Details for: HSPD1

Gene ID: 3329

Symbol: HSPD1

Ensembl ID: ENSG00000144381

Description: heat shock protein family D (Hsp60) member 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 7.76
    Marker Score: 137,835
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 4.12
    Marker Score: 4,297
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.95
    Marker Score: 3,371
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.91
    Marker Score: 133,006
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.6
    Marker Score: 8,793
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.57
    Marker Score: 3,814
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.1
    Marker Score: 20,133
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 3.05
    Marker Score: 1,124
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.97
    Marker Score: 39,167
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.9
    Marker Score: 1,208
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.88
    Marker Score: 99,691
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.88
    Marker Score: 2,252
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.84
    Marker Score: 10,092
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.83
    Marker Score: 4,005
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.81
    Marker Score: 4,892
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 2.78
    Marker Score: 2,107
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.78
    Marker Score: 7,438
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.76
    Marker Score: 13,565
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 2.74
    Marker Score: 2,065
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.7
    Marker Score: 4,157
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.69
    Marker Score: 2,115
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.68
    Marker Score: 5,588
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.67
    Marker Score: 2,102
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.64
    Marker Score: 1,659
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 2.64
    Marker Score: 844
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.62
    Marker Score: 4,299
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.61
    Marker Score: 2,200
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.6
    Marker Score: 1,860
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.58
    Marker Score: 10,540
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.57
    Marker Score: 15,259
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.53
    Marker Score: 3,643
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.53
    Marker Score: 18,858
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.53
    Marker Score: 2,377
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.53
    Marker Score: 2,699
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.51
    Marker Score: 827
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.51
    Marker Score: 3,027
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.5
    Marker Score: 4,251
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.48
    Marker Score: 2,910
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.47
    Marker Score: 1,407
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.46
    Marker Score: 6,691
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.45
    Marker Score: 24,696
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.43
    Marker Score: 1,214
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.42
    Marker Score: 1,086
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.42
    Marker Score: 4,282
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.4
    Marker Score: 27,051
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.4
    Marker Score: 1,600
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.39
    Marker Score: 5,636
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.39
    Marker Score: 2,517
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.38
    Marker Score: 2,395
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.38
    Marker Score: 899
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.35
    Marker Score: 2,827
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.35
    Marker Score: 561
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.35
    Marker Score: 6,966
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.35
    Marker Score: 1,056
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.34
    Marker Score: 3,882
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 2.34
    Marker Score: 1,249
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.34
    Marker Score: 1,692
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.33
    Marker Score: 2,479
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.33
    Marker Score: 20,255
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.33
    Marker Score: 3,275
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.33
    Marker Score: 4,154
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.33
    Marker Score: 23,027
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.32
    Marker Score: 2,452
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.32
    Marker Score: 8,581
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.31
    Marker Score: 1,751
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.31
    Marker Score: 2,491
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.3
    Marker Score: 5,473
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.3
    Marker Score: 4,323
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.29
    Marker Score: 6,437
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 2.29
    Marker Score: 1,051
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.29
    Marker Score: 9,874
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.28
    Marker Score: 1,644
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.27
    Marker Score: 26,443
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.27
    Marker Score: 1,308
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.26
    Marker Score: 3,329
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.26
    Marker Score: 877
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 2.25
    Marker Score: 1,535
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.24
    Marker Score: 2,897
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.24
    Marker Score: 7,021
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.22
    Marker Score: 8,743
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 2.22
    Marker Score: 2,142
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.22
    Marker Score: 4,429
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.22
    Marker Score: 2,410
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 2.21
    Marker Score: 1,379
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.21
    Marker Score: 1,467
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.2
    Marker Score: 706
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.19
    Marker Score: 2,322
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 2.18
    Marker Score: 759
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.17
    Marker Score: 1,144
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.16
    Marker Score: 8,339
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.16
    Marker Score: 982
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 2.15
    Marker Score: 1,055
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.15
    Marker Score: 3,420
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.15
    Marker Score: 3,455
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.15
    Marker Score: 4,895
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.13
    Marker Score: 1,555
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 2.13
    Marker Score: 2,837
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.12
    Marker Score: 529
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2.11
    Marker Score: 996
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.11
    Marker Score: 529

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HSPD1 is characterized by its involvement in multiple cellular pathways, including: 1. **Protein Folding and Degradation:** HSPD1 acts as an ATP-dependent chaperone, ensuring proper folding and degradation of proteins, particularly those involved in mitochondrial function. 2. **Cell Surface Adhesion:** HSPD1 is involved in the adhesion of symbionts to host cells, facilitating symbiotic relationships. 3. **Immune Response Modulation:** HSPD1 regulates various immune responses, including B cell activation, proliferation, and cytokine production (e.g., IL-6, IL-10, and IL-12). 4. **Mitochondrial Unfolded Protein Response (UPR):** HSPD1 is essential for mitigating mitochondrial UPR, a stress response mechanism that ensures mitochondrial homeostasis. **Pathways and Functions:** HSPD1 is implicated in numerous biological processes, including: 1. **De novo Protein Folding:** HSPD1 facilitates the folding of newly synthesized proteins, preventing protein misfolding and aggregation. 2. **Apoptotic Mitochondrial Changes:** HSPD1 regulates mitochondrial changes during apoptosis, ensuring proper mitochondrial function and preventing excessive mitochondrial damage. 3. **B Cell Activation and Proliferation:** HSPD1 modulates B cell activation, proliferation, and cytokine production, influencing immune responses. 4. **Sperm Midpiece and Plasma Membrane Function:** HSPD1 is expressed in sperm cells, where it regulates sperm midpiece and plasma membrane function, essential for fertilization. **Clinical Significance:** Dysregulation of HSPD1 has been implicated in various diseases, including: 1. **Autoimmune Disorders:** HSPD1 dysregulation may contribute to autoimmune diseases, such as rheumatoid arthritis and lupus, by modulating immune responses. 2. **Cancer:** HSPD1 may play a role in cancer development and progression, particularly in mitochondrial dysfunction and apoptosis regulation. 3. **Neurodegenerative Diseases:** HSPD1 dysregulation may contribute to neurodegenerative diseases, such as Alzheimer's and Parkinson's, by impairing mitochondrial function and protein folding. In conclusion, HSPD1 is a multifaceted gene that plays a crucial role in various cellular processes, including protein folding, cell surface adhesion, and immune response modulation. Further research is necessary to fully elucidate the functions and clinical significance of HSPD1, with potential implications for the treatment of autoimmune disorders, cancer, and neurodegenerative diseases.

Genular Protein ID: 2962778335

Symbol: CH60_HUMAN

Name: 60 kDa heat shock protein, mitochondrial

UniProtKB Accession Codes:

P10809 B2R5M6 B7Z712 Q38L19 Q9UCR6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 2 CPTC 1 CTD 1 CarbonylDB 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 13 EMDB 14 EPD 1 Ensembl 9 ExpressionAtlas 1 GO 65 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 MoonProt 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 12 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 3 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2568584

Title: Primary structure of a human mitochondrial protein homologous to the bacterial and plant chaperonins and to the 65-kilodalton mycobacterial antigen.

PubMed ID: 2568584

DOI: 10.1128/mcb.9.5.2279-2283.1989

PubMed ID: 1980192

Title: Nucleotide sequences and novel structural features of human and Chinese hamster hsp60 (chaperonin) gene families.

PubMed ID: 1980192

DOI: 10.1089/dna.1990.9.545

PubMed ID: 12483302

Title: Genomic structure of the human mitochondrial chaperonin genes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoter.

PubMed ID: 12483302

DOI: 10.1007/s00439-002-0837-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2907406

Title: Amino-acid sequence homology of a polymorphic cellular protein from human lymphocytes and the chaperonins from Escherichia coli (groEL) and chloroplasts (Rubisco-binding protein).

PubMed ID: 2907406

DOI: 10.1515/bchm3.1988.369.2.1185

PubMed ID: 2079031

Title: Development of a database of amino acid sequences for human colon carcinoma proteins separated by two-dimensional polyacrylamide gel electrophoresis.

PubMed ID: 2079031

DOI: 10.1002/elps.1150111019

PubMed ID: 1731090

Title: Complex formation of human T-cell leukemia virus type I p40tax transactivator with cellular polypeptides.

PubMed ID: 1731090

DOI: 10.1128/jvi.66.2.1040-1049.1992

PubMed ID: 9150946

Title: Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2.

PubMed ID: 9150946

DOI: 10.1002/elps.1150180342

PubMed ID: 7895732

Title: The human myocardial two-dimensional gel protein database: update 1994.

PubMed ID: 7895732

DOI: 10.1002/elps.11501501209

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 1286669

Title: Human liver protein map: a reference database established by microsequencing and gel comparison.

PubMed ID: 1286669

DOI: 10.1002/elps.11501301201

PubMed ID: 15242332

Title: Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.

PubMed ID: 15242332

DOI: 10.1042/bj20040647

PubMed ID: 9150948

Title: A two-dimensional gel database of human colon carcinoma proteins.

PubMed ID: 9150948

DOI: 10.1002/elps.1150180344

PubMed ID: 1972619

Title: Mitochondrial import of the human chaperonin (HSP60) protein.

PubMed ID: 1972619

DOI: 10.1016/0006-291x(90)90344-m

PubMed ID: 1346131

Title: Mammalian mitochondrial chaperonin 60 functions as a single toroidal ring.

PubMed ID: 1346131

DOI: 10.1016/s0021-9258(18)48338-x

PubMed ID: 11422376

Title: The effect of nucleotides and mitochondrial chaperonin 10 on the structure and chaperone activity of mitochondrial chaperonin 60.

PubMed ID: 11422376

DOI: 10.1046/j.1432-1327.2001.02243.x

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15120623

Title: Interaction of the hepatitis B virus X protein (HBx) with heat shock protein 60 enhances HBx-mediated apoptosis.

PubMed ID: 15120623

DOI: 10.1016/j.bbrc.2004.04.046

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21908771

Title: The first identification of lysine malonylation substrates and its regulatory enzyme.

PubMed ID: 21908771

DOI: 10.1074/mcp.m111.012658

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 22664726

Title: ATAD3B is a human embryonic stem cell specific mitochondrial protein, re-expressed in cancer cells, that functions as dominant negative for the ubiquitous ATAD3A.

PubMed ID: 22664726

DOI: 10.1016/j.mito.2012.05.005

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23349634

Title: A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.

PubMed ID: 23349634

DOI: 10.1371/journal.pgen.1003210

PubMed ID: 24286120

Title: GTP binding controls complex formation by the human ROCO protein MASL1.

PubMed ID: 24286120

DOI: 10.1111/febs.12593

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 25918392

Title: Crystal structure of the human mitochondrial chaperonin symmetrical football complex.

PubMed ID: 25918392

DOI: 10.1073/pnas.1411718112

PubMed ID: 11898127

Title: Hereditary spastic paraplegia SPG13 is associated with a mutation in the gene encoding the mitochondrial chaperonin Hsp60.

PubMed ID: 11898127

DOI: 10.1086/339935

PubMed ID: 18571143

Title: Mitochondrial Hsp60 chaperonopathy causes an autosomal-recessive neurodegenerative disorder linked to brain hypomyelination and leukodystrophy.

PubMed ID: 18571143

DOI: 10.1016/j.ajhg.2008.05.016

Sequence Information:

  • Length: 573
  • Mass: 61055
  • Checksum: E51E1BAD9615899C
  • Sequence:
    • MLRLPTVFRQ MRPVSRVLAP HLTRAYAKDV KFGADARALM LQGVDLLADA VAVTMGPKGR 
TVIIEQSWGS PKVTKDGVTV AKSIDLKDKY KNIGAKLVQD VANNTNEEAG DGTTTATVLA 
RSIAKEGFEK ISKGANPVEI RRGVMLAVDA VIAELKKQSK PVTTPEEIAQ VATISANGDK 
EIGNIISDAM KKVGRKGVIT VKDGKTLNDE LEIIEGMKFD RGYISPYFIN TSKGQKCEFQ 
DAYVLLSEKK ISSIQSIVPA LEIANAHRKP LVIIAEDVDG EALSTLVLNR LKVGLQVVAV 
KAPGFGDNRK NQLKDMAIAT GGAVFGEEGL TLNLEDVQPH DLGKVGEVIV TKDDAMLLKG 
KGDKAQIEKR IQEIIEQLDV TTSEYEKEKL NERLAKLSDG VAVLKVGGTS DVEVNEKKDR 
VTDALNATRA AVEEGIVLGG GCALLRCIPA LDSLTPANED QKIGIEIIKR TLKIPAMTIA 
KNAGVEGSLI VEKIMQSSSE VGYDAMAGDF VNMVEKGIID PTKVVRTALL DAAGVASLLT 
TAEVVVTEIP KEEKDPGMGA MGGMGGGMGG GMF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.