Details for: HSPB2

Gene ID: 3316

Symbol: HSPB2

Ensembl ID: ENSG00000170276

Description: heat shock protein family B (small) member 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.32
    Marker Score: 764
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.62
    Marker Score: 475
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.53
    Marker Score: 1056
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.47
    Marker Score: 6339
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 865
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.16
    Marker Score: 18073
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7626
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 1.08
    Marker Score: 447
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.03
    Marker Score: 238
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71814
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48036
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.98
    Marker Score: 2571
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.94
    Marker Score: 670
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5347
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.91
    Marker Score: 1714.5
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.9
    Marker Score: 593
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.82
    Marker Score: 1926
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 607
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.79
    Marker Score: 531
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.72
    Marker Score: 273
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.65
    Marker Score: 617
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.6
    Marker Score: 399
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.6
    Marker Score: 191
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.58
    Marker Score: 185
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.55
    Marker Score: 262
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.54
    Marker Score: 238
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.53
    Marker Score: 1075
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.52
    Marker Score: 677
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.5
    Marker Score: 214
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 473
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.48
    Marker Score: 461
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.47
    Marker Score: 503
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.47
    Marker Score: 116
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.47
    Marker Score: 494
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.46
    Marker Score: 15674
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.46
    Marker Score: 117
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.45
    Marker Score: 265
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.43
    Marker Score: 429
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.41
    Marker Score: 189
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4
    Marker Score: 4510
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.39
    Marker Score: 142
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.38
    Marker Score: 215
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.37
    Marker Score: 515
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.36
    Marker Score: 554
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.35
    Marker Score: 831
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.35
    Marker Score: 90
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.34
    Marker Score: 387
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.34
    Marker Score: 87
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.34
    Marker Score: 156
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.33
    Marker Score: 75
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.33
    Marker Score: 221
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.33
    Marker Score: 353
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.33
    Marker Score: 147
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.32
    Marker Score: 611
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.31
    Marker Score: 1113
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.31
    Marker Score: 310
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.3
    Marker Score: 510
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.3
    Marker Score: 122
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.3
    Marker Score: 1779.5
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.29
    Marker Score: 120
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.28
    Marker Score: 149
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.28
    Marker Score: 112
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.27
    Marker Score: 554
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.26
    Marker Score: 158
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.26
    Marker Score: 139
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.26
    Marker Score: 325
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.26
    Marker Score: 534.5
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.26
    Marker Score: 152
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.26
    Marker Score: 145
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.25
    Marker Score: 122
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.25
    Marker Score: 71
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.25
    Marker Score: 274
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.25
    Marker Score: 100
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.25
    Marker Score: 74
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.24
    Marker Score: 226
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.24
    Marker Score: 58
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.22
    Marker Score: 118
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.22
    Marker Score: 79
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.22
    Marker Score: 56
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.22
    Marker Score: 61
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.21
    Marker Score: 266
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.21
    Marker Score: 179
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.21
    Marker Score: 149
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.21
    Marker Score: 129
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.21
    Marker Score: 69
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.2
    Marker Score: 238
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.2
    Marker Score: 100
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.2
    Marker Score: 228
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.2
    Marker Score: 2603

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Other Information

**Key characteristics:** * HSPB2 is a large protein with a molecular weight of approximately 110 kDa. * It is a member of the HSPB family of chaperones, which are a group of proteins that help to protect other proteins from damage by binding to misfolded or damaged proteins and preventing them from aggregation. * HSPB2 is found in the cytoplasm of cells, where it is involved in a variety of cellular processes. * It is also found in the nucleus, where it helps to regulate gene expression. * HSPB2 is a key regulator of the heat shock response, which is a physiological response to heat stress. **Pathways and functions:** * HSPB2 is a key regulator of the heat shock response. * It is induced by heat shock factors (HSFs), which are proteins that are produced in response to heat stress. * Once HSPB2 is induced, it binds to misfolded or damaged proteins and prevents them from aggregation. * This prevents the proteins from damaging the cell and allows them to refold properly. * HSPB2 also plays a role in the folding of other proteins, including enzymes and transcription factors. **Clinical significance:** * Mutations in the HSPB2 gene have been linked to a number of human diseases, including heat-related illnesses, cardiomyopathy, and cancer. * HSPB2 is a potential therapeutic target for these diseases. * Studies of HSPB2 have shown that blocking HSPB2 can protect cells from heat stress and prevent the development of disease. **Other important points:** * HSPB2 is a highly conserved protein, with similar sequences found in organisms from yeast to humans. * It is a member of the HSP70 family of chaperones, which are also involved in the heat shock response. * HSPB2 is a very important protein that plays a crucial role in maintaining cellular health and preventing the development of disease.

Genular Protein ID: 173642965

Symbol: HSPB2_HUMAN

Name: Heat shock protein beta-2

UniProtKB Accession Codes:

Q16082 Q6I9U7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9344664

Title: Identification and characterization of the gene encoding a new member of the alpha-crystallin/small hsp family, closely linked to the alphaB-crystallin gene in a head-to-head manner.

PubMed ID: 9344664

DOI: 10.1006/geno.1997.4956

PubMed ID: 9490724

Title: MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase.

PubMed ID: 9490724

DOI: 10.1083/jcb.140.5.1113

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8227983

Title: Muscle autoantigens in thyroid associated ophthalmopathy: the limits of molecular genetics.

PubMed ID: 8227983

DOI: 10.1007/bf03348900

PubMed ID: 19464326

Title: HSPB7 is a SC35 speckle resident small heat shock protein.

PubMed ID: 19464326

DOI: 10.1016/j.bbamcr.2009.05.005

Sequence Information:

  • Length: 182
  • Mass: 20233
  • Checksum: 7586DCE8FBD19F6D
  • Sequence:
    • MSGRSVPHAH PATAEYEFAN PSRLGEQRFG EGLLPEEILT PTLYHGYYVR PRAAPAGEGS 
RAGASELRLS EGKFQAFLDV SHFTPDEVTV RTVDNLLEVS ARHPQRLDRH GFVSREFCRT 
YVLPADVDPW RVRAALSHDG ILNLEAPRGG RHLDTEVNEV YISLLPAPPD PEEEEEAAIV 
EP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.