Details for: HOXC4

Gene ID: 3221

Symbol: HOXC4

Ensembl ID: ENSG00000198353

Description: homeobox C4

Associated with

  • Activation of anterior hox genes in hindbrain development during early embryogenesis
    (R-HSA-5617472)
  • Activation of hox genes during differentiation
    (R-HSA-5619507)
  • Developmental biology
    (R-HSA-1266738)
  • Anterior/posterior pattern specification
    (GO:0009952)
  • Cartilage development
    (GO:0051216)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Embryonic skeletal system morphogenesis
    (GO:0048704)
  • Hmg box domain binding
    (GO:0071837)
  • Nucleoplasm
    (GO:0005654)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 2.86
    Marker Score: 5925
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1166
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.27
    Marker Score: 1266.5
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.22
    Marker Score: 2343.5
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7691
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4811
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 793
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71823
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48048
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.94
    Marker Score: 2210
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.94
    Marker Score: 595
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5349
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.88
    Marker Score: 364
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.86
    Marker Score: 581
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.82
    Marker Score: 378
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 310
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.76
    Marker Score: 720
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.68
    Marker Score: 737.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.67
    Marker Score: 209
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.64
    Marker Score: 343
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.64
    Marker Score: 215
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.63
    Marker Score: 278
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.63
    Marker Score: 9791
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.61
    Marker Score: 293
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.57
    Marker Score: 1080
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.55
    Marker Score: 231
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.54
    Marker Score: 345.5
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.52
    Marker Score: 324
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.49
    Marker Score: 461
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.48
    Marker Score: 970
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.47
    Marker Score: 1272
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 275
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.46
    Marker Score: 490
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.45
    Marker Score: 146
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.45
    Marker Score: 213
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.45
    Marker Score: 270
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.44
    Marker Score: 115
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.43
    Marker Score: 285
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.41
    Marker Score: 292
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.41
    Marker Score: 243
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.41
    Marker Score: 195
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.39
    Marker Score: 347
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.39
    Marker Score: 176
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.38
    Marker Score: 544
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.38
    Marker Score: 123
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.37
    Marker Score: 216
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.34
    Marker Score: 346
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.34
    Marker Score: 712
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.34
    Marker Score: 123
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.34
    Marker Score: 571
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.32
    Marker Score: 537
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.32
    Marker Score: 748
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.31
    Marker Score: 347
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.3
    Marker Score: 321
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.28
    Marker Score: 251
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.28
    Marker Score: 494
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.27
    Marker Score: 64
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.27
    Marker Score: 298
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.27
    Marker Score: 287
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.27
    Marker Score: 99
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.25
    Marker Score: 192
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.24
    Marker Score: 3124
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.23
    Marker Score: 248
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.23
    Marker Score: 357
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.23
    Marker Score: 423
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.23
    Marker Score: 623
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.22
    Marker Score: 57
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.21
    Marker Score: 305
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.2
    Marker Score: 721
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.2
    Marker Score: 115
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2
    Marker Score: 1298
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.2
    Marker Score: 80
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.2
    Marker Score: 129
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.19
    Marker Score: 67
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.19
    Marker Score: 146
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.19
    Marker Score: 217
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.18
    Marker Score: 96
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.17
    Marker Score: 433
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.17
    Marker Score: 1726
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.17
    Marker Score: 212
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.17
    Marker Score: 112
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.17
    Marker Score: 111
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.17
    Marker Score: 95

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - HOXC4 is a homeobox C4 protein. - It is expressed in a variety of cell types in the human body, including kidney proximal convoluted tubule epithelial cell, colon goblet cell, enterocyte of epithelium of large intestine, kidney interstitial fibroblast, goblet cell, enterocyte of epithelium of small intestine, early T lineage precursor, cerebral cortex GABAergic interneuron, forebrain radial glial cell, and tuft cell of colon. - It is a key transcription factor that is essential for the specification of the A/P axis of the hindbrain during early embryogenesis. **Pathways and functions:** - HOXC4 is involved in the activation of anterior hox genes in hindbrain development during early embryogenesis. - It is a key regulator of the development of the A/P axis of the hindbrain. - It is involved in the specification of the identity of the developing somites. - It is also involved in the regulation of cartilage development and the differentiation of other tissues. **Clinical significance:** - Mutations in HOXC4 have been linked to a number of human diseases, including lissencephaly, which is a condition characterized by a lack of brain development in the central nervous system. - HOXC4 is a potential therapeutic target for lissencephaly.

Genular Protein ID: 2110962987

Symbol: HXC4_HUMAN

Name: Homeobox protein Hox-C4

UniProtKB Accession Codes:

P09017

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2898768

Title: At least three human homeoboxes on chromosome 12 belong to the same transcription unit.

PubMed ID: 2898768

DOI: 10.1093/nar/16.12.5379

PubMed ID: 11857506

Title: Complete mutation analysis panel of the 39 human HOX genes.

PubMed ID: 11857506

DOI: 10.1002/tera.10009

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 2576652

Title: Organization of human class I homeobox genes.

PubMed ID: 2576652

DOI: 10.1139/g89-133

Sequence Information:

  • Length: 264
  • Mass: 29811
  • Checksum: 5CCD13995574226E
  • Sequence:
    • MIMSSYLMDS NYIDPKFPPC EEYSQNSYIP EHSPEYYGRT RESGFQHHHQ ELYPPPPPRP 
SYPERQYSCT SLQGPGNSRG HGPAQAGHHH PEKSQSLCEP APLSGASASP SPAPPACSQP 
APDHPSSAAS KQPIVYPWMK KIHVSTVNPN YNGGEPKRSR TAYTRQQVLE LEKEFHYNRY 
LTRRRRIEIA HSLCLSERQI KIWFQNRRMK WKKDHRLPNT KVRSAPPAGA APSTLSAATP 
GTSEDHSQSA TPPEQQRAED ITRL

Genular Protein ID: 1990223159

Symbol: Q86TF7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86TF7

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 IntAct 1 InterPro 6 KEGG 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 2 RuleBase 2 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 264
  • Mass: 29784
  • Checksum: B1CD1A0B08C2F903
  • Sequence:
    • MIMSSYLMDS NYIDPKFPPC EEYSQNSYIP EHSPEYYGRT RESGFQHHHQ ELYPPPPPRP 
SYPERQYSCT SLQGPGNSRG HGPAQAGHHH PEKSQSLCEP APLSGASASP SPAPPACSQP 
APDHPSSAAS KQPIVYPWMK KIHVSTVNPS YNGGEPKRSR TAYTRQQVLE LEKEFHYNRY 
LTRRRRIEIA HSLCLSERQI KIWFQNRRMK WKKDHRLPNT KVRSAPPAGA APSTLSAATP 
GTSEDHSQSA TPPEQQRAED ITRL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.