Details for: HOXA5

Gene ID: 3202

Symbol: HOXA5

Ensembl ID: ENSG00000106004

Description: homeobox A5

Associated with

  • Anterior/posterior pattern specification
    (GO:0009952)
  • Bronchiole development
    (GO:0060435)
  • Cell-cell signaling involved in mammary gland development
    (GO:0060764)
  • Cell migration
    (GO:0016477)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Embryonic skeletal system morphogenesis
    (GO:0048704)
  • Epithelial tube branching involved in lung morphogenesis
    (GO:0060441)
  • Intestinal epithelial cell maturation
    (GO:0060574)
  • Lung-associated mesenchyme development
    (GO:0060484)
  • Lung alveolus development
    (GO:0048286)
  • Lung goblet cell differentiation
    (GO:0060480)
  • Mammary gland alveolus development
    (GO:0060749)
  • Mammary gland epithelial cell differentiation
    (GO:0060644)
  • Mesenchymal-epithelial cell signaling
    (GO:0060638)
  • Multicellular organism growth
    (GO:0035264)
  • Negative regulation of angiogenesis
    (GO:0016525)
  • Negative regulation of erythrocyte differentiation
    (GO:0045647)
  • Nucleus
    (GO:0005634)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of myeloid cell differentiation
    (GO:0045639)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of mammary gland epithelial cell proliferation
    (GO:0033599)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Respiratory system process
    (GO:0003016)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Thyroid gland development
    (GO:0030878)
  • Trachea cartilage morphogenesis
    (GO:0060535)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.89
    Marker Score: 2116
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.73
    Marker Score: 1025.5
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.71
    Marker Score: 1071
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.67
    Marker Score: 1748
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.63
    Marker Score: 1741
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.55
    Marker Score: 1461
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.51
    Marker Score: 714
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.51
    Marker Score: 506
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.36
    Marker Score: 2844.5
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.2
    Marker Score: 796
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.17
    Marker Score: 1412
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4796
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.1
    Marker Score: 259
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.07
    Marker Score: 7095
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71807
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48032
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.99
    Marker Score: 13096
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.97
    Marker Score: 649.5
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.97
    Marker Score: 1693
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5270
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.86
    Marker Score: 2013
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.85
    Marker Score: 2216
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.81
    Marker Score: 862
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.79
    Marker Score: 2014
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 595.5
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.77
    Marker Score: 1189.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.76
    Marker Score: 1119
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.75
    Marker Score: 644
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 675
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.73
    Marker Score: 7391
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.72
    Marker Score: 476
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 459
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.65
    Marker Score: 939
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.64
    Marker Score: 1726
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.64
    Marker Score: 599
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.62
    Marker Score: 157
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6
    Marker Score: 10681
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.59
    Marker Score: 1390
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.57
    Marker Score: 196
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.56
    Marker Score: 560
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.56
    Marker Score: 271
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.55
    Marker Score: 172
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.54
    Marker Score: 225
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.51
    Marker Score: 192
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.51
    Marker Score: 2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.51
    Marker Score: 5710
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.5
    Marker Score: 148
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.49
    Marker Score: 494
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.48
    Marker Score: 2369
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.47
    Marker Score: 310
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.47
    Marker Score: 451
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 275
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.46
    Marker Score: 243.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.46
    Marker Score: 864
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.46
    Marker Score: 440
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.43
    Marker Score: 107
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.43
    Marker Score: 244
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.42
    Marker Score: 134
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.41
    Marker Score: 569
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.41
    Marker Score: 575
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.4
    Marker Score: 288
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.38
    Marker Score: 160
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.37
    Marker Score: 215
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.36
    Marker Score: 167
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.36
    Marker Score: 135
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.35
    Marker Score: 836
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.35
    Marker Score: 376
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.34
    Marker Score: 119
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.34
    Marker Score: 168
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.34
    Marker Score: 1058
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.33
    Marker Score: 100
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.33
    Marker Score: 1180
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.33
    Marker Score: 584
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.33
    Marker Score: 224
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.33
    Marker Score: 222
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.32
    Marker Score: 288
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.32
    Marker Score: 283.5
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.31
    Marker Score: 386
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.31
    Marker Score: 166
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.31
    Marker Score: 628
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.31
    Marker Score: 611
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.3
    Marker Score: 507
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.3
    Marker Score: 108
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.3
    Marker Score: 94
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.29
    Marker Score: 83
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.29
    Marker Score: 133
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.29
    Marker Score: 287
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.29
    Marker Score: 698

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Other Information

## Summary HOXA5 is a homeobox A5 gene that plays a crucial role in regulating the development and function of various cell types in the human body. It is highly expressed in the developing central nervous system, particularly in neural crest cells and neurons. HOXA5 is also expressed in various other cell types, including epithelial cells, immune cells, and blood cells. ## Key characteristics * HOXA5 is a large gene with 18 exons and 145 predicted proteins. * It is a member of the HOX family of homeobox genes, which are known for their ability to regulate the expression of other genes by interacting with DNA. * HOXA5 is a key regulator of neural tube formation and survival. * It is also involved in the regulation of various other developmental processes, including organogenesis, tissue development, and cell migration. ## Pathways and functions * HOXA5 is a key regulator of anterior/posterior (A/P) pattern specification in the developing neural tube. * It is also involved in cell migration, as it is expressed in cells that migrate along the neural tube. * HOXA5 is a key regulator of the development of the central nervous system, including the formation of the brain and spinal cord. * It is also involved in the development of various other tissues and organs, including the heart, liver, and kidneys. ## Clinical significance HOXA5 mutations are associated with a number of human diseases, including Angelman syndrome, which is caused by a mutation in the HOXA5 gene. Angelman syndrome is characterized by a variety of developmental and intellectual disabilities, including intellectual disability, seizures, and behavioral problems. HOXA5 is a promising target for the treatment of Angelman syndrome and other neurological disorders that are caused by HOXA5 mutations. Researchers are currently exploring the use of HOXA5 inhibitors to treat these disorders.

Genular Protein ID: 2650595323

Symbol: HXA5_HUMAN

Name: Homeobox protein Hox-A5

UniProtKB Accession Codes:

P20719 A4D179 O43367 Q96CY6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 1 GO 33 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2568583

Title: Remarkable intron and exon sequence conservation in human and mouse homeobox Hox 1.3 genes.

PubMed ID: 2568583

DOI: 10.1128/mcb.9.5.2273-2278.1989

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2576652

Title: Organization of human class I homeobox genes.

PubMed ID: 2576652

DOI: 10.1139/g89-133

PubMed ID: 7791786

Title: Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes.

PubMed ID: 7791786

DOI: 10.1128/mcb.15.7.3786

PubMed ID: 9191052

Title: The highest affinity DNA element bound by Pbx complexes in t(1;19) leukemic cells fails to mediate cooperative DNA-binding or cooperative transactivation by E2a-Pbx1 and class I Hox proteins - evidence for selective targetting of E2a-Pbx1 to a subset of Pbx-recognition elements.

PubMed ID: 9191052

DOI: 10.1038/sj.onc.1201097

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

Sequence Information:

  • Length: 270
  • Mass: 29345
  • Checksum: 2093BB73101AFCCC
  • Sequence:
    • MSSYFVNSFC GRYPNGPDYQ LHNYGDHSSV SEQFRDSASM HSGRYGYGYN GMDLSVGRSG 
SGHFGSGERA RSYAASASAA PAEPRYSQPA TSTHSPQPDP LPCSAVAPSP GSDSHHGGKN 
SLSNSSGASA DAGSTHISSR EGVGTASGAE EDAPASSEQA SAQSEPSPAP PAQPQIYPWM 
RKLHISHDNI GGPEGKRART AYTRYQTLEL EKEFHFNRYL TRRRRIEIAH ALCLSERQIK 
IWFQNRRMKW KKDNKLKSMS MAAAGGAFRP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.