Details for: HSPD1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 617.7624
Cell Significance Index: -96.0900 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 335.2049
Cell Significance Index: -85.0200 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 295.2924
Cell Significance Index: -121.6500 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 251.3118
Cell Significance Index: -118.6500 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 241.9896
Cell Significance Index: -98.3100 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 229.3709
Cell Significance Index: -117.9900 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 177.4755
Cell Significance Index: -119.0900 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 104.7926
Cell Significance Index: -100.0500 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 91.6578
Cell Significance Index: -113.0100 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 38.9046
Cell Significance Index: -104.2200 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 29.9084
Cell Significance Index: -118.0200 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 26.0040
Cell Significance Index: -79.8700 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 12.5012
Cell Significance Index: -27.3600 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 9.0816
Cell Significance Index: 243.3500 - Cell Name: kidney cell (CL1000497)
Fold Change: 6.9405
Cell Significance Index: 55.4200 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 6.3867
Cell Significance Index: 183.0800 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 6.0471
Cell Significance Index: 65.7400 - Cell Name: granulosa cell (CL0000501)
Fold Change: 5.9475
Cell Significance Index: 156.3900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 4.8079
Cell Significance Index: 1383.3600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 4.4664
Cell Significance Index: 886.3700 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 4.2567
Cell Significance Index: 200.0600 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 4.0412
Cell Significance Index: 140.4300 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 3.6223
Cell Significance Index: 75.8200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 3.3549
Cell Significance Index: 460.7200 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.2370
Cell Significance Index: 41.4600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 3.0626
Cell Significance Index: 376.5800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 3.0534
Cell Significance Index: 1667.5500 - Cell Name: theca cell (CL0000503)
Fold Change: 3.0434
Cell Significance Index: 17.8800 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 2.8652
Cell Significance Index: 202.6400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.8429
Cell Significance Index: 75.9100 - Cell Name: peg cell (CL4033014)
Fold Change: 2.8108
Cell Significance Index: 64.9400 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.8008
Cell Significance Index: 76.2400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.6339
Cell Significance Index: 310.6200 - Cell Name: lactocyte (CL0002325)
Fold Change: 2.4784
Cell Significance Index: 320.2000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 2.4443
Cell Significance Index: 440.6300 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 2.4323
Cell Significance Index: 2196.2200 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 2.1164
Cell Significance Index: 15.2000 - Cell Name: odontoblast (CL0000060)
Fold Change: 2.0395
Cell Significance Index: 261.4500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 2.0356
Cell Significance Index: 44.1000 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.6414
Cell Significance Index: 105.9000 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.6283
Cell Significance Index: 719.9100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.2127
Cell Significance Index: 90.3800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.1569
Cell Significance Index: 197.5600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.8650
Cell Significance Index: 40.3300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.8602
Cell Significance Index: 38.9900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.8191
Cell Significance Index: 164.3100 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.7509
Cell Significance Index: 8.5300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.5690
Cell Significance Index: 29.5600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.5301
Cell Significance Index: 190.1500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4129
Cell Significance Index: 67.1600 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.3054
Cell Significance Index: 8.9700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.2734
Cell Significance Index: 7.6400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.2626
Cell Significance Index: 13.7900 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2604
Cell Significance Index: 49.5600 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.2593
Cell Significance Index: 190.1200 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.2543
Cell Significance Index: 1.9600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.1655
Cell Significance Index: 125.2900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1616
Cell Significance Index: 5.6800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0909
Cell Significance Index: 171.0700 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.0881
Cell Significance Index: 4.5900 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0379
Cell Significance Index: 3.7500 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.0369
Cell Significance Index: 0.3400 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0366
Cell Significance Index: 2.2500 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0225
Cell Significance Index: 34.6700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0198
Cell Significance Index: 36.5400 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0125
Cell Significance Index: -0.2100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0275
Cell Significance Index: -17.4800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0312
Cell Significance Index: -1.7500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0366
Cell Significance Index: -49.7200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0475
Cell Significance Index: -35.1900 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0644
Cell Significance Index: -6.5800 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1018
Cell Significance Index: -63.5900 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.1057
Cell Significance Index: -1.2600 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.1061
Cell Significance Index: -1.8800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1336
Cell Significance Index: -75.3300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1449
Cell Significance Index: -65.7700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.2382
Cell Significance Index: -16.4800 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2409
Cell Significance Index: -50.7300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.3872
Cell Significance Index: -11.1600 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.3890
Cell Significance Index: -56.5400 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4780
Cell Significance Index: -37.8600 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.5363
Cell Significance Index: -13.7000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.5626
Cell Significance Index: -64.4600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.6230
Cell Significance Index: -72.6000 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.6536
Cell Significance Index: -11.0100 - Cell Name: germ cell (CL0000586)
Fold Change: -0.6794
Cell Significance Index: -5.1300 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.7724
Cell Significance Index: -88.1700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.7822
Cell Significance Index: -60.0300 - Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: -0.8437
Cell Significance Index: -7.2500 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.8669
Cell Significance Index: -58.2900 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.8987
Cell Significance Index: -5.4300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.9169
Cell Significance Index: -29.3700 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.9420
Cell Significance Index: -25.2000 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.0175
Cell Significance Index: -64.1300 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.0852
Cell Significance Index: -113.0000 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.3061
Cell Significance Index: -17.8200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.5102
Cell Significance Index: -37.7500 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.6128
Cell Significance Index: -98.8800 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -1.6860
Cell Significance Index: -24.8900 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.9899
Cell Significance Index: -88.0200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2962778335
Symbol: CH60_HUMAN
Name: 60 kDa heat shock protein, mitochondrial
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2568584
Title: Primary structure of a human mitochondrial protein homologous to the bacterial and plant chaperonins and to the 65-kilodalton mycobacterial antigen.
PubMed ID: 2568584
PubMed ID: 1980192
Title: Nucleotide sequences and novel structural features of human and Chinese hamster hsp60 (chaperonin) gene families.
PubMed ID: 1980192
PubMed ID: 12483302
Title: Genomic structure of the human mitochondrial chaperonin genes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoter.
PubMed ID: 12483302
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2907406
Title: Amino-acid sequence homology of a polymorphic cellular protein from human lymphocytes and the chaperonins from Escherichia coli (groEL) and chloroplasts (Rubisco-binding protein).
PubMed ID: 2907406
PubMed ID: 2079031
Title: Development of a database of amino acid sequences for human colon carcinoma proteins separated by two-dimensional polyacrylamide gel electrophoresis.
PubMed ID: 2079031
PubMed ID: 1731090
Title: Complex formation of human T-cell leukemia virus type I p40tax transactivator with cellular polypeptides.
PubMed ID: 1731090
PubMed ID: 9150946
Title: Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2.
PubMed ID: 9150946
PubMed ID: 7895732
Title: The human myocardial two-dimensional gel protein database: update 1994.
PubMed ID: 7895732
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 1286669
Title: Human liver protein map: a reference database established by microsequencing and gel comparison.
PubMed ID: 1286669
PubMed ID: 15242332
Title: Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.
PubMed ID: 15242332
DOI: 10.1042/bj20040647
PubMed ID: 9150948
Title: A two-dimensional gel database of human colon carcinoma proteins.
PubMed ID: 9150948
PubMed ID: 1972619
Title: Mitochondrial import of the human chaperonin (HSP60) protein.
PubMed ID: 1972619
PubMed ID: 1346131
Title: Mammalian mitochondrial chaperonin 60 functions as a single toroidal ring.
PubMed ID: 1346131
PubMed ID: 11422376
Title: The effect of nucleotides and mitochondrial chaperonin 10 on the structure and chaperone activity of mitochondrial chaperonin 60.
PubMed ID: 11422376
PubMed ID: 14654843
Title: Proteomic characterization of the human centrosome by protein correlation profiling.
PubMed ID: 14654843
DOI: 10.1038/nature02166
PubMed ID: 15120623
Title: Interaction of the hepatitis B virus X protein (HBx) with heat shock protein 60 enhances HBx-mediated apoptosis.
PubMed ID: 15120623
PubMed ID: 15592455
Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
PubMed ID: 15592455
DOI: 10.1038/nbt1046
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21908771
Title: The first identification of lysine malonylation substrates and its regulatory enzyme.
PubMed ID: 21908771
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22905912
Title: Resveratrol-induced changes of the human adipocyte secretion profile.
PubMed ID: 22905912
DOI: 10.1021/pr300539b
PubMed ID: 22664726
Title: ATAD3B is a human embryonic stem cell specific mitochondrial protein, re-expressed in cancer cells, that functions as dominant negative for the ubiquitous ATAD3A.
PubMed ID: 22664726
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23349634
Title: A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.
PubMed ID: 23349634
PubMed ID: 24286120
Title: GTP binding controls complex formation by the human ROCO protein MASL1.
PubMed ID: 24286120
DOI: 10.1111/febs.12593
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 25918392
Title: Crystal structure of the human mitochondrial chaperonin symmetrical football complex.
PubMed ID: 25918392
PubMed ID: 11898127
Title: Hereditary spastic paraplegia SPG13 is associated with a mutation in the gene encoding the mitochondrial chaperonin Hsp60.
PubMed ID: 11898127
DOI: 10.1086/339935
PubMed ID: 18571143
Title: Mitochondrial Hsp60 chaperonopathy causes an autosomal-recessive neurodegenerative disorder linked to brain hypomyelination and leukodystrophy.
PubMed ID: 18571143
Sequence Information:
- Length: 573
- Mass: 61055
- Checksum: E51E1BAD9615899C
- Sequence:
MLRLPTVFRQ MRPVSRVLAP HLTRAYAKDV KFGADARALM LQGVDLLADA VAVTMGPKGR TVIIEQSWGS PKVTKDGVTV AKSIDLKDKY KNIGAKLVQD VANNTNEEAG DGTTTATVLA RSIAKEGFEK ISKGANPVEI RRGVMLAVDA VIAELKKQSK PVTTPEEIAQ VATISANGDK EIGNIISDAM KKVGRKGVIT VKDGKTLNDE LEIIEGMKFD RGYISPYFIN TSKGQKCEFQ DAYVLLSEKK ISSIQSIVPA LEIANAHRKP LVIIAEDVDG EALSTLVLNR LKVGLQVVAV KAPGFGDNRK NQLKDMAIAT GGAVFGEEGL TLNLEDVQPH DLGKVGEVIV TKDDAMLLKG KGDKAQIEKR IQEIIEQLDV TTSEYEKEKL NERLAKLSDG VAVLKVGGTS DVEVNEKKDR VTDALNATRA AVEEGIVLGG GCALLRCIPA LDSLTPANED QKIGIEIIKR TLKIPAMTIA KNAGVEGSLI VEKIMQSSSE VGYDAMAGDF VNMVEKGIID PTKVVRTALL DAAGVASLLT TAEVVVTEIP KEEKDPGMGA MGGMGGGMGG GMF
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.