Details for: HSPB2

Gene ID: 3316

Symbol: HSPB2

Ensembl ID: ENSG00000170276

Description: heat shock protein family B (small) member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 20.1643
    Cell Significance Index: -9.5200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 11.5284
    Cell Significance Index: 184.9600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 4.8739
    Cell Significance Index: 40.9400
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 4.3653
    Cell Significance Index: 12.5100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.3697
    Cell Significance Index: 14.8900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.9724
    Cell Significance Index: 4.4900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.9184
    Cell Significance Index: 14.5700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.5659
    Cell Significance Index: 8.1100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3874
    Cell Significance Index: 49.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3339
    Cell Significance Index: 45.8500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.2829
    Cell Significance Index: 5.0000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2801
    Cell Significance Index: 8.0300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0588
    Cell Significance Index: 1.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0283
    Cell Significance Index: 3.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0122
    Cell Significance Index: 0.9400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0080
    Cell Significance Index: 0.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0041
    Cell Significance Index: 1.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0049
    Cell Significance Index: -1.7500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0111
    Cell Significance Index: -8.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0124
    Cell Significance Index: -9.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0142
    Cell Significance Index: -10.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0183
    Cell Significance Index: -9.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0187
    Cell Significance Index: -3.7500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0204
    Cell Significance Index: -11.5100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0230
    Cell Significance Index: -0.2400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0275
    Cell Significance Index: -0.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0284
    Cell Significance Index: -2.9000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0315
    Cell Significance Index: -1.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0378
    Cell Significance Index: -6.8200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0503
    Cell Significance Index: -6.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0559
    Cell Significance Index: -9.5400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0562
    Cell Significance Index: -8.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0794
    Cell Significance Index: -3.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0803
    Cell Significance Index: -9.3600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0856
    Cell Significance Index: -9.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1017
    Cell Significance Index: -6.4100
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1058
    Cell Significance Index: -1.0200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1107
    Cell Significance Index: -8.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1113
    Cell Significance Index: -8.3000
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.1143
    Cell Significance Index: -1.7100
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.1401
    Cell Significance Index: -1.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1406
    Cell Significance Index: -7.3800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1424
    Cell Significance Index: -2.7800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1458
    Cell Significance Index: -3.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1488
    Cell Significance Index: -6.9400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1504
    Cell Significance Index: -6.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1599
    Cell Significance Index: -8.9700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1622
    Cell Significance Index: -4.4200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1639
    Cell Significance Index: -4.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1781
    Cell Significance Index: -9.2500
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: -0.1794
    Cell Significance Index: -1.8100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1813
    Cell Significance Index: -6.3000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1818
    Cell Significance Index: -2.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1873
    Cell Significance Index: -11.5100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1941
    Cell Significance Index: -4.4900
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: -0.1992
    Cell Significance Index: -0.4600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2018
    Cell Significance Index: -7.0700
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.2028
    Cell Significance Index: -1.9000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2071
    Cell Significance Index: -6.1000
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.2095
    Cell Significance Index: -3.3800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2178
    Cell Significance Index: -3.1000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2292
    Cell Significance Index: -3.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2331
    Cell Significance Index: -10.3100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2362
    Cell Significance Index: -4.9300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2474
    Cell Significance Index: -8.1000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2491
    Cell Significance Index: -2.8300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2643
    Cell Significance Index: -5.7100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2698
    Cell Significance Index: -4.6700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2708
    Cell Significance Index: -10.2600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2727
    Cell Significance Index: -10.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2757
    Cell Significance Index: -8.7800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2813
    Cell Significance Index: -7.0200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2980
    Cell Significance Index: -6.3700
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.2983
    Cell Significance Index: -2.9200
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.3024
    Cell Significance Index: -3.5000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.3100
    Cell Significance Index: -2.4800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3255
    Cell Significance Index: -8.1300
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.3345
    Cell Significance Index: -1.7600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3348
    Cell Significance Index: -8.9400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3425
    Cell Significance Index: -7.2700
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.3477
    Cell Significance Index: -2.1300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3536
    Cell Significance Index: -8.8200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3546
    Cell Significance Index: -9.0400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3548
    Cell Significance Index: -9.3300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3619
    Cell Significance Index: -9.6800
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.3658
    Cell Significance Index: -3.4800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3698
    Cell Significance Index: -16.0800
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.3708
    Cell Significance Index: -4.2700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.3733
    Cell Significance Index: -7.6000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3800
    Cell Significance Index: -5.6100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3985
    Cell Significance Index: -10.1800
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.3993
    Cell Significance Index: -5.2300
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.4003
    Cell Significance Index: -3.7200
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: -0.4041
    Cell Significance Index: -3.0300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.4090
    Cell Significance Index: -3.8400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.4107
    Cell Significance Index: -7.0800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4109
    Cell Significance Index: -8.2500
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.4185
    Cell Significance Index: -3.6200
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.4205
    Cell Significance Index: -3.9700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4225
    Cell Significance Index: -8.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Expression:** HSPB2 is predominantly expressed in cells that require rapid protein folding and cellular homeostasis, such as muscle cells, neurons, and immune cells. 2. **Structure and Function:** HSPB2 is a small heat shock protein that belongs to the HspB family, which is characterized by a highly conserved structure and a molecular weight of approximately 22 kDa. HSPB2 has been shown to interact with various proteins, including HSF1, chaperones, and other heat shock proteins, to regulate protein folding and stress response. 3. **Stress Response:** HSPB2 is activated in response to various forms of stress, including heat, oxidative stress, and unfolded protein stress. It acts as a molecular chaperone, helping to maintain protein homeostasis and prevent protein misfolding and aggregation. 4. **Regulation of Apoptosis:** HSPB2 has been shown to inhibit apoptosis by interacting with pro-apoptotic proteins and promoting the formation of anti-apoptotic protein complexes. **Pathways and Functions:** 1. **Heat Shock Response:** HSPB2 plays a crucial role in regulating the heat shock response by interacting with HSF1, a transcription factor that activates the expression of heat shock proteins. 2. **Protein Folding:** HSPB2 acts as a molecular chaperone to help maintain protein homeostasis by preventing protein misfolding and aggregation. 3. **Unfolded Protein Response:** HSPB2 is activated in response to unfolded protein stress and helps to regulate the unfolded protein response (UPR) by interacting with UPR signaling pathways. 4. **Apoptosis Regulation:** HSPB2 inhibits apoptosis by interacting with pro-apoptotic proteins and promoting the formation of anti-apoptotic protein complexes. **Clinical Significance:** HSPB2 has been implicated in various human diseases, including: 1. **Muscular Dystrophy:** Mutations in the HSPB2 gene have been associated with certain forms of muscular dystrophy, highlighting the importance of HSPB2 in muscle cell function and survival. 2. **Neurodegenerative Diseases:** HSPB2 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it may play a role in regulating protein folding and stress response in neurons. 3. **Cancer:** HSPB2 has been shown to inhibit apoptosis in cancer cells, suggesting its potential as a therapeutic target in cancer treatment. 4. **Cardiac Disease:** HSPB2 has been implicated in cardiac disease, where it may play a role in regulating protein folding and stress response in cardiac cells. In conclusion, HSPB2 is a critical regulator of cellular stress response and protein folding, and its dysregulation has been implicated in various human diseases. Further research is needed to fully understand the mechanisms by which HSPB2 regulates cellular stress response and its implications in human health and disease.

Genular Protein ID: 173642965

Symbol: HSPB2_HUMAN

Name: Heat shock protein beta-2

UniProtKB Accession Codes:

Q16082 Q6I9U7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9344664

Title: Identification and characterization of the gene encoding a new member of the alpha-crystallin/small hsp family, closely linked to the alphaB-crystallin gene in a head-to-head manner.

PubMed ID: 9344664

DOI: 10.1006/geno.1997.4956

PubMed ID: 9490724

Title: MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase.

PubMed ID: 9490724

DOI: 10.1083/jcb.140.5.1113

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8227983

Title: Muscle autoantigens in thyroid associated ophthalmopathy: the limits of molecular genetics.

PubMed ID: 8227983

DOI: 10.1007/bf03348900

PubMed ID: 19464326

Title: HSPB7 is a SC35 speckle resident small heat shock protein.

PubMed ID: 19464326

DOI: 10.1016/j.bbamcr.2009.05.005

Sequence Information:

  • Length: 182
  • Mass: 20233
  • Checksum: 7586DCE8FBD19F6D
  • Sequence:
    • MSGRSVPHAH PATAEYEFAN PSRLGEQRFG EGLLPEEILT PTLYHGYYVR PRAAPAGEGS 
RAGASELRLS EGKFQAFLDV SHFTPDEVTV RTVDNLLEVS ARHPQRLDRH GFVSREFCRT 
YVLPADVDPW RVRAALSHDG ILNLEAPRGG RHLDTEVNEV YISLLPAPPD PEEEEEAAIV 
EP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.