Gene ILK - ENSG00000166333 | NCBI Gene ID: 3611

Details for: ILK

Gene ID: 3611

Symbol: ILK

Ensembl ID: ENSG00000166333

Description: integrin linked kinase

Associated with

Cell-cell communication
(R-HSA-1500931)
Cell-extracellular matrix interactions
(R-HSA-446353)
Cell junction organization
(R-HSA-446728)
Localization of the pinch-ilk-parvin complex to focal adhesions
(R-HSA-446343)
Atp binding
(GO:0005524)
Branching involved in ureteric bud morphogenesis
(GO:0001658)
Cell-matrix adhesion
(GO:0007160)
Cell morphogenesis
(GO:0000902)
Cell projection organization
(GO:0030030)
Cytosol
(GO:0005829)
Establishment or maintenance of epithelial cell apical/basal polarity
(GO:0045197)
Fibroblast migration
(GO:0010761)
Focal adhesion
(GO:0005925)
Integrin-mediated signaling pathway
(GO:0007229)
Lamellipodium
(GO:0030027)
Membrane
(GO:0016020)
Myelination in peripheral nervous system
(GO:0022011)
Negative regulation of neural precursor cell proliferation
(GO:2000178)
Nerve development
(GO:0021675)
Neural precursor cell proliferation
(GO:0061351)
Outflow tract morphogenesis
(GO:0003151)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Plasma membrane
(GO:0005886)
Platelet aggregation
(GO:0070527)
Positive regulation of bmp signaling pathway
(GO:0030513)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of osteoblast differentiation
(GO:0045669)
Positive regulation of phosphorylation
(GO:0042327)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of signal transduction
(GO:0009967)
Positive regulation of substrate adhesion-dependent cell spreading
(GO:1900026)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Sarcomere
(GO:0030017)
Stress fiber
(GO:0001725)
Substrate adhesion-dependent cell spreading
(GO:0034446)
Tumor necrosis factor-mediated signaling pathway
(GO:0033209)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 2.96
Marker Score: 3850
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 2.54
Marker Score: 962
Cell Name: supporting cell (CL0000630)
Fold Change: 2.37
Marker Score: 4446.5
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 2.32
Marker Score: 970.5
Cell Name: decidual cell (CL2000002)
Fold Change: 2.18
Marker Score: 9413
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 2.16
Marker Score: 1262
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 2.11
Marker Score: 4975
Cell Name: mesodermal cell (CL0000222)
Fold Change: 2.09
Marker Score: 27514
Cell Name: muscle cell (CL0000187)
Fold Change: 1.91
Marker Score: 540
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 1.89
Marker Score: 1246.5
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.84
Marker Score: 468
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.78
Marker Score: 20098
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 1.75
Marker Score: 1644
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.74
Marker Score: 6842
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 1.69
Marker Score: 1203
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 1.67
Marker Score: 2421
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 1.67
Marker Score: 2015
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.65
Marker Score: 10748
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 1.63
Marker Score: 479
Cell Name: preosteoblast (CL0007010)
Fold Change: 1.63
Marker Score: 462
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.63
Marker Score: 1551
Cell Name: neural crest cell (CL0011012)
Fold Change: 1.59
Marker Score: 1704
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.59
Marker Score: 3499.5
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.56
Marker Score: 861
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 1.55
Marker Score: 1459
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.53
Marker Score: 1593
Cell Name: kidney cell (CL1000497)
Fold Change: 1.53
Marker Score: 1018.5
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 1.52
Marker Score: 4201.5
Cell Name: platelet (CL0000233)
Fold Change: 1.51
Marker Score: 683
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.5
Marker Score: 3427.5
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.5
Marker Score: 4089
Cell Name: blood cell (CL0000081)
Fold Change: 1.47
Marker Score: 17095
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1.46
Marker Score: 3057
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.46
Marker Score: 1638
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 1.46
Marker Score: 2001
Cell Name: Sertoli cell (CL0000216)
Fold Change: 1.45
Marker Score: 8601
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.45
Marker Score: 1530
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1.45
Marker Score: 32322
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.45
Marker Score: 796
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 1.44
Marker Score: 824
Cell Name: Unknown (CL0000548)
Fold Change: 1.43
Marker Score: 1041.5
Cell Name: fibroblast (CL0000057)
Fold Change: 1.42
Marker Score: 1369
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 1.41
Marker Score: 2173
Cell Name: pericyte (CL0000669)
Fold Change: 1.41
Marker Score: 823
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 1.4
Marker Score: 3567
Cell Name: Leydig cell (CL0000178)
Fold Change: 1.4
Marker Score: 1512
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 1.4
Marker Score: 1732
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.4
Marker Score: 47737
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.39
Marker Score: 8908
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 1.39
Marker Score: 716
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 1.39
Marker Score: 481
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 1.37
Marker Score: 1476
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.37
Marker Score: 3588
Cell Name: stromal cell (CL0000499)
Fold Change: 1.36
Marker Score: 1596
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.34
Marker Score: 3977
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 1.33
Marker Score: 882
Cell Name: lung macrophage (CL1001603)
Fold Change: 1.32
Marker Score: 1506
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 1.31
Marker Score: 822
Cell Name: cardiac neuron (CL0010022)
Fold Change: 1.3
Marker Score: 1624
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 1.29
Marker Score: 2517
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 1.29
Marker Score: 6343
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.28
Marker Score: 3199
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1.28
Marker Score: 2181
Cell Name: Unknown (CL0002371)
Fold Change: 1.28
Marker Score: 1359
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.28
Marker Score: 305
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 1.27
Marker Score: 518
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.26
Marker Score: 5274
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.25
Marker Score: 309
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.24
Marker Score: 10850
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 1.23
Marker Score: 1112
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 1.23
Marker Score: 387.5
Cell Name: osteoblast (CL0000062)
Fold Change: 1.22
Marker Score: 654
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.21
Marker Score: 12201
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.21
Marker Score: 1987.5
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.21
Marker Score: 2141
Cell Name: endothelial cell (CL0000115)
Fold Change: 1.21
Marker Score: 1082
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.21
Marker Score: 283
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.21
Marker Score: 1775
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 1.2
Marker Score: 492
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.2
Marker Score: 1509.5
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 1.2
Marker Score: 566
Cell Name: melanocyte (CL0000148)
Fold Change: 1.19
Marker Score: 484
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 1.19
Marker Score: 1066
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 1.19
Marker Score: 3729
Cell Name: osteoclast (CL0000092)
Fold Change: 1.19
Marker Score: 591
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 1.18
Marker Score: 397
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.18
Marker Score: 1187
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 1.18
Marker Score: 300
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.17
Marker Score: 1420
Cell Name: ventricular cardiac muscle cell (CL2000046)
Fold Change: 1.17
Marker Score: 486
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.17
Marker Score: 2950
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 1.17
Marker Score: 570
Cell Name: epithelial cell (CL0000066)
Fold Change: 1.16
Marker Score: 1848
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.16
Marker Score: 1177
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 1.16
Marker Score: 307
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 1.15
Marker Score: 1175
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.15
Marker Score: 64233
Cell Name: keratocyte (CL0002363)
Fold Change: 1.15
Marker Score: 264
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 1.15
Marker Score: 377.5
Cell Name: enteric neuron (CL0007011)
Fold Change: 1.14
Marker Score: 609

Hover over a box to see details here...

**Key characteristics:** * ILK is a serine/threonine kinase that is expressed in a variety of cell types. * It is a key regulator of cell adhesion, migration, and signaling in the female reproductive tract. * It is involved in the formation and maintenance of the uterine smooth muscle, the lining of the fallopian tube, and the development of the female reproductive tract. * It is also involved in cell migration and invasion, and in the regulation of cell proliferation and survival. **Pathways and functions:** * ILK is a key regulator of cell adhesion, migration, and signaling in the female reproductive tract. * It is involved in the formation and maintenance of the uterine smooth muscle, the lining of the fallopian tube, and the development of the female reproductive tract. * It is also involved in cell migration and invasion, and in the regulation of cell proliferation and survival. * ILK is thought to play a role in the regulation of uterine smooth muscle tone and function. * It is also involved in the development of the female reproductive tract, including the fallopian tube and the uterus. **Clinical significance:** * Mutations in the ILK gene have been linked to a number of human diseases, including infertility, endometriosis, and uterine fibroids. * In some cases, mutations in the ILK gene can also cause cancer. * ILK is a promising target for the treatment of human diseases that are caused by mutations in the ILK gene.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

ILK_HUMAN

Genular Protein ID: 2312628422

Symbol: ILK_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q13418 B7Z1I0 B7Z418 D3DQU0 P57043 Q68DZ3

Database IDs:

Citations:

PubMed ID: 8538749

Title: Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase.

PubMed ID: 8538749

DOI: 10.1038/379091a0

PubMed ID: 10871859

Title: Cloning of an isoform of integrin-linked kinase (ILK) that is upregulated in HT-144 melanoma cells following TGF-beta1 stimulation.

PubMed ID: 10871859

DOI: 10.1038/sj.onc.1203640

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9736715

Title: Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase.

PubMed ID: 9736715

DOI: 10.1073/pnas.95.19.11211

PubMed ID: 10712922

Title: Cell-substrate interactions and signaling through ILK.

PubMed ID: 10712922

DOI: 10.1016/s0955-0674(99)00083-6

PubMed ID: 11402068

Title: A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction.

PubMed ID: 11402068

DOI: 10.1083/jcb.153.6.1251

PubMed ID: 12167643

Title: Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration.

PubMed ID: 12167643

DOI: 10.1074/jbc.m205576200

PubMed ID: 15284246

Title: Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival.

PubMed ID: 15284246

DOI: 10.1074/jbc.m401563200

PubMed ID: 15817463

Title: Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin.

PubMed ID: 15817463

DOI: 10.1074/jbc.m500752200

PubMed ID: 19118217

Title: EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility.

PubMed ID: 19118217

DOI: 10.1242/jcs.036467

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24590809

Title: LIMD2 is a small LIM-only protein overexpressed in metastatic lesions that regulates cell motility and tumor progression by directly binding to and activating the integrin-linked kinase.

PubMed ID: 24590809

DOI: 10.1158/0008-5472.can-13-1275

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 32528174

Title: DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25.

PubMed ID: 32528174

DOI: 10.1038/s41586-020-2394-6

PubMed ID: 19074270

Title: The structural basis of integrin-linked kinase-PINCH interactions.

PubMed ID: 19074270

DOI: 10.1073/pnas.0811415106

PubMed ID: 19117955

Title: Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase.

PubMed ID: 19117955

DOI: 10.1074/jbc.m805319200

PubMed ID: 20005845

Title: The pseudoactive site of ILK is essential for its binding to alpha-parvin and localization to focal adhesions.

PubMed ID: 20005845

DOI: 10.1016/j.molcel.2009.11.028

PubMed ID: 20117114

Title: Structural basis for asymmetric association of the betaPIX coiled coil and shank PDZ.

PubMed ID: 20117114

DOI: 10.1016/j.jmb.2010.01.048

PubMed ID: 17646580

Title: Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells.

PubMed ID: 17646580

DOI: 10.1161/circulationaha.107.689984

Sequence Information:

Length: 452
Mass: 51419
Checksum: E37DC2AD5311A1C2
Sequence:

MDDIFTQCRE GNAVAVRLWL DNTENDLNQG DDHGFSPLHW ACREGRSAVV EMLIMRGARI 
NVMNRGDDTP LHLAASHGHR DIVQKLLQYK ADINAVNEHG NVPLHYACFW GQDQVAEDLV 
ANGALVSICN KYGEMPVDKA KAPLRELLRE RAEKMGQNLN RIPYKDTFWK GTTRTRPRNG 
TLNKHSGIDF KQLNFLTKLN ENHSGELWKG RWQGNDIVVK VLKVRDWSTR KSRDFNEECP 
RLRIFSHPNV LPVLGACQSP PAPHPTLITH WMPYGSLYNV LHEGTNFVVD QSQAVKFALD 
MARGMAFLHT LEPLIPRHAL NSRSVMIDED MTARISMADV KFSFQCPGRM YAPAWVAPEA 
LQKKPEDTNR RSADMWSFAV LLWELVTREV PFADLSNMEI GMKVALEGLR PTIPPGISPH 
VCKLMKICMN EDPAKRPKFD MIVPILEKMQ DK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: ILK

Associated with

Cells (max top 100)

Other Information

Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. PubMed ID: 8538749

Cloning of an isoform of integrin-linked kinase (ILK) that is upregulated in HT-144 melanoma cells following TGF-beta1 stimulation. PubMed ID: 10871859

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. PubMed ID: 9736715

Cell-substrate interactions and signaling through ILK. PubMed ID: 10712922

A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction. PubMed ID: 11402068

Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration. PubMed ID: 12167643

Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival. PubMed ID: 15284246

Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin. PubMed ID: 15817463

EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility. PubMed ID: 19118217

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

LIMD2 is a small LIM-only protein overexpressed in metastatic lesions that regulates cell motility and tumor progression by directly binding to and activating the integrin-linked kinase. PubMed ID: 24590809

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25. PubMed ID: 32528174

The structural basis of integrin-linked kinase-PINCH interactions. PubMed ID: 19074270

Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase. PubMed ID: 19117955

The pseudoactive site of ILK is essential for its binding to alpha-parvin and localization to focal adhesions. PubMed ID: 20005845

Structural basis for asymmetric association of the betaPIX coiled coil and shank PDZ. PubMed ID: 20117114

Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells. PubMed ID: 17646580