Details for: ILK
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 275.0325
Cell Significance Index: -42.7800 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 180.4502
Cell Significance Index: -45.7700 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 121.6174
Cell Significance Index: -50.1000 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 109.7914
Cell Significance Index: -51.8400 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 107.5673
Cell Significance Index: -43.7000 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 96.7952
Cell Significance Index: -49.7900 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 46.4209
Cell Significance Index: -44.3200 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 40.2853
Cell Significance Index: -49.6700 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 13.5879
Cell Significance Index: -36.4000 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 12.9040
Cell Significance Index: -50.9200 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 10.7824
Cell Significance Index: 90.5700 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 10.0506
Cell Significance Index: -30.8700 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 8.3227
Cell Significance Index: -18.2200 - Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 3.6355
Cell Significance Index: 19.1300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 3.0502
Cell Significance Index: 355.4700 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.6167
Cell Significance Index: 33.8400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.2941
Cell Significance Index: 177.7200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.0696
Cell Significance Index: 49.8700 - Cell Name: odontoblast (CL0000060)
Fold Change: 1.0238
Cell Significance Index: 131.2400 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.9993
Cell Significance Index: 27.2000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.9288
Cell Significance Index: 48.3800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.8537
Cell Significance Index: 40.1200 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.8239
Cell Significance Index: 97.1600 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.8183
Cell Significance Index: 21.8500 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.6197
Cell Significance Index: 18.2000 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.6088
Cell Significance Index: 332.5000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.6065
Cell Significance Index: 109.3300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.5754
Cell Significance Index: 70.7500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.5136
Cell Significance Index: 39.4200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.4930
Cell Significance Index: 97.8400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.4486
Cell Significance Index: 89.9900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3642
Cell Significance Index: 16.5100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3027
Cell Significance Index: 29.9400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2898
Cell Significance Index: 128.1300 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.2760
Cell Significance Index: 17.8100 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.2730
Cell Significance Index: 35.2700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.2488
Cell Significance Index: 42.4900 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.2445
Cell Significance Index: 18.2200 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2377
Cell Significance Index: 45.2400 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.2177
Cell Significance Index: 6.2400 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1907
Cell Significance Index: 131.9200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1768
Cell Significance Index: 12.2300 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1599
Cell Significance Index: 217.4300 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.1592
Cell Significance Index: 4.1900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1388
Cell Significance Index: 49.8000 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1145
Cell Significance Index: 3.3000 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1129
Cell Significance Index: 1.8900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0954
Cell Significance Index: 179.7200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0844
Cell Significance Index: 5.9700 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.0761
Cell Significance Index: 0.9800 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0684
Cell Significance Index: 105.3200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0651
Cell Significance Index: 29.5500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0562
Cell Significance Index: 1.9800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0397
Cell Significance Index: 2.0600 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.0348
Cell Significance Index: 1.2100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0329
Cell Significance Index: 60.6100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0048
Cell Significance Index: -3.0400 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.0054
Cell Significance Index: -0.0800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0232
Cell Significance Index: -17.5900 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0237
Cell Significance Index: -2.4200 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0276
Cell Significance Index: -20.2500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: -0.0278
Cell Significance Index: -25.1200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0301
Cell Significance Index: -22.2700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0364
Cell Significance Index: -22.7600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0512
Cell Significance Index: -1.1100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0651
Cell Significance Index: -36.7400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0885
Cell Significance Index: -12.8700 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1383
Cell Significance Index: -29.1400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1458
Cell Significance Index: -41.9600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1526
Cell Significance Index: -17.4800 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1644
Cell Significance Index: -10.3600 - Cell Name: kidney cell (CL1000497)
Fold Change: -0.1741
Cell Significance Index: -1.3900 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1817
Cell Significance Index: -9.5400 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.1998
Cell Significance Index: -32.5000 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.2051
Cell Significance Index: -2.2300 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2131
Cell Significance Index: -13.1000 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2174
Cell Significance Index: -4.6300 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3302
Cell Significance Index: -18.5300 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.3484
Cell Significance Index: -6.8000 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.3603
Cell Significance Index: -9.2100 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3695
Cell Significance Index: -38.4700 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.3956
Cell Significance Index: -2.3900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.4387
Cell Significance Index: -12.2600 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4590
Cell Significance Index: -52.4000 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.4951
Cell Significance Index: -9.1500 - Cell Name: peg cell (CL4033014)
Fold Change: -0.5069
Cell Significance Index: -11.7100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5385
Cell Significance Index: -42.6500 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.5517
Cell Significance Index: -13.7900 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.5534
Cell Significance Index: -37.2100 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.6371
Cell Significance Index: -32.2000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.6523
Cell Significance Index: -39.9900 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.7008
Cell Significance Index: -18.7500 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.7174
Cell Significance Index: -10.7500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.7258
Cell Significance Index: -23.2500 - Cell Name: perivascular cell (CL4033054)
Fold Change: -0.7602
Cell Significance Index: -3.5100 - Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.7778
Cell Significance Index: -10.9100 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.7905
Cell Significance Index: -13.9700 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.8225
Cell Significance Index: -11.8300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.8989
Cell Significance Index: -39.7600 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.9119
Cell Significance Index: -10.3600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2312628422
Symbol: ILK_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8538749
Title: Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase.
PubMed ID: 8538749
DOI: 10.1038/379091a0
PubMed ID: 10871859
Title: Cloning of an isoform of integrin-linked kinase (ILK) that is upregulated in HT-144 melanoma cells following TGF-beta1 stimulation.
PubMed ID: 10871859
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9736715
Title: Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase.
PubMed ID: 9736715
PubMed ID: 10712922
Title: Cell-substrate interactions and signaling through ILK.
PubMed ID: 10712922
PubMed ID: 11402068
Title: A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction.
PubMed ID: 11402068
PubMed ID: 12167643
Title: Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration.
PubMed ID: 12167643
PubMed ID: 15284246
Title: Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival.
PubMed ID: 15284246
PubMed ID: 15817463
Title: Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin.
PubMed ID: 15817463
PubMed ID: 19118217
Title: EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility.
PubMed ID: 19118217
DOI: 10.1242/jcs.036467
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 24590809
Title: LIMD2 is a small LIM-only protein overexpressed in metastatic lesions that regulates cell motility and tumor progression by directly binding to and activating the integrin-linked kinase.
PubMed ID: 24590809
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 32528174
Title: DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25.
PubMed ID: 32528174
PubMed ID: 19074270
Title: The structural basis of integrin-linked kinase-PINCH interactions.
PubMed ID: 19074270
PubMed ID: 19117955
Title: Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase.
PubMed ID: 19117955
PubMed ID: 20005845
Title: The pseudoactive site of ILK is essential for its binding to alpha-parvin and localization to focal adhesions.
PubMed ID: 20005845
PubMed ID: 20117114
Title: Structural basis for asymmetric association of the betaPIX coiled coil and shank PDZ.
PubMed ID: 20117114
PubMed ID: 17646580
Title: Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells.
PubMed ID: 17646580
Sequence Information:
- Length: 452
- Mass: 51419
- Checksum: E37DC2AD5311A1C2
- Sequence:
MDDIFTQCRE GNAVAVRLWL DNTENDLNQG DDHGFSPLHW ACREGRSAVV EMLIMRGARI NVMNRGDDTP LHLAASHGHR DIVQKLLQYK ADINAVNEHG NVPLHYACFW GQDQVAEDLV ANGALVSICN KYGEMPVDKA KAPLRELLRE RAEKMGQNLN RIPYKDTFWK GTTRTRPRNG TLNKHSGIDF KQLNFLTKLN ENHSGELWKG RWQGNDIVVK VLKVRDWSTR KSRDFNEECP RLRIFSHPNV LPVLGACQSP PAPHPTLITH WMPYGSLYNV LHEGTNFVVD QSQAVKFALD MARGMAFLHT LEPLIPRHAL NSRSVMIDED MTARISMADV KFSFQCPGRM YAPAWVAPEA LQKKPEDTNR RSADMWSFAV LLWELVTREV PFADLSNMEI GMKVALEGLR PTIPPGISPH VCKLMKICMN EDPAKRPKFD MIVPILEKMQ DK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.