Details for: CXCL2
Gene ID: 2920
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: CXCL2
Ensembl ID: ENSG00000081041
Description: C-X-C motif chemokine ligand 2
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 77.37rCSI 59.98%PRS 87.05
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CSI 36.86rCSI 31.78%PRS 83.84
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CSI 31.77rCSI 43.23%PRS 90.81
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CSI 26.28rCSI 24.13%PRS 90.34
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CSI 26.17rCSI 33.56%PRS 86.41
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CSI 25.48rCSI 36.73%PRS 89.07
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CSI 24.09rCSI 37.37%PRS 86.63
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CSI 23.87rCSI 77.43%PRS 81.87
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CSI 23.24rCSI 30.89%PRS 88.4
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CSI 21.99rCSI 39.96%PRS 91.74
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CSI 21.87rCSI 41.72%PRS 91.67
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CSI 20rCSI 20.72%PRS 86.91
-
CSI 17.21rCSI 41.3%PRS 86.14
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CSI 15.71rCSI 58.87%PRS 76.72
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CSI 14.59rCSI 15.22%PRS 82.97
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CSI 14.55rCSI 13.54%PRS 84.48
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CSI 13.65rCSI 26.54%PRS 86.53
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CSI 13.51rCSI 16.32%PRS 90.33
-
CSI 12.8rCSI 29.27%PRS 84.52
-
CSI 12.72rCSI 9.8%PRS 86.8
-
CSI 12.13rCSI 17.77%PRS 88.54
-
CSI 11.3rCSI 17.04%PRS 88.53
-
CSI 10.77rCSI 8.93%PRS 84.76
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CSI 10.57rCSI 21.93%PRS 80.78
-
CSI 10.32rCSI 19.49%PRS 90.4
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CSI 9rCSI 21.11%PRS 82.74
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CSI 8.69rCSI 10.83%PRS 91.39
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CSI 8.35rCSI 38.58%PRS 93.37
-
CSI 8.22rCSI 35.53%PRS 88.95
-
CSI 8.21rCSI 18.44%PRS 93.25
-
CSI 8.19rCSI 19.57%PRS 87.05
-
CSI 8.06rCSI 21.02%PRS 81.32
-
CSI 8.01rCSI 14.48%PRS 87.02
-
CSI 7.97rCSI 11.04%PRS 80.49
-
CSI 7.24rCSI 28.94%PRS 89.73
-
CSI 7.2rCSI 6.5%PRS 82.22
-
CSI 7.1rCSI 43.82%PRS 89.85
-
CSI 6.88rCSI 12.32%PRS 82.81
-
CSI 6.76rCSI 12.39%PRS 86.41
-
CSI 6.7rCSI 30.72%PRS 86.91
-
CSI 6.4rCSI 38.71%PRS 92.48
-
CSI 6.16rCSI 9.02%PRS 88.08
-
CSI 6.1rCSI 5.41%PRS 81.36
-
CSI 6rCSI 24.22%PRS 83.84
-
CSI 5.83rCSI 13.03%PRS 89.94
-
CSI 5.71rCSI 4.64%PRS 83.12
-
CSI 5.59rCSI 15.72%PRS 78.97
-
CSI 5.52rCSI 4.15%PRS 88.86
-
CSI 5.51rCSI 21.44%PRS 82.17
-
CSI 5.48rCSI 9.02%PRS 87.07
-
CSI 5.43rCSI 5.42%PRS 77.78
-
CSI 5.43rCSI 5.24%PRS 77.99
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CSI 5.42rCSI 14.78%PRS 89.3
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CSI 5.31rCSI 11.69%PRS 86.98
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CSI 5.24rCSI 4.95%PRS 81.96
-
CSI 5.2rCSI 35.67%PRS 88.97
-
CSI 5.14rCSI 10.18%PRS 87.67
-
CSI 5.06rCSI 7.47%PRS 91.89
-
CSI 4.96rCSI 6.5%PRS 92.54
-
CSI 4.79rCSI 16.82%PRS 90.24
-
CSI 4.58rCSI 7%PRS 89.77
-
CSI 4.36rCSI 6.25%PRS 83.57
-
CSI 4.33rCSI 4.53%PRS 81.11
-
CSI 4.27rCSI 7.29%PRS 95.26
-
CSI 4.19rCSI 4.45%PRS 87.72
-
CSI 4.13rCSI 5.03%PRS 89.19
-
CSI 4.04rCSI 4.68%PRS 86.49
-
CSI 4rCSI 6.39%PRS 86.97
-
CSI 4rCSI 6.11%PRS 83.64
-
CSI 3.99rCSI 5.33%PRS 81.68
-
CSI 3.97rCSI 6.09%PRS 90.79
-
CSI 3.96rCSI 5.81%PRS 91.48
-
CSI 3.95rCSI 4.97%PRS 91.51
-
CSI 3.92rCSI 4.53%PRS 76.62
-
CSI 3.81rCSI 8.88%PRS 92.27
-
CSI 3.42rCSI 33.64%PRS 91.52
-
CSI 3.34rCSI 5.3%PRS 90.69
-
CSI 3.31rCSI 6.26%PRS 91.97
-
CSI 3.3rCSI 8.16%PRS 83.86
-
CSI 3.3rCSI 3.87%PRS 85.1
-
CSI 3.27rCSI 16.53%PRS 93.12
-
CSI 3.23rCSI 8.39%PRS 83.57
-
CSI 3.13rCSI 7.42%PRS 82.97
-
CSI 3.13rCSI 2.08%PRS 85.97
-
CSI 3.08rCSI 3.37%PRS 85.37
-
CSI 3rCSI 12.62%PRS 87.22
-
CSI 2.96rCSI 4.77%PRS 82.12
-
CSI 2.96rCSI 18.91%PRS 87.4
-
CSI 2.94rCSI 5.24%PRS 90.47
-
CSI 2.87rCSI 4.53%PRS 84.93
-
CSI 2.83rCSI 16.33%PRS 80.02
-
CSI 2.83rCSI 4.89%PRS 75.95
-
CSI 2.77rCSI 15.78%PRS 89.45
-
CSI 2.72rCSI 64.95%PRS 90.21
-
CSI 2.69rCSI 2.18%PRS 85.69
-
CSI 2.56rCSI 5.44%PRS 88.53
-
CSI 2.46rCSI 10.69%PRS 87.73
-
CSI 2.43rCSI 26.38%PRS 89.65
-
CSI 2.38rCSI 1.99%PRS 85.73
-
CSI 2.36rCSI 18.11%PRS 84.7
-
CSI 0.3rCSI 6.1%PRS 96.0%
-
CSI 0.4rCSI 2.1%PRS 86.7%
-
CSI 0.4rCSI 2.3%PRS 96.2%
-
CSI 0.4rCSI 10.3%PRS 92.3%
-
CSI 0.5rCSI 3.4%PRS 95.5%
-
CSI 0.6rCSI 4.7%PRS 78.6%
-
CSI 0.7rCSI 3.3%PRS 89.9%
-
CSI 0.8rCSI 4.3%PRS 90.2%
-
CSI 0.9rCSI 4.2%PRS 93.0%
-
CSI 1.0rCSI 7.1%PRS 91.4%
-
CSI 1.1rCSI 3.7%PRS 80.3%
-
CSI 1.2rCSI 2.7%PRS 88.9%
-
CSI 1.3rCSI 7.7%PRS 88.3%
-
CSI 1.5rCSI 1.6%PRS 81.3%
-
CSI 1.6rCSI 12.8%PRS 90.4%
-
CSI 1.7rCSI 4.5%PRS 93.0%
-
CSI 1.8rCSI 5.4%PRS 87.2%
-
CSI 1.8rCSI 2.6%PRS 88.2%
-
CSI 1.8rCSI 19.5%PRS 91.4%
-
CSI 1.8rCSI 5.2%PRS 88.7%
-
CSI 2.1rCSI 1.9%PRS 88.2%
-
CSI 2.2rCSI 1.9%PRS 73.5%
-
CSI 2.3rCSI 3.2%PRS 87.9%
-
CSI 2.4rCSI 18.1%PRS 84.7%
-
CSI 2.4rCSI 2.0%PRS 85.7%
-
CSI 2.4rCSI 26.4%PRS 89.7%
-
CSI 2.5rCSI 10.7%PRS 87.7%
-
CSI 2.6rCSI 5.4%PRS 88.5%
-
CSI 2.7rCSI 2.2%PRS 85.7%
-
CSI 2.7rCSI 65.0%PRS 90.2%
-
CSI 2.8rCSI 15.8%PRS 89.5%
-
CSI 2.8rCSI 4.9%PRS 76.0%
-
CSI 2.8rCSI 16.3%PRS 80.0%
-
CSI 2.9rCSI 4.5%PRS 84.9%
-
CSI 2.9rCSI 5.2%PRS 90.5%
-
CSI 3.0rCSI 18.9%PRS 87.4%
-
CSI 3.0rCSI 4.8%PRS 82.1%
-
CSI 3.0rCSI 12.6%PRS 87.2%
-
CSI 3.1rCSI 3.4%PRS 85.4%
-
CSI 3.1rCSI 2.1%PRS 86.0%
-
CSI 3.1rCSI 7.4%PRS 83.0%
-
CSI 3.2rCSI 8.4%PRS 83.6%
-
CSI 3.3rCSI 16.5%PRS 93.1%
-
CSI 3.3rCSI 3.9%PRS 85.1%
-
CSI 3.3rCSI 8.2%PRS 83.9%
-
CSI 3.3rCSI 6.3%PRS 92.0%
-
CSI 3.3rCSI 5.3%PRS 90.7%
-
CSI 3.4rCSI 33.6%PRS 91.5%
-
CSI 3.8rCSI 8.9%PRS 92.3%
-
CSI 3.9rCSI 4.5%PRS 76.6%
-
CSI 4.0rCSI 5.0%PRS 91.5%
-
CSI 4.0rCSI 5.8%PRS 91.5%
-
CSI 4.0rCSI 6.1%PRS 90.8%
-
CSI 4.0rCSI 5.3%PRS 81.7%
-
CSI 4.0rCSI 6.1%PRS 83.6%
-
CSI 4.0rCSI 6.4%PRS 87.0%
-
CSI 4.0rCSI 4.7%PRS 86.5%
-
CSI 4.1rCSI 5.0%PRS 89.2%
-
CSI 4.2rCSI 4.5%PRS 87.7%
-
CSI 4.3rCSI 7.3%PRS 95.3%
-
CSI 4.3rCSI 4.5%PRS 81.1%
-
CSI 4.4rCSI 6.3%PRS 83.6%
-
CSI 4.6rCSI 7.0%PRS 89.8%
-
CSI 4.8rCSI 16.8%PRS 90.2%
-
CSI 5.0rCSI 6.5%PRS 92.5%
-
CSI 5.1rCSI 7.5%PRS 91.9%
-
CSI 5.1rCSI 10.2%PRS 87.7%
-
CSI 5.2rCSI 35.7%PRS 89.0%
-
CSI 5.2rCSI 5.0%PRS 82.0%
-
CSI 5.3rCSI 11.7%PRS 87.0%
-
CSI 5.4rCSI 14.8%PRS 89.3%
-
CSI 5.4rCSI 5.2%PRS 78.0%
-
CSI 5.4rCSI 5.4%PRS 77.8%
-
CSI 5.5rCSI 9.0%PRS 87.1%
-
CSI 5.5rCSI 21.4%PRS 82.2%
-
CSI 5.5rCSI 4.2%PRS 88.9%
-
CSI 5.6rCSI 15.7%PRS 79.0%
-
CSI 5.7rCSI 4.6%PRS 83.1%
-
CSI 5.8rCSI 13.0%PRS 89.9%
-
CSI 6.0rCSI 24.2%PRS 83.8%
-
CSI 6.1rCSI 5.4%PRS 81.4%
-
CSI 6.2rCSI 9.0%PRS 88.1%
-
CSI 6.4rCSI 38.7%PRS 92.5%
-
CSI 6.7rCSI 30.7%PRS 86.9%
-
CSI 6.8rCSI 12.4%PRS 86.4%
-
CSI 6.9rCSI 12.3%PRS 82.8%
-
CSI 7.1rCSI 43.8%PRS 89.9%
-
CSI 7.2rCSI 6.5%PRS 82.2%
-
CSI 7.2rCSI 28.9%PRS 89.7%
-
CSI 8.0rCSI 11.0%PRS 80.5%
-
CSI 8.0rCSI 14.5%PRS 87.0%
-
CSI 8.1rCSI 21.0%PRS 81.3%
-
CSI 8.2rCSI 19.6%PRS 87.1%
-
CSI 8.2rCSI 18.4%PRS 93.3%
-
CSI 8.2rCSI 35.5%PRS 89.0%
-
CSI 8.4rCSI 38.6%PRS 93.4%
-
CSI 8.7rCSI 10.8%PRS 91.4%
-
CSI 9.0rCSI 21.1%PRS 82.7%
-
CSI 10.3rCSI 19.5%PRS 90.4%
-
CSI 10.6rCSI 21.9%PRS 80.8%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Comma-separated if multiple.
Comma-separated if multiple.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.
Genular Protein ID: 2445090362
Symbol: CXCL2_HUMAN
Name: C-X-C motif chemokine 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2201751
Title: Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues.
PubMed ID: 2201751
PubMed ID: 2078213
Title: Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue.
PubMed ID: 2078213
PubMed ID: 2217207
Title: Identification of three related human GRO genes encoding cytokine functions.
PubMed ID: 2217207
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2341726
Title: Monocyte adherence results in selective induction of novel genes sharing homology with mediators of inflammation and tissue repair.
PubMed ID: 2341726
PubMed ID: 10725737
Title: Identification of unique truncated KC/GRO beta chemokines with potent hematopoietic and anti-infective activities.
PubMed ID: 10725737
PubMed ID: 10600366
Title: Nuclear magnetic resonance solution structure of truncated human GRObeta [5-73] and its structural comparison with CXC chemokine family members GROalpha and IL-8.
PubMed ID: 10600366
Sequence Information:
- Length: 107
- Mass: 11389
- Checksum: 740F277E928571BA
- Sequence:
MARATLSAAP SNPRLLRVAL LLLLLVAASR RAAGAPLATE LRCQCLQTLQ GIHLKNIQSV KVKSPGPHCA QTEVIATLKN GQKACLNPAS PMVKKIIEKM LKNGKSN