Details for: HSPD1

Gene ID: 3329

Symbol: HSPD1

Ensembl ID: ENSG00000144381

Description: heat shock protein family D (Hsp60) member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 617.7624
    Cell Significance Index: -96.0900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 335.2049
    Cell Significance Index: -85.0200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 295.2924
    Cell Significance Index: -121.6500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 251.3118
    Cell Significance Index: -118.6500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 241.9896
    Cell Significance Index: -98.3100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 229.3709
    Cell Significance Index: -117.9900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 177.4755
    Cell Significance Index: -119.0900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 104.7926
    Cell Significance Index: -100.0500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 91.6578
    Cell Significance Index: -113.0100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 38.9046
    Cell Significance Index: -104.2200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 29.9084
    Cell Significance Index: -118.0200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 26.0040
    Cell Significance Index: -79.8700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.5012
    Cell Significance Index: -27.3600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 9.0816
    Cell Significance Index: 243.3500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 6.9405
    Cell Significance Index: 55.4200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 6.3867
    Cell Significance Index: 183.0800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 6.0471
    Cell Significance Index: 65.7400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 5.9475
    Cell Significance Index: 156.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 4.8079
    Cell Significance Index: 1383.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 4.4664
    Cell Significance Index: 886.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 4.2567
    Cell Significance Index: 200.0600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 4.0412
    Cell Significance Index: 140.4300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.6223
    Cell Significance Index: 75.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.3549
    Cell Significance Index: 460.7200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.2370
    Cell Significance Index: 41.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.0626
    Cell Significance Index: 376.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.0534
    Cell Significance Index: 1667.5500
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.0434
    Cell Significance Index: 17.8800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.8652
    Cell Significance Index: 202.6400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.8429
    Cell Significance Index: 75.9100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.8108
    Cell Significance Index: 64.9400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.8008
    Cell Significance Index: 76.2400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.6339
    Cell Significance Index: 310.6200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.4784
    Cell Significance Index: 320.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.4443
    Cell Significance Index: 440.6300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.4323
    Cell Significance Index: 2196.2200
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.1164
    Cell Significance Index: 15.2000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.0395
    Cell Significance Index: 261.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.0356
    Cell Significance Index: 44.1000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.6414
    Cell Significance Index: 105.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.6283
    Cell Significance Index: 719.9100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.2127
    Cell Significance Index: 90.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.1569
    Cell Significance Index: 197.5600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8650
    Cell Significance Index: 40.3300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8602
    Cell Significance Index: 38.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8191
    Cell Significance Index: 164.3100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.7509
    Cell Significance Index: 8.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5690
    Cell Significance Index: 29.5600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5301
    Cell Significance Index: 190.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4129
    Cell Significance Index: 67.1600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3054
    Cell Significance Index: 8.9700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2734
    Cell Significance Index: 7.6400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2626
    Cell Significance Index: 13.7900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2604
    Cell Significance Index: 49.5600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2593
    Cell Significance Index: 190.1200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.2543
    Cell Significance Index: 1.9600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1655
    Cell Significance Index: 125.2900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1616
    Cell Significance Index: 5.6800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0909
    Cell Significance Index: 171.0700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0881
    Cell Significance Index: 4.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0379
    Cell Significance Index: 3.7500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0369
    Cell Significance Index: 0.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0366
    Cell Significance Index: 2.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0225
    Cell Significance Index: 34.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0198
    Cell Significance Index: 36.5400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0125
    Cell Significance Index: -0.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0275
    Cell Significance Index: -17.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0312
    Cell Significance Index: -1.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0366
    Cell Significance Index: -49.7200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0475
    Cell Significance Index: -35.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0644
    Cell Significance Index: -6.5800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1018
    Cell Significance Index: -63.5900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1057
    Cell Significance Index: -1.2600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1061
    Cell Significance Index: -1.8800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1336
    Cell Significance Index: -75.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1449
    Cell Significance Index: -65.7700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2382
    Cell Significance Index: -16.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2409
    Cell Significance Index: -50.7300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3872
    Cell Significance Index: -11.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3890
    Cell Significance Index: -56.5400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4780
    Cell Significance Index: -37.8600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5363
    Cell Significance Index: -13.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5626
    Cell Significance Index: -64.4600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6230
    Cell Significance Index: -72.6000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.6536
    Cell Significance Index: -11.0100
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.6794
    Cell Significance Index: -5.1300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.7724
    Cell Significance Index: -88.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.7822
    Cell Significance Index: -60.0300
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.8437
    Cell Significance Index: -7.2500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8669
    Cell Significance Index: -58.2900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.8987
    Cell Significance Index: -5.4300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9169
    Cell Significance Index: -29.3700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9420
    Cell Significance Index: -25.2000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.0175
    Cell Significance Index: -64.1300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.0852
    Cell Significance Index: -113.0000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.3061
    Cell Significance Index: -17.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.5102
    Cell Significance Index: -37.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.6128
    Cell Significance Index: -98.8800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.6860
    Cell Significance Index: -24.8900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.9899
    Cell Significance Index: -88.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HSPD1 is characterized by its involvement in multiple cellular pathways, including: 1. **Protein Folding and Degradation:** HSPD1 acts as an ATP-dependent chaperone, ensuring proper folding and degradation of proteins, particularly those involved in mitochondrial function. 2. **Cell Surface Adhesion:** HSPD1 is involved in the adhesion of symbionts to host cells, facilitating symbiotic relationships. 3. **Immune Response Modulation:** HSPD1 regulates various immune responses, including B cell activation, proliferation, and cytokine production (e.g., IL-6, IL-10, and IL-12). 4. **Mitochondrial Unfolded Protein Response (UPR):** HSPD1 is essential for mitigating mitochondrial UPR, a stress response mechanism that ensures mitochondrial homeostasis. **Pathways and Functions:** HSPD1 is implicated in numerous biological processes, including: 1. **De novo Protein Folding:** HSPD1 facilitates the folding of newly synthesized proteins, preventing protein misfolding and aggregation. 2. **Apoptotic Mitochondrial Changes:** HSPD1 regulates mitochondrial changes during apoptosis, ensuring proper mitochondrial function and preventing excessive mitochondrial damage. 3. **B Cell Activation and Proliferation:** HSPD1 modulates B cell activation, proliferation, and cytokine production, influencing immune responses. 4. **Sperm Midpiece and Plasma Membrane Function:** HSPD1 is expressed in sperm cells, where it regulates sperm midpiece and plasma membrane function, essential for fertilization. **Clinical Significance:** Dysregulation of HSPD1 has been implicated in various diseases, including: 1. **Autoimmune Disorders:** HSPD1 dysregulation may contribute to autoimmune diseases, such as rheumatoid arthritis and lupus, by modulating immune responses. 2. **Cancer:** HSPD1 may play a role in cancer development and progression, particularly in mitochondrial dysfunction and apoptosis regulation. 3. **Neurodegenerative Diseases:** HSPD1 dysregulation may contribute to neurodegenerative diseases, such as Alzheimer's and Parkinson's, by impairing mitochondrial function and protein folding. In conclusion, HSPD1 is a multifaceted gene that plays a crucial role in various cellular processes, including protein folding, cell surface adhesion, and immune response modulation. Further research is necessary to fully elucidate the functions and clinical significance of HSPD1, with potential implications for the treatment of autoimmune disorders, cancer, and neurodegenerative diseases.

Genular Protein ID: 2962778335

Symbol: CH60_HUMAN

Name: 60 kDa heat shock protein, mitochondrial

UniProtKB Accession Codes:

P10809 B2R5M6 B7Z712 Q38L19 Q9UCR6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 2 CPTC 1 CTD 1 CarbonylDB 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 13 EMDB 14 Ensembl 9 EvolutionaryTrace 1 ExpressionAtlas 1 GO 65 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 MoonProt 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2568584

Title: Primary structure of a human mitochondrial protein homologous to the bacterial and plant chaperonins and to the 65-kilodalton mycobacterial antigen.

PubMed ID: 2568584

DOI: 10.1128/mcb.9.5.2279-2283.1989

PubMed ID: 1980192

Title: Nucleotide sequences and novel structural features of human and Chinese hamster hsp60 (chaperonin) gene families.

PubMed ID: 1980192

DOI: 10.1089/dna.1990.9.545

PubMed ID: 12483302

Title: Genomic structure of the human mitochondrial chaperonin genes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoter.

PubMed ID: 12483302

DOI: 10.1007/s00439-002-0837-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2907406

Title: Amino-acid sequence homology of a polymorphic cellular protein from human lymphocytes and the chaperonins from Escherichia coli (groEL) and chloroplasts (Rubisco-binding protein).

PubMed ID: 2907406

DOI: 10.1515/bchm3.1988.369.2.1185

PubMed ID: 2079031

Title: Development of a database of amino acid sequences for human colon carcinoma proteins separated by two-dimensional polyacrylamide gel electrophoresis.

PubMed ID: 2079031

DOI: 10.1002/elps.1150111019

PubMed ID: 1731090

Title: Complex formation of human T-cell leukemia virus type I p40tax transactivator with cellular polypeptides.

PubMed ID: 1731090

DOI: 10.1128/jvi.66.2.1040-1049.1992

PubMed ID: 9150946

Title: Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2.

PubMed ID: 9150946

DOI: 10.1002/elps.1150180342

PubMed ID: 7895732

Title: The human myocardial two-dimensional gel protein database: update 1994.

PubMed ID: 7895732

DOI: 10.1002/elps.11501501209

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 1286669

Title: Human liver protein map: a reference database established by microsequencing and gel comparison.

PubMed ID: 1286669

DOI: 10.1002/elps.11501301201

PubMed ID: 15242332

Title: Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.

PubMed ID: 15242332

DOI: 10.1042/bj20040647

PubMed ID: 9150948

Title: A two-dimensional gel database of human colon carcinoma proteins.

PubMed ID: 9150948

DOI: 10.1002/elps.1150180344

PubMed ID: 1972619

Title: Mitochondrial import of the human chaperonin (HSP60) protein.

PubMed ID: 1972619

DOI: 10.1016/0006-291x(90)90344-m

PubMed ID: 1346131

Title: Mammalian mitochondrial chaperonin 60 functions as a single toroidal ring.

PubMed ID: 1346131

DOI: 10.1016/s0021-9258(18)48338-x

PubMed ID: 11422376

Title: The effect of nucleotides and mitochondrial chaperonin 10 on the structure and chaperone activity of mitochondrial chaperonin 60.

PubMed ID: 11422376

DOI: 10.1046/j.1432-1327.2001.02243.x

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15120623

Title: Interaction of the hepatitis B virus X protein (HBx) with heat shock protein 60 enhances HBx-mediated apoptosis.

PubMed ID: 15120623

DOI: 10.1016/j.bbrc.2004.04.046

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21908771

Title: The first identification of lysine malonylation substrates and its regulatory enzyme.

PubMed ID: 21908771

DOI: 10.1074/mcp.m111.012658

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 22664726

Title: ATAD3B is a human embryonic stem cell specific mitochondrial protein, re-expressed in cancer cells, that functions as dominant negative for the ubiquitous ATAD3A.

PubMed ID: 22664726

DOI: 10.1016/j.mito.2012.05.005

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23349634

Title: A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.

PubMed ID: 23349634

DOI: 10.1371/journal.pgen.1003210

PubMed ID: 24286120

Title: GTP binding controls complex formation by the human ROCO protein MASL1.

PubMed ID: 24286120

DOI: 10.1111/febs.12593

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 25918392

Title: Crystal structure of the human mitochondrial chaperonin symmetrical football complex.

PubMed ID: 25918392

DOI: 10.1073/pnas.1411718112

PubMed ID: 11898127

Title: Hereditary spastic paraplegia SPG13 is associated with a mutation in the gene encoding the mitochondrial chaperonin Hsp60.

PubMed ID: 11898127

DOI: 10.1086/339935

PubMed ID: 18571143

Title: Mitochondrial Hsp60 chaperonopathy causes an autosomal-recessive neurodegenerative disorder linked to brain hypomyelination and leukodystrophy.

PubMed ID: 18571143

DOI: 10.1016/j.ajhg.2008.05.016

Sequence Information:

  • Length: 573
  • Mass: 61055
  • Checksum: E51E1BAD9615899C
  • Sequence:
    • MLRLPTVFRQ MRPVSRVLAP HLTRAYAKDV KFGADARALM LQGVDLLADA VAVTMGPKGR 
TVIIEQSWGS PKVTKDGVTV AKSIDLKDKY KNIGAKLVQD VANNTNEEAG DGTTTATVLA 
RSIAKEGFEK ISKGANPVEI RRGVMLAVDA VIAELKKQSK PVTTPEEIAQ VATISANGDK 
EIGNIISDAM KKVGRKGVIT VKDGKTLNDE LEIIEGMKFD RGYISPYFIN TSKGQKCEFQ 
DAYVLLSEKK ISSIQSIVPA LEIANAHRKP LVIIAEDVDG EALSTLVLNR LKVGLQVVAV 
KAPGFGDNRK NQLKDMAIAT GGAVFGEEGL TLNLEDVQPH DLGKVGEVIV TKDDAMLLKG 
KGDKAQIEKR IQEIIEQLDV TTSEYEKEKL NERLAKLSDG VAVLKVGGTS DVEVNEKKDR 
VTDALNATRA AVEEGIVLGG GCALLRCIPA LDSLTPANED QKIGIEIIKR TLKIPAMTIA 
KNAGVEGSLI VEKIMQSSSE VGYDAMAGDF VNMVEKGIID PTKVVRTALL DAAGVASLLT 
TAEVVVTEIP KEEKDPGMGA MGGMGGGMGG GMF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.