Details for: HNRNPH2

Gene ID: 3188

Symbol: HNRNPH2

Ensembl ID: ENSG00000126945

Description: heterogeneous nuclear ribonucleoprotein H2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 242.7590
    Cell Significance Index: -37.7600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 137.3976
    Cell Significance Index: -34.8500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 118.4617
    Cell Significance Index: -48.8000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 89.5742
    Cell Significance Index: -42.2900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 78.4971
    Cell Significance Index: -31.8900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 73.9524
    Cell Significance Index: -38.0400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 35.9783
    Cell Significance Index: -34.3500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 32.7911
    Cell Significance Index: -40.4300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.5549
    Cell Significance Index: -41.6500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.1834
    Cell Significance Index: -27.2800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.7218
    Cell Significance Index: -29.8600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.4481
    Cell Significance Index: 238.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.9615
    Cell Significance Index: 154.2600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.7291
    Cell Significance Index: 21.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.8542
    Cell Significance Index: 50.4700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.7205
    Cell Significance Index: 187.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.5249
    Cell Significance Index: 113.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2300
    Cell Significance Index: 200.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.2081
    Cell Significance Index: 63.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1567
    Cell Significance Index: 142.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9593
    Cell Significance Index: 523.8900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9154
    Cell Significance Index: 125.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9134
    Cell Significance Index: 164.6600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8791
    Cell Significance Index: 55.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8288
    Cell Significance Index: 107.0800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.7835
    Cell Significance Index: 13.8500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7427
    Cell Significance Index: 25.8100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6672
    Cell Significance Index: 294.9800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5916
    Cell Significance Index: 75.8400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5307
    Cell Significance Index: 52.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4990
    Cell Significance Index: 32.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4746
    Cell Significance Index: 95.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4657
    Cell Significance Index: 24.1900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4476
    Cell Significance Index: 9.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4315
    Cell Significance Index: 20.1200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.4106
    Cell Significance Index: 4.2500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4086
    Cell Significance Index: 28.9000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3776
    Cell Significance Index: 4.2900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3269
    Cell Significance Index: 3.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2632
    Cell Significance Index: 94.4000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2612
    Cell Significance Index: 49.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2419
    Cell Significance Index: 11.3700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1493
    Cell Significance Index: 2.7600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1053
    Cell Significance Index: 2.7700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0750
    Cell Significance Index: 8.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0326
    Cell Significance Index: 6.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0210
    Cell Significance Index: 0.5600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0170
    Cell Significance Index: 12.9000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0150
    Cell Significance Index: 0.4300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0106
    Cell Significance Index: 7.7700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0048
    Cell Significance Index: 0.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0107
    Cell Significance Index: -20.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0296
    Cell Significance Index: -54.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0329
    Cell Significance Index: -50.6800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0361
    Cell Significance Index: -49.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0380
    Cell Significance Index: -24.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0400
    Cell Significance Index: -29.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0488
    Cell Significance Index: -4.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0610
    Cell Significance Index: -6.9900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0617
    Cell Significance Index: -34.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0695
    Cell Significance Index: -31.5500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0748
    Cell Significance Index: -12.7800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0752
    Cell Significance Index: -46.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1454
    Cell Significance Index: -41.8400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1597
    Cell Significance Index: -7.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1698
    Cell Significance Index: -19.7900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1713
    Cell Significance Index: -10.5300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1900
    Cell Significance Index: -4.3900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2127
    Cell Significance Index: -30.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2194
    Cell Significance Index: -46.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2204
    Cell Significance Index: -6.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2533
    Cell Significance Index: -17.0300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2624
    Cell Significance Index: -5.6900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3220
    Cell Significance Index: -25.5000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3339
    Cell Significance Index: -3.6300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3462
    Cell Significance Index: -9.2600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3584
    Cell Significance Index: -27.5000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3773
    Cell Significance Index: -9.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3828
    Cell Significance Index: -21.4800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3975
    Cell Significance Index: -12.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4060
    Cell Significance Index: -42.2700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4452
    Cell Significance Index: -7.4500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4889
    Cell Significance Index: -6.6700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5286
    Cell Significance Index: -15.5700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5537
    Cell Significance Index: -6.6000
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.5539
    Cell Significance Index: -5.2700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5901
    Cell Significance Index: -36.1800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6634
    Cell Significance Index: -9.9400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.6878
    Cell Significance Index: -4.6600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7152
    Cell Significance Index: -20.4100
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.7262
    Cell Significance Index: -4.5600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.7265
    Cell Significance Index: -12.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7892
    Cell Significance Index: -34.9100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.7941
    Cell Significance Index: -6.6700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.8718
    Cell Significance Index: -5.3700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8878
    Cell Significance Index: -32.5900
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.9253
    Cell Significance Index: -6.0200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.9396
    Cell Significance Index: -35.5800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.9554
    Cell Significance Index: -28.0600
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.9993
    Cell Significance Index: -6.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **RNA Splicing Regulation:** HNRNPH2 is a key component of the spliceosome, a complex that facilitates the removal of introns and the joining of exons during mRNA splicing. This process is essential for the generation of mature mRNAs, which can then be translated into proteins. 2. **Protein Binding:** HNRNPH2 interacts with various proteins, including other RNA-binding proteins, to regulate mRNA splicing and stability. 3. **Cellular Localization:** HNRNPH2 is predominantly localized in the nucleus, where it plays a crucial role in regulating RNA splicing and transcription. 4. **Diversity in Expression:** HNRNPH2 is highly expressed in various cell types, including extravillous trophoblast, pancreatic acinar cell, lung endothelial cell, and myeloid dendritic cell. **Pathways and Functions:** 1. **mRNA Splicing:** HNRNPH2 is involved in the regulation of mRNA splicing, which is a critical process in gene expression. It interacts with other RNA-binding proteins to facilitate the removal of introns and the joining of exons. 2. **Transcription Regulation:** HNRNPH2 plays a role in regulating transcription, particularly in the context of mRNA splicing. It interacts with transcription factors to modulate the expression of genes involved in various cellular processes. 3. **Protein Binding:** HNRNPH2 interacts with various proteins, including other RNA-binding proteins, to regulate mRNA splicing and stability. 4. **Regulation of RNA Stability:** HNRNPH2 is involved in regulating RNA stability, particularly in the context of mRNA splicing. It interacts with other proteins to modulate the degradation of mRNAs. **Clinical Significance:** 1. **Cancer:** HNRNPH2 has been implicated in various cancers, including breast cancer and lung cancer. Its dysregulation can lead to aberrant mRNA splicing and the generation of oncogenic mRNAs. 2. **Neurological Disorders:** HNRNPH2 has been linked to neurological disorders, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Its dysregulation can lead to aberrant mRNA splicing and the generation of toxic mRNAs. 3. **Immunological Disorders:** HNRNPH2 is expressed in myeloid dendritic cells, which play a crucial role in the immune system. Its dysregulation can lead to impaired immune function and an increased risk of infections. 4. **Developmental Disorders:** HNRNPH2 has been implicated in developmental disorders, including autism spectrum disorder (ASD) and schizophrenia. Its dysregulation can lead to aberrant mRNA splicing and the generation of toxic mRNAs. In conclusion, HNRNPH2 is a critical gene involved in the regulation of RNA splicing, transcription regulation, and protein binding. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, immunological disorders, and developmental disorders. Further research is necessary to fully understand the functions and significance of HNRNPH2 and its role in human disease.

Genular Protein ID: 2175865705

Symbol: HNRH2_HUMAN

Name: Heterogeneous nuclear ribonucleoprotein H2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7959728

Title: Isolation of cosmid and cDNA clones in the region surrounding the BTK gene at Xq21.3-q22.

PubMed ID: 7959728

DOI: 10.1006/geno.1994.1310

PubMed ID: 9110171

Title: Large-scale comparative sequence analysis of the human and murine Bruton's tyrosine kinase loci reveals conserved regulatory domains.

PubMed ID: 9110171

DOI: 10.1101/gr.7.4.315

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 7499401

Title: Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes.

PubMed ID: 7499401

DOI: 10.1074/jbc.270.48.28780

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11054566

Title: Evidence that Dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for Dim1 interactions with hnRNP F and Npw38/PQBP-1.

PubMed ID: 11054566

DOI: 10.1016/s0378-1119(00)00372-3

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24644279

Title: Nuclear ARVCF protein binds splicing factors and contributes to the regulation of alternative splicing.

PubMed ID: 24644279

DOI: 10.1074/jbc.m113.530717

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 27545675

Title: Variants in HNRNPH2 on the X chromosome are associated with a neurodevelopmental disorder in females.

PubMed ID: 27545675

DOI: 10.1016/j.ajhg.2016.06.028

Sequence Information:

  • Length: 449
  • Mass: 49264
  • Checksum: C892523A638F07C7
  • Sequence:
  • MMLSTEGREG FVVKVRGLPW SCSADEVMRF FSDCKIQNGT SGIRFIYTRE GRPSGEAFVE 
    LESEEEVKLA LKKDRETMGH RYVEVFKSNS VEMDWVLKHT GPNSPDTAND GFVRLRGLPF 
    GCSKEEIVQF FSGLEIVPNG MTLPVDFQGR STGEAFVQFA SQEIAEKALK KHKERIGHRY 
    IEIFKSSRAE VRTHYDPPRK LMAMQRPGPY DRPGAGRGYN SIGRGAGFER MRRGAYGGGY 
    GGYDDYGGYN DGYGFGSDRF GRDLNYCFSG MSDHRYGDGG SSFQSTTGHC VHMRGLPYRA 
    TENDIYNFFS PLNPMRVHIE IGPDGRVTGE ADVEFATHED AVAAMAKDKA NMQHRYVELF 
    LNSTAGTSGG AYDHSYVELF LNSTAGASGG AYGSQMMGGM GLSNQSSYGG PASQQLSGGY 
    GGGYGGQSSM SGYDQVLQEN SSDYQSNLA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.