Details for: H1 3

Gene ID: 3007

Symbol: H1 3

Ensembl ID: ENSG00000124575

Description: H1.3 linker histone, cluster member

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 3.14
    Marker Score: 2303
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.89
    Marker Score: 1246
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.49
    Marker Score: 25201
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.36
    Marker Score: 1177
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.14
    Marker Score: 1682.5
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 1.9
    Marker Score: 524
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.88
    Marker Score: 2260.5
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.88
    Marker Score: 1100
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.85
    Marker Score: 21544
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.82
    Marker Score: 564
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.8
    Marker Score: 3150
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.78
    Marker Score: 4845
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.74
    Marker Score: 4878
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.59
    Marker Score: 1872.5
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.54
    Marker Score: 1488
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.51
    Marker Score: 1007
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.5
    Marker Score: 5536
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.47
    Marker Score: 2874
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.36
    Marker Score: 1372
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.31
    Marker Score: 458
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.3
    Marker Score: 2209
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.28
    Marker Score: 1607
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.26
    Marker Score: 3080
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.18
    Marker Score: 359
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.17
    Marker Score: 797.5
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.12
    Marker Score: 390
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.09
    Marker Score: 360
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.06
    Marker Score: 719
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.06
    Marker Score: 1891
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.06
    Marker Score: 523
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.05
    Marker Score: 239
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.05
    Marker Score: 1399
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.04
    Marker Score: 2184
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.04
    Marker Score: 508
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 1.03
    Marker Score: 271
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.03
    Marker Score: 541
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 1.02
    Marker Score: 398
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.02
    Marker Score: 54009
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.01
    Marker Score: 4137
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1
    Marker Score: 1474
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71749
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47974
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.99
    Marker Score: 2701
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.99
    Marker Score: 1070.5
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.98
    Marker Score: 878
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30401
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.97
    Marker Score: 709
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.97
    Marker Score: 643
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.95
    Marker Score: 512
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 489
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2404
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 444
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.94
    Marker Score: 823
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.93
    Marker Score: 700
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.93
    Marker Score: 743
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5257
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.91
    Marker Score: 7972
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2719
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.89
    Marker Score: 2638
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.88
    Marker Score: 232
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.88
    Marker Score: 5628
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 314
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.87
    Marker Score: 820
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.87
    Marker Score: 1197
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5256
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.87
    Marker Score: 770
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.86
    Marker Score: 2728
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.86
    Marker Score: 1220
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.85
    Marker Score: 1030
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.85
    Marker Score: 887
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.85
    Marker Score: 414
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.84
    Marker Score: 535
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.84
    Marker Score: 894
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.83
    Marker Score: 510
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.82
    Marker Score: 1461
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.82
    Marker Score: 599.5
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.81
    Marker Score: 677
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.81
    Marker Score: 1311
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.79
    Marker Score: 273
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.79
    Marker Score: 379
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 311
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.76
    Marker Score: 429.5
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.75
    Marker Score: 480
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.74
    Marker Score: 962
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.74
    Marker Score: 695
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.74
    Marker Score: 306
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.73
    Marker Score: 687
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 380
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 557
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.73
    Marker Score: 488
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.72
    Marker Score: 398
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 656
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.71
    Marker Score: 4236
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.71
    Marker Score: 261
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.71
    Marker Score: 511
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.71
    Marker Score: 502
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.69
    Marker Score: 435
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.68
    Marker Score: 237

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Other Information

**Key characteristics**: - H1.3 is a histone with a conserved N-terminal tail rich in lysine and arginine residues. - It is found in the nucleus of eukaryotic cells and is associated with chromatin remodeling complexes. - H1.3 is a key regulator of cell death and is involved in the regulation of apoptosis, DNA damage response, and cellular senescence. **Pathways and functions**: - H1.3 is involved in apoptosis by promoting the formation of senescence-associated heterochromatin foci (sahf), which are characterized by the presence of heterochromatin domains. - It also interacts with DNA damage response pathways and regulates the expression of genes involved in DNA repair and cell cycle checkpoints. - H1.3 is involved in cellular responses to stress, such as DNA damage and nutrient deprivation. - It plays a role in cellular senescence by promoting the formation of heterochromatin and inhibiting gene expression. - It is also involved in the regulation of immune responses, as it is expressed in immune cells and regulates the differentiation and function of effector and regulatory T cells. **Clinical significance**: - Mutations in H1.3 have been linked to various human diseases, including cancer, autoimmune disorders, and neurodegenerative diseases. - Targeting H1.3 has emerged as a potential therapeutic strategy for cancer and other diseases that are characterized by genomic instability.

Genular Protein ID: 3120776653

Symbol: H13_HUMAN

Name: Histone H1.3

UniProtKB Accession Codes:

P16402 B2R751 Q2M2I2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 2 EPD 1 Ensembl 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PDB 1 PDBsum 1 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1916825

Title: Isolation and characterization of two human H1 histone genes within clusters of core histone genes.

PubMed ID: 1916825

DOI: 10.1016/0888-7543(91)90183-f

PubMed ID: 12408966

Title: The human and mouse replication-dependent histone genes.

PubMed ID: 12408966

DOI: 10.1016/s0888-7543(02)96850-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2613692

Title: Human spleen histone H1. Isolation and amino acid sequences of three minor variants, H1a, H1c, and H1d.

PubMed ID: 2613692

DOI: 10.1093/oxfordjournals.jbchem.a122941

PubMed ID: 8003976

Title: A proposal for a coherent mammalian histone H1 nomenclature correlated with amino acid sequences.

PubMed ID: 8003976

DOI: 10.1002/pro.5560030406

PubMed ID: 10997781

Title: The distribution of somatic H1 subtypes is non-random on active vs. inactive chromatin: distribution in human fetal fibroblasts.

PubMed ID: 10997781

DOI: 10.1023/a:1009262819961

PubMed ID: 11746507

Title: Distribution of somatic H1 subtypes is non-random on active vs. inactive chromatin II: distribution in human adult fibroblasts.

PubMed ID: 11746507

DOI: 10.1002/jcb.1224

PubMed ID: 15911621

Title: H1 family histones in the nucleus. Control of binding and localization by the C-terminal domain.

PubMed ID: 15911621

DOI: 10.1074/jbc.m501627200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27105115

Title: Metabolic regulation of gene expression by histone lysine beta-hydroxybutyrylation.

PubMed ID: 27105115

DOI: 10.1016/j.molcel.2016.03.036

Sequence Information:

  • Length: 221
  • Mass: 22350
  • Checksum: DB987FE8DE034D12
  • Sequence:
    • MSETAPLAPT IPAPAEKTPV KKKAKKAGAT AGKRKASGPP VSELITKAVA ASKERSGVSL 
AALKKALAAA GYDVEKNNSR IKLGLKSLVS KGTLVQTKGT GASGSFKLNK KAASGEGKPK 
AKKAGAAKPR KPAGAAKKPK KVAGAATPKK SIKKTPKKVK KPATAAGTKK VAKSAKKVKT 
PQPKKAAKSP AKAKAPKPKA AKPKSGKPKV TKAKKAAPKK K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.