Details for: CCN1

Gene ID: 3491

Symbol: CCN1

Ensembl ID: ENSG00000142871

Description: cellular communication network factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 347.1016
    Cell Significance Index: -53.9900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 213.8041
    Cell Significance Index: -54.2300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 127.6801
    Cell Significance Index: -52.6000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 110.3527
    Cell Significance Index: -52.1000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 109.4627
    Cell Significance Index: -44.4700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 46.4523
    Cell Significance Index: -44.3500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 43.8053
    Cell Significance Index: -54.0100
  • Cell Name: theca cell (CL0000503)
    Fold Change: 21.6565
    Cell Significance Index: 127.2300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.5832
    Cell Significance Index: -53.6000
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 12.8454
    Cell Significance Index: 59.3100
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 12.4201
    Cell Significance Index: 36.9400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 8.5825
    Cell Significance Index: 68.5300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 6.7379
    Cell Significance Index: 73.2500
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 6.0461
    Cell Significance Index: 31.8200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.4394
    Cell Significance Index: 155.9300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 5.2982
    Cell Significance Index: 110.9000
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 4.6189
    Cell Significance Index: 48.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 4.1004
    Cell Significance Index: 525.6500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 4.0587
    Cell Significance Index: 27.5000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.6232
    Cell Significance Index: 98.6200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.1801
    Cell Significance Index: 410.8500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.0518
    Cell Significance Index: 53.9300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.9819
    Cell Significance Index: 78.4100
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 2.7969
    Cell Significance Index: 16.7600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.6687
    Cell Significance Index: 188.7400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 2.3923
    Cell Significance Index: 14.7200
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.3448
    Cell Significance Index: 10.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.1363
    Cell Significance Index: 159.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.9941
    Cell Significance Index: 93.7200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.7314
    Cell Significance Index: 945.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.5671
    Cell Significance Index: 692.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2189
    Cell Significance Index: 167.3900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.0132
    Cell Significance Index: 35.2100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.9691
    Cell Significance Index: 8.1400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.8260
    Cell Significance Index: 5.1100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.6793
    Cell Significance Index: 8.7000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5804
    Cell Significance Index: 67.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3236
    Cell Significance Index: 39.8000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.2781
    Cell Significance Index: 1.6800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1946
    Cell Significance Index: 37.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1067
    Cell Significance Index: 200.8900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0936
    Cell Significance Index: 84.5400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0484
    Cell Significance Index: 0.8100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0469
    Cell Significance Index: 86.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0346
    Cell Significance Index: 26.2100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0093
    Cell Significance Index: 6.8100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0035
    Cell Significance Index: 5.3500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0113
    Cell Significance Index: -2.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0184
    Cell Significance Index: -0.4900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0247
    Cell Significance Index: -1.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0394
    Cell Significance Index: -53.6400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0498
    Cell Significance Index: -31.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0768
    Cell Significance Index: -56.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0869
    Cell Significance Index: -39.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0930
    Cell Significance Index: -4.3400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0933
    Cell Significance Index: -1.0600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0954
    Cell Significance Index: -15.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0976
    Cell Significance Index: -55.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0983
    Cell Significance Index: -11.2600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1013
    Cell Significance Index: -4.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1174
    Cell Significance Index: -11.9900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1345
    Cell Significance Index: -10.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1352
    Cell Significance Index: -48.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1392
    Cell Significance Index: -4.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1410
    Cell Significance Index: -27.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1436
    Cell Significance Index: -24.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1476
    Cell Significance Index: -29.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1625
    Cell Significance Index: -46.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2454
    Cell Significance Index: -7.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2556
    Cell Significance Index: -11.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.2642
    Cell Significance Index: -26.1400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2794
    Cell Significance Index: -58.8600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.3049
    Cell Significance Index: -33.1700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3259
    Cell Significance Index: -6.3600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3334
    Cell Significance Index: -48.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3520
    Cell Significance Index: -19.7500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4312
    Cell Significance Index: -10.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4410
    Cell Significance Index: -52.0100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4684
    Cell Significance Index: -48.7700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4784
    Cell Significance Index: -6.7100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5708
    Cell Significance Index: -29.7300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.5731
    Cell Significance Index: -39.6400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6133
    Cell Significance Index: -17.1400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6225
    Cell Significance Index: -49.3000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.6503
    Cell Significance Index: -39.0400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6904
    Cell Significance Index: -36.2500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7017
    Cell Significance Index: -43.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7197
    Cell Significance Index: -17.9900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.7543
    Cell Significance Index: -11.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7652
    Cell Significance Index: -39.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7693
    Cell Significance Index: -51.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7724
    Cell Significance Index: -24.7400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7874
    Cell Significance Index: -48.4000
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.8651
    Cell Significance Index: -5.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8682
    Cell Significance Index: -54.7200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.8800
    Cell Significance Index: -9.1100
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.9249
    Cell Significance Index: -5.7900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.9650
    Cell Significance Index: -14.4600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.0243
    Cell Significance Index: -26.3300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.0600
    Cell Significance Index: -38.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The CCN1 gene is a member of the CCN family of genes, which are known for their involvement in cellular communication and tissue development. The CCN1 protein is a secreted glycoprotein that contains four conserved cysteine-rich domains. It is highly expressed in tissues undergoing rapid growth and development, such as the heart, lungs, and placenta. The CCN1 protein has been shown to interact with various signaling pathways, including the BMP, ERK, and PI3K/AKT signaling pathways, which are involved in cell proliferation, differentiation, and survival. **Pathways and Functions:** The CCN1 gene is involved in a wide range of biological processes, including: 1. **Cell adhesion:** CCN1 promotes cell-substrate adhesion and cell-cell adhesion, which is essential for tissue development and maintenance. 2. **Cell migration:** CCN1 regulates cell migration, which is critical for tissue development, wound healing, and cancer metastasis. 3. **Cell differentiation:** CCN1 promotes cell differentiation, which is essential for tissue development and maintenance. 4. **Signaling:** CCN1 interacts with various signaling pathways, including the BMP, ERK, and PI3K/AKT signaling pathways, which regulate cell proliferation, differentiation, and survival. 5. **Tissue development:** CCN1 is involved in the development of various tissues, including the heart, lungs, and placenta. 6. **Fibrosis:** CCN1 has been implicated in the development of fibrosis, which is a common feature of various diseases, including cardiovascular disease and cancer. **Clinical Significance:** The dysregulation of the CCN1 gene has been implicated in various diseases, including: 1. **Cardiovascular disease:** CCN1 has been shown to play a critical role in the development of cardiovascular disease, including atherosclerosis and cardiac fibrosis. 2. **Cancer:** CCN1 has been implicated in the development and progression of various types of cancer, including breast, lung, and colon cancer. 3. **Fibrosis:** CCN1 has been shown to play a critical role in the development of fibrosis, which is a common feature of various diseases, including cardiovascular disease and cancer. 4. **Neurological disorders:** CCN1 has been implicated in the development of various neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, the CCN1 gene is a multifunctional gene that plays a critical role in various biological processes, including tissue development, cell adhesion, and signaling. Its dysregulation has been implicated in various diseases, including cardiovascular disease, cancer, and fibrosis. Further studies are needed to fully understand the mechanisms by which CCN1 regulates these processes and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 3572995500

Symbol: CCN1_HUMAN

Name: Cysteine-rich angiogenic inducer 61

UniProtKB Accession Codes:

O00622 O14934 O43775 Q9BZL7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 1 ExpressionAtlas 1 GO 37 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIRSF 1 PRO 1 PROSITE 7 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9135077

Title: The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p.

PubMed ID: 9135077

DOI: 10.1038/sj.onc.1200986

PubMed ID: 9536281

Title: Chromosomal mapping and expression of the human cyr61 gene in tumour cells from the nervous system.

PubMed ID: 9536281

DOI: 10.1136/mp.50.6.310

PubMed ID: 10852911

Title: Muscarinic acetylcholine receptors induce the expression of the immediate early growth regulatory gene CYR61.

PubMed ID: 10852911

DOI: 10.1074/jbc.m003053200

PubMed ID: 11810026

Title: Organization and expression of the Cyr61 gene in normal human fibroblasts.

PubMed ID: 11810026

DOI: 10.1007/bf02256579

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11584015

Title: The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts.

PubMed ID: 11584015

DOI: 10.1074/jbc.m107666200

PubMed ID: 9446626

Title: Adhesion of human umbilical vein endothelial cells to the immediate-early gene product Cyr61 is mediated through integrin alphavbeta3.

PubMed ID: 9446626

DOI: 10.1074/jbc.273.5.3090

PubMed ID: 10446209

Title: Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(IIb)beta(3).

PubMed ID: 10446209

DOI: 10.1074/jbc.274.34.24321

PubMed ID: 10821835

Title: Adhesion of human skin fibroblasts to Cyr61 is mediated through integrin alpha 6beta 1 and cell surface heparan sulfate proteoglycans.

PubMed ID: 10821835

DOI: 10.1074/jbc.m003040200

PubMed ID: 11287419

Title: CYR61 stimulates human skin fibroblast migration through Integrin alpha vbeta 5 and enhances mitogenesis through integrin alpha vbeta 3, independent of its carboxyl-terminal domain.

PubMed ID: 11287419

DOI: 10.1074/jbc.m100978200

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

Sequence Information:

  • Length: 381
  • Mass: 42027
  • Checksum: FC0BD39C078CA0B1
  • Sequence:
    • MSSRIARALA LVVTLLHLTR LALSTCPAAC HCPLEAPKCA PGVGLVRDGC GCCKVCAKQL 
NEDCSKTQPC DHTKGLECNF GASSTALKGI CRAQSEGRPC EYNSRIYQNG ESFQPNCKHQ 
CTCIDGAVGC IPLCPQELSL PNLGCPNPRL VKVTGQCCEE WVCDEDSIKD PMEDQDGLLG 
KELGFDASEV ELTRNNELIA VGKGSSLKRL PVFGMEPRIL YNPLQGQKCI VQTTSWSQCS 
KTCGTGISTR VTNDNPECRL VKETRICEVR PCGQPVYSSL KKGKKCSKTK KSPEPVRFTY 
AGCLSVKKYR PKYCGSCVDG RCCTPQLTRT VKMRFRCEDG ETFSKNVMMI QSCKCNYNCP 
HANEAAFPFY RLFNDIHKFR D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.