Details for: POLR1H

Gene ID: 30834

Symbol: POLR1H

Ensembl ID: ENSG00000066379

Description: RNA polymerase I subunit H

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 151.7887
    Cell Significance Index: -23.6100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 71.7810
    Cell Significance Index: -29.5700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 68.2327
    Cell Significance Index: -27.7200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 61.7001
    Cell Significance Index: -29.1300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 57.5055
    Cell Significance Index: -29.5800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 56.6938
    Cell Significance Index: -14.3800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 43.3667
    Cell Significance Index: -29.1000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 29.6467
    Cell Significance Index: -28.3100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.2984
    Cell Significance Index: -26.2600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.0247
    Cell Significance Index: -27.7200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 5.1520
    Cell Significance Index: 128.4800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.9618
    Cell Significance Index: -15.2400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.6775
    Cell Significance Index: -5.8600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.0872
    Cell Significance Index: 125.3100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.0525
    Cell Significance Index: 60.2800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.9063
    Cell Significance Index: 207.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.7767
    Cell Significance Index: 48.3600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.7532
    Cell Significance Index: 19.0600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.5426
    Cell Significance Index: 19.7600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5003
    Cell Significance Index: 244.0100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4359
    Cell Significance Index: 74.5900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.1423
    Cell Significance Index: 23.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8869
    Cell Significance Index: 57.2200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8682
    Cell Significance Index: 61.4000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8552
    Cell Significance Index: 100.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8407
    Cell Significance Index: 115.4500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.8283
    Cell Significance Index: 9.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8073
    Cell Significance Index: 99.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7580
    Cell Significance Index: 136.6400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7443
    Cell Significance Index: 51.4800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7174
    Cell Significance Index: 24.9300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7000
    Cell Significance Index: 20.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6628
    Cell Significance Index: 293.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6148
    Cell Significance Index: 335.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5629
    Cell Significance Index: 26.4600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5312
    Cell Significance Index: 479.6000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4799
    Cell Significance Index: 12.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3935
    Cell Significance Index: 38.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3629
    Cell Significance Index: 16.4500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3603
    Cell Significance Index: 10.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3361
    Cell Significance Index: 15.6700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3360
    Cell Significance Index: 7.2800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.3225
    Cell Significance Index: 4.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3116
    Cell Significance Index: 23.2300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2445
    Cell Significance Index: 31.3400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.2357
    Cell Significance Index: 1.9800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1766
    Cell Significance Index: 4.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1638
    Cell Significance Index: 31.1800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1443
    Cell Significance Index: 18.6400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1170
    Cell Significance Index: 3.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1119
    Cell Significance Index: 5.8300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1099
    Cell Significance Index: 18.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0738
    Cell Significance Index: 8.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0480
    Cell Significance Index: 9.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0469
    Cell Significance Index: 9.4000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0269
    Cell Significance Index: 0.4500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0245
    Cell Significance Index: 1.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0044
    Cell Significance Index: 3.3100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0012
    Cell Significance Index: 0.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0017
    Cell Significance Index: -0.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0045
    Cell Significance Index: -8.5400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0046
    Cell Significance Index: -3.3900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0162
    Cell Significance Index: -29.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0187
    Cell Significance Index: -6.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0189
    Cell Significance Index: -29.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0234
    Cell Significance Index: -31.7900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0238
    Cell Significance Index: -0.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0261
    Cell Significance Index: -2.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0329
    Cell Significance Index: -20.9100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0353
    Cell Significance Index: -26.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0481
    Cell Significance Index: -27.1400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0535
    Cell Significance Index: -2.1900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0538
    Cell Significance Index: -24.4300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0596
    Cell Significance Index: -37.2200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0723
    Cell Significance Index: -1.9300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0734
    Cell Significance Index: -2.5800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0775
    Cell Significance Index: -1.9800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0909
    Cell Significance Index: -2.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1004
    Cell Significance Index: -28.9000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1424
    Cell Significance Index: -7.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1524
    Cell Significance Index: -22.1600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1617
    Cell Significance Index: -2.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1674
    Cell Significance Index: -35.2500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1787
    Cell Significance Index: -1.8500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.1841
    Cell Significance Index: -1.4700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1922
    Cell Significance Index: -2.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2626
    Cell Significance Index: -27.3400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2761
    Cell Significance Index: -4.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2853
    Cell Significance Index: -16.0100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2882
    Cell Significance Index: -22.8300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2888
    Cell Significance Index: -6.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3125
    Cell Significance Index: -23.9800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3367
    Cell Significance Index: -5.9500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3947
    Cell Significance Index: -24.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4405
    Cell Significance Index: -6.0100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4713
    Cell Significance Index: -4.3400
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.4830
    Cell Significance Index: -4.0000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4866
    Cell Significance Index: -2.9400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5034
    Cell Significance Index: -12.9400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5718
    Cell Significance Index: -25.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** POLR1H is a protein-coding gene that encodes a subunit of the RNA polymerase I complex, which is responsible for the transcription of rRNA genes. The POLR1H gene is characterized by its high expression levels in specific cell types and tissues, as well as its involvement in various cellular processes, including gene expression, epigenetic regulation, and transcription initiation and termination. The gene's expression is tightly regulated, and its dysregulation has been implicated in various diseases, including cancer and autoimmune disorders. **Pathways and Functions** The POLR1H gene is involved in several key pathways, including: 1. **B-cell receptor (BCR) signaling**: POLR1H is expressed in B cells and is involved in the regulation of gene expression in response to BCR signaling. 2. **Immune cell development**: POLR1H is expressed in T cells, monocytes, and other immune cells, and plays a role in their development and function. 3. **Cell proliferation and differentiation**: POLR1H is involved in the regulation of cell proliferation and differentiation in various cell types, including skeletal muscle satellite cells and fibroblasts. 4. **Epigenetic regulation**: POLR1H is involved in the regulation of gene expression through epigenetic mechanisms, including DNA methylation and histone modification. The POLR1H gene functions as a subunit of the RNA polymerase I complex, which is responsible for the transcription of rRNA genes. The complex is composed of five subunits, including POLR1H, and is involved in the initiation, elongation, and termination of transcription. The POLR1H subunit is responsible for the recognition of the rRNA gene promoter and the recruitment of other subunits to the transcription complex. **Clinical Significance** Dysregulation of the POLR1H gene has been implicated in various diseases, including: 1. **Cancer**: Elevated expression of POLR1H has been observed in various types of cancer, including leukemia and lymphoma. 2. **Autoimmune disorders**: POLR1H has been implicated in the regulation of gene expression in autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis. 3. **Neurological disorders**: POLR1H has been implicated in the regulation of gene expression in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Developmental disorders**: POLR1H has been implicated in the regulation of gene expression in developmental disorders, such as Down syndrome and Turner syndrome. In summary, the POLR1H gene plays a crucial role in the transcription of rRNA genes and is involved in various cellular processes, including gene expression, epigenetic regulation, and transcription initiation and termination. Its dysregulation has been implicated in various diseases, highlighting its importance as a potential therapeutic target.

Genular Protein ID: 3786512058

Symbol: RPA12_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9P1U0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 8 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 7 Ensembl 32 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIRSF 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10662553

Title: A new zinc ribbon gene (ZNRD1) is cloned from the human MHC class I region.

PubMed ID: 10662553

DOI: 10.1006/geno.1999.6040

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 34671025

Title: Structure of the human RNA polymerase I elongation complex.

PubMed ID: 34671025

DOI: 10.1038/s41421-021-00335-5

PubMed ID: 34887565

Title: Cryo-EM structures of human RNA polymerase I.

PubMed ID: 34887565

DOI: 10.1038/s41594-021-00693-4

PubMed ID: 36271492

Title: The human RNA polymerase I structure reveals an HMG-like docking domain specific to metazoans.

PubMed ID: 36271492

DOI: 10.26508/lsa.202201568

Sequence Information:

  • Length: 126
  • Mass: 13904
  • Checksum: C678AC7132A91432
  • Sequence:
    • MSVMDLANTC SSFQSDLDFC SDCGSVLPLP GAQDTVTCIR CGFNINVRDF EGKVVKTSVV 
FHQLGTAMPM SVEEGPECQG PVVDRRCPRC GHEGMAYHTR QMRSADEGQT VFYTCTNCKF 
QEKEDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.