Details for: NXT1

Gene ID: 29107

Symbol: NXT1

Ensembl ID: ENSG00000132661

Description: nuclear transport factor 2 like export factor 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.64
    Marker Score: 4,610
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.25
    Marker Score: 2,406
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.97
    Marker Score: 66,891
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.78
    Marker Score: 6,575
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.67
    Marker Score: 4,091
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.66
    Marker Score: 563
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.58
    Marker Score: 3,343
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.48
    Marker Score: 1,169
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.48
    Marker Score: 616
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.41
    Marker Score: 5,560
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4
    Marker Score: 2,056
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.38
    Marker Score: 5,658
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.38
    Marker Score: 1,982
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.31
    Marker Score: 2,147
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.31
    Marker Score: 3,608
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.29
    Marker Score: 2,576
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.27
    Marker Score: 367
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.26
    Marker Score: 1,076
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.26
    Marker Score: 490
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.26
    Marker Score: 313
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.25
    Marker Score: 5,406
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.25
    Marker Score: 313
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.24
    Marker Score: 2,099
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.22
    Marker Score: 734
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.2
    Marker Score: 815
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.19
    Marker Score: 5,120
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.19
    Marker Score: 377
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.19
    Marker Score: 4,576
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.16
    Marker Score: 735
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.16
    Marker Score: 1,399
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.15
    Marker Score: 840
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.13
    Marker Score: 403
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.13
    Marker Score: 929
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.13
    Marker Score: 484
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.12
    Marker Score: 1,198
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.12
    Marker Score: 807
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.12
    Marker Score: 3,131
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.09
    Marker Score: 1,101
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.09
    Marker Score: 2,277
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 1.09
    Marker Score: 327
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.09
    Marker Score: 1,024
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.08
    Marker Score: 1,491
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.08
    Marker Score: 1,355
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.05
    Marker Score: 579
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.05
    Marker Score: 1,782
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.03
    Marker Score: 5,065
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 1.03
    Marker Score: 433
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.03
    Marker Score: 867
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.03
    Marker Score: 54,341
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.03
    Marker Score: 586
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.01
    Marker Score: 756
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.01
    Marker Score: 1,756
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1
    Marker Score: 736
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1
    Marker Score: 13,249
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1
    Marker Score: 6,515
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1
    Marker Score: 1,064
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1
    Marker Score: 2,715
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,628
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1
    Marker Score: 1,014
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.99
    Marker Score: 1,047
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,853
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.99
    Marker Score: 350
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.99
    Marker Score: 1,066
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.99
    Marker Score: 1,522
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.99
    Marker Score: 443
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.98
    Marker Score: 618
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.98
    Marker Score: 9,736
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,380
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.98
    Marker Score: 2,388
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.98
    Marker Score: 15,311
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.98
    Marker Score: 561
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.97
    Marker Score: 10,907
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.97
    Marker Score: 366
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.97
    Marker Score: 909
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.96
    Marker Score: 337
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.96
    Marker Score: 894
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.95
    Marker Score: 940
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.95
    Marker Score: 347
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.94
    Marker Score: 982
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.94
    Marker Score: 10,921
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.94
    Marker Score: 838
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.94
    Marker Score: 1,489
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 482
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.93
    Marker Score: 2,376
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.93
    Marker Score: 183
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.93
    Marker Score: 457
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.93
    Marker Score: 237
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.93
    Marker Score: 380
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.92
    Marker Score: 451
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.92
    Marker Score: 446
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.92
    Marker Score: 724
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.92
    Marker Score: 1,647
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.92
    Marker Score: 2,901
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.92
    Marker Score: 583
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.92
    Marker Score: 1,301
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.92
    Marker Score: 865
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.92
    Marker Score: 827
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.91
    Marker Score: 1,718
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.91
    Marker Score: 1,071

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **RNA Export Function**: NXT1 is primarily involved in the export of RNA from the nucleus to the cytoplasm, where it can be translated into proteins. 2. **Structural Similarities**: NXT1 shares structural similarities with other NTF2 family members, including NTF2 itself, suggesting a conserved evolutionary pathway. 3. **Cell Type-Specific Expression**: NXT1 is significantly expressed in various cell types, including germ cells, stem cells, and epithelial cells, indicating its involvement in cellular proliferation and differentiation. 4. **Multifunctional Protein**: NXT1 has been implicated in multiple cellular processes, including protein binding, small GTPase binding, and transport of mature RNA derived from intron-containing transcripts. **Pathways and Functions:** 1. **RNA Export from the Nucleus**: NXT1 is involved in the export of RNA from the nucleus to the cytoplasm, where it can be translated into proteins. 2. **Nuclear Pore Complex**: NXT1 interacts with the nuclear pore complex, facilitating the transport of RNA and other molecules across the nuclear membrane. 3. **Metabolic Pathways**: NXT1 is involved in the regulation of metabolic pathways, including the metabolism of RNA, which is essential for cellular function and survival. 4. **Cellular Proliferation and Differentiation**: NXT1 plays a critical role in regulating cellular proliferation and differentiation, particularly in stem cells and epithelial cells. **Clinical Significance:** 1. **Cancer Progression**: NXT1 has been implicated in the progression of various cancers, including prostate cancer, breast cancer, and pancreatic cancer, suggesting its potential as a therapeutic target. 2. **Stem Cell Biology**: NXT1 plays a critical role in regulating stem cell biology, including the maintenance of stem cell pluripotency and differentiation. 3. **RNA Dysregulation**: NXT1 dysregulation has been implicated in various diseases, including cancer, neurodegenerative disorders, and infectious diseases, highlighting the importance of NXT1 in maintaining cellular homeostasis. 4. **Diagnostic and Therapeutic Applications**: NXT1 has potential as a biomarker for cancer diagnosis and as a therapeutic target for the development of novel cancer therapies. In conclusion, NXT1 is a multifunctional protein that plays a critical role in regulating RNA transport and cellular proliferation. Its dysregulation has been implicated in various diseases, highlighting the importance of NXT1 in maintaining cellular homeostasis. Further studies are necessary to fully elucidate the mechanisms of NXT1 and its clinical significance, but its potential as a therapeutic target and biomarker makes it an exciting area of research.

Genular Protein ID: 3560755876

Symbol: NXT1_HUMAN

Name: NTF2-related export protein 1

UniProtKB Accession Codes:

Q9UKK6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 4 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 4 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10567585

Title: Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export.

PubMed ID: 10567585

DOI: 10.1128/mcb.19.12.8616

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10848583

Title: RanGTP-binding protein NXT1 facilitates nuclear export of different classes of RNA in vitro.

PubMed ID: 10848583

DOI: 10.1128/mcb.20.13.4562-4571.2000

PubMed ID: 11259602

Title: NXT1 (p15) is a crucial cellular cofactor in TAP-dependent export of intron-containing RNA in mammalian cells.

PubMed ID: 11259602

DOI: 10.1128/mcb.21.7.2545-2554.2001

PubMed ID: 14729961

Title: RanBP2/Nup358 provides a major binding site for NXF1-p15 dimers at the nuclear pore complex and functions in nuclear mRNA export.

PubMed ID: 14729961

DOI: 10.1128/mcb.24.3.1155-1167.2004

PubMed ID: 19165146

Title: Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA.

PubMed ID: 19165146

DOI: 10.1038/emboj.2009.5

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 11583626

Title: Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor.

PubMed ID: 11583626

DOI: 10.1016/s1097-2765(01)00348-3

Sequence Information:

  • Length: 140
  • Mass: 15847
  • Checksum: 358FA86AC3944594
  • Sequence:
    • MASVDFKTYV DQACRAAEEF VNVYYTTMDK RRRLLSRLYM GTATLVWNGN AVSGQESLSE 
FFEMLPSSEF QISVVDCQPV HDEATPSQTT VLVVICGSVK FEGNKQRDFN QNFILTAQAS 
PSNTVWKIAS DCFRFQDWAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.