Details for: MRM2

Gene ID: 29960

Symbol: MRM2

Ensembl ID: ENSG00000122687

Description: mitochondrial rRNA methyltransferase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 31.1995
    Cell Significance Index: -14.7300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 28.5584
    Cell Significance Index: -14.6900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 4.9272
    Cell Significance Index: 102.2100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.6135
    Cell Significance Index: -9.6800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.3372
    Cell Significance Index: -10.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.4275
    Cell Significance Index: 69.9400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 2.2388
    Cell Significance Index: 47.6800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.1637
    Cell Significance Index: 29.7300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8721
    Cell Significance Index: 787.4300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7556
    Cell Significance Index: 122.9000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.6975
    Cell Significance Index: 22.3400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5169
    Cell Significance Index: 51.1300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4911
    Cell Significance Index: 33.9600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4875
    Cell Significance Index: 16.9400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4873
    Cell Significance Index: 13.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4020
    Cell Significance Index: 55.2100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4018
    Cell Significance Index: 28.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3989
    Cell Significance Index: 71.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3563
    Cell Significance Index: 70.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3534
    Cell Significance Index: 43.4500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3447
    Cell Significance Index: 40.6600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3363
    Cell Significance Index: 21.7000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3339
    Cell Significance Index: 3.0800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2928
    Cell Significance Index: 129.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2489
    Cell Significance Index: 135.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2088
    Cell Significance Index: 26.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1843
    Cell Significance Index: 4.8500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1781
    Cell Significance Index: 2.5000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1744
    Cell Significance Index: 4.3600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1715
    Cell Significance Index: 3.5900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1547
    Cell Significance Index: 31.0400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1379
    Cell Significance Index: 26.2400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1106
    Cell Significance Index: 1.1500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0892
    Cell Significance Index: 0.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0834
    Cell Significance Index: 4.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0790
    Cell Significance Index: 5.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0590
    Cell Significance Index: 7.6200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0521
    Cell Significance Index: 18.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0507
    Cell Significance Index: 2.3900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0440
    Cell Significance Index: 1.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0335
    Cell Significance Index: 1.8800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0252
    Cell Significance Index: 0.7400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0117
    Cell Significance Index: 8.8400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0052
    Cell Significance Index: 0.1400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0050
    Cell Significance Index: 0.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0014
    Cell Significance Index: 1.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0064
    Cell Significance Index: -0.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0117
    Cell Significance Index: -8.6900
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0128
    Cell Significance Index: -0.0800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0129
    Cell Significance Index: -1.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0157
    Cell Significance Index: -0.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0181
    Cell Significance Index: -10.2000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0243
    Cell Significance Index: -15.2000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0265
    Cell Significance Index: -0.3400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0335
    Cell Significance Index: -9.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0451
    Cell Significance Index: -7.7000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0466
    Cell Significance Index: -0.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0511
    Cell Significance Index: -3.9300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0511
    Cell Significance Index: -0.5800
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0543
    Cell Significance Index: -0.4100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0690
    Cell Significance Index: -14.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0714
    Cell Significance Index: -8.3300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0718
    Cell Significance Index: -1.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0741
    Cell Significance Index: -1.2400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0830
    Cell Significance Index: -0.9900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0935
    Cell Significance Index: -2.1600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0984
    Cell Significance Index: -4.4600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0989
    Cell Significance Index: -4.0500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1020
    Cell Significance Index: -6.2700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.1159
    Cell Significance Index: -0.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1206
    Cell Significance Index: -9.5500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1228
    Cell Significance Index: -2.6600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1583
    Cell Significance Index: -4.0700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1683
    Cell Significance Index: -10.3200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2153
    Cell Significance Index: -3.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2205
    Cell Significance Index: -9.7600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2272
    Cell Significance Index: -4.2000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2379
    Cell Significance Index: -3.9200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2403
    Cell Significance Index: -12.5200
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.2504
    Cell Significance Index: -3.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2646
    Cell Significance Index: -10.0200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2838
    Cell Significance Index: -8.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2863
    Cell Significance Index: -14.8700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3051
    Cell Significance Index: -9.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3108
    Cell Significance Index: -14.4900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3160
    Cell Significance Index: -11.0700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3190
    Cell Significance Index: -11.7100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3286
    Cell Significance Index: -10.4700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.3438
    Cell Significance Index: -2.0400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.3443
    Cell Significance Index: -4.8300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3461
    Cell Significance Index: -9.9200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3722
    Cell Significance Index: -10.1300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3796
    Cell Significance Index: -5.4400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3845
    Cell Significance Index: -3.2300
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.3922
    Cell Significance Index: -3.3700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3941
    Cell Significance Index: -8.6300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3955
    Cell Significance Index: -2.6800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4084
    Cell Significance Index: -7.9700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4146
    Cell Significance Index: -8.8000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4274
    Cell Significance Index: -10.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MRM2 is a mitochondrial enzyme responsible for the 2'-O-methylation of mitochondrial rRNA (mRNA). This process is essential for the proper folding and maturation of mitochondrial ribosomes, which are responsible for protein synthesis in the mitochondria. MRM2 is a member of the RNA methyltransferase family and shares homology with other enzymes involved in RNA methylation, such as Nop1 and Nop2 in yeast. **Pathways and Functions:** The MRM2 gene is involved in several cellular pathways, including: 1. **Mitochondrial large ribosomal subunit assembly**: MRM2 plays a crucial role in the assembly of the large ribosomal subunit, which is essential for protein synthesis in the mitochondria. 2. **Mitochondrial matrix**: MRM2 is also involved in the regulation of mitochondrial matrix function, which is critical for energy production and cellular metabolism. 3. **RNA methylation**: MRM2 is a key enzyme in the methylation of mitochondrial rRNA, which is essential for the proper folding and maturation of ribosomes. 4. **RNA processing**: MRM2 is involved in the processing of mitochondrial rRNA, which is necessary for the production of functional ribosomes. **Clinical Significance:** Dysregulation of MRM2 has been implicated in various diseases, including: 1. **Mitochondrial disorders**: Mutations in the MRM2 gene have been associated with mitochondrial disorders, such as MERRF syndrome, which is characterized by muscle weakness, ataxia, and neuropathy. 2. **Cancer**: Aberrant expression of MRM2 has been observed in certain types of cancer, including leukemia and lymphoma, suggesting its potential role in tumorigenesis. 3. **Neurodegenerative diseases**: MRM2 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where mitochondrial dysfunction is a hallmark of the disease. In conclusion, the MRM2 gene plays a critical role in the regulation of mitochondrial function and cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of this enzyme in maintaining cellular health. Further research is necessary to fully elucidate the role of MRM2 in human disease and to explore its potential as a therapeutic target. **Significantly expressed cells:** Tracheal goblet cell, cardiac endothelial cell, extravillous trophoblast, placental villous trophoblast, cardiac muscle myoblast, pancreatic A cell, enterocyte of epithelium of small intestine, proerythroblast, primordial germ cell, myeloid dendritic cell. **Proteins:** MRM2_HUMAN **References:** [Insert relevant references] Note: The references section is not provided as it is not part of the original text. However, it is essential to include relevant references to support the discussion and provide a comprehensive understanding of the topic.

Genular Protein ID: 3768740574

Symbol: MRM2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UI43 Q24JR8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 9 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 EMDB 3 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11827451

Title: Identification and characterization of FTSJ2, a novel human nucleolar protein homologous to bacterial ribosomal RNA methyltransferase.

PubMed ID: 11827451

DOI: 10.1006/geno.2001.6670

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24036117

Title: Mitochondrial ribosomal RNA (rRNA) methyltransferase family members are positioned to modify nascent rRNA in foci near the mitochondrial DNA nucleoid.

PubMed ID: 24036117

DOI: 10.1074/jbc.m113.515692

PubMed ID: 25074936

Title: Assignment of 2'-O-methyltransferases to modification sites on the mammalian mitochondrial large subunit 16S rRNA.

PubMed ID: 25074936

DOI: 10.1074/jbc.c114.581868

PubMed ID: 25009282

Title: MRM2 and MRM3 are involved in biogenesis of the large subunit of the mitochondrial ribosome.

PubMed ID: 25009282

DOI: 10.1091/mbc.e14-01-0014

PubMed ID: 35177605

Title: A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.

PubMed ID: 35177605

DOI: 10.1038/s41467-022-28503-5

PubMed ID: 28973171

Title: Defective mitochondrial rRNA methyltransferase MRM2 causes MELAS-like clinical syndrome.

PubMed ID: 28973171

DOI: 10.1093/hmg/ddx314

Sequence Information:

  • Length: 246
  • Mass: 27424
  • Checksum: DB7B9978695409D1
  • Sequence:
    • MAGYLKLVCV SFQRQGFHTV GSRCKNRTGA EHLWLTRHLR DPFVKAAKVE SYRCRSAFKL 
LEVNERHQIL RPGLRVLDCG AAPGAWSQVA VQKVNAAGTD PSSPVGFVLG VDLLHIFPLE 
GATFLCPADV TDPRTSQRIL EVLPGRRADV ILSDMAPNAT GFRDLDHDRL ISLCLTLLSV 
TPDILQPGGT FLCKTWAGSQ SRRLQRRLTE EFQNVRIIKP EASRKESSEV YFLATQYHGR 
KGTVKQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.