Details for: HOXA5

Gene ID: 3202

Symbol: HOXA5

Ensembl ID: ENSG00000106004

Description: homeobox A5

Associated with

  • Anterior/posterior pattern specification
    (GO:0009952)
  • Bronchiole development
    (GO:0060435)
  • Cell-cell signaling involved in mammary gland development
    (GO:0060764)
  • Cell migration
    (GO:0016477)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Embryonic skeletal system morphogenesis
    (GO:0048704)
  • Epithelial tube branching involved in lung morphogenesis
    (GO:0060441)
  • Intestinal epithelial cell maturation
    (GO:0060574)
  • Lung-associated mesenchyme development
    (GO:0060484)
  • Lung alveolus development
    (GO:0048286)
  • Lung goblet cell differentiation
    (GO:0060480)
  • Mammary gland alveolus development
    (GO:0060749)
  • Mammary gland epithelial cell differentiation
    (GO:0060644)
  • Mesenchymal-epithelial cell signaling
    (GO:0060638)
  • Multicellular organism growth
    (GO:0035264)
  • Negative regulation of angiogenesis
    (GO:0016525)
  • Negative regulation of erythrocyte differentiation
    (GO:0045647)
  • Nucleus
    (GO:0005634)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of myeloid cell differentiation
    (GO:0045639)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of mammary gland epithelial cell proliferation
    (GO:0033599)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Respiratory system process
    (GO:0003016)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Thyroid gland development
    (GO:0030878)
  • Trachea cartilage morphogenesis
    (GO:0060535)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 78.2409
    Cell Significance Index: -12.1700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 39.4649
    Cell Significance Index: -10.0100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 19.9736
    Cell Significance Index: -9.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.9274
    Cell Significance Index: -12.2400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.1044
    Cell Significance Index: -12.2500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.7400
    Cell Significance Index: 73.4200
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.6403
    Cell Significance Index: 16.3400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.1004
    Cell Significance Index: 16.7700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.0863
    Cell Significance Index: 397.0300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.4809
    Cell Significance Index: 51.4600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3042
    Cell Significance Index: 67.7500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.1856
    Cell Significance Index: 25.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8697
    Cell Significance Index: 39.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8352
    Cell Significance Index: 150.5600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.8162
    Cell Significance Index: 24.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8122
    Cell Significance Index: 52.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6770
    Cell Significance Index: 110.1100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.6758
    Cell Significance Index: 11.3100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6523
    Cell Significance Index: 70.9600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4931
    Cell Significance Index: 29.6000
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.4297
    Cell Significance Index: 2.6900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3381
    Cell Significance Index: 305.2800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3339
    Cell Significance Index: 3.6300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2860
    Cell Significance Index: 35.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2839
    Cell Significance Index: 19.6400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2772
    Cell Significance Index: 5.7500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2771
    Cell Significance Index: 13.0300
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.2727
    Cell Significance Index: 1.5500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2202
    Cell Significance Index: 4.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2121
    Cell Significance Index: 6.1100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1960
    Cell Significance Index: 1.8100
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.1750
    Cell Significance Index: 1.9000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.1657
    Cell Significance Index: 2.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0884
    Cell Significance Index: 8.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0833
    Cell Significance Index: 10.7600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0578
    Cell Significance Index: 2.0300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0546
    Cell Significance Index: 0.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0511
    Cell Significance Index: 5.9600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0483
    Cell Significance Index: 2.4400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0415
    Cell Significance Index: 0.9000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0381
    Cell Significance Index: 2.7000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.0282
    Cell Significance Index: 0.2400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0233
    Cell Significance Index: 0.3600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0206
    Cell Significance Index: 15.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0204
    Cell Significance Index: 9.0100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0067
    Cell Significance Index: 0.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0063
    Cell Significance Index: -0.8700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0122
    Cell Significance Index: -6.6400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0128
    Cell Significance Index: -0.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0157
    Cell Significance Index: -11.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0179
    Cell Significance Index: -13.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0223
    Cell Significance Index: -12.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0428
    Cell Significance Index: -12.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0489
    Cell Significance Index: -5.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0663
    Cell Significance Index: -13.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0682
    Cell Significance Index: -8.0400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0698
    Cell Significance Index: -5.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0816
    Cell Significance Index: -13.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1026
    Cell Significance Index: -7.6500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1096
    Cell Significance Index: -2.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1138
    Cell Significance Index: -6.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1181
    Cell Significance Index: -13.5300
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.1248
    Cell Significance Index: -0.9700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1248
    Cell Significance Index: -2.4400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1546
    Cell Significance Index: -2.3300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1777
    Cell Significance Index: -1.8400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1833
    Cell Significance Index: -5.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1999
    Cell Significance Index: -5.4400
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.2080
    Cell Significance Index: -2.0100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2333
    Cell Significance Index: -6.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2367
    Cell Significance Index: -13.2800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2425
    Cell Significance Index: -6.9500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2647
    Cell Significance Index: -12.3400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2980
    Cell Significance Index: -10.9400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3000
    Cell Significance Index: -6.9300
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.3109
    Cell Significance Index: -1.8300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3336
    Cell Significance Index: -13.6700
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.3421
    Cell Significance Index: -4.7300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3437
    Cell Significance Index: -8.5900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3476
    Cell Significance Index: -10.2100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3599
    Cell Significance Index: -6.3600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.3769
    Cell Significance Index: -5.2900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3829
    Cell Significance Index: -16.6500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.4013
    Cell Significance Index: -5.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4024
    Cell Significance Index: -10.7500
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.4028
    Cell Significance Index: -3.6300
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.4029
    Cell Significance Index: -2.1200
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.4051
    Cell Significance Index: -4.3900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.4106
    Cell Significance Index: -5.3700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4171
    Cell Significance Index: -7.7100
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.4185
    Cell Significance Index: -4.8600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4190
    Cell Significance Index: -10.1500
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.4277
    Cell Significance Index: -2.6200
  • Cell Name: motor neuron (CL0000100)
    Fold Change: -0.4286
    Cell Significance Index: -2.9200
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.4315
    Cell Significance Index: -4.3800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4339
    Cell Significance Index: -9.5000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4431
    Cell Significance Index: -11.2900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4522
    Cell Significance Index: -11.8900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.4534
    Cell Significance Index: -5.2900
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.4703
    Cell Significance Index: -3.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HOXA5 is a highly conserved homeobox gene that belongs to the Hox-A subfamily. It is characterized by its ability to regulate gene expression through DNA binding and transcriptional activation. HOXA5 is specifically expressed in various cell types, including peripheral nervous system neurons, motor neurons, and thymocytes. Its expression is tightly regulated during development, with significant fluctuations observed in different tissues and stages of life. **Pathways and Functions:** HOXA5 is involved in multiple signaling pathways, including: 1. **Anterior/posterior pattern specification:** HOXA5 plays a crucial role in regulating the anterior/posterior axis of the embryo, influencing the development of various tissues and organs. 2. **Cell migration:** HOXA5 is involved in regulating cell migration during development, including the migration of epithelial cells and neural crest cells. 3. **Cell differentiation:** HOXA5 regulates the differentiation of various cell types, including epithelial cells, neural crest cells, and thymocytes. 4. **Apoptosis:** HOXA5 is involved in regulating the apoptotic process, influencing the survival and death of cells. 5. **Angiogenesis:** HOXA5 negatively regulates angiogenesis, preventing excessive blood vessel formation. **Clinical Significance:** Dysregulation of HOXA5 has been implicated in various diseases, including: 1. **Cancer:** HOXA5 is overexpressed in several types of cancer, including lung, breast, and colon cancer, where it promotes tumor growth and metastasis. 2. **Autoimmune diseases:** HOXA5 is involved in the regulation of immune responses, and its dysregulation has been linked to autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. 3. **Neurological disorders:** HOXA5 is expressed in the nervous system and has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Respiratory diseases:** HOXA5 is involved in regulating lung development and function, and its dysregulation has been linked to respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). In conclusion, HOXA5 is a multifaceted gene that plays a crucial role in regulating developmental and immunological processes. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its functions and mechanisms of action. Further research is needed to elucidate the complex relationships between HOXA5 and different diseases, ultimately leading to the development of novel therapeutic strategies.

Genular Protein ID: 2650595323

Symbol: HXA5_HUMAN

Name: Homeobox protein Hox-A5

UniProtKB Accession Codes:

P20719 A4D179 O43367 Q96CY6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 GO 33 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2568583

Title: Remarkable intron and exon sequence conservation in human and mouse homeobox Hox 1.3 genes.

PubMed ID: 2568583

DOI: 10.1128/mcb.9.5.2273-2278.1989

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2576652

Title: Organization of human class I homeobox genes.

PubMed ID: 2576652

DOI: 10.1139/g89-133

PubMed ID: 7791786

Title: Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes.

PubMed ID: 7791786

DOI: 10.1128/mcb.15.7.3786

PubMed ID: 9191052

Title: The highest affinity DNA element bound by Pbx complexes in t(1;19) leukemic cells fails to mediate cooperative DNA-binding or cooperative transactivation by E2a-Pbx1 and class I Hox proteins - evidence for selective targetting of E2a-Pbx1 to a subset of Pbx-recognition elements.

PubMed ID: 9191052

DOI: 10.1038/sj.onc.1201097

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

Sequence Information:

  • Length: 270
  • Mass: 29345
  • Checksum: 2093BB73101AFCCC
  • Sequence:
    • MSSYFVNSFC GRYPNGPDYQ LHNYGDHSSV SEQFRDSASM HSGRYGYGYN GMDLSVGRSG 
SGHFGSGERA RSYAASASAA PAEPRYSQPA TSTHSPQPDP LPCSAVAPSP GSDSHHGGKN 
SLSNSSGASA DAGSTHISSR EGVGTASGAE EDAPASSEQA SAQSEPSPAP PAQPQIYPWM 
RKLHISHDNI GGPEGKRART AYTRYQTLEL EKEFHFNRYL TRRRRIEIAH ALCLSERQIK 
IWFQNRRMKW KKDNKLKSMS MAAAGGAFRP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.