Details for: NXT1

Gene ID: 29107

Symbol: NXT1

Ensembl ID: ENSG00000132661

Description: nuclear transport factor 2 like export factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 145.6811
    Cell Significance Index: -22.6600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 74.9576
    Cell Significance Index: -19.0100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 66.0642
    Cell Significance Index: -27.2200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 59.9620
    Cell Significance Index: -24.3600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 57.8028
    Cell Significance Index: -27.2900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 53.6174
    Cell Significance Index: -27.5800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 40.8332
    Cell Significance Index: -27.4000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 26.1536
    Cell Significance Index: -24.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.0608
    Cell Significance Index: -27.2000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.2021
    Cell Significance Index: -28.4200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.7590
    Cell Significance Index: -20.7600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.6778
    Cell Significance Index: -15.2100
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.6597
    Cell Significance Index: 7.9100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.6227
    Cell Significance Index: -5.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.1342
    Cell Significance Index: 58.0900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.0307
    Cell Significance Index: 35.8900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.9933
    Cell Significance Index: 57.1400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5985
    Cell Significance Index: 158.1300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0490
    Cell Significance Index: 49.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0326
    Cell Significance Index: 53.6400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9331
    Cell Significance Index: 842.5000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8406
    Cell Significance Index: 136.7200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.8183
    Cell Significance Index: 60.9900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7975
    Cell Significance Index: 56.4000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.7736
    Cell Significance Index: 8.4100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.7580
    Cell Significance Index: 4.6700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7354
    Cell Significance Index: 25.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6877
    Cell Significance Index: 304.0400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6613
    Cell Significance Index: 81.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6435
    Cell Significance Index: 83.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5909
    Cell Significance Index: 81.1500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5585
    Cell Significance Index: 11.6900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5336
    Cell Significance Index: 14.0300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4833
    Cell Significance Index: 5.4900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4381
    Cell Significance Index: 78.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4158
    Cell Significance Index: 227.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3960
    Cell Significance Index: 46.7000
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.3954
    Cell Significance Index: 2.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3477
    Cell Significance Index: 22.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3119
    Cell Significance Index: 39.9800
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.2974
    Cell Significance Index: 2.4600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2884
    Cell Significance Index: 7.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2775
    Cell Significance Index: 12.9400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2755
    Cell Significance Index: 19.0500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2602
    Cell Significance Index: 16.4000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1536
    Cell Significance Index: 8.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1353
    Cell Significance Index: 26.8500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1243
    Cell Significance Index: 3.3200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1233
    Cell Significance Index: 1.1400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1059
    Cell Significance Index: 3.1100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0976
    Cell Significance Index: 0.8200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0974
    Cell Significance Index: 2.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0966
    Cell Significance Index: 18.3800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0933
    Cell Significance Index: 1.2000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0476
    Cell Significance Index: 1.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0243
    Cell Significance Index: 1.1000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0212
    Cell Significance Index: 0.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0054
    Cell Significance Index: 4.0800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0073
    Cell Significance Index: -0.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0076
    Cell Significance Index: -14.3500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0168
    Cell Significance Index: -12.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0189
    Cell Significance Index: -34.8400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0197
    Cell Significance Index: -2.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0217
    Cell Significance Index: -7.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0217
    Cell Significance Index: -33.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0233
    Cell Significance Index: -31.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0269
    Cell Significance Index: -0.7800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0299
    Cell Significance Index: -5.9900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0309
    Cell Significance Index: -22.9100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0343
    Cell Significance Index: -1.1000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0347
    Cell Significance Index: -1.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0368
    Cell Significance Index: -10.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0387
    Cell Significance Index: -24.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0429
    Cell Significance Index: -24.1800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0486
    Cell Significance Index: -30.3800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0517
    Cell Significance Index: -1.1000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0554
    Cell Significance Index: -0.3400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0571
    Cell Significance Index: -1.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0598
    Cell Significance Index: -27.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0686
    Cell Significance Index: -11.7100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0732
    Cell Significance Index: -1.8700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0747
    Cell Significance Index: -8.7000
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1188
    Cell Significance Index: -1.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1424
    Cell Significance Index: -16.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1487
    Cell Significance Index: -31.3200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1599
    Cell Significance Index: -4.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1684
    Cell Significance Index: -24.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2197
    Cell Significance Index: -7.7200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2294
    Cell Significance Index: -3.1300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2702
    Cell Significance Index: -28.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2983
    Cell Significance Index: -18.2900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3011
    Cell Significance Index: -23.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3426
    Cell Significance Index: -21.0600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3566
    Cell Significance Index: -27.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3685
    Cell Significance Index: -20.6800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3741
    Cell Significance Index: -11.0200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4010
    Cell Significance Index: -16.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4082
    Cell Significance Index: -27.4500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4379
    Cell Significance Index: -5.2200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4435
    Cell Significance Index: -11.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **RNA Export Function**: NXT1 is primarily involved in the export of RNA from the nucleus to the cytoplasm, where it can be translated into proteins. 2. **Structural Similarities**: NXT1 shares structural similarities with other NTF2 family members, including NTF2 itself, suggesting a conserved evolutionary pathway. 3. **Cell Type-Specific Expression**: NXT1 is significantly expressed in various cell types, including germ cells, stem cells, and epithelial cells, indicating its involvement in cellular proliferation and differentiation. 4. **Multifunctional Protein**: NXT1 has been implicated in multiple cellular processes, including protein binding, small GTPase binding, and transport of mature RNA derived from intron-containing transcripts. **Pathways and Functions:** 1. **RNA Export from the Nucleus**: NXT1 is involved in the export of RNA from the nucleus to the cytoplasm, where it can be translated into proteins. 2. **Nuclear Pore Complex**: NXT1 interacts with the nuclear pore complex, facilitating the transport of RNA and other molecules across the nuclear membrane. 3. **Metabolic Pathways**: NXT1 is involved in the regulation of metabolic pathways, including the metabolism of RNA, which is essential for cellular function and survival. 4. **Cellular Proliferation and Differentiation**: NXT1 plays a critical role in regulating cellular proliferation and differentiation, particularly in stem cells and epithelial cells. **Clinical Significance:** 1. **Cancer Progression**: NXT1 has been implicated in the progression of various cancers, including prostate cancer, breast cancer, and pancreatic cancer, suggesting its potential as a therapeutic target. 2. **Stem Cell Biology**: NXT1 plays a critical role in regulating stem cell biology, including the maintenance of stem cell pluripotency and differentiation. 3. **RNA Dysregulation**: NXT1 dysregulation has been implicated in various diseases, including cancer, neurodegenerative disorders, and infectious diseases, highlighting the importance of NXT1 in maintaining cellular homeostasis. 4. **Diagnostic and Therapeutic Applications**: NXT1 has potential as a biomarker for cancer diagnosis and as a therapeutic target for the development of novel cancer therapies. In conclusion, NXT1 is a multifunctional protein that plays a critical role in regulating RNA transport and cellular proliferation. Its dysregulation has been implicated in various diseases, highlighting the importance of NXT1 in maintaining cellular homeostasis. Further studies are necessary to fully elucidate the mechanisms of NXT1 and its clinical significance, but its potential as a therapeutic target and biomarker makes it an exciting area of research.

Genular Protein ID: 3560755876

Symbol: NXT1_HUMAN

Name: NTF2-related export protein 1

UniProtKB Accession Codes:

Q9UKK6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 4 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10567585

Title: Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export.

PubMed ID: 10567585

DOI: 10.1128/mcb.19.12.8616

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10848583

Title: RanGTP-binding protein NXT1 facilitates nuclear export of different classes of RNA in vitro.

PubMed ID: 10848583

DOI: 10.1128/mcb.20.13.4562-4571.2000

PubMed ID: 11259602

Title: NXT1 (p15) is a crucial cellular cofactor in TAP-dependent export of intron-containing RNA in mammalian cells.

PubMed ID: 11259602

DOI: 10.1128/mcb.21.7.2545-2554.2001

PubMed ID: 14729961

Title: RanBP2/Nup358 provides a major binding site for NXF1-p15 dimers at the nuclear pore complex and functions in nuclear mRNA export.

PubMed ID: 14729961

DOI: 10.1128/mcb.24.3.1155-1167.2004

PubMed ID: 19165146

Title: Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA.

PubMed ID: 19165146

DOI: 10.1038/emboj.2009.5

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 11583626

Title: Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor.

PubMed ID: 11583626

DOI: 10.1016/s1097-2765(01)00348-3

Sequence Information:

  • Length: 140
  • Mass: 15847
  • Checksum: 358FA86AC3944594
  • Sequence:
    • MASVDFKTYV DQACRAAEEF VNVYYTTMDK RRRLLSRLYM GTATLVWNGN AVSGQESLSE 
FFEMLPSSEF QISVVDCQPV HDEATPSQTT VLVVICGSVK FEGNKQRDFN QNFILTAQAS 
PSNTVWKIAS DCFRFQDWAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.