Details for: HOXA9

Gene ID: 3205

Symbol: HOXA9

Ensembl ID: ENSG00000078399

Description: homeobox A9

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.29
    Marker Score: 4776
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.99
    Marker Score: 1326
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.76
    Marker Score: 17832
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.67
    Marker Score: 391
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.4
    Marker Score: 1479
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.15
    Marker Score: 294
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4806
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.13
    Marker Score: 553
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.12
    Marker Score: 7458
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.06
    Marker Score: 721.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.05
    Marker Score: 2469
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71817.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48043
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.99
    Marker Score: 717
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5304
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.88
    Marker Score: 644
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.87
    Marker Score: 1480.5
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.84
    Marker Score: 9516
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.8
    Marker Score: 391
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.78
    Marker Score: 292
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 682
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.74
    Marker Score: 1089
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.73
    Marker Score: 233.5
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.73
    Marker Score: 1027
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.72
    Marker Score: 188
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 548
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.72
    Marker Score: 251
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.71
    Marker Score: 1132
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 453
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.7
    Marker Score: 2862.5
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.7
    Marker Score: 460
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.69
    Marker Score: 1204
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.67
    Marker Score: 189
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.65
    Marker Score: 664
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.65
    Marker Score: 1324
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.65
    Marker Score: 8582
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.64
    Marker Score: 339
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.63
    Marker Score: 2249
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.63
    Marker Score: 253
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.63
    Marker Score: 634
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.62
    Marker Score: 1026
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.61
    Marker Score: 328
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.6
    Marker Score: 463
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.58
    Marker Score: 1098
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.57
    Marker Score: 1525
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.53
    Marker Score: 338
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.53
    Marker Score: 1252
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.52
    Marker Score: 354
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.52
    Marker Score: 547
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.51
    Marker Score: 513
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.51
    Marker Score: 135
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.51
    Marker Score: 1590
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.5
    Marker Score: 186
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.5
    Marker Score: 208
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.48
    Marker Score: 149
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.47
    Marker Score: 275
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 276
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.46
    Marker Score: 147
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.45
    Marker Score: 2228
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.45
    Marker Score: 1052
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.44
    Marker Score: 628.5
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.41
    Marker Score: 295
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.41
    Marker Score: 825.5
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.4
    Marker Score: 379
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.39
    Marker Score: 238
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.39
    Marker Score: 140
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.38
    Marker Score: 408.5
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.38
    Marker Score: 262
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.38
    Marker Score: 93
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.37
    Marker Score: 257
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.37
    Marker Score: 1592
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.37
    Marker Score: 127
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.36
    Marker Score: 164
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.35
    Marker Score: 147
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.35
    Marker Score: 877
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.35
    Marker Score: 309
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.35
    Marker Score: 183
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 0.35
    Marker Score: 99
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.34
    Marker Score: 662
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.34
    Marker Score: 327
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.33
    Marker Score: 830
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.32
    Marker Score: 494
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.32
    Marker Score: 370
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.32
    Marker Score: 592
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.31
    Marker Score: 106
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 0.31
    Marker Score: 233.5
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.31
    Marker Score: 163
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3
    Marker Score: 4764

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Other Information

**Key characteristics:** - HOXA9 is a key transcription factor for anterior/posterior (AP) patterning. - It is expressed in a pattern that is opposite to that of Hox1 and Hox3, which are responsible for posterior (P) patterning. - HOXA9 targets DNA sequences involved in the specification of the heart and other AP-related structures. **Pathways and functions:** - HOXA9 is a key regulator of the development of the cardiovascular system. - It is required for the specification of the heart field, the neural tube, and the surrounding tissues. - HOXA9 is also involved in the development of the female reproductive tract and the prostate gland. - It plays a role in the regulation of male gonad development and the maintenance of male reproductive cells. - HOXA9 is also involved in the regulation of epithelial cell differentiation and the maintenance of tissue integrity. **Clinical significance:** - Mutations in the HOXA9 gene have been linked to several human diseases, including heart defects, kidney disorders, and female reproductive tract disorders. - Targeting HOXA9 has been explored as a therapeutic strategy for these diseases. **Conclusion:** HOXA9 is a critical transcription factor that plays a crucial role in the specification of anterior/posterior patterns during embryonic development. Its mutations have significant implications for human health and disease.

Genular Protein ID: 2022596337

Symbol: HXA9_HUMAN

Name: Homeobox protein Hox-A9

UniProtKB Accession Codes:

P31269 O43369 O43429 Q99820

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 27 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9880515

Title: Endothelial cells express a novel, tumor necrosis factor-alpha-regulated variant of HOXA9.

PubMed ID: 9880515

DOI: 10.1074/jbc.274.3.1415

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8563754

Title: The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9.

PubMed ID: 8563754

DOI: 10.1038/ng0296-159

PubMed ID: 2574852

Title: The human HOX gene family.

PubMed ID: 2574852

DOI: 10.1093/nar/17.24.10385

PubMed ID: 15657436

Title: Eukaryotic translation initiation factor 4E activity is modulated by HOXA9 at multiple levels.

PubMed ID: 15657436

DOI: 10.1128/mcb.25.3.1100-1112.2005

PubMed ID: 12649177

Title: A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease progression of chronic myeloid leukemia and forms a fusion gene with HOXA9 as a result of the cryptic t(7;17)(p15;q23).

PubMed ID: 12649177

PubMed ID: 22269951

Title: HOXA9 methylation by PRMT5 is essential for endothelial cell expression of leukocyte adhesion molecules.

PubMed ID: 22269951

DOI: 10.1128/mcb.05977-11

PubMed ID: 8563753

Title: Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia.

PubMed ID: 8563753

DOI: 10.1038/ng0296-154

PubMed ID: 34163069

Title: Phase separation drives aberrant chromatin looping and cancer development.

PubMed ID: 34163069

DOI: 10.1038/s41586-021-03662-5

Sequence Information:

  • Length: 272
  • Mass: 30172
  • Checksum: 823A1A22BB07A881
  • Sequence:
    • MATTGALGNY YVDSFLLGAD AADELSVGRY APGTLGQPPR QAATLAEHPD FSPCSFQSKA 
TVFGASWNPV HAAGANAVPA AVYHHHHHHP YVHPQAPVAA AAPDGRYMRS WLEPTPGALS 
FAGLPSSRPY GIKPEPLSAR RGDCPTLDTH TLSLTDYACG SPPVDREKQP SEGAFSENNA 
ENESGGDKPP IDPNNPAANW LHARSTRKKR CPYTKHQTLE LEKEFLFNMY LTRDRRYEVA 
RLLNLTERQV KIWFQNRRMK MKKINKDRAK DE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.