Details for: HSD17B1

Gene ID: 3292

Symbol: HSD17B1

Ensembl ID: ENSG00000108786

Description: hydroxysteroid 17-beta dehydrogenase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 45.8388
    Cell Significance Index: -7.1300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 27.7949
    Cell Significance Index: -7.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 20.5524
    Cell Significance Index: 548.7800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 6.1273
    Cell Significance Index: -5.8500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.8153
    Cell Significance Index: -7.1700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.8757
    Cell Significance Index: 75.6200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.8221
    Cell Significance Index: -7.1900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3994
    Cell Significance Index: 266.3100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7765
    Cell Significance Index: 701.1600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.6860
    Cell Significance Index: 5.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6370
    Cell Significance Index: 33.0900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5426
    Cell Significance Index: 59.0200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5218
    Cell Significance Index: 84.8700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4506
    Cell Significance Index: 27.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4322
    Cell Significance Index: 19.5900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3821
    Cell Significance Index: 24.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2941
    Cell Significance Index: 13.7100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2923
    Cell Significance Index: 20.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2843
    Cell Significance Index: 8.1900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.2416
    Cell Significance Index: 1.9700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2355
    Cell Significance Index: 6.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1993
    Cell Significance Index: 27.3700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1955
    Cell Significance Index: 35.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1915
    Cell Significance Index: 18.9400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1759
    Cell Significance Index: 3.8100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1520
    Cell Significance Index: 30.1600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.1420
    Cell Significance Index: 1.4700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1390
    Cell Significance Index: 96.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1221
    Cell Significance Index: 15.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1144
    Cell Significance Index: 62.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1111
    Cell Significance Index: 12.9500
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.1088
    Cell Significance Index: 0.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1021
    Cell Significance Index: 45.1600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0961
    Cell Significance Index: 0.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0873
    Cell Significance Index: 17.5200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0817
    Cell Significance Index: 6.0900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0796
    Cell Significance Index: 1.8400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0699
    Cell Significance Index: 0.9000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0685
    Cell Significance Index: 1.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0681
    Cell Significance Index: 8.8000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.0547
    Cell Significance Index: 0.3400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0529
    Cell Significance Index: 1.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0464
    Cell Significance Index: 2.1800
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0400
    Cell Significance Index: 0.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0385
    Cell Significance Index: 13.8200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0375
    Cell Significance Index: 1.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0340
    Cell Significance Index: 0.9500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0308
    Cell Significance Index: 0.7700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0146
    Cell Significance Index: 0.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0067
    Cell Significance Index: 0.4400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0066
    Cell Significance Index: 0.0400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0038
    Cell Significance Index: 0.2000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0028
    Cell Significance Index: 2.0200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0010
    Cell Significance Index: 0.0700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0032
    Cell Significance Index: -0.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0038
    Cell Significance Index: -7.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0057
    Cell Significance Index: -4.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0058
    Cell Significance Index: -0.9900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0078
    Cell Significance Index: -5.7900
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: -0.0097
    Cell Significance Index: -0.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0099
    Cell Significance Index: -5.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0107
    Cell Significance Index: -6.7800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0108
    Cell Significance Index: -0.1800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0113
    Cell Significance Index: -0.2900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0124
    Cell Significance Index: -7.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0127
    Cell Significance Index: -1.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0161
    Cell Significance Index: -4.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0193
    Cell Significance Index: -2.2100
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.0223
    Cell Significance Index: -0.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0286
    Cell Significance Index: -0.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0328
    Cell Significance Index: -3.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0361
    Cell Significance Index: -7.6100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0403
    Cell Significance Index: -1.4000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0406
    Cell Significance Index: -1.3000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0461
    Cell Significance Index: -5.4400
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.0523
    Cell Significance Index: -0.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0554
    Cell Significance Index: -8.0600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0566
    Cell Significance Index: -3.4800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0590
    Cell Significance Index: -3.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0611
    Cell Significance Index: -4.8400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0618
    Cell Significance Index: -3.4700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0760
    Cell Significance Index: -2.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0834
    Cell Significance Index: -5.6100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0839
    Cell Significance Index: -1.0000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0887
    Cell Significance Index: -1.2300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0941
    Cell Significance Index: -4.9000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0983
    Cell Significance Index: -0.7900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1014
    Cell Significance Index: -4.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1054
    Cell Significance Index: -4.6600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1123
    Cell Significance Index: -3.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1187
    Cell Significance Index: -4.5000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1222
    Cell Significance Index: -1.7500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1261
    Cell Significance Index: -1.7700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1310
    Cell Significance Index: -4.8100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1321
    Cell Significance Index: -1.9900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1487
    Cell Significance Index: -4.3800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1531
    Cell Significance Index: -1.1800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1604
    Cell Significance Index: -5.6200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1682
    Cell Significance Index: -3.5200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1705
    Cell Significance Index: -4.5600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HSD17B1 is a member of the short-chain dehydrogenase/reductase family and exhibits NADPH-dependent 17-beta hydroxysteroid dehydrogenase activity. The enzyme catalyzes the interconversion of 17-hydroxysteroids, playing a pivotal role in the biosynthesis and metabolism of steroid hormones. HSD17B1 has been shown to be highly expressed in placental villous trophoblast cells, suggesting its involvement in fetal development and pregnancy. **Pathways and Functions:** HSD17B1 is involved in various cellular processes, including: 1. **Steroid hormone biosynthesis**: HSD17B1 catalyzes the conversion of pregnenolone to progesterone, a crucial step in the biosynthesis of steroid hormones. 2. **Estrogen metabolism**: HSD17B1 is involved in the metabolism of estrogen, regulating its levels and activity in the body. 3. **Testosterone biosynthesis**: The enzyme plays a role in the biosynthesis of testosterone from pregnenolone. 4. **Immune function**: HSD17B1 is expressed in immune cells, such as GABAergic interneurons and intestinal epithelial cells, suggesting its involvement in immune regulation and response. 5. **Lysosome organization**: HSD17B1 has been shown to regulate lysosome organization and function, which is essential for cellular homeostasis. **Clinical Significance:** Dysregulation of HSD17B1 has been implicated in various diseases, including: 1. **Reproductive disorders**: Abnormalities in HSD17B1 expression have been linked to infertility, miscarriage, and gestational diabetes. 2. **Neurological disorders**: HSD17B1 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Cancer**: The enzyme has been shown to play a role in cancer development and progression, particularly in estrogen receptor-positive breast cancer. 4. **Immune disorders**: HSD17B1 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, HSD17B1 is a multifunctional enzyme that plays a critical role in regulating steroid hormone metabolism, immune function, and cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of this enzyme in human health and disease. Further research is needed to fully elucidate the mechanisms by which HSD17B1 influences disease processes and to explore potential therapeutic strategies for targeting this enzyme.

Genular Protein ID: 1490448463

Symbol: DHB1_HUMAN

Name: 20 alpha-hydroxysteroid dehydrogenase

UniProtKB Accession Codes:

P14061 B3KXS1 Q2M2L8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 18 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 9 DrugCentral 1 EC 3 EMBL 10 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 28 PDBsum 28 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 5 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2846351

Title: Complete amino acid sequence of human placental 17 beta-hydroxysteroid dehydrogenase deduced from cDNA.

PubMed ID: 2846351

DOI: 10.1016/0014-5793(88)80548-9

PubMed ID: 2779584

Title: Characterization of cDNAs for human estradiol 17 beta-dehydrogenase and assignment of the gene to chromosome 17: evidence of two mRNA species with distinct 5'-termini in human placenta.

PubMed ID: 2779584

DOI: 10.1210/mend-3-8-1301

PubMed ID: 2330005

Title: Structure of two in tandem human 17 beta-hydroxysteroid dehydrogenase genes.

PubMed ID: 2330005

DOI: 10.1210/mend-4-2-268

PubMed ID: 2197970

Title: Purification, cloning, complementary DNA structure, and predicted amino acid sequence of human estradiol 17 beta-dehydrogenase.

PubMed ID: 2197970

DOI: 10.1111/j.1749-6632.1990.tb34281.x

PubMed ID: 1327779

Title: Genomic organization and DNA sequences of human 17 beta-hydroxysteroid dehydrogenase genes and flanking regions. Localization of multiple Alu sequences and putative cis-acting elements.

PubMed ID: 1327779

DOI: 10.1111/j.1432-1033.1992.tb17310.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 5045524

Title: Amino acid composition and subunit structure. Human placental 17 - estradiol dehydrogenase.

PubMed ID: 5045524

DOI: 10.1021/bi00764a023

PubMed ID: 4719204

Title: Human placental 17 -oestradiol dehydrogenase. Sequence of a tryptic peptide containing an essential cysteine.

PubMed ID: 4719204

DOI: 10.1016/0014-5793(73)80554-x

PubMed ID: 3456799

Title: Human placental estradiol 17 beta-dehydrogenase: sequence of a histidine-bearing peptide in the catalytic region.

PubMed ID: 3456799

DOI: 10.1021/bi00351a019

PubMed ID: 6578212

Title: Human placental estradiol 17 beta-dehydrogenase. Identification of a single histidine residue affinity-labeled by both 3-bromoacetoxyestrone and 12 beta-bromoacetoxy-4-estrene-3,17-dione.

PubMed ID: 6578212

DOI: 10.1016/s0021-9258(17)44248-7

PubMed ID: 2547159

Title: Human placental 17 beta-hydroxysteroid dehydrogenase is homologous to NodG protein of Rhizobium meliloti.

PubMed ID: 2547159

DOI: 10.1210/mend-3-5-881

PubMed ID: 8994190

Title: Characterization of structural and functional properties of human 17 beta-hydroxysteroid dehydrogenase type 1 using recombinant enzymes and site-directed mutagenesis.

PubMed ID: 8994190

DOI: 10.1210/mend.11.1.9872

PubMed ID: 7663947

Title: Structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase at 2.20-A resolution.

PubMed ID: 7663947

DOI: 10.1016/s0969-2126(01)00183-6

PubMed ID: 8756321

Title: Crystal structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase complexed with 17 beta-estradiol.

PubMed ID: 8756321

DOI: 10.1038/nsb0896-665

PubMed ID: 8805577

Title: The structure of a complex of human 17beta-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors.

PubMed ID: 8805577

DOI: 10.1016/s0969-2126(96)00098-6

PubMed ID: 9525918

Title: Unusual charge stabilization of NADP+ in 17beta-hydroxysteroid dehydrogenase.

PubMed ID: 9525918

DOI: 10.1074/jbc.273.14.8145

PubMed ID: 9927655

Title: Structure of the ternary complex of human 17beta-hydroxysteroid dehydrogenase type 1 with 3-hydroxyestra-1,3,5,7-tetraen-17-one (equilin) and NADP+.

PubMed ID: 9927655

DOI: 10.1073/pnas.96.3.840

PubMed ID: 10625652

Title: Dehydroepiandrosterone and dihydrotestosterone recognition by human estrogenic 17beta-hydroxysteroid dehydrogenase. C-18/c-19 steroid discrimination and enzyme-induced strain.

PubMed ID: 10625652

DOI: 10.1074/jbc.275.2.1105

PubMed ID: 12223444

Title: A concerted, rational design of type 1 17beta-hydroxysteroid dehydrogenase inhibitors: estradiol-adenosine hybrids with high affinity.

PubMed ID: 12223444

DOI: 10.1096/fj.02-0026fje

PubMed ID: 12490543

Title: Pseudo-symmetry of C19 steroids, alternative binding orientations, and multispecificity in human estrogenic 17beta-hydroxysteroid dehydrogenase.

PubMed ID: 12490543

DOI: 10.1096/fj.02-0397fje

PubMed ID: 14966133

Title: Cofactor hydrogen bonding onto the protein main chain is conserved in the short chain dehydrogenase/reductase family and contributes to nicotinamide orientation.

PubMed ID: 14966133

DOI: 10.1074/jbc.m313156200

PubMed ID: 8389226

Title: Detection of polymorphisms in the estradiol 17 beta-hydroxysteroid dehydrogenase II gene at the EDH17B2 locus on 17q11-q21.

PubMed ID: 8389226

DOI: 10.1093/hmg/2.4.479

Sequence Information:

  • Length: 328
  • Mass: 34950
  • Checksum: 5B5C8909F9120832
  • Sequence:
    • MARTVVLITG CSSGIGLHLA VRLASDPSQS FKVYATLRDL KTQGRLWEAA RALACPPGSL 
ETLQLDVRDS KSVAAARERV TEGRVDVLVC NAGLGLLGPL EALGEDAVAS VLDVNVVGTV 
RMLQAFLPDM KRRGSGRVLV TGSVGGLMGL PFNDVYCASK FALEGLCESL AVLLLPFGVH 
LSLIECGPVH TAFMEKVLGS PEEVLDRTDI HTFHRFYQYL AHSKQVFREA AQNPEEVAEV 
FLTALRAPKP TLRYFTTERF LPLLRMRLDD PSGSNYVTAM HREVFGDVPA KAEAGAEAGG 
GAGPGAEDEA GRGAVGDPEL GDPPAAPQ

Genular Protein ID: 1265518793

Symbol: A0A0A0MQS7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MQS7

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 13 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 IntAct 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 2 PRINTS 2 PROSITE 1 PeptideAtlas 2 Pfam 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 2 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 UniPathway 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 329
  • Mass: 35037
  • Checksum: E8170FB5A0D14A3D
  • Sequence:
    • MARTVVLITG CSSGIGLHLA VRLASDPSQS FKVYATLRDL KTQGRLWEAA RALACPPGSL 
ETLQLDVRDS KSVAAARERV TEGRVDVLVC NAGLGLLGPL EALGEDAVAS VLDVNVVGTV 
RMLQAFLPDM KRRGSGRVLV TGSVGGLMGL PFNDVYCASK FALEGLCESL AVLLLPFGVH 
SLSLIECGPV HTAFMEKVLG SPEEVLDRTD IHTFHRFYQY LAHSKQVFRE AAQNPEEVAE 
VFLTALRAPK PTLRYFTTER FLPLLRMRLD DPSGSNYVTA MHREVFGDVP AKAEAGAEAG 
GGAGPGAEDE AGRGAVGDPE LGDPPAAPQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.