Details for: CCN1

Gene ID: 3491

Symbol: CCN1

Ensembl ID: ENSG00000142871

Description: cellular communication network factor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 4.42
    Marker Score: 2959
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 4.17
    Marker Score: 5437
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.67
    Marker Score: 3272
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.46
    Marker Score: 2708
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.39
    Marker Score: 3618
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.21
    Marker Score: 2298
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.96
    Marker Score: 39053
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.88
    Marker Score: 7539
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.82
    Marker Score: 12177
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.79
    Marker Score: 3356.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.75
    Marker Score: 93438
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.74
    Marker Score: 1035
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.57
    Marker Score: 6268
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.57
    Marker Score: 4822
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.49
    Marker Score: 843
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.48
    Marker Score: 12170
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.33
    Marker Score: 3232
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 2.27
    Marker Score: 1247.5
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.19
    Marker Score: 1441
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.09
    Marker Score: 1394
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.06
    Marker Score: 2199
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.98
    Marker Score: 853
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.97
    Marker Score: 700
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.96
    Marker Score: 4101
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.96
    Marker Score: 3014
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.94
    Marker Score: 4571
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.92
    Marker Score: 7405
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.92
    Marker Score: 1802
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.9
    Marker Score: 21353
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.9
    Marker Score: 7019
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.88
    Marker Score: 1240
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.88
    Marker Score: 64975
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.81
    Marker Score: 1541
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.8
    Marker Score: 2481
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.74
    Marker Score: 392
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.72
    Marker Score: 983
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.69
    Marker Score: 2779
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.66
    Marker Score: 923
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.64
    Marker Score: 876.5
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.62
    Marker Score: 836
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.62
    Marker Score: 4397
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.56
    Marker Score: 366
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.55
    Marker Score: 3105
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.53
    Marker Score: 639
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.52
    Marker Score: 2579
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.48
    Marker Score: 385
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.48
    Marker Score: 932
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.47
    Marker Score: 2490
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.46
    Marker Score: 1452
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167911
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.43
    Marker Score: 19077.5
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.43
    Marker Score: 9275
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.41
    Marker Score: 1746
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.4
    Marker Score: 7372
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.39
    Marker Score: 321
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.37
    Marker Score: 1418
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.36
    Marker Score: 2872
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.34
    Marker Score: 262
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.32
    Marker Score: 327
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.32
    Marker Score: 8608
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.32
    Marker Score: 641
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.28
    Marker Score: 849
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.26
    Marker Score: 860
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.26
    Marker Score: 314
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.26
    Marker Score: 369
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.25
    Marker Score: 314
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.24
    Marker Score: 1197
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 1.24
    Marker Score: 556
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.21
    Marker Score: 500
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.19
    Marker Score: 2299
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.18
    Marker Score: 379
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.18
    Marker Score: 11838.5
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.15
    Marker Score: 610
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.14
    Marker Score: 4482
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.14
    Marker Score: 980
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.12
    Marker Score: 408
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.09
    Marker Score: 488
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.08
    Marker Score: 1567
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.07
    Marker Score: 491
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.07
    Marker Score: 273
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.07
    Marker Score: 402
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.06
    Marker Score: 501
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.05
    Marker Score: 1687
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.03
    Marker Score: 356
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.02
    Marker Score: 13747
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.01
    Marker Score: 1259
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1
    Marker Score: 317
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71720
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47947
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.99
    Marker Score: 399
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30400
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.98
    Marker Score: 472
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.98
    Marker Score: 456
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.97
    Marker Score: 5761
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.97
    Marker Score: 233
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 499
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.96
    Marker Score: 563
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.96
    Marker Score: 1123
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.95
    Marker Score: 1008

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Other Information

**Key characteristics:** * CCN1 is a transmembrane protein with a molecular weight of approximately 130 kDa. * It is a member of the immunoglobulin superfamily and shares structural similarities with vascular endothelial growth factor (VEGF). * CCN1 is a key regulator of cell adhesion, migration, and signaling in various tissues, including the heart, where it is involved in cardiac morphogenesis, valve development, and vascular remodeling. * It is also involved in cell migration, angiogenesis, and tissue repair. **Pathways and functions:** * CCN1 is a key regulator of apoptosis in the heart. * It interacts with other proteins to regulate the expression of genes involved in cell survival, proliferation, and apoptosis. * It is involved in the development and morphogenesis of the heart, including the formation of the atrioventricular valve, ventricular septum, and cardiac chambers. * CCN1 also plays a role in cell adhesion, migration, and angiogenesis. * It is involved in the regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps). * CCN1 is also involved in the regulation of cell-substrate adhesion and signaling in various tissues. **Clinical significance:** * Mutations in the CCN1 gene have been linked to various cardiovascular diseases, including congenital heart defects, heart failure, and stroke. * CCN1 is a potential therapeutic target for cardiovascular diseases, as it can be used to inhibit cardiac remodeling and improve heart function. **Conclusion:** CCN1 is a key regulator of cell-cell adhesion and signaling in the heart. Its mutations can lead to various cardiovascular diseases, underscoring its critical role in maintaining cardiovascular health.

Genular Protein ID: 3572995500

Symbol: CCN1_HUMAN

Name: Cysteine-rich angiogenic inducer 61

UniProtKB Accession Codes:

O00622 O14934 O43775 Q9BZL7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 11 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 35 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIRSF 1 PRO 1 PROSITE 7 PROSITE-ProRule 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9135077

Title: The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p.

PubMed ID: 9135077

DOI: 10.1038/sj.onc.1200986

PubMed ID: 9536281

Title: Chromosomal mapping and expression of the human cyr61 gene in tumour cells from the nervous system.

PubMed ID: 9536281

DOI: 10.1136/mp.50.6.310

PubMed ID: 10852911

Title: Muscarinic acetylcholine receptors induce the expression of the immediate early growth regulatory gene CYR61.

PubMed ID: 10852911

DOI: 10.1074/jbc.m003053200

PubMed ID: 11810026

Title: Organization and expression of the Cyr61 gene in normal human fibroblasts.

PubMed ID: 11810026

DOI: 10.1007/bf02256579

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11584015

Title: The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts.

PubMed ID: 11584015

DOI: 10.1074/jbc.m107666200

PubMed ID: 9446626

Title: Adhesion of human umbilical vein endothelial cells to the immediate-early gene product Cyr61 is mediated through integrin alphavbeta3.

PubMed ID: 9446626

DOI: 10.1074/jbc.273.5.3090

PubMed ID: 10446209

Title: Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(IIb)beta(3).

PubMed ID: 10446209

DOI: 10.1074/jbc.274.34.24321

PubMed ID: 10821835

Title: Adhesion of human skin fibroblasts to Cyr61 is mediated through integrin alpha 6beta 1 and cell surface heparan sulfate proteoglycans.

PubMed ID: 10821835

DOI: 10.1074/jbc.m003040200

PubMed ID: 11287419

Title: CYR61 stimulates human skin fibroblast migration through Integrin alpha vbeta 5 and enhances mitogenesis through integrin alpha vbeta 3, independent of its carboxyl-terminal domain.

PubMed ID: 11287419

DOI: 10.1074/jbc.m100978200

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

Sequence Information:

  • Length: 381
  • Mass: 42027
  • Checksum: FC0BD39C078CA0B1
  • Sequence:
    • MSSRIARALA LVVTLLHLTR LALSTCPAAC HCPLEAPKCA PGVGLVRDGC GCCKVCAKQL 
NEDCSKTQPC DHTKGLECNF GASSTALKGI CRAQSEGRPC EYNSRIYQNG ESFQPNCKHQ 
CTCIDGAVGC IPLCPQELSL PNLGCPNPRL VKVTGQCCEE WVCDEDSIKD PMEDQDGLLG 
KELGFDASEV ELTRNNELIA VGKGSSLKRL PVFGMEPRIL YNPLQGQKCI VQTTSWSQCS 
KTCGTGISTR VTNDNPECRL VKETRICEVR PCGQPVYSSL KKGKKCSKTK KSPEPVRFTY 
AGCLSVKKYR PKYCGSCVDG RCCTPQLTRT VKMRFRCEDG ETFSKNVMMI QSCKCNYNCP 
HANEAAFPFY RLFNDIHKFR D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.