Details for: PDIA3
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 3.78
Marker Score: 2,959 - Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 3.26
Marker Score: 9,526 - Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 3.19
Marker Score: 10,063 - Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 3.17
Marker Score: 8,754 - Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 3.15
Marker Score: 2,689 - Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 3.13
Marker Score: 4,298 - Cell Name: acinar cell (CL0000622)
Fold Change: 3.11
Marker Score: 2,191 - Cell Name: blood cell (CL0000081)
Fold Change: 3.08
Marker Score: 35,788 - Cell Name: secretory cell (CL0000151)
Fold Change: 3.07
Marker Score: 5,597 - Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 3.06
Marker Score: 7,782 - Cell Name: mature T cell (CL0002419)
Fold Change: 3.06
Marker Score: 30,292 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3
Marker Score: 7,335 - Cell Name: mesodermal cell (CL0000222)
Fold Change: 2.97
Marker Score: 39,141 - Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 2.94
Marker Score: 2,845 - Cell Name: cell in vitro (CL0001034)
Fold Change: 2.89
Marker Score: 100,136 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.86
Marker Score: 18,595 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 2.86
Marker Score: 7,659 - Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 2.85
Marker Score: 4,130 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.83
Marker Score: 6,447 - Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 2.81
Marker Score: 2,468 - Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 2.81
Marker Score: 20,880 - Cell Name: lung secretory cell (CL1000272)
Fold Change: 2.8
Marker Score: 2,496 - Cell Name: double negative thymocyte (CL0002489)
Fold Change: 2.8
Marker Score: 3,860 - Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 2.79
Marker Score: 897 - Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 2.79
Marker Score: 7,817 - Cell Name: decidual cell (CL2000002)
Fold Change: 2.74
Marker Score: 11,803 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.73
Marker Score: 93,012 - Cell Name: fibroblast of lung (CL0002553)
Fold Change: 2.73
Marker Score: 7,143 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.71
Marker Score: 648 - Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 2.7
Marker Score: 11,597 - Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 2.7
Marker Score: 6,810 - Cell Name: mucous neck cell (CL0000651)
Fold Change: 2.67
Marker Score: 6,052 - Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 2.67
Marker Score: 1,110 - Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 2.66
Marker Score: 2,178 - Cell Name: myofibroblast cell (CL0000186)
Fold Change: 2.66
Marker Score: 3,278 - Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 2.65
Marker Score: 2,847 - Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 2.65
Marker Score: 4,075 - Cell Name: fibroblast of breast (CL4006000)
Fold Change: 2.64
Marker Score: 1,506 - Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 2.63
Marker Score: 3,870 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.61
Marker Score: 10,062 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 2.6
Marker Score: 16,606 - Cell Name: serous secreting cell (CL0000313)
Fold Change: 2.6
Marker Score: 1,038 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 2.59
Marker Score: 3,124 - Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 2.58
Marker Score: 2,293 - Cell Name: club cell (CL0000158)
Fold Change: 2.55
Marker Score: 2,981 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.55
Marker Score: 28,672 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 2.54
Marker Score: 5,299 - Cell Name: IgA plasma cell (CL0000987)
Fold Change: 2.54
Marker Score: 2,161 - Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 2.53
Marker Score: 2,129 - Cell Name: oogonial cell (CL0000024)
Fold Change: 2.52
Marker Score: 3,623 - Cell Name: Unknown (CL0000548)
Fold Change: 2.51
Marker Score: 1,829 - Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 2.5
Marker Score: 4,905 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 2.5
Marker Score: 2,538 - Cell Name: pneumocyte (CL0000322)
Fold Change: 2.5
Marker Score: 4,019 - Cell Name: theca cell (CL0000503)
Fold Change: 2.48
Marker Score: 1,778 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 2.48
Marker Score: 1,443 - Cell Name: endothelial cell (CL0000115)
Fold Change: 2.47
Marker Score: 2,216 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 2.47
Marker Score: 130,433 - Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 2.46
Marker Score: 4,041 - Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 2.46
Marker Score: 12,926 - Cell Name: epithelial cell (CL0000066)
Fold Change: 2.46
Marker Score: 3,910 - Cell Name: lung macrophage (CL1001603)
Fold Change: 2.45
Marker Score: 2,805 - Cell Name: paneth cell (CL0000510)
Fold Change: 2.42
Marker Score: 1,686 - Cell Name: intestine goblet cell (CL0019031)
Fold Change: 2.42
Marker Score: 2,318 - Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 2.42
Marker Score: 1,625 - Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 2.42
Marker Score: 1,042 - Cell Name: chondrocyte (CL0000138)
Fold Change: 2.41
Marker Score: 1,087 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 2.4
Marker Score: 4,083 - Cell Name: duct epithelial cell (CL0000068)
Fold Change: 2.4
Marker Score: 1,121 - Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 2.4
Marker Score: 2,063 - Cell Name: Sertoli cell (CL0000216)
Fold Change: 2.39
Marker Score: 14,173 - Cell Name: adventitial cell (CL0002503)
Fold Change: 2.38
Marker Score: 588 - Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 2.38
Marker Score: 5,803 - Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 2.38
Marker Score: 1,800 - Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 2.37
Marker Score: 3,936 - Cell Name: basal cell (CL0000646)
Fold Change: 2.36
Marker Score: 3,046 - Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 2.36
Marker Score: 1,071 - Cell Name: stromal cell (CL0000499)
Fold Change: 2.36
Marker Score: 2,760 - Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 2.36
Marker Score: 6,411 - Cell Name: tracheobronchial goblet cell (CL0019003)
Fold Change: 2.35
Marker Score: 644 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 2.34
Marker Score: 4,155 - Cell Name: type II pneumocyte (CL0002063)
Fold Change: 2.34
Marker Score: 15,272 - Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 2.34
Marker Score: 2,547 - Cell Name: kidney cell (CL1000497)
Fold Change: 2.34
Marker Score: 1,560 - Cell Name: endocardial cell (CL0002350)
Fold Change: 2.33
Marker Score: 1,319 - Cell Name: ependymal cell (CL0000065)
Fold Change: 2.33
Marker Score: 813 - Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 2.33
Marker Score: 868 - Cell Name: preosteoblast (CL0007010)
Fold Change: 2.31
Marker Score: 655 - Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 2.31
Marker Score: 1,963 - Cell Name: granulosa cell (CL0000501)
Fold Change: 2.31
Marker Score: 23,257 - Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 2.3
Marker Score: 4,115 - Cell Name: lung ciliated cell (CL1000271)
Fold Change: 2.29
Marker Score: 1,088 - Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 2.29
Marker Score: 660 - Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 2.29
Marker Score: 788 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.28
Marker Score: 127,579 - Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 2.28
Marker Score: 2,143 - Cell Name: promonocyte (CL0000559)
Fold Change: 2.27
Marker Score: 1,465 - Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 2.27
Marker Score: 2,003 - Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 2.27
Marker Score: 786 - Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 2.27
Marker Score: 3,209
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1459090779
Symbol: PDIA3_HUMAN
Name: Protein disulfide-isomerase A3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7945384
Title: Molecular cloning and characterization of a cDNA for bovine phospholipase C-alpha: proposal of redesignation of phospholipase C-alpha.
PubMed ID: 7945384
PubMed ID: 7487104
Title: cDNA cloning and baculovirus expression of the human liver endoplasmic reticulum P58: characterization as a protein disulfide isomerase isoform, but not as a protease or a carnitine acyltransferase.
PubMed ID: 7487104
PubMed ID: 8687406
Title: ERp60 does not substitute for protein disulphide isomerase as the beta-subunit of prolyl 4-hydroxylase.
PubMed ID: 8687406
DOI: 10.1042/bj3160599
PubMed ID: 8624847
Title: Cloning, expression and genomic organization of human placental protein disulfide isomerase (previously identified as phospholipase C alpha).
PubMed ID: 8624847
PubMed ID: 9205111
Title: Structures of the human gene for the protein disulfide isomerase-related polypeptide ERp60 and a processed gene and assignment of these genes to 15q15 and 1q21.
PubMed ID: 9205111
PubMed ID: 9399589
Title: Functions of characteristic Cys-Gly-His-Cys (CGHC) and Gln-Glu-Asp-Leu (QEDL) motifs of microsomal ER-60 protease.
PubMed ID: 9399589
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9150948
Title: A two-dimensional gel database of human colon carcinoma proteins.
PubMed ID: 9150948
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 1286669
Title: Human liver protein map: a reference database established by microsequencing and gel comparison.
PubMed ID: 1286669
PubMed ID: 9150946
Title: Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2.
PubMed ID: 9150946
PubMed ID: 1286667
Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.
PubMed ID: 1286667
PubMed ID: 11825568
Title: Disulfide bond isomerization and the assembly of MHC class I-peptide complexes.
PubMed ID: 11825568
PubMed ID: 11840567
Title: Cluster analysis of an extensive human breast cancer cell line protein expression map database.
PubMed ID: 11840567
DOI: 10.1002/1615-9861(200202)2:2<212::aid-prot212>3.0.co;2-h
PubMed ID: 12643545
Title: Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.
PubMed ID: 12643545
DOI: 10.1021/pr025562r
PubMed ID: 16193070
Title: Tapasin and ERp57 form a stable disulfide-linked dimer within the MHC class I peptide-loading complex.
PubMed ID: 16193070
PubMed ID: 16940051
Title: ERp27, a new non-catalytic endoplasmic reticulum-located human protein disulfide isomerase family member, interacts with ERp57.
PubMed ID: 16940051
PubMed ID: 17081065
Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.
PubMed ID: 17081065
DOI: 10.1021/pr060363j
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20400973
Title: Glucose-regulated protein precursor (GRP78) and tumor rejection antigen (GP96) are unique to hamster caput epididymal spermatozoa.
PubMed ID: 20400973
DOI: 10.1038/aja.2010.19
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22905912
Title: Resveratrol-induced changes of the human adipocyte secretion profile.
PubMed ID: 22905912
DOI: 10.1021/pr300539b
PubMed ID: 24188822
Title: Modulation of H(+),K(+)-ATPase activity by the molecular chaperone ERp57 highly expressed in gastric parietal cells.
PubMed ID: 24188822
PubMed ID: 23826168
Title: SERPINA2 is a novel gene with a divergent function from SERPINA1.
PubMed ID: 23826168
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27897272
Title: Analysis of the interaction of calcitriol with the disulfide isomerase ERp57.
PubMed ID: 27897272
DOI: 10.1038/srep37957
PubMed ID: 16258833
Title: NMR assignment of the N-terminal domain a of the glycoprotein chaperone ERp57.
PubMed ID: 16258833
PubMed ID: 16905107
Title: Crystal structure of the bb' domains of the protein disulfide isomerase ERp57.
PubMed ID: 16905107
PubMed ID: 19119025
Title: Insights into MHC class I peptide loading from the structure of the tapasin-ERp57 thiol oxidoreductase heterodimer.
PubMed ID: 19119025
PubMed ID: 35948544
Title: Molecular basis of MHC I quality control in the peptide loading complex.
PubMed ID: 35948544
PubMed ID: 36104323
Title: Structure of an MHC I-tapasin-ERp57 editing complex defines chaperone promiscuity.
PubMed ID: 36104323
Sequence Information:
- Length: 505
- Mass: 56782
- Checksum: 529E5B6692D0D7E9
- Sequence:
MRLRRLALFP GVALLLAAAR LAAASDVLEL TDDNFESRIS DTGSAGLMLV EFFAPWCGHC KRLAPEYEAA ATRLKGIVPL AKVDCTANTN TCNKYGVSGY PTLKIFRDGE EAGAYDGPRT ADGIVSHLKK QAGPASVPLR TEEEFKKFIS DKDASIVGFF DDSFSEAHSE FLKAASNLRD NYRFAHTNVE SLVNEYDDNG EGIILFRPSH LTNKFEDKTV AYTEQKMTSG KIKKFIQENI FGICPHMTED NKDLIQGKDL LIAYYDVDYE KNAKGSNYWR NRVMMVAKKF LDAGHKLNFA VASRKTFSHE LSDFGLESTA GEIPVVAIRT AKGEKFVMQE EFSRDGKALE RFLQDYFDGN LKRYLKSEPI PESNDGPVKV VVAENFDEIV NNENKDVLIE FYAPWCGHCK NLEPKYKELG EKLSKDPNIV IAKMDATAND VPSPYEVRGF PTIYFSPANK KLNPKKYEGG RELSDFISYL QREATNPPVI QEEKPKKKKK AQEDL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.