.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.3567
    Cell Significance Index: 95.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2189
    Cell Significance Index: 63.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0832
    Cell Significance Index: 50.9100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0105
    Cell Significance Index: 182.1600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9903
    Cell Significance Index: 437.8600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9424
    Cell Significance Index: 514.6800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9373
    Cell Significance Index: 115.2500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7777
    Cell Significance Index: 53.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7554
    Cell Significance Index: 35.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7218
    Cell Significance Index: 99.1200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.7107
    Cell Significance Index: 16.4200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6507
    Cell Significance Index: 19.1100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6342
    Cell Significance Index: 74.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6146
    Cell Significance Index: 554.9700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5843
    Cell Significance Index: 12.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5787
    Cell Significance Index: 37.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5732
    Cell Significance Index: 97.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5702
    Cell Significance Index: 113.1600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5460
    Cell Significance Index: 70.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5400
    Cell Significance Index: 108.3300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5321
    Cell Significance Index: 4.9000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5206
    Cell Significance Index: 38.8000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4944
    Cell Significance Index: 10.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4678
    Cell Significance Index: 46.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4167
    Cell Significance Index: 53.4200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3494
    Cell Significance Index: 9.3300
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.3390
    Cell Significance Index: 2.5600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2945
    Cell Significance Index: 13.3500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2783
    Cell Significance Index: 52.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2483
    Cell Significance Index: 89.0500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1373
    Cell Significance Index: 1.5600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1243
    Cell Significance Index: 3.9800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1072
    Cell Significance Index: 2.8200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0564
    Cell Significance Index: 1.9600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0268
    Cell Significance Index: 20.3000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0098
    Cell Significance Index: 7.1900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0008
    Cell Significance Index: 1.5900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0019
    Cell Significance Index: -1.3800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0082
    Cell Significance Index: -0.4300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0100
    Cell Significance Index: -0.6300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0151
    Cell Significance Index: -27.7600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0196
    Cell Significance Index: -30.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0250
    Cell Significance Index: -15.6300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0253
    Cell Significance Index: -34.3700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0293
    Cell Significance Index: -2.9900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0307
    Cell Significance Index: -19.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0413
    Cell Significance Index: -23.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0523
    Cell Significance Index: -23.7500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0541
    Cell Significance Index: -0.9100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0568
    Cell Significance Index: -1.4500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0836
    Cell Significance Index: -17.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0848
    Cell Significance Index: -9.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1008
    Cell Significance Index: -29.0000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1209
    Cell Significance Index: -9.2800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1233
    Cell Significance Index: -1.3400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1693
    Cell Significance Index: -5.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1748
    Cell Significance Index: -4.8900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1929
    Cell Significance Index: -22.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1959
    Cell Significance Index: -22.8300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2153
    Cell Significance Index: -31.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2584
    Cell Significance Index: -15.8800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3547
    Cell Significance Index: -28.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3674
    Cell Significance Index: -7.8300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3809
    Cell Significance Index: -25.6100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3964
    Cell Significance Index: -3.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3988
    Cell Significance Index: -41.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4008
    Cell Significance Index: -22.4900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4598
    Cell Significance Index: -23.9500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4678
    Cell Significance Index: -12.5400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4762
    Cell Significance Index: -8.4200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4783
    Cell Significance Index: -2.8900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5273
    Cell Significance Index: -26.6500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5626
    Cell Significance Index: -8.4300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5916
    Cell Significance Index: -15.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6066
    Cell Significance Index: -37.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6267
    Cell Significance Index: -16.1100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6653
    Cell Significance Index: -19.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7323
    Cell Significance Index: -32.3900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.7434
    Cell Significance Index: -12.7400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7924
    Cell Significance Index: -23.3400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.8213
    Cell Significance Index: -15.1800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.8231
    Cell Significance Index: -8.7500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.8410
    Cell Significance Index: -11.9500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8559
    Cell Significance Index: -31.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **RNA Methyltransferase Activity:** METTL5 exhibits N6-adenosine methyltransferase activity, which involves the transfer of an adenosine moiety to the N6 position of adenine in RNAs, resulting in the formation of N6-methyladenosine (m6A) modifications. 2. **Specificity to mRNAs:** METTL5 primarily targets mRNAs for m6A methylation, which can regulate translation efficiency, splicing, and stability. 3. **Interactions with Translation Factors:** METTL5 interacts with translation factors, such as eIF4E and eIF4A, to regulate translation initiation and elongation. 4. **Cellular Expression:** METTL5 is expressed in various cell types, including erythroid progenitor cells, pulmonary interstitial fibroblasts, and oogonial cells, suggesting its involvement in cellular differentiation and development. **Pathways and Functions:** 1. **Positive Regulation of Translation:** METTL5 promotes translation by enhancing the recruitment of translation initiation factors to the ribosome. 2. **Regulation of RNA Stability:** m6A modifications mediated by METTL5 can influence RNA stability, which in turn affects translation efficiency. 3. **Cellular Differentiation:** METTL5 plays a crucial role in the regulation of cellular differentiation, particularly in the development of erythroid and germ cells. 4. **Stem Cell Maintenance:** METTL5 is involved in the maintenance of stem cell pluripotency and self-renewal. **Clinical Significance:** Dysregulation of METTL5 has been implicated in various diseases, including: 1. **Cancer:** Altered m6A methylation patterns have been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Neurological Disorders:** METTL5 has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Immune Disorders:**METTL5 has been implicated in immune disorders, including rheumatoid arthritis and multiple sclerosis. In conclusion, METTL5 is a vital enzyme involved in the regulation of RNA methylation and translation. Its dysregulation has been linked to various diseases, highlighting the importance of METTL5 in maintaining cellular homeostasis and preventing disease. Further research is necessary to fully elucidate the mechanisms underlying METTL5-mediated functions and to explore its therapeutic potential in disease treatment.

Genular Protein ID: 1113713443

Symbol: METL5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9NRN9 D3DPC9 Q9NVX1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 12 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 3 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 Rhea 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 31564433

Title: Bi-allelic variants in METTL5 cause autosomal-recessive intellectual disability and microcephaly.

PubMed ID: 31564433

DOI: 10.1016/j.ajhg.2019.09.007

PubMed ID: 33357433

Title: Ribosome 18S m6A methyltransferase METTL5 promotes translation initiation and breast cancer cell growth.

PubMed ID: 33357433

DOI: 10.1016/j.celrep.2020.108544

PubMed ID: 32217665

Title: The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs.

PubMed ID: 32217665

DOI: 10.1101/gad.333369.119

PubMed ID: 34948388

Title: Human TRMT112-Methyltransferase Network Consists of Seven Partners Interacting with a Common Co-Factor.

PubMed ID: 34948388

DOI: 10.3390/ijms222413593

PubMed ID: 33428944

Title: Enzymatic characterization of three human RNA adenosine methyltransferases reveals diverse substrate affinities and reaction optima.

PubMed ID: 33428944

DOI: 10.1016/j.jbc.2021.100270

PubMed ID: 35033535

Title: The METTL5-TRMT112 N6-methyladenosine methyltransferase complex regulates mRNA translation via 18S rRNA methylation.

PubMed ID: 35033535

DOI: 10.1016/j.jbc.2022.101590

PubMed ID: 31328227

Title: The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112.

PubMed ID: 31328227

DOI: 10.1093/nar/gkz619

Sequence Information:

  • Length: 209
  • Mass: 23719
  • Checksum: 060B1C2C0D2BA169
  • Sequence:
    • MKKVRLKELE SRLQQVDGFE KPKLLLEQYP TRPHIAACML YTIHNTYDDI ENKVVADLGC 
GCGVLSIGTA MLGAGLCVGF DIDEDALEIF NRNAEEFELT NIDMVQCDVC LLSNRMSKSF 
DTVIMNPPFG TKNNKGTDMA FLKTALEMAR TAVYSLHKSS TREHVQKKAA EWKIKIDIIA 
ELRYDLPASY KFHKKKSVDI EVDLIRFSF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.