Details for: ILK

Gene ID: 3611

Symbol: ILK

Ensembl ID: ENSG00000166333

Description: integrin linked kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 275.0325
    Cell Significance Index: -42.7800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 180.4502
    Cell Significance Index: -45.7700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 121.6174
    Cell Significance Index: -50.1000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 109.7914
    Cell Significance Index: -51.8400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 107.5673
    Cell Significance Index: -43.7000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 96.7952
    Cell Significance Index: -49.7900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 46.4209
    Cell Significance Index: -44.3200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 40.2853
    Cell Significance Index: -49.6700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.5879
    Cell Significance Index: -36.4000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.9040
    Cell Significance Index: -50.9200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 10.7824
    Cell Significance Index: 90.5700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.0506
    Cell Significance Index: -30.8700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.3227
    Cell Significance Index: -18.2200
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 3.6355
    Cell Significance Index: 19.1300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.0502
    Cell Significance Index: 355.4700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.6167
    Cell Significance Index: 33.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2941
    Cell Significance Index: 177.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0696
    Cell Significance Index: 49.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.0238
    Cell Significance Index: 131.2400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9993
    Cell Significance Index: 27.2000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.9288
    Cell Significance Index: 48.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8537
    Cell Significance Index: 40.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8239
    Cell Significance Index: 97.1600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8183
    Cell Significance Index: 21.8500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6197
    Cell Significance Index: 18.2000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6088
    Cell Significance Index: 332.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6065
    Cell Significance Index: 109.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5754
    Cell Significance Index: 70.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5136
    Cell Significance Index: 39.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4930
    Cell Significance Index: 97.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4486
    Cell Significance Index: 89.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3642
    Cell Significance Index: 16.5100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3027
    Cell Significance Index: 29.9400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2898
    Cell Significance Index: 128.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2760
    Cell Significance Index: 17.8100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2730
    Cell Significance Index: 35.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2488
    Cell Significance Index: 42.4900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2445
    Cell Significance Index: 18.2200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2377
    Cell Significance Index: 45.2400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2177
    Cell Significance Index: 6.2400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1907
    Cell Significance Index: 131.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1768
    Cell Significance Index: 12.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1599
    Cell Significance Index: 217.4300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1592
    Cell Significance Index: 4.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1388
    Cell Significance Index: 49.8000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1145
    Cell Significance Index: 3.3000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1129
    Cell Significance Index: 1.8900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0954
    Cell Significance Index: 179.7200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0844
    Cell Significance Index: 5.9700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0761
    Cell Significance Index: 0.9800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0684
    Cell Significance Index: 105.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0651
    Cell Significance Index: 29.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0562
    Cell Significance Index: 1.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0397
    Cell Significance Index: 2.0600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0348
    Cell Significance Index: 1.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0329
    Cell Significance Index: 60.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0048
    Cell Significance Index: -3.0400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0054
    Cell Significance Index: -0.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0232
    Cell Significance Index: -17.5900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0237
    Cell Significance Index: -2.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0276
    Cell Significance Index: -20.2500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0278
    Cell Significance Index: -25.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0301
    Cell Significance Index: -22.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0364
    Cell Significance Index: -22.7600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0512
    Cell Significance Index: -1.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0651
    Cell Significance Index: -36.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0885
    Cell Significance Index: -12.8700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1383
    Cell Significance Index: -29.1400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1458
    Cell Significance Index: -41.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1526
    Cell Significance Index: -17.4800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1644
    Cell Significance Index: -10.3600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.1741
    Cell Significance Index: -1.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1817
    Cell Significance Index: -9.5400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1998
    Cell Significance Index: -32.5000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2051
    Cell Significance Index: -2.2300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2131
    Cell Significance Index: -13.1000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2174
    Cell Significance Index: -4.6300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3302
    Cell Significance Index: -18.5300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3484
    Cell Significance Index: -6.8000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3603
    Cell Significance Index: -9.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3695
    Cell Significance Index: -38.4700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3956
    Cell Significance Index: -2.3900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4387
    Cell Significance Index: -12.2600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4590
    Cell Significance Index: -52.4000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4951
    Cell Significance Index: -9.1500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5069
    Cell Significance Index: -11.7100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5385
    Cell Significance Index: -42.6500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5517
    Cell Significance Index: -13.7900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5534
    Cell Significance Index: -37.2100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6371
    Cell Significance Index: -32.2000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6523
    Cell Significance Index: -39.9900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7008
    Cell Significance Index: -18.7500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.7174
    Cell Significance Index: -10.7500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7258
    Cell Significance Index: -23.2500
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.7602
    Cell Significance Index: -3.5100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.7778
    Cell Significance Index: -10.9100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.7905
    Cell Significance Index: -13.9700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.8225
    Cell Significance Index: -11.8300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8989
    Cell Significance Index: -39.7600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.9119
    Cell Significance Index: -10.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Cellular localization**: ILK is predominantly expressed in the cytoplasm and nucleus of cells, where it interacts with integrins and other signaling molecules. 2. **Serine/threonine kinase activity**: ILK possesses intrinsic kinase activity, allowing it to phosphorylate and regulate the activity of downstream targets. 3. **Integrin-mediated signaling**: ILK interacts with integrins, modulating their activity and influencing cell adhesion, migration, and proliferation. 4. **Regulation of signaling pathways**: ILK modulates various signaling pathways, including the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway, the canonical NF-κB pathway, and the Wnt signaling pathway. **Pathways and Functions** ILK's role in various signaling pathways is multifaceted: 1. **Cell adhesion and migration**: ILK regulates the activity of integrins, influencing cell adhesion, migration, and proliferation. 2. **Cell growth and survival**: ILK modulates the PI3K/Akt pathway, promoting cell survival and inhibiting apoptosis. 3. **Differentiation and development**: ILK regulates the Wnt signaling pathway, influencing cell differentiation and development. 4. **Tissue repair and remodeling**: ILK is involved in the regulation of fibroblast migration and the establishment of epithelial cell polarity. 5. **Cancer and tumor progression**: ILK's overexpression has been implicated in various types of cancer, including breast, lung, and colon cancer, where it promotes tumor growth, invasion, and metastasis. **Clinical Significance** ILK's dysregulation has been implicated in various diseases and disorders, including: 1. **Cancer**: ILK's overexpression is associated with tumor progression, metastasis, and poor prognosis. 2. **Cardiovascular disease**: ILK's role in smooth muscle cell proliferation and migration has been linked to atherosclerosis and restenosis. 3. **Neurological disorders**: ILK's involvement in neural precursor cell proliferation and differentiation has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Osteoporosis**: ILK's regulation of osteoblast differentiation and bone remodeling has been linked to osteoporosis and bone fractures. In conclusion, ILK is a critical regulator of various cellular processes, including cell adhesion, migration, proliferation, and differentiation. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of ILK in maintaining tissue homeostasis and preventing disease.

Genular Protein ID: 2312628422

Symbol: ILK_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8538749

Title: Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase.

PubMed ID: 8538749

DOI: 10.1038/379091a0

PubMed ID: 10871859

Title: Cloning of an isoform of integrin-linked kinase (ILK) that is upregulated in HT-144 melanoma cells following TGF-beta1 stimulation.

PubMed ID: 10871859

DOI: 10.1038/sj.onc.1203640

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9736715

Title: Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase.

PubMed ID: 9736715

DOI: 10.1073/pnas.95.19.11211

PubMed ID: 10712922

Title: Cell-substrate interactions and signaling through ILK.

PubMed ID: 10712922

DOI: 10.1016/s0955-0674(99)00083-6

PubMed ID: 11402068

Title: A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction.

PubMed ID: 11402068

DOI: 10.1083/jcb.153.6.1251

PubMed ID: 12167643

Title: Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration.

PubMed ID: 12167643

DOI: 10.1074/jbc.m205576200

PubMed ID: 15284246

Title: Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival.

PubMed ID: 15284246

DOI: 10.1074/jbc.m401563200

PubMed ID: 15817463

Title: Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin.

PubMed ID: 15817463

DOI: 10.1074/jbc.m500752200

PubMed ID: 19118217

Title: EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility.

PubMed ID: 19118217

DOI: 10.1242/jcs.036467

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24590809

Title: LIMD2 is a small LIM-only protein overexpressed in metastatic lesions that regulates cell motility and tumor progression by directly binding to and activating the integrin-linked kinase.

PubMed ID: 24590809

DOI: 10.1158/0008-5472.can-13-1275

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 32528174

Title: DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25.

PubMed ID: 32528174

DOI: 10.1038/s41586-020-2394-6

PubMed ID: 19074270

Title: The structural basis of integrin-linked kinase-PINCH interactions.

PubMed ID: 19074270

DOI: 10.1073/pnas.0811415106

PubMed ID: 19117955

Title: Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase.

PubMed ID: 19117955

DOI: 10.1074/jbc.m805319200

PubMed ID: 20005845

Title: The pseudoactive site of ILK is essential for its binding to alpha-parvin and localization to focal adhesions.

PubMed ID: 20005845

DOI: 10.1016/j.molcel.2009.11.028

PubMed ID: 20117114

Title: Structural basis for asymmetric association of the betaPIX coiled coil and shank PDZ.

PubMed ID: 20117114

DOI: 10.1016/j.jmb.2010.01.048

PubMed ID: 17646580

Title: Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells.

PubMed ID: 17646580

DOI: 10.1161/circulationaha.107.689984

Sequence Information:

  • Length: 452
  • Mass: 51419
  • Checksum: E37DC2AD5311A1C2
  • Sequence:
  • MDDIFTQCRE GNAVAVRLWL DNTENDLNQG DDHGFSPLHW ACREGRSAVV EMLIMRGARI 
    NVMNRGDDTP LHLAASHGHR DIVQKLLQYK ADINAVNEHG NVPLHYACFW GQDQVAEDLV 
    ANGALVSICN KYGEMPVDKA KAPLRELLRE RAEKMGQNLN RIPYKDTFWK GTTRTRPRNG 
    TLNKHSGIDF KQLNFLTKLN ENHSGELWKG RWQGNDIVVK VLKVRDWSTR KSRDFNEECP 
    RLRIFSHPNV LPVLGACQSP PAPHPTLITH WMPYGSLYNV LHEGTNFVVD QSQAVKFALD 
    MARGMAFLHT LEPLIPRHAL NSRSVMIDED MTARISMADV KFSFQCPGRM YAPAWVAPEA 
    LQKKPEDTNR RSADMWSFAV LLWELVTREV PFADLSNMEI GMKVALEGLR PTIPPGISPH 
    VCKLMKICMN EDPAKRPKFD MIVPILEKMQ DK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.