Details for: HOXA9

Gene ID: 3205

Symbol: HOXA9

Ensembl ID: ENSG00000078399

Description: homeobox A9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 61.0755
    Cell Significance Index: -9.5000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 33.0363
    Cell Significance Index: 280.7900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 23.6591
    Cell Significance Index: -11.1700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 21.6119
    Cell Significance Index: -8.7800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 8.4629
    Cell Significance Index: 67.5700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.4269
    Cell Significance Index: -10.3900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 8.1216
    Cell Significance Index: -2.0600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.5131
    Cell Significance Index: -12.0900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.5569
    Cell Significance Index: 123.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.9141
    Cell Significance Index: 288.2700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.7344
    Cell Significance Index: -10.7900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.7022
    Cell Significance Index: 79.5900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.6567
    Cell Significance Index: 171.4000
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 2.2808
    Cell Significance Index: 1.6300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.9594
    Cell Significance Index: 41.7300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.7519
    Cell Significance Index: 91.0100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.6658
    Cell Significance Index: 18.1100
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 1.3652
    Cell Significance Index: 7.7600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.3484
    Cell Significance Index: 3.0400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.1743
    Cell Significance Index: 24.5800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.0545
    Cell Significance Index: 15.8000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9631
    Cell Significance Index: 156.6500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9418
    Cell Significance Index: 42.6900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9273
    Cell Significance Index: 55.6700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8468
    Cell Significance Index: 152.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7584
    Cell Significance Index: 21.8500
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.6457
    Cell Significance Index: 3.7900
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.6384
    Cell Significance Index: 8.0900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.6305
    Cell Significance Index: -1.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5646
    Cell Significance Index: 39.0500
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.4048
    Cell Significance Index: 1.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3602
    Cell Significance Index: 9.8100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3031
    Cell Significance Index: 4.6900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2646
    Cell Significance Index: 13.3700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.2439
    Cell Significance Index: 3.4700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.2325
    Cell Significance Index: 2.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2308
    Cell Significance Index: 8.1100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2205
    Cell Significance Index: 199.1000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1975
    Cell Significance Index: 6.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1831
    Cell Significance Index: 22.5100
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.1391
    Cell Significance Index: 0.1800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.1324
    Cell Significance Index: 1.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1162
    Cell Significance Index: 22.1200
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: 0.1143
    Cell Significance Index: 0.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0461
    Cell Significance Index: 2.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0135
    Cell Significance Index: 9.9100
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.0105
    Cell Significance Index: 0.0800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0033
    Cell Significance Index: 0.0300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0032
    Cell Significance Index: 0.0400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0020
    Cell Significance Index: -1.5000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0024
    Cell Significance Index: -1.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0028
    Cell Significance Index: -0.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0032
    Cell Significance Index: -0.0700
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0062
    Cell Significance Index: -0.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0154
    Cell Significance Index: -11.6900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0201
    Cell Significance Index: -1.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0212
    Cell Significance Index: -11.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0219
    Cell Significance Index: -11.9500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0221
    Cell Significance Index: -10.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0335
    Cell Significance Index: -2.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0347
    Cell Significance Index: -4.4800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0364
    Cell Significance Index: -0.2200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0382
    Cell Significance Index: -1.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0402
    Cell Significance Index: -1.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0457
    Cell Significance Index: -9.1600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0499
    Cell Significance Index: -5.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0546
    Cell Significance Index: -9.3300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0559
    Cell Significance Index: -4.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0572
    Cell Significance Index: -11.3600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0601
    Cell Significance Index: -8.7300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0615
    Cell Significance Index: -1.5800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0673
    Cell Significance Index: -0.4600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0768
    Cell Significance Index: -0.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0772
    Cell Significance Index: -9.1100
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0799
    Cell Significance Index: -0.9200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0851
    Cell Significance Index: -1.6600
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0956
    Cell Significance Index: -0.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0959
    Cell Significance Index: -4.4700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1008
    Cell Significance Index: -2.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1071
    Cell Significance Index: -12.2800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1129
    Cell Significance Index: -1.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1234
    Cell Significance Index: -7.5700
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1431
    Cell Significance Index: -1.3800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1523
    Cell Significance Index: -1.7300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1557
    Cell Significance Index: -4.1700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1684
    Cell Significance Index: -8.7700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1736
    Cell Significance Index: -4.3400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1741
    Cell Significance Index: -5.7000
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.1825
    Cell Significance Index: -1.4500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1971
    Cell Significance Index: -8.5700
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.1978
    Cell Significance Index: -2.6900
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.1980
    Cell Significance Index: -2.0700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2074
    Cell Significance Index: -2.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2212
    Cell Significance Index: -12.4100
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.2268
    Cell Significance Index: -2.4000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2273
    Cell Significance Index: -3.1900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.2325
    Cell Significance Index: -1.6700
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.2326
    Cell Significance Index: -3.4800
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.2375
    Cell Significance Index: -1.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional regulation:** HOXA9 is a DNA-binding transcription factor that regulates the expression of target genes by binding to specific DNA sequences. 2. **Homeobox gene family:** HOXA9 belongs to the homeobox gene family, which plays a crucial role in embryonic development and tissue patterning. 3. **Anterior/posterior pattern specification:** HOXA9 is involved in the specification of anterior and posterior patterns during embryonic development. 4. **Diverse tissue expression:** HOXA9 is expressed in various tissues, including the kidney, hematopoietic cells, and reproductive organs. **Pathways and Functions:** 1. **Anterior/posterior pattern specification:** HOXA9 regulates the expression of target genes involved in the specification of anterior and posterior patterns during embryonic development. 2. **Hematopoiesis:** HOXA9 is involved in the regulation of hematopoietic cell development and differentiation. 3. **Embryonic pattern formation:** HOXA9 plays a critical role in the formation of embryonic patterns, including the specification of embryonic axes and organogenesis. 4. **Cell differentiation:** HOXA9 regulates the expression of target genes involved in cell differentiation, including the differentiation of hematopoietic cells and renal cells. 5. **Organ development:** HOXA9 is involved in the regulation of organ development, including the development of the kidney, prostate gland, and mammary gland. **Clinical Significance:** 1. **Cancer:** Abnormal expression of HOXA9 has been implicated in various cancers, including leukemia, lymphoma, and breast cancer. 2. **Cardiovascular disorders:** HOXA9 is involved in the regulation of cardiovascular development and has been implicated in cardiovascular disorders, including aortic aneurysm and cardiac hypertrophy. 3. **Reproductive abnormalities:** HOXA9 is involved in the regulation of reproductive organ development and has been implicated in reproductive abnormalities, including infertility and testicular cancer. 4. **Kidney disease:** HOXA9 has been implicated in the regulation of kidney development and function, and its dysregulation has been linked to kidney disease. In conclusion, HOXA9 is a critical transcription factor that plays a pivotal role in embryonic development, cell differentiation, and tissue homeostasis. Its dysregulation has been implicated in various diseases, including cancer, cardiovascular disorders, and reproductive abnormalities. Further research is needed to fully understand the mechanisms by which HOXA9 regulates gene expression and to explore its potential as a therapeutic target for the treatment of these diseases.

Genular Protein ID: 2022596337

Symbol: HXA9_HUMAN

Name: Homeobox protein Hox-A9

UniProtKB Accession Codes:

P31269 O43369 O43429 Q99820

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 27 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9880515

Title: Endothelial cells express a novel, tumor necrosis factor-alpha-regulated variant of HOXA9.

PubMed ID: 9880515

DOI: 10.1074/jbc.274.3.1415

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8563754

Title: The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9.

PubMed ID: 8563754

DOI: 10.1038/ng0296-159

PubMed ID: 2574852

Title: The human HOX gene family.

PubMed ID: 2574852

DOI: 10.1093/nar/17.24.10385

PubMed ID: 15657436

Title: Eukaryotic translation initiation factor 4E activity is modulated by HOXA9 at multiple levels.

PubMed ID: 15657436

DOI: 10.1128/mcb.25.3.1100-1112.2005

PubMed ID: 12649177

Title: A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease progression of chronic myeloid leukemia and forms a fusion gene with HOXA9 as a result of the cryptic t(7;17)(p15;q23).

PubMed ID: 12649177

PubMed ID: 22269951

Title: HOXA9 methylation by PRMT5 is essential for endothelial cell expression of leukocyte adhesion molecules.

PubMed ID: 22269951

DOI: 10.1128/mcb.05977-11

PubMed ID: 8563753

Title: Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia.

PubMed ID: 8563753

DOI: 10.1038/ng0296-154

PubMed ID: 34163069

Title: Phase separation drives aberrant chromatin looping and cancer development.

PubMed ID: 34163069

DOI: 10.1038/s41586-021-03662-5

Sequence Information:

  • Length: 272
  • Mass: 30172
  • Checksum: 823A1A22BB07A881
  • Sequence:
    • MATTGALGNY YVDSFLLGAD AADELSVGRY APGTLGQPPR QAATLAEHPD FSPCSFQSKA 
TVFGASWNPV HAAGANAVPA AVYHHHHHHP YVHPQAPVAA AAPDGRYMRS WLEPTPGALS 
FAGLPSSRPY GIKPEPLSAR RGDCPTLDTH TLSLTDYACG SPPVDREKQP SEGAFSENNA 
ENESGGDKPP IDPNNPAANW LHARSTRKKR CPYTKHQTLE LEKEFLFNMY LTRDRRYEVA 
RLLNLTERQV KIWFQNRRMK MKKINKDRAK DE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.