Details for: IL5RA

Gene ID: 3568

Symbol: IL5RA

Ensembl ID: ENSG00000091181

Description: interleukin 5 receptor subunit alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 33.6237
    Cell Significance Index: -5.2300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 20.6589
    Cell Significance Index: -5.2400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 10.3629
    Cell Significance Index: -4.2100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 4.3781
    Cell Significance Index: -4.1800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.2418
    Cell Significance Index: -5.2300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.4347
    Cell Significance Index: 20.8300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.9474
    Cell Significance Index: -2.9100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.3456
    Cell Significance Index: 4.8500
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.1449
    Cell Significance Index: 1.4400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0748
    Cell Significance Index: 40.8500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0676
    Cell Significance Index: 0.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0499
    Cell Significance Index: 10.0100
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.0440
    Cell Significance Index: 0.4300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0426
    Cell Significance Index: 0.7300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0269
    Cell Significance Index: 9.6600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0075
    Cell Significance Index: 5.2200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0019
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0006
    Cell Significance Index: -1.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0039
    Cell Significance Index: -7.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0041
    Cell Significance Index: -0.7500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0045
    Cell Significance Index: -2.8300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0058
    Cell Significance Index: -8.9000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0061
    Cell Significance Index: -4.4400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0062
    Cell Significance Index: -8.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0068
    Cell Significance Index: -5.1500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0089
    Cell Significance Index: -5.5700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0095
    Cell Significance Index: -5.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0095
    Cell Significance Index: -7.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0099
    Cell Significance Index: -2.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0114
    Cell Significance Index: -5.1600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0123
    Cell Significance Index: -1.5800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0131
    Cell Significance Index: -1.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0151
    Cell Significance Index: -3.0000
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0166
    Cell Significance Index: -0.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0238
    Cell Significance Index: -2.9300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0251
    Cell Significance Index: -0.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0287
    Cell Significance Index: -4.9000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0292
    Cell Significance Index: -1.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0307
    Cell Significance Index: -4.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0348
    Cell Significance Index: -7.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0482
    Cell Significance Index: -3.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0485
    Cell Significance Index: -5.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0490
    Cell Significance Index: -5.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0594
    Cell Significance Index: -6.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0617
    Cell Significance Index: -7.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0683
    Cell Significance Index: -5.2400
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0697
    Cell Significance Index: -0.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0797
    Cell Significance Index: -4.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0797
    Cell Significance Index: -5.1400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0827
    Cell Significance Index: -2.3100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0830
    Cell Significance Index: -5.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0871
    Cell Significance Index: -4.8900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0891
    Cell Significance Index: -3.9400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0911
    Cell Significance Index: -3.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0927
    Cell Significance Index: -4.3600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0968
    Cell Significance Index: -3.3900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0982
    Cell Significance Index: -2.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1002
    Cell Significance Index: -4.6700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1099
    Cell Significance Index: -2.8300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1164
    Cell Significance Index: -6.1100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1194
    Cell Significance Index: -2.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1222
    Cell Significance Index: -6.3500
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1279
    Cell Significance Index: -1.4500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1301
    Cell Significance Index: -4.2600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1339
    Cell Significance Index: -0.7300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1355
    Cell Significance Index: -4.7100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1395
    Cell Significance Index: -5.7200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1400
    Cell Significance Index: -2.9300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1438
    Cell Significance Index: -4.5800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1465
    Cell Significance Index: -7.4000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1512
    Cell Significance Index: -5.5500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1521
    Cell Significance Index: -4.8100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1543
    Cell Significance Index: -4.2000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1550
    Cell Significance Index: -3.2900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1564
    Cell Significance Index: -3.9000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1575
    Cell Significance Index: -3.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1594
    Cell Significance Index: -4.2700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1636
    Cell Significance Index: -4.6700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1650
    Cell Significance Index: -3.0500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1674
    Cell Significance Index: -3.3600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1691
    Cell Significance Index: -3.5300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1711
    Cell Significance Index: -5.0400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1757
    Cell Significance Index: -4.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1779
    Cell Significance Index: -4.7500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1794
    Cell Significance Index: -5.2700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1823
    Cell Significance Index: -5.2300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1831
    Cell Significance Index: -4.2300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1841
    Cell Significance Index: -3.6400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1847
    Cell Significance Index: -6.4900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1851
    Cell Significance Index: -4.0000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1891
    Cell Significance Index: -2.7100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1897
    Cell Significance Index: -2.5600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1908
    Cell Significance Index: -4.8600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1922
    Cell Significance Index: -5.1400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1942
    Cell Significance Index: -4.8500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1946
    Cell Significance Index: -2.7000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1985
    Cell Significance Index: -5.0700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1996
    Cell Significance Index: -2.9200
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.2032
    Cell Significance Index: -2.7400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2044
    Cell Significance Index: -5.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IL5RA is a transmembrane protein that belongs to the class I cytokine receptor family. It is composed of two subunits, α and β, with the α subunit being the focus of this discussion. The α subunit is a transmembrane protein with an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain binds to IL-5, while the intracellular domain interacts with signal transduction molecules, such as Janus kinase (JAK) and signal transducer and activator of transcription (STAT) proteins. IL5RA is highly expressed in cells of the immune system, including eosinophils, T cells, and mast cells, as well as in epithelial tissues, such as those of the respiratory and gastrointestinal tracts. **Pathways and Functions:** IL5RA plays a crucial role in the regulation of immune responses, including: 1. **Leukocyte proliferation:** IL5RA mediates the proliferation of eosinophils, T cells, and mast cells, which are essential for the defense against parasites and in the pathogenesis of allergic diseases. 2. **Inflammation:** IL5RA is involved in the regulation of inflammatory responses, particularly in the context of asthma and other allergic disorders. 3. **Cytokine production:** IL5RA influences the production of cytokines, such as IL-4, IL-5, and IL-13, which are critical in the regulation of immune responses. 4. **Neurotransmission:** IL5RA is expressed in neurons, particularly in the retina, where it may play a role in the regulation of neurotransmission and the response to immune stimuli. **Clinical Significance:** Dysregulation of IL5RA has been implicated in various diseases, including: 1. **Asthma:** Overexpression of IL5RA in eosinophils contributes to the pathogenesis of asthma, a chronic inflammatory disease characterized by airway hyperresponsiveness and eosinophilic inflammation. 2. **Allergic diseases:** IL5RA plays a crucial role in the regulation of allergic responses, including atopic dermatitis, allergic rhinitis, and food allergies. 3. **Parasitic infections:** IL5RA is essential for the defense against parasitic infections, such as schistosomiasis and hookworm infections. 4. **Cancer:** IL5RA has been implicated in the pathogenesis of certain cancers, including lung cancer and leukemia. In conclusion, IL5RA is a critical component of the IL-5 receptor complex, playing a pivotal role in the regulation of immune responses, inflammation, and cytokine production. Its dysregulation has been implicated in various diseases, including asthma, allergic diseases, parasitic infections, and cancer. Further research is needed to fully elucidate the functions and clinical implications of IL5RA.

Genular Protein ID: 644320098

Symbol: IL5RA_HUMAN

Name: Interleukin-5 receptor subunit alpha

UniProtKB Accession Codes:

Q01344 B3IU77 B4E2G0 Q14633 Q15469 Q6ISX9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 ELM 1 EMBL 10 EMDB 1 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 3 RefSeq 7 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1833065

Title: A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF.

PubMed ID: 1833065

DOI: 10.1016/0092-8674(91)90040-6

PubMed ID: 1732409

Title: Molecular cloning and expression of the human interleukin 5 receptor.

PubMed ID: 1732409

DOI: 10.1084/jem.175.2.341

PubMed ID: 1495999

Title: Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit.

PubMed ID: 1495999

DOI: 10.1073/pnas.89.15.7041

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 9378992

Title: Attenuation of IL-5-mediated signal transduction, eosinophil survival, and inflammatory mediator release by a soluble human IL-5 receptor.

PubMed ID: 9378992

PubMed ID: 9516124

Title: JAK2 and JAK1 constitutively associate with an interleukin-5 (IL-5) receptor alpha and betac subunit, respectively, and are activated upon IL-5 stimulation.

PubMed ID: 9516124

PubMed ID: 12842047

Title: Molecular roots of degenerate specificity in syntenin's PDZ2 domain: reassessment of the PDZ recognition paradigm.

PubMed ID: 12842047

DOI: 10.1016/s0969-2126(03)00125-4

PubMed ID: 22153509

Title: Structure analysis of the IL-5 ligand-receptor complex reveals a wrench-like architecture for IL-5Ralpha.

PubMed ID: 22153509

DOI: 10.1016/j.str.2011.08.015

PubMed ID: 22528658

Title: Structural basis of interleukin-5 dimer recognition by its alpha receptor.

PubMed ID: 22528658

DOI: 10.1002/pro.2072

Sequence Information:

  • Length: 420
  • Mass: 47685
  • Checksum: 4E0A5F2838B9C4FE
  • Sequence:
    • MIIVAHVLLI LLGATEILQA DLLPDEKISL LPPVNFTIKV TGLAQVLLQW KPNPDQEQRN 
VNLEYQVKIN APKEDDYETR ITESKCVTIL HKGFSASVRT ILQNDHSLLA SSWASAELHA 
PPGSPGTSIV NLTCTTNTTE DNYSRLRSYQ VSLHCTWLVG TDAPEDTQYF LYYRYGSWTE 
ECQEYSKDTL GRNIACWFPR TFILSKGRDW LAVLVNGSSK HSAIRPFDQL FALHAIDQIN 
PPLNVTAEIE GTRLSIQWEK PVSAFPIHCF DYEVKIHNTR NGYLQIEKLM TNAFISIIDD 
LSKYDVQVRA AVSSMCREAG LWSEWSQPIY VGNDEHKPLR EWFVIVIMAT ICFILLILSL 
ICKICHLWIK LFPPIPAPKS NIKDLFVTTN YEKAGSSETE IEVICYIEKP GVETLEDSVF

Genular Protein ID: 3305091683

Symbol: Q8NHV7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8NHV7

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 335
  • Mass: 37985
  • Checksum: 4AE70762398E5E11
  • Sequence:
    • MIIVAHVLLI LLGATEILQA DLLPDEKISL LPPVNFTIKV TGLAQVLLQW KPNPDQEQRN 
VNLEYQVKIN APKEDDYETR ITESKCVTIL HKGFSASVRT ILQNDHSLLA SSWASAELHA 
PPGSPGTSIV NLTCTTNTTE DNYSRLRSYQ VSLHCTWLVG TDAPEDTQYF LYYRYGSWTE 
ECQEYSKDTL GRNIACWFPR TFILSKGRDW LAVLVDGSSK HSAIRPFDQL FALHAIDQIN 
PPLNVTAEIE GTRLSIQWEK PVSAFPIHCF DYEVKIHNTR NGYLQIEKLM TNAFISIIDD 
LSKYDVQVRA AVSSMCREAG LWSEWSQPIY VGFSR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.