Details for: H1 3

Gene ID: 3007

Symbol: H1 3

Ensembl ID: ENSG00000124575

Description: H1.3 linker histone, cluster member

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 46.3531
    Cell Significance Index: -7.2100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 42.8300
    Cell Significance Index: -17.4000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 42.0669
    Cell Significance Index: -10.6700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 37.7974
    Cell Significance Index: -17.8500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.5760
    Cell Significance Index: -18.6900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.8553
    Cell Significance Index: -15.8500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.7211
    Cell Significance Index: 304.5800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.2169
    Cell Significance Index: -16.6400
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 3.4917
    Cell Significance Index: 19.8500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.3209
    Cell Significance Index: -10.2000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.9113
    Cell Significance Index: 15.8800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.4354
    Cell Significance Index: -5.3300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.0445
    Cell Significance Index: 20.5000
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.7580
    Cell Significance Index: 18.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3338
    Cell Significance Index: 131.9400
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.1027
    Cell Significance Index: 9.1200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.0513
    Cell Significance Index: 54.7600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.0218
    Cell Significance Index: 14.3300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9511
    Cell Significance Index: 103.4500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8935
    Cell Significance Index: 53.6400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8920
    Cell Significance Index: 105.1900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8506
    Cell Significance Index: 138.3500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.7607
    Cell Significance Index: 22.3400
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.6145
    Cell Significance Index: 5.9900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.6092
    Cell Significance Index: 9.1800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.5859
    Cell Significance Index: 6.3700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5371
    Cell Significance Index: 485.0000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4364
    Cell Significance Index: 30.1800
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 0.3733
    Cell Significance Index: 0.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3532
    Cell Significance Index: 19.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3455
    Cell Significance Index: 15.6600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3148
    Cell Significance Index: 6.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3068
    Cell Significance Index: 8.8400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3064
    Cell Significance Index: 4.7400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2984
    Cell Significance Index: 7.4600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2678
    Cell Significance Index: 3.4300
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.2652
    Cell Significance Index: 1.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1738
    Cell Significance Index: 76.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1468
    Cell Significance Index: 6.9000
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.1254
    Cell Significance Index: 1.3000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1108
    Cell Significance Index: 2.4000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1042
    Cell Significance Index: 7.3700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0995
    Cell Significance Index: 54.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0801
    Cell Significance Index: 11.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0656
    Cell Significance Index: 11.8300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0640
    Cell Significance Index: 12.1800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0428
    Cell Significance Index: 1.3700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0272
    Cell Significance Index: 0.7600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0228
    Cell Significance Index: 0.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0139
    Cell Significance Index: 0.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0026
    Cell Significance Index: -0.9400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0082
    Cell Significance Index: -15.3900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0104
    Cell Significance Index: -0.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0124
    Cell Significance Index: -9.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0143
    Cell Significance Index: -22.0000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0146
    Cell Significance Index: -9.1000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0215
    Cell Significance Index: -0.8800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0216
    Cell Significance Index: -16.3600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0263
    Cell Significance Index: -0.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0284
    Cell Significance Index: -16.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0287
    Cell Significance Index: -21.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0302
    Cell Significance Index: -13.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0328
    Cell Significance Index: -20.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0381
    Cell Significance Index: -7.5600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0438
    Cell Significance Index: -9.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0448
    Cell Significance Index: -5.5100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0517
    Cell Significance Index: -1.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0577
    Cell Significance Index: -9.8600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0617
    Cell Significance Index: -17.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0652
    Cell Significance Index: -1.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0693
    Cell Significance Index: -8.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0719
    Cell Significance Index: -4.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0734
    Cell Significance Index: -7.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0799
    Cell Significance Index: -16.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1317
    Cell Significance Index: -15.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1360
    Cell Significance Index: -19.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1409
    Cell Significance Index: -18.2000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1493
    Cell Significance Index: -15.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1767
    Cell Significance Index: -9.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1961
    Cell Significance Index: -15.0500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2253
    Cell Significance Index: -3.7700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2307
    Cell Significance Index: -5.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2368
    Cell Significance Index: -17.6500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2434
    Cell Significance Index: -2.5200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2443
    Cell Significance Index: -6.5400
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.2444
    Cell Significance Index: -2.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2670
    Cell Significance Index: -21.1500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.3050
    Cell Significance Index: -1.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3146
    Cell Significance Index: -16.5200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3385
    Cell Significance Index: -2.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3439
    Cell Significance Index: -8.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3642
    Cell Significance Index: -16.9800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3835
    Cell Significance Index: -24.1700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3870
    Cell Significance Index: -5.2800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3920
    Cell Significance Index: -17.3400
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.3975
    Cell Significance Index: -2.8900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4138
    Cell Significance Index: -15.1900
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.4228
    Cell Significance Index: -2.6600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.4249
    Cell Significance Index: -2.6400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.4339
    Cell Significance Index: -6.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural role:** H1.3 linker histone is a small, positively charged protein that associates with linker DNA between nucleosomes, helping to compact chromatin and maintain its structure. 2. **Regulatory function:** H1.3 linker histone regulates gene expression by influencing chromatin conformation and accessibility to transcriptional machinery. 3. **Cellular localization:** H1.3 linker histone is predominantly expressed in immune cells, including T cells, B cells, and NK cells. 4. **Protein-protein interactions:** H1.3 linker histone interacts with other chromatin-associated proteins, such as histones, non-histone chromatin proteins, and transcription factors. **Pathways and Functions:** 1. **Apoptosis and DNA fragmentation:** H1.3 linker histone is involved in the regulation of apoptosis-induced DNA fragmentation, a process critical for eliminating damaged or unwanted cells. 2. **Cellular responses to stress:** H1.3 linker histone plays a role in responding to cellular stress, including DNA damage, telomere stress, and senescence. 3. **Chromatin remodeling:** H1.3 linker histone participates in chromatin remodeling, a process that reorganizes chromatin structure to facilitate gene expression. 4. **Transcriptional regulation:** H1.3 linker histone influences transcriptional regulation by modulating chromatin conformation and accessibility to transcriptional machinery. **Clinical Significance:** 1. **Cancer:** Dysregulation of H1.3 linker histone has been implicated in various cancers, including lymphoma and leukemia, where it contributes to chromatin instability and aberrant gene expression. 2. **Autoimmune disorders:** H1.3 linker histone has been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where it influences chromatin structure and immune cell function. 3. **Immunotherapy:** H1.3 linker histone may serve as a therapeutic target for immunotherapies, such as checkpoint inhibitors, which aim to modulate immune cell function and enhance anti-tumor responses. 4. **Gene expression regulation:** Understanding the role of H1.3 linker histone in regulating gene expression may provide insights into the development of novel therapeutic strategies for various diseases. In conclusion, the H1.3 linker histone is a critical component of chromatin structure and function, playing a pivotal role in regulating gene expression, apoptosis, and cellular responses to stress. Its dysregulation has been implicated in various diseases, including cancer and autoimmune disorders, making it a promising target for therapeutic interventions.

Genular Protein ID: 3120776653

Symbol: H13_HUMAN

Name: Histone H1.3

UniProtKB Accession Codes:

P16402 B2R751 Q2M2I2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1916825

Title: Isolation and characterization of two human H1 histone genes within clusters of core histone genes.

PubMed ID: 1916825

DOI: 10.1016/0888-7543(91)90183-f

PubMed ID: 12408966

Title: The human and mouse replication-dependent histone genes.

PubMed ID: 12408966

DOI: 10.1016/s0888-7543(02)96850-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2613692

Title: Human spleen histone H1. Isolation and amino acid sequences of three minor variants, H1a, H1c, and H1d.

PubMed ID: 2613692

DOI: 10.1093/oxfordjournals.jbchem.a122941

PubMed ID: 8003976

Title: A proposal for a coherent mammalian histone H1 nomenclature correlated with amino acid sequences.

PubMed ID: 8003976

DOI: 10.1002/pro.5560030406

PubMed ID: 10997781

Title: The distribution of somatic H1 subtypes is non-random on active vs. inactive chromatin: distribution in human fetal fibroblasts.

PubMed ID: 10997781

DOI: 10.1023/a:1009262819961

PubMed ID: 11746507

Title: Distribution of somatic H1 subtypes is non-random on active vs. inactive chromatin II: distribution in human adult fibroblasts.

PubMed ID: 11746507

DOI: 10.1002/jcb.1224

PubMed ID: 15911621

Title: H1 family histones in the nucleus. Control of binding and localization by the C-terminal domain.

PubMed ID: 15911621

DOI: 10.1074/jbc.m501627200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27105115

Title: Metabolic regulation of gene expression by histone lysine beta-hydroxybutyrylation.

PubMed ID: 27105115

DOI: 10.1016/j.molcel.2016.03.036

Sequence Information:

  • Length: 221
  • Mass: 22350
  • Checksum: DB987FE8DE034D12
  • Sequence:
    • MSETAPLAPT IPAPAEKTPV KKKAKKAGAT AGKRKASGPP VSELITKAVA ASKERSGVSL 
AALKKALAAA GYDVEKNNSR IKLGLKSLVS KGTLVQTKGT GASGSFKLNK KAASGEGKPK 
AKKAGAAKPR KPAGAAKKPK KVAGAATPKK SIKKTPKKVK KPATAAGTKK VAKSAKKVKT 
PQPKKAAKSP AKAKAPKPKA AKPKSGKPKV TKAKKAAPKK K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.