Details for: PDIA3

Gene ID: 2923

Symbol: PDIA3

Ensembl ID: ENSG00000167004

Description: protein disulfide isomerase family A member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 699.2179
    Cell Significance Index: -108.7600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 422.8378
    Cell Significance Index: -107.2500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 307.5391
    Cell Significance Index: -126.6900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 273.2129
    Cell Significance Index: -128.9900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 271.4291
    Cell Significance Index: -110.2700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 243.5626
    Cell Significance Index: -125.2900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 192.9296
    Cell Significance Index: -129.4600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 116.1988
    Cell Significance Index: -110.9400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 96.4674
    Cell Significance Index: -118.9400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 30.9170
    Cell Significance Index: -122.0000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 30.9012
    Cell Significance Index: -82.7800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 29.6667
    Cell Significance Index: -91.1200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.9633
    Cell Significance Index: -30.5600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 6.4739
    Cell Significance Index: 149.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.7169
    Cell Significance Index: 173.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.6844
    Cell Significance Index: 505.9700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.5850
    Cell Significance Index: 75.0400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.0766
    Cell Significance Index: 80.9000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.9579
    Cell Significance Index: 851.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.9177
    Cell Significance Index: 1593.4000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.6389
    Cell Significance Index: 21.0700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.6283
    Cell Significance Index: 70.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.5089
    Cell Significance Index: 68.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.3253
    Cell Significance Index: 173.3000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.2602
    Cell Significance Index: 289.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.2013
    Cell Significance Index: 396.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.1589
    Cell Significance Index: 265.4600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.0054
    Cell Significance Index: 138.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.8604
    Cell Significance Index: 87.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.6626
    Cell Significance Index: 86.6000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4850
    Cell Significance Index: 241.5100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.4716
    Cell Significance Index: 650.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.4640
    Cell Significance Index: 172.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.4620
    Cell Significance Index: 188.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3996
    Cell Significance Index: 277.7500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1991
    Cell Significance Index: 228.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.9837
    Cell Significance Index: 167.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9629
    Cell Significance Index: 193.1600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.9393
    Cell Significance Index: 32.6400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9237
    Cell Significance Index: 65.3300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.8767
    Cell Significance Index: 9.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8363
    Cell Significance Index: 53.9600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8105
    Cell Significance Index: 17.5600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7217
    Cell Significance Index: 20.8000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.6760
    Cell Significance Index: 4.2000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6722
    Cell Significance Index: 30.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5800
    Cell Significance Index: 208.0500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5156
    Cell Significance Index: 14.7800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3698
    Cell Significance Index: 10.8600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3491
    Cell Significance Index: 19.5900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2964
    Cell Significance Index: 204.9900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2575
    Cell Significance Index: 232.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2202
    Cell Significance Index: 166.7000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1335
    Cell Significance Index: 97.8800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0249
    Cell Significance Index: 46.8000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0239
    Cell Significance Index: 0.4000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0227
    Cell Significance Index: 1.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0046
    Cell Significance Index: 8.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0378
    Cell Significance Index: -27.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0389
    Cell Significance Index: -59.9000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0497
    Cell Significance Index: -5.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0653
    Cell Significance Index: -3.4300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0675
    Cell Significance Index: -0.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0743
    Cell Significance Index: -46.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0756
    Cell Significance Index: -102.8500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1133
    Cell Significance Index: -71.9300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1481
    Cell Significance Index: -1.6100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1512
    Cell Significance Index: -68.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1534
    Cell Significance Index: -86.4900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1696
    Cell Significance Index: -4.7400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2338
    Cell Significance Index: -49.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.2594
    Cell Significance Index: -25.6600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3833
    Cell Significance Index: -3.5300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4309
    Cell Significance Index: -15.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5185
    Cell Significance Index: -59.4100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5383
    Cell Significance Index: -9.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.6393
    Cell Significance Index: -92.9300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6805
    Cell Significance Index: -79.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.7110
    Cell Significance Index: -54.5600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7746
    Cell Significance Index: -4.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.8890
    Cell Significance Index: -54.6400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.0065
    Cell Significance Index: -25.1600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.0283
    Cell Significance Index: -26.2700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.0509
    Cell Significance Index: -119.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.1182
    Cell Significance Index: -116.4300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.2408
    Cell Significance Index: -39.7400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.2415
    Cell Significance Index: -24.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.3523
    Cell Significance Index: -90.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.4032
    Cell Significance Index: -111.1300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.4178
    Cell Significance Index: -37.9300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.5414
    Cell Significance Index: -21.0300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.6151
    Cell Significance Index: -28.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.6663
    Cell Significance Index: -105.0200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.7153
    Cell Significance Index: -86.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.8411
    Cell Significance Index: -112.8800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.8987
    Cell Significance Index: -19.6600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.9332
    Cell Significance Index: -56.9400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.0148
    Cell Significance Index: -89.1200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -2.3846
    Cell Significance Index: -63.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -2.5389
    Cell Significance Index: -96.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PDIA3 is a member of the protein disulfide isomerase family, enzymes that catalyze the formation and rearrangement of disulfide bonds in proteins. The protein has a molecular weight of approximately 40 kDa and is composed of three domains: an N-terminal domain, a central catalytic domain, and a C-terminal domain. The catalytic domain is responsible for the isomerase activity, while the N-terminal and C-terminal domains interact with other proteins and facilitate the folding and assembly of antigens on MHC I molecules. **Pathways and Functions** PDIA3 is involved in several key cellular processes, including: 1. **Antigen Presentation and Processing**: PDIA3 facilitates the folding, assembly, and presentation of antigens on MHC I molecules. This process involves the interaction of PDIA3 with the tapasin protein, which recruits MHC I molecules to the endoplasmic reticulum (ER) and facilitates their loading with peptide antigens. 2. **Endoplasmic Reticulum Stress Response**: PDIA3 plays a role in the ER stress response, which is triggered by the accumulation of misfolded proteins in the ER. PDIA3 helps to alleviate ER stress by facilitating the folding and assembly of proteins and promoting the degradation of misfolded proteins. 3. **Glycosylation and Protein Modification**: PDIA3 is involved in the asparagine N-linked glycosylation pathway, which is essential for the proper functioning of MHC I molecules. PDIA3 also interacts with the calnexin/calreticulin cycle, which involves the recognition and folding of proteins in the ER. **Clinical Significance** The dysregulation of PDIA3 has been implicated in various diseases, including: 1. **Autoimmune Diseases**: Altered PDIA3 expression has been observed in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where the immune system mistakenly targets self-antigens. 2. **Cancer**: PDIA3 expression is often upregulated in cancer cells, where it facilitates the folding and presentation of tumor antigens on MHC I molecules, promoting immune evasion. 3. **Infectious Diseases**: PDIA3 plays a role in the immune response to viral infections, where it helps to facilitate the presentation of viral antigens on MHC I molecules. In conclusion, PDIA3 is a crucial protein involved in the folding, assembly, and presentation of antigens on the surface of cells. Its dysregulation has been implicated in various diseases, highlighting the importance of this protein in maintaining immune homeostasis and preventing disease. Further research is needed to fully elucidate the mechanisms by which PDIA3 regulates antigen presentation and to explore its potential as a therapeutic target in disease.

Genular Protein ID: 1459090779

Symbol: PDIA3_HUMAN

Name: Protein disulfide-isomerase A3

UniProtKB Accession Codes:

P30101 Q13453 Q14255 Q8IYF8 Q9UMU7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CPTAC 2 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EC 1 EMBL 18 EMDB 2 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 28 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 2 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 4 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7945384

Title: Molecular cloning and characterization of a cDNA for bovine phospholipase C-alpha: proposal of redesignation of phospholipase C-alpha.

PubMed ID: 7945384

DOI: 10.1006/bbrc.1994.2469

PubMed ID: 7487104

Title: cDNA cloning and baculovirus expression of the human liver endoplasmic reticulum P58: characterization as a protein disulfide isomerase isoform, but not as a protease or a carnitine acyltransferase.

PubMed ID: 7487104

DOI: 10.1006/abbi.1995.0060

PubMed ID: 8687406

Title: ERp60 does not substitute for protein disulphide isomerase as the beta-subunit of prolyl 4-hydroxylase.

PubMed ID: 8687406

DOI: 10.1042/bj3160599

PubMed ID: 8624847

Title: Cloning, expression and genomic organization of human placental protein disulfide isomerase (previously identified as phospholipase C alpha).

PubMed ID: 8624847

DOI: 10.1016/1357-2725(95)00120-4

PubMed ID: 9205111

Title: Structures of the human gene for the protein disulfide isomerase-related polypeptide ERp60 and a processed gene and assignment of these genes to 15q15 and 1q21.

PubMed ID: 9205111

DOI: 10.1006/geno.1997.4750

PubMed ID: 9399589

Title: Functions of characteristic Cys-Gly-His-Cys (CGHC) and Gln-Glu-Asp-Leu (QEDL) motifs of microsomal ER-60 protease.

PubMed ID: 9399589

DOI: 10.1093/oxfordjournals.jbchem.a021830

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9150948

Title: A two-dimensional gel database of human colon carcinoma proteins.

PubMed ID: 9150948

DOI: 10.1002/elps.1150180344

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 1286669

Title: Human liver protein map: a reference database established by microsequencing and gel comparison.

PubMed ID: 1286669

DOI: 10.1002/elps.11501301201

PubMed ID: 9150946

Title: Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2.

PubMed ID: 9150946

DOI: 10.1002/elps.1150180342

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 11825568

Title: Disulfide bond isomerization and the assembly of MHC class I-peptide complexes.

PubMed ID: 11825568

DOI: 10.1016/s1074-7613(02)00263-7

PubMed ID: 11840567

Title: Cluster analysis of an extensive human breast cancer cell line protein expression map database.

PubMed ID: 11840567

DOI: 10.1002/1615-9861(200202)2:2<212::aid-prot212>3.0.co;2-h

PubMed ID: 12643545

Title: Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.

PubMed ID: 12643545

DOI: 10.1021/pr025562r

PubMed ID: 16193070

Title: Tapasin and ERp57 form a stable disulfide-linked dimer within the MHC class I peptide-loading complex.

PubMed ID: 16193070

DOI: 10.1038/sj.emboj.7600814

PubMed ID: 16940051

Title: ERp27, a new non-catalytic endoplasmic reticulum-located human protein disulfide isomerase family member, interacts with ERp57.

PubMed ID: 16940051

DOI: 10.1074/jbc.m604314200

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20400973

Title: Glucose-regulated protein precursor (GRP78) and tumor rejection antigen (GP96) are unique to hamster caput epididymal spermatozoa.

PubMed ID: 20400973

DOI: 10.1038/aja.2010.19

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 24188822

Title: Modulation of H(+),K(+)-ATPase activity by the molecular chaperone ERp57 highly expressed in gastric parietal cells.

PubMed ID: 24188822

DOI: 10.1016/j.febslet.2013.10.030

PubMed ID: 23826168

Title: SERPINA2 is a novel gene with a divergent function from SERPINA1.

PubMed ID: 23826168

DOI: 10.1371/journal.pone.0066889

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27897272

Title: Analysis of the interaction of calcitriol with the disulfide isomerase ERp57.

PubMed ID: 27897272

DOI: 10.1038/srep37957

PubMed ID: 16258833

Title: NMR assignment of the N-terminal domain a of the glycoprotein chaperone ERp57.

PubMed ID: 16258833

DOI: 10.1007/s10858-005-2720-1

PubMed ID: 16905107

Title: Crystal structure of the bb' domains of the protein disulfide isomerase ERp57.

PubMed ID: 16905107

DOI: 10.1016/j.str.2006.06.019

PubMed ID: 19119025

Title: Insights into MHC class I peptide loading from the structure of the tapasin-ERp57 thiol oxidoreductase heterodimer.

PubMed ID: 19119025

DOI: 10.1016/j.immuni.2008.10.018

PubMed ID: 35948544

Title: Molecular basis of MHC I quality control in the peptide loading complex.

PubMed ID: 35948544

DOI: 10.1038/s41467-022-32384-z

PubMed ID: 36104323

Title: Structure of an MHC I-tapasin-ERp57 editing complex defines chaperone promiscuity.

PubMed ID: 36104323

DOI: 10.1038/s41467-022-32841-9

Sequence Information:

  • Length: 505
  • Mass: 56782
  • Checksum: 529E5B6692D0D7E9
  • Sequence:
    • MRLRRLALFP GVALLLAAAR LAAASDVLEL TDDNFESRIS DTGSAGLMLV EFFAPWCGHC 
KRLAPEYEAA ATRLKGIVPL AKVDCTANTN TCNKYGVSGY PTLKIFRDGE EAGAYDGPRT 
ADGIVSHLKK QAGPASVPLR TEEEFKKFIS DKDASIVGFF DDSFSEAHSE FLKAASNLRD 
NYRFAHTNVE SLVNEYDDNG EGIILFRPSH LTNKFEDKTV AYTEQKMTSG KIKKFIQENI 
FGICPHMTED NKDLIQGKDL LIAYYDVDYE KNAKGSNYWR NRVMMVAKKF LDAGHKLNFA 
VASRKTFSHE LSDFGLESTA GEIPVVAIRT AKGEKFVMQE EFSRDGKALE RFLQDYFDGN 
LKRYLKSEPI PESNDGPVKV VVAENFDEIV NNENKDVLIE FYAPWCGHCK NLEPKYKELG 
EKLSKDPNIV IAKMDATAND VPSPYEVRGF PTIYFSPANK KLNPKKYEGG RELSDFISYL 
QREATNPPVI QEEKPKKKKK AQEDL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.