Details for: HNRNPH2

Gene ID: 3188

Symbol: HNRNPH2

Ensembl ID: ENSG00000126945

Description: heterogeneous nuclear ribonucleoprotein H2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.5
    Marker Score: 2227
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.33
    Marker Score: 4913
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.21
    Marker Score: 19402
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 2.15
    Marker Score: 1610
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 2.02
    Marker Score: 1228
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.93
    Marker Score: 1364
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.87
    Marker Score: 7345
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.81
    Marker Score: 6972
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.78
    Marker Score: 3727
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.75
    Marker Score: 1167
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.71
    Marker Score: 7380
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.69
    Marker Score: 14568
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.67
    Marker Score: 3398
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.66
    Marker Score: 487
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.64
    Marker Score: 1755
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.62
    Marker Score: 1716
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.54
    Marker Score: 3769
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.51
    Marker Score: 2676
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.48
    Marker Score: 51314
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.45
    Marker Score: 541
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.45
    Marker Score: 2131
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.44
    Marker Score: 1995
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.42
    Marker Score: 5900.5
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.36
    Marker Score: 1413
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.36
    Marker Score: 1642
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.36
    Marker Score: 758.5
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.34
    Marker Score: 315
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.34
    Marker Score: 737
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.32
    Marker Score: 394
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.3
    Marker Score: 293
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.29
    Marker Score: 1213
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.28
    Marker Score: 1067
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.28
    Marker Score: 3644
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.25
    Marker Score: 5997
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.25
    Marker Score: 2008
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.24
    Marker Score: 4600.5
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.23
    Marker Score: 838
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.22
    Marker Score: 353
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.22
    Marker Score: 1760.5
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.22
    Marker Score: 310
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.21
    Marker Score: 1027
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.2
    Marker Score: 759
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.19
    Marker Score: 635
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.17
    Marker Score: 2953.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.17
    Marker Score: 1232
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.17
    Marker Score: 1247
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.16
    Marker Score: 663
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.16
    Marker Score: 1322
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.15
    Marker Score: 1911
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.15
    Marker Score: 1950
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.15
    Marker Score: 1132
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.15
    Marker Score: 4699.5
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.15
    Marker Score: 363
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.15
    Marker Score: 902.5
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.14
    Marker Score: 935
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.13
    Marker Score: 2120
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.13
    Marker Score: 2250
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.13
    Marker Score: 3019
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.11
    Marker Score: 628
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.1
    Marker Score: 1700
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.1
    Marker Score: 2702
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.1
    Marker Score: 2495
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1
    Marker Score: 2505
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.1
    Marker Score: 61476.5
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.1
    Marker Score: 568
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.09
    Marker Score: 1739
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.09
    Marker Score: 36957
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.08
    Marker Score: 12215
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 1.08
    Marker Score: 660
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.08
    Marker Score: 212
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.07
    Marker Score: 775
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.07
    Marker Score: 264
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.06
    Marker Score: 6758
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.06
    Marker Score: 6423
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 1.06
    Marker Score: 583
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.06
    Marker Score: 527
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.06
    Marker Score: 27021
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.05
    Marker Score: 1054
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.05
    Marker Score: 9154
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.05
    Marker Score: 988
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.05
    Marker Score: 408
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.05
    Marker Score: 386
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.04
    Marker Score: 493.5
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.04
    Marker Score: 605
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.03
    Marker Score: 1049
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.03
    Marker Score: 622
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.03
    Marker Score: 960.5
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.02
    Marker Score: 913
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.02
    Marker Score: 679.5
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.02
    Marker Score: 682
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.02
    Marker Score: 1441
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.01
    Marker Score: 688
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.01
    Marker Score: 2525
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.01
    Marker Score: 6595
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.01
    Marker Score: 2376
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1
    Marker Score: 1060
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1
    Marker Score: 716
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71612
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.99
    Marker Score: 5222
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47832

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Other Information

**Key characteristics:** * HNRNPH2 is a large protein with a molecular weight of approximately 120 kDa. * It is a cytosol protein that is found in both nuclear and cytoplasmic compartments. * It is a key component of the splicing complex for the U6 small nuclear RNA (snRNA). * It is also a component of the ribosome assembly complex. **Pathways and functions:** * HNRNPH2 is involved in the regulation of RNA splicing by interacting with the splicing factor SF3b. * It is a key regulator of the processing of capped intron-containing pre-mRNA. * It is involved in the formation of the mature mRNA by removing the cap structure from the pre-mRNA. * It also plays a role in the processing of mRNA in the nucleus. **Clinical significance:** * Mutations in HNRNPH2 have been linked to a number of human diseases, including cancer, cardiovascular disease, and developmental disorders. * These mutations can disrupt the splicing of pre-mRNAs, leading to the production of abnormal proteins that can cause disease. * Therefore, HNRNPH2 is a promising target for the development of new drugs for these diseases.

Genular Protein ID: 2175865705

Symbol: HNRH2_HUMAN

Name: Heterogeneous nuclear ribonucleoprotein H2

UniProtKB Accession Codes:

P55795 A1L400 Q9HHA7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 1 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 4 PRIDE 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7959728

Title: Isolation of cosmid and cDNA clones in the region surrounding the BTK gene at Xq21.3-q22.

PubMed ID: 7959728

DOI: 10.1006/geno.1994.1310

PubMed ID: 9110171

Title: Large-scale comparative sequence analysis of the human and murine Bruton's tyrosine kinase loci reveals conserved regulatory domains.

PubMed ID: 9110171

DOI: 10.1101/gr.7.4.315

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 7499401

Title: Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes.

PubMed ID: 7499401

DOI: 10.1074/jbc.270.48.28780

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11054566

Title: Evidence that Dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for Dim1 interactions with hnRNP F and Npw38/PQBP-1.

PubMed ID: 11054566

DOI: 10.1016/s0378-1119(00)00372-3

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24644279

Title: Nuclear ARVCF protein binds splicing factors and contributes to the regulation of alternative splicing.

PubMed ID: 24644279

DOI: 10.1074/jbc.m113.530717

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 27545675

Title: Variants in HNRNPH2 on the X chromosome are associated with a neurodevelopmental disorder in females.

PubMed ID: 27545675

DOI: 10.1016/j.ajhg.2016.06.028

Sequence Information:

  • Length: 449
  • Mass: 49264
  • Checksum: C892523A638F07C7
  • Sequence:
    • MMLSTEGREG FVVKVRGLPW SCSADEVMRF FSDCKIQNGT SGIRFIYTRE GRPSGEAFVE 
LESEEEVKLA LKKDRETMGH RYVEVFKSNS VEMDWVLKHT GPNSPDTAND GFVRLRGLPF 
GCSKEEIVQF FSGLEIVPNG MTLPVDFQGR STGEAFVQFA SQEIAEKALK KHKERIGHRY 
IEIFKSSRAE VRTHYDPPRK LMAMQRPGPY DRPGAGRGYN SIGRGAGFER MRRGAYGGGY 
GGYDDYGGYN DGYGFGSDRF GRDLNYCFSG MSDHRYGDGG SSFQSTTGHC VHMRGLPYRA 
TENDIYNFFS PLNPMRVHIE IGPDGRVTGE ADVEFATHED AVAAMAKDKA NMQHRYVELF 
LNSTAGTSGG AYDHSYVELF LNSTAGASGG AYGSQMMGGM GLSNQSSYGG PASQQLSGGY 
GGGYGGQSSM SGYDQVLQEN SSDYQSNLA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.