Details for: IK

Gene ID: 3550

Symbol: IK

Ensembl ID: ENSG00000113141

Description: IK cytokine

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.33
    Marker Score: 28937
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.84
    Marker Score: 9754
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.34
    Marker Score: 4453
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.08
    Marker Score: 71971
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.06
    Marker Score: 3878
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.06
    Marker Score: 23937
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.04
    Marker Score: 2933.5
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.02
    Marker Score: 20004
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2
    Marker Score: 947.5
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.95
    Marker Score: 19762.5
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.91
    Marker Score: 923
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.89
    Marker Score: 659.5
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.89
    Marker Score: 815
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.86
    Marker Score: 98253
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.84
    Marker Score: 15878
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.83
    Marker Score: 5144
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.82
    Marker Score: 1243
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.82
    Marker Score: 910.5
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.8
    Marker Score: 2175
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.8
    Marker Score: 3756
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.79
    Marker Score: 20135
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.77
    Marker Score: 1784
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.76
    Marker Score: 3113
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.75
    Marker Score: 1638
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.75
    Marker Score: 6475
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.75
    Marker Score: 521
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.73
    Marker Score: 6817
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.73
    Marker Score: 7072
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.73
    Marker Score: 535
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.72
    Marker Score: 1839
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.71
    Marker Score: 492
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.71
    Marker Score: 5388
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.71
    Marker Score: 1780
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.69
    Marker Score: 2494
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.69
    Marker Score: 1794
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.68
    Marker Score: 1319
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.67
    Marker Score: 2833
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.66
    Marker Score: 4528
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.66
    Marker Score: 1110
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.65
    Marker Score: 333
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.65
    Marker Score: 1744
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.63
    Marker Score: 1187
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.63
    Marker Score: 21471
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.62
    Marker Score: 599
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.62
    Marker Score: 388
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.62
    Marker Score: 4407.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.61
    Marker Score: 3670
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.61
    Marker Score: 969.5
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.6
    Marker Score: 2012
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.6
    Marker Score: 4574
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.59
    Marker Score: 1541.5
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.59
    Marker Score: 728
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.59
    Marker Score: 2116
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.58
    Marker Score: 1054
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.58
    Marker Score: 2166
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.58
    Marker Score: 2230
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.57
    Marker Score: 10190
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.57
    Marker Score: 1757
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.57
    Marker Score: 3067
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.56
    Marker Score: 15693
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.55
    Marker Score: 2534
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.54
    Marker Score: 3085.5
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.54
    Marker Score: 2759
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.54
    Marker Score: 468
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.54
    Marker Score: 6608
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.54
    Marker Score: 85980.5
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.53
    Marker Score: 1285
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.53
    Marker Score: 6578
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.52
    Marker Score: 537
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.52
    Marker Score: 524
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.51
    Marker Score: 994
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.51
    Marker Score: 1637
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.5
    Marker Score: 1669
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.5
    Marker Score: 1004
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.5
    Marker Score: 1579
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.5
    Marker Score: 1446
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 1.49
    Marker Score: 961
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.48
    Marker Score: 393
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.48
    Marker Score: 366
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.48
    Marker Score: 11026
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.48
    Marker Score: 4082
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.47
    Marker Score: 1583
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.47
    Marker Score: 363
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.47
    Marker Score: 1110
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.46
    Marker Score: 856
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.46
    Marker Score: 1516
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.46
    Marker Score: 509
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.46
    Marker Score: 994
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.45
    Marker Score: 1215
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.45
    Marker Score: 420
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.45
    Marker Score: 986
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.44
    Marker Score: 2933
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.44
    Marker Score: 1556
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.44
    Marker Score: 1089
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.44
    Marker Score: 1417.5
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.44
    Marker Score: 378.5
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.44
    Marker Score: 966
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.43
    Marker Score: 541.5
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.43
    Marker Score: 788
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.43
    Marker Score: 9125

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Other Information

**Key characteristics:** * It is a cytokine that is primarily produced and secreted by epithelial cells in the body. * It is a heterodimeric protein consisting of two subunits, each encoded by a different gene. * It is a key cytokine in the regulation of epithelial cell proliferation, survival, and differentiation. **Pathways and functions:** * The main pathway of action of Ik is through the activation of the MAPK signaling pathway. * It also binds to the DNA-binding protein p38 and modulates its activity. * It plays a role in cell cycle regulation, cell migration, and angiogenesis. * It also regulates the differentiation of epithelial cells into secretory or ciliated cells. * It is involved in the regulation of tissue development, wound healing, and cancer progression. **Clinical significance:** * Mutations in the IK gene have been linked to various human diseases, including cancer and inflammatory diseases. * In cancer, IK signaling is often dysregulated, leading to the growth and metastasis of cancer cells. * Targeting IK signaling has emerged as a promising therapeutic strategy for cancer treatment. **Conclusion:** The IK cytokine is a key cytokine that plays a crucial role in regulating cell growth, differentiation, and survival. Its dysregulation has been linked to various human diseases, including cancer and inflammatory diseases. Targeting IK signaling has emerged as a promising therapeutic strategy for cancer treatment.

Genular Protein ID: 2009417501

Symbol: RED_HUMAN

Name: Protein RER

UniProtKB Accession Codes:

Q13123 Q6IPD8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EMDB 1 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 12 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10216252

Title: Isolation, sequencing and expression of RED, a novel human gene encoding an acidic-basic dipeptide repeat.

PubMed ID: 10216252

DOI: 10.1016/s0378-1119(99)00066-9

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7970704

Title: A new cytokine (IK) down-regulating HLA class II: monoclonal antibodies, cloning and chromosome localization.

PubMed ID: 7970704

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22351768

Title: RED, a spindle pole-associated protein, is required for kinetochore localization of MAD1, mitotic progression, and activation of the spindle assembly checkpoint.

PubMed ID: 22351768

DOI: 10.1074/jbc.m111.299131

PubMed ID: 22365833

Title: Dynamic protein-protein interaction wiring of the human spliceosome.

PubMed ID: 22365833

DOI: 10.1016/j.molcel.2011.12.034

PubMed ID: 24252166

Title: Nuclear protein IK undergoes dynamic subcellular translocation and forms unique nuclear bodies during the cell cycle.

PubMed ID: 24252166

DOI: 10.1186/2050-7771-1-11

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 24945353

Title: Recruitment of RED-SMU1 complex by Influenza A Virus RNA polymerase to control Viral mRNA splicing.

PubMed ID: 24945353

DOI: 10.1371/journal.ppat.1004164

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28781166

Title: Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.

PubMed ID: 28781166

DOI: 10.1016/j.cell.2017.07.011

Sequence Information:

  • Length: 557
  • Mass: 65602
  • Checksum: BE7B332985D5F4CA
  • Sequence:
    • MPERDSEPFS NPLAPDGHDV DDPHSFHQSK LTNEDFRKLL MTPRAAPTSA PPSKSRHHEM 
PREYNEDEDP AARRRKKKSY YAKLRQQEIE RERELAEKYR DRAKERRDGV NKDYEETELI 
STTANYRAVG PTAEADKSAA EKRRQLIQES KFLGGDMEHT HLVKGLDFAL LQKVRAEIAS 
KEKEEEELME KPQKETKKDE DPENKIEFKT RLGRNVYRML FKSKAYERNE LFLPGRMAYV 
VDLDDEYADT DIPTTLIRSK ADCPTMEAQT TLTTNDIVIS KLTQILSYLR QGTRNKKLKK 
KDKGKLEEKK PPEADMNIFE DIGDYVPSTT KTPRDKERER YRERERDRER DRDRDRERER 
ERDRERERER DREREEEKKR HSYFEKPKVD DEPMDVDKGP GSTKELIKSI NEKFAGSAGW 
EGTESLKKPE DKKQLGDFFG MSNSYAECYP ATMDDMAVDS DEEVDYSKMD QGNKKGPLGR 
WDFDTQEEYS EYMNNKEALP KAAFQYGIKM SEGRKTRRFK ETNDKAELDR QWKKISAIIE 
KRKKMEADGV EVKRPKY

Genular Protein ID: 1484038833

Symbol: Q9UK43_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UK43

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 1 Genevisible 1 GenomeRNAi 1 IntAct 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 557
  • Mass: 65586
  • Checksum: D27B332EE9D5F4C6
  • Sequence:
    • MPERDSEPFS NPLAPDGHDV DDPHSFHQSK LTNEDFRKLL MTPRAAPTSA PPSKSRHHEM 
PREYNEDEDP AARRRKKKSY YAKLRQQEIE RERELAEKYR DRAKERRDGV NKDYEETELI 
STTANYRAVG PTAEADKSAA EKRRQLIQES KFLGGDMEHT HLVKGLDFAL LQKVRAEIAS 
KEKEEEELME KPQKETKKDE DPENKIEFKT RLGRNVYRML FKSKAYERNE LFLPGRMAYV 
VDLDDEYADT DIPTTLIRSK ADCPTMEAQT TLTTNDIVIS KLTQILSYLR QGTRNKKLKK 
KDKGKPEEKK PPEADMNIFE DIGDYVPSTT KTPRDKERER YRERERDRER DRDRDRERER 
ERDRERERER DREREEEKKR HSYFEKPKVD DEPMDVDKGP GSTKELIKSI NEKFAGSAGW 
EGTESLKKPE DKKQLGDFFG MSNSYAECYP ATMDDMAVDS DEEVDYSKMD QGNKKGPLGR 
WDFDTQEEYS EYMNNKEALP KAAFQYGIKM SEGRKTRRFK ETNDKAELDR QWKKISAIIE 
KRKKMEADGV EVKRPKY

Genular Protein ID: 2861496663

Symbol: Q95HA6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q95HA6

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 1 Genevisible 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 1 SAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 557
  • Mass: 65632
  • Checksum: F80A84533914F8B2
  • Sequence:
    • MPERDSEPFS NPLAPDGHDV DDPHSFHQSK LTNEDFRKLL MTPRAAPTSA PPSKSRHHEM 
PREYNEDEDP AARRRKKKSY YAKLRQQEIE RERELAEKYR DRAKERRDGV NKDYEETELI 
STTANYRAVG PTAEADKSAA EKRRQLIQES KFLGGDMEHT HLVKGLDFAL LQKVRAEIAS 
KEKEEEELME KPQKETKKDE DPENKIEFKT RLGRNVYRML FKSKAYERNE LFLPGRMTYV 
VDLDDEYADT DIPTTLIRSK ADCPTMEAQT TLTTNDIVIS KLTQILSYLR QGTRNKKLKK 
KDKGKLEEKK PPEADMNIFE DIGDYVPSTT KTPRDKERER YRERERDRER DRDRDRERER 
ERDRERERER DREREEEKKR HSYFEKPKVD DEPMDVDKGP GSTKELIKSI NEKFAGSAGW 
EGTESLKKPE DKKQLGDFFG MSNSYAECYP ATMDDMAVDS DEEVDYSKMD QGNKKGPLGR 
WDFDTQEEYS EYMNNKEALP KAAFQYGIKM SEGRKTRRFK ETNDKAELDR QWKKISAIIE 
KRKKMEADGV EVKRPKY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.