Details for: PDIA3
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 699.2179
Cell Significance Index: -108.7600 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 422.8378
Cell Significance Index: -107.2500 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 307.5391
Cell Significance Index: -126.6900 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 273.2129
Cell Significance Index: -128.9900 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 271.4291
Cell Significance Index: -110.2700 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 243.5626
Cell Significance Index: -125.2900 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 192.9296
Cell Significance Index: -129.4600 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 116.1988
Cell Significance Index: -110.9400 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 96.4674
Cell Significance Index: -118.9400 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 30.9170
Cell Significance Index: -122.0000 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 30.9012
Cell Significance Index: -82.7800 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 29.6667
Cell Significance Index: -91.1200 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 13.9633
Cell Significance Index: -30.5600 - Cell Name: peg cell (CL4033014)
Fold Change: 6.4739
Cell Significance Index: 149.5700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 3.7169
Cell Significance Index: 173.3000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 3.6844
Cell Significance Index: 505.9700 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 3.5850
Cell Significance Index: 75.0400 - Cell Name: granulosa cell (CL0000501)
Fold Change: 3.0766
Cell Significance Index: 80.9000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 2.9579
Cell Significance Index: 851.0800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 2.9177
Cell Significance Index: 1593.4000 - Cell Name: kidney cell (CL1000497)
Fold Change: 2.6389
Cell Significance Index: 21.0700 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.6283
Cell Significance Index: 70.1800 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.5089
Cell Significance Index: 68.2900 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.3253
Cell Significance Index: 173.3000 - Cell Name: odontoblast (CL0000060)
Fold Change: 2.2602
Cell Significance Index: 289.7500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 2.2013
Cell Significance Index: 396.8300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 2.1589
Cell Significance Index: 265.4600 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.0054
Cell Significance Index: 138.6800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.8604
Cell Significance Index: 87.4400 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.6626
Cell Significance Index: 86.6000 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.4850
Cell Significance Index: 241.5100 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.4716
Cell Significance Index: 650.6500 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.4640
Cell Significance Index: 172.6500 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.4620
Cell Significance Index: 188.8800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.3996
Cell Significance Index: 277.7500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.1991
Cell Significance Index: 228.1900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.9837
Cell Significance Index: 167.9700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.9629
Cell Significance Index: 193.1600 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.9393
Cell Significance Index: 32.6400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.9237
Cell Significance Index: 65.3300 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.8767
Cell Significance Index: 9.9600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.8363
Cell Significance Index: 53.9600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.8105
Cell Significance Index: 17.5600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7217
Cell Significance Index: 20.8000 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.6760
Cell Significance Index: 4.2000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.6722
Cell Significance Index: 30.4700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.5800
Cell Significance Index: 208.0500 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.5156
Cell Significance Index: 14.7800 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.3698
Cell Significance Index: 10.8600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.3491
Cell Significance Index: 19.5900 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2964
Cell Significance Index: 204.9900 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2575
Cell Significance Index: 232.5100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.2202
Cell Significance Index: 166.7000 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.1335
Cell Significance Index: 97.8800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0249
Cell Significance Index: 46.8000 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0239
Cell Significance Index: 0.4000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0227
Cell Significance Index: 1.1800 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0046
Cell Significance Index: 8.5200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0378
Cell Significance Index: -27.9900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0389
Cell Significance Index: -59.9000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0497
Cell Significance Index: -5.0800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0653
Cell Significance Index: -3.4300 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.0675
Cell Significance Index: -0.8600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0743
Cell Significance Index: -46.4200 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0756
Cell Significance Index: -102.8500 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1133
Cell Significance Index: -71.9300 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.1481
Cell Significance Index: -1.6100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1512
Cell Significance Index: -68.6400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1534
Cell Significance Index: -86.4900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1696
Cell Significance Index: -4.7400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2338
Cell Significance Index: -49.2400 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.2594
Cell Significance Index: -25.6600 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.3833
Cell Significance Index: -3.5300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.4309
Cell Significance Index: -15.1400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.5185
Cell Significance Index: -59.4100 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.5383
Cell Significance Index: -9.9500 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.6393
Cell Significance Index: -92.9300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.6805
Cell Significance Index: -79.3100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.7110
Cell Significance Index: -54.5600 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.7746
Cell Significance Index: -4.6800 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.8890
Cell Significance Index: -54.6400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.0065
Cell Significance Index: -25.1600 - Cell Name: pro-T cell (CL0000827)
Fold Change: -1.0283
Cell Significance Index: -26.2700 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -1.0509
Cell Significance Index: -119.9600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.1182
Cell Significance Index: -116.4300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.2408
Cell Significance Index: -39.7400 - Cell Name: preadipocyte (CL0002334)
Fold Change: -1.2415
Cell Significance Index: -24.2300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.3523
Cell Significance Index: -90.9300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.4032
Cell Significance Index: -111.1300 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -1.4178
Cell Significance Index: -37.9300 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.5414
Cell Significance Index: -21.0300 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -1.6151
Cell Significance Index: -28.5400 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.6663
Cell Significance Index: -105.0200 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -1.7153
Cell Significance Index: -86.6900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.8411
Cell Significance Index: -112.8800 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -1.8987
Cell Significance Index: -19.6600 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.9332
Cell Significance Index: -56.9400 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -2.0148
Cell Significance Index: -89.1200 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -2.3846
Cell Significance Index: -63.9000 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -2.5389
Cell Significance Index: -96.1400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1459090779
Symbol: PDIA3_HUMAN
Name: Protein disulfide-isomerase A3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7945384
Title: Molecular cloning and characterization of a cDNA for bovine phospholipase C-alpha: proposal of redesignation of phospholipase C-alpha.
PubMed ID: 7945384
PubMed ID: 7487104
Title: cDNA cloning and baculovirus expression of the human liver endoplasmic reticulum P58: characterization as a protein disulfide isomerase isoform, but not as a protease or a carnitine acyltransferase.
PubMed ID: 7487104
PubMed ID: 8687406
Title: ERp60 does not substitute for protein disulphide isomerase as the beta-subunit of prolyl 4-hydroxylase.
PubMed ID: 8687406
DOI: 10.1042/bj3160599
PubMed ID: 8624847
Title: Cloning, expression and genomic organization of human placental protein disulfide isomerase (previously identified as phospholipase C alpha).
PubMed ID: 8624847
PubMed ID: 9205111
Title: Structures of the human gene for the protein disulfide isomerase-related polypeptide ERp60 and a processed gene and assignment of these genes to 15q15 and 1q21.
PubMed ID: 9205111
PubMed ID: 9399589
Title: Functions of characteristic Cys-Gly-His-Cys (CGHC) and Gln-Glu-Asp-Leu (QEDL) motifs of microsomal ER-60 protease.
PubMed ID: 9399589
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9150948
Title: A two-dimensional gel database of human colon carcinoma proteins.
PubMed ID: 9150948
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 1286669
Title: Human liver protein map: a reference database established by microsequencing and gel comparison.
PubMed ID: 1286669
PubMed ID: 9150946
Title: Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2.
PubMed ID: 9150946
PubMed ID: 1286667
Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.
PubMed ID: 1286667
PubMed ID: 11825568
Title: Disulfide bond isomerization and the assembly of MHC class I-peptide complexes.
PubMed ID: 11825568
PubMed ID: 11840567
Title: Cluster analysis of an extensive human breast cancer cell line protein expression map database.
PubMed ID: 11840567
DOI: 10.1002/1615-9861(200202)2:2<212::aid-prot212>3.0.co;2-h
PubMed ID: 12643545
Title: Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.
PubMed ID: 12643545
DOI: 10.1021/pr025562r
PubMed ID: 16193070
Title: Tapasin and ERp57 form a stable disulfide-linked dimer within the MHC class I peptide-loading complex.
PubMed ID: 16193070
PubMed ID: 16940051
Title: ERp27, a new non-catalytic endoplasmic reticulum-located human protein disulfide isomerase family member, interacts with ERp57.
PubMed ID: 16940051
PubMed ID: 17081065
Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.
PubMed ID: 17081065
DOI: 10.1021/pr060363j
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20400973
Title: Glucose-regulated protein precursor (GRP78) and tumor rejection antigen (GP96) are unique to hamster caput epididymal spermatozoa.
PubMed ID: 20400973
DOI: 10.1038/aja.2010.19
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22905912
Title: Resveratrol-induced changes of the human adipocyte secretion profile.
PubMed ID: 22905912
DOI: 10.1021/pr300539b
PubMed ID: 24188822
Title: Modulation of H(+),K(+)-ATPase activity by the molecular chaperone ERp57 highly expressed in gastric parietal cells.
PubMed ID: 24188822
PubMed ID: 23826168
Title: SERPINA2 is a novel gene with a divergent function from SERPINA1.
PubMed ID: 23826168
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27897272
Title: Analysis of the interaction of calcitriol with the disulfide isomerase ERp57.
PubMed ID: 27897272
DOI: 10.1038/srep37957
PubMed ID: 16258833
Title: NMR assignment of the N-terminal domain a of the glycoprotein chaperone ERp57.
PubMed ID: 16258833
PubMed ID: 16905107
Title: Crystal structure of the bb' domains of the protein disulfide isomerase ERp57.
PubMed ID: 16905107
PubMed ID: 19119025
Title: Insights into MHC class I peptide loading from the structure of the tapasin-ERp57 thiol oxidoreductase heterodimer.
PubMed ID: 19119025
PubMed ID: 35948544
Title: Molecular basis of MHC I quality control in the peptide loading complex.
PubMed ID: 35948544
PubMed ID: 36104323
Title: Structure of an MHC I-tapasin-ERp57 editing complex defines chaperone promiscuity.
PubMed ID: 36104323
Sequence Information:
- Length: 505
- Mass: 56782
- Checksum: 529E5B6692D0D7E9
- Sequence:
MRLRRLALFP GVALLLAAAR LAAASDVLEL TDDNFESRIS DTGSAGLMLV EFFAPWCGHC KRLAPEYEAA ATRLKGIVPL AKVDCTANTN TCNKYGVSGY PTLKIFRDGE EAGAYDGPRT ADGIVSHLKK QAGPASVPLR TEEEFKKFIS DKDASIVGFF DDSFSEAHSE FLKAASNLRD NYRFAHTNVE SLVNEYDDNG EGIILFRPSH LTNKFEDKTV AYTEQKMTSG KIKKFIQENI FGICPHMTED NKDLIQGKDL LIAYYDVDYE KNAKGSNYWR NRVMMVAKKF LDAGHKLNFA VASRKTFSHE LSDFGLESTA GEIPVVAIRT AKGEKFVMQE EFSRDGKALE RFLQDYFDGN LKRYLKSEPI PESNDGPVKV VVAENFDEIV NNENKDVLIE FYAPWCGHCK NLEPKYKELG EKLSKDPNIV IAKMDATAND VPSPYEVRGF PTIYFSPANK KLNPKKYEGG RELSDFISYL QREATNPPVI QEEKPKKKKK AQEDL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.