Details for: PDIA3

Gene ID: 2923

Symbol: PDIA3

Ensembl ID: ENSG00000167004

Description: protein disulfide isomerase family A member 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.78
    Marker Score: 2959
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.26
    Marker Score: 9526
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.19
    Marker Score: 10063
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.17
    Marker Score: 8754
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.15
    Marker Score: 2689
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.13
    Marker Score: 4298
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 3.11
    Marker Score: 2191
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.08
    Marker Score: 35788
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 3.07
    Marker Score: 5597
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.06
    Marker Score: 7782
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.06
    Marker Score: 30291.5
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3
    Marker Score: 7335
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.97
    Marker Score: 39141
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.94
    Marker Score: 2845
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.89
    Marker Score: 100136
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.86
    Marker Score: 18595
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.86
    Marker Score: 7659
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.85
    Marker Score: 4130
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.83
    Marker Score: 6447
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.81
    Marker Score: 2468
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.81
    Marker Score: 20880
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.8
    Marker Score: 2495.5
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.8
    Marker Score: 3859.5
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.79
    Marker Score: 897
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.79
    Marker Score: 7817
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.74
    Marker Score: 11803
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.73
    Marker Score: 93012
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.73
    Marker Score: 7143
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.71
    Marker Score: 648
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.7
    Marker Score: 11597
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.7
    Marker Score: 6810
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.67
    Marker Score: 6052
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.67
    Marker Score: 1110
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 2.66
    Marker Score: 2178
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.66
    Marker Score: 3278
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.65
    Marker Score: 2847
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.65
    Marker Score: 4074.5
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.64
    Marker Score: 1506
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.63
    Marker Score: 3870
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.61
    Marker Score: 10062
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.6
    Marker Score: 16606
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.6
    Marker Score: 1038
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.59
    Marker Score: 3124
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.58
    Marker Score: 2293
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.55
    Marker Score: 2981
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.55
    Marker Score: 28672
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.54
    Marker Score: 5299
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.54
    Marker Score: 2161
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.53
    Marker Score: 2129
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.52
    Marker Score: 3623
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.51
    Marker Score: 1829
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.5
    Marker Score: 4905
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.5
    Marker Score: 2538
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.5
    Marker Score: 4019
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.48
    Marker Score: 1778
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.48
    Marker Score: 1443
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.47
    Marker Score: 2216
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.47
    Marker Score: 130433
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.46
    Marker Score: 4041
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.46
    Marker Score: 12926
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.46
    Marker Score: 3910
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.45
    Marker Score: 2805
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 2.42
    Marker Score: 1686
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.42
    Marker Score: 2318
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 2.42
    Marker Score: 1625
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.42
    Marker Score: 1042
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.41
    Marker Score: 1087
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.4
    Marker Score: 4082.5
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.4
    Marker Score: 1121
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.4
    Marker Score: 2063
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.39
    Marker Score: 14173
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 2.38
    Marker Score: 588
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.38
    Marker Score: 5803
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 2.38
    Marker Score: 1800
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.37
    Marker Score: 3936
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.36
    Marker Score: 3046
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.36
    Marker Score: 1071
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.36
    Marker Score: 2760
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.36
    Marker Score: 6411
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 2.35
    Marker Score: 644
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.34
    Marker Score: 4155
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.34
    Marker Score: 15272
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.34
    Marker Score: 2547
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.34
    Marker Score: 1560
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.33
    Marker Score: 1319
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 2.33
    Marker Score: 813
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.33
    Marker Score: 868
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.31
    Marker Score: 655
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 2.31
    Marker Score: 1963
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.31
    Marker Score: 23257
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.3
    Marker Score: 4115
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.29
    Marker Score: 1088
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.29
    Marker Score: 660
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.29
    Marker Score: 788
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.28
    Marker Score: 127579
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.28
    Marker Score: 2143
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 2.27
    Marker Score: 1465
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 2.27
    Marker Score: 2003
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 2.27
    Marker Score: 786
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.27
    Marker Score: 3209

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Other Information

**Key characteristics:** * PDIA3 is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is expressed in high levels in cells of the immune system, particularly in dendritic cells and macrophages. * PDIA3 is a key regulator of the immune response. * It is involved in the processing and presentation of antigens to cytotoxic T cells. * It is also involved in the regulation of inflammation. **Pathways and functions:** * PDIA3 is involved in the folding and assembly of class i MHC molecules. * It is also involved in the processing and cross-presentation of antigens to T cells. * PDIA3 is involved in the regulation of inflammation. * It is also involved in the regulation of the immune response to pathogens. **Clinical significance:** PDIA3 is a potential therapeutic target for a variety of diseases. It is expressed in high levels in tumor cells, and inhibition of PDIA3 has been shown to be effective in tumor growth and metastasis. PDIA3 is also involved in the regulation of inflammation, and inhibition of PDIA3 has been shown to be effective in reducing inflammation-associated diseases. **Conclusion:** PDIA3 is a key regulator of the immune response. It is involved in the folding, assembly, and peptide loading of class i MHC molecules, as well as in the antigen processing-cross presentation pathway. PDIA3 is also involved in the regulation of inflammation and is a potential therapeutic target for a variety of diseases.

Genular Protein ID: 1459090779

Symbol: PDIA3_HUMAN

Name: Protein disulfide-isomerase A3

UniProtKB Accession Codes:

P30101 Q13453 Q14255 Q8IYF8 Q9UMU7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CPTAC 2 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 5 EC 1 EMBL 18 EMDB 2 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 28 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 2 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 7 PIR 4 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 3 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7945384

Title: Molecular cloning and characterization of a cDNA for bovine phospholipase C-alpha: proposal of redesignation of phospholipase C-alpha.

PubMed ID: 7945384

DOI: 10.1006/bbrc.1994.2469

PubMed ID: 7487104

Title: cDNA cloning and baculovirus expression of the human liver endoplasmic reticulum P58: characterization as a protein disulfide isomerase isoform, but not as a protease or a carnitine acyltransferase.

PubMed ID: 7487104

DOI: 10.1006/abbi.1995.0060

PubMed ID: 8687406

Title: ERp60 does not substitute for protein disulphide isomerase as the beta-subunit of prolyl 4-hydroxylase.

PubMed ID: 8687406

DOI: 10.1042/bj3160599

PubMed ID: 8624847

Title: Cloning, expression and genomic organization of human placental protein disulfide isomerase (previously identified as phospholipase C alpha).

PubMed ID: 8624847

DOI: 10.1016/1357-2725(95)00120-4

PubMed ID: 9205111

Title: Structures of the human gene for the protein disulfide isomerase-related polypeptide ERp60 and a processed gene and assignment of these genes to 15q15 and 1q21.

PubMed ID: 9205111

DOI: 10.1006/geno.1997.4750

PubMed ID: 9399589

Title: Functions of characteristic Cys-Gly-His-Cys (CGHC) and Gln-Glu-Asp-Leu (QEDL) motifs of microsomal ER-60 protease.

PubMed ID: 9399589

DOI: 10.1093/oxfordjournals.jbchem.a021830

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9150948

Title: A two-dimensional gel database of human colon carcinoma proteins.

PubMed ID: 9150948

DOI: 10.1002/elps.1150180344

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 1286669

Title: Human liver protein map: a reference database established by microsequencing and gel comparison.

PubMed ID: 1286669

DOI: 10.1002/elps.11501301201

PubMed ID: 9150946

Title: Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2.

PubMed ID: 9150946

DOI: 10.1002/elps.1150180342

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 11825568

Title: Disulfide bond isomerization and the assembly of MHC class I-peptide complexes.

PubMed ID: 11825568

DOI: 10.1016/s1074-7613(02)00263-7

PubMed ID: 11840567

Title: Cluster analysis of an extensive human breast cancer cell line protein expression map database.

PubMed ID: 11840567

DOI: 10.1002/1615-9861(200202)2:2<212::aid-prot212>3.0.co;2-h

PubMed ID: 12643545

Title: Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.

PubMed ID: 12643545

DOI: 10.1021/pr025562r

PubMed ID: 16193070

Title: Tapasin and ERp57 form a stable disulfide-linked dimer within the MHC class I peptide-loading complex.

PubMed ID: 16193070

DOI: 10.1038/sj.emboj.7600814

PubMed ID: 16940051

Title: ERp27, a new non-catalytic endoplasmic reticulum-located human protein disulfide isomerase family member, interacts with ERp57.

PubMed ID: 16940051

DOI: 10.1074/jbc.m604314200

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20400973

Title: Glucose-regulated protein precursor (GRP78) and tumor rejection antigen (GP96) are unique to hamster caput epididymal spermatozoa.

PubMed ID: 20400973

DOI: 10.1038/aja.2010.19

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 24188822

Title: Modulation of H(+),K(+)-ATPase activity by the molecular chaperone ERp57 highly expressed in gastric parietal cells.

PubMed ID: 24188822

DOI: 10.1016/j.febslet.2013.10.030

PubMed ID: 23826168

Title: SERPINA2 is a novel gene with a divergent function from SERPINA1.

PubMed ID: 23826168

DOI: 10.1371/journal.pone.0066889

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27897272

Title: Analysis of the interaction of calcitriol with the disulfide isomerase ERp57.

PubMed ID: 27897272

DOI: 10.1038/srep37957

PubMed ID: 16258833

Title: NMR assignment of the N-terminal domain a of the glycoprotein chaperone ERp57.

PubMed ID: 16258833

DOI: 10.1007/s10858-005-2720-1

PubMed ID: 16905107

Title: Crystal structure of the bb' domains of the protein disulfide isomerase ERp57.

PubMed ID: 16905107

DOI: 10.1016/j.str.2006.06.019

PubMed ID: 19119025

Title: Insights into MHC class I peptide loading from the structure of the tapasin-ERp57 thiol oxidoreductase heterodimer.

PubMed ID: 19119025

DOI: 10.1016/j.immuni.2008.10.018

PubMed ID: 35948544

Title: Molecular basis of MHC I quality control in the peptide loading complex.

PubMed ID: 35948544

DOI: 10.1038/s41467-022-32384-z

PubMed ID: 36104323

Title: Structure of an MHC I-tapasin-ERp57 editing complex defines chaperone promiscuity.

PubMed ID: 36104323

DOI: 10.1038/s41467-022-32841-9

Sequence Information:

  • Length: 505
  • Mass: 56782
  • Checksum: 529E5B6692D0D7E9
  • Sequence:
    • MRLRRLALFP GVALLLAAAR LAAASDVLEL TDDNFESRIS DTGSAGLMLV EFFAPWCGHC 
KRLAPEYEAA ATRLKGIVPL AKVDCTANTN TCNKYGVSGY PTLKIFRDGE EAGAYDGPRT 
ADGIVSHLKK QAGPASVPLR TEEEFKKFIS DKDASIVGFF DDSFSEAHSE FLKAASNLRD 
NYRFAHTNVE SLVNEYDDNG EGIILFRPSH LTNKFEDKTV AYTEQKMTSG KIKKFIQENI 
FGICPHMTED NKDLIQGKDL LIAYYDVDYE KNAKGSNYWR NRVMMVAKKF LDAGHKLNFA 
VASRKTFSHE LSDFGLESTA GEIPVVAIRT AKGEKFVMQE EFSRDGKALE RFLQDYFDGN 
LKRYLKSEPI PESNDGPVKV VVAENFDEIV NNENKDVLIE FYAPWCGHCK NLEPKYKELG 
EKLSKDPNIV IAKMDATAND VPSPYEVRGF PTIYFSPANK KLNPKKYEGG RELSDFISYL 
QREATNPPVI QEEKPKKKKK AQEDL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.