Details for: ITGAE

Gene ID: 3682

Symbol: ITGAE

Ensembl ID: ENSG00000083457

Description: integrin subunit alpha E

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 190.4912
    Cell Significance Index: -29.6300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 101.9542
    Cell Significance Index: -25.8600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 80.9326
    Cell Significance Index: -33.3400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 75.1864
    Cell Significance Index: -30.5500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 70.2360
    Cell Significance Index: -33.1600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 64.5236
    Cell Significance Index: -33.1900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 49.6854
    Cell Significance Index: -33.3400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 32.1762
    Cell Significance Index: -30.7200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.1729
    Cell Significance Index: -32.2700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.2562
    Cell Significance Index: -28.4300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.5605
    Cell Significance Index: -33.7800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.0274
    Cell Significance Index: -15.3800
  • Cell Name: centroblast (CL0009112)
    Fold Change: 4.3719
    Cell Significance Index: 10.2000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.7960
    Cell Significance Index: -7.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.5101
    Cell Significance Index: 161.9400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.0783
    Cell Significance Index: 245.0900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4292
    Cell Significance Index: 85.8000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.3692
    Cell Significance Index: 28.6600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3158
    Cell Significance Index: 143.1200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.2114
    Cell Significance Index: 11.1600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0096
    Cell Significance Index: 47.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9676
    Cell Significance Index: 118.9700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8874
    Cell Significance Index: 484.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8856
    Cell Significance Index: 159.6400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.8710
    Cell Significance Index: 25.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8674
    Cell Significance Index: 45.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7923
    Cell Significance Index: 157.2400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6955
    Cell Significance Index: 24.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6482
    Cell Significance Index: 89.0200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6404
    Cell Significance Index: 44.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5728
    Cell Significance Index: 253.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4886
    Cell Significance Index: 13.3000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4198
    Cell Significance Index: 22.0400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4073
    Cell Significance Index: 40.2900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3986
    Cell Significance Index: 28.1900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3790
    Cell Significance Index: 10.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3568
    Cell Significance Index: 71.5700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3311
    Cell Significance Index: 3.6000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3116
    Cell Significance Index: 281.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3051
    Cell Significance Index: 39.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2859
    Cell Significance Index: 54.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2840
    Cell Significance Index: 13.3500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1920
    Cell Significance Index: 2.6200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1489
    Cell Significance Index: 4.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1461
    Cell Significance Index: 4.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1205
    Cell Significance Index: 43.2300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1087
    Cell Significance Index: 17.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0576
    Cell Significance Index: 4.2900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0555
    Cell Significance Index: 0.6300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0359
    Cell Significance Index: 0.9500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0227
    Cell Significance Index: 0.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0195
    Cell Significance Index: 2.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0141
    Cell Significance Index: 26.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0122
    Cell Significance Index: 9.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0041
    Cell Significance Index: -3.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0051
    Cell Significance Index: -0.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0056
    Cell Significance Index: -8.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0074
    Cell Significance Index: -1.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0074
    Cell Significance Index: -13.6800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0096
    Cell Significance Index: -13.0500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0152
    Cell Significance Index: -0.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0160
    Cell Significance Index: -1.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0192
    Cell Significance Index: -12.2200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0219
    Cell Significance Index: -0.5900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0366
    Cell Significance Index: -27.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0481
    Cell Significance Index: -21.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0481
    Cell Significance Index: -27.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0577
    Cell Significance Index: -2.6200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0584
    Cell Significance Index: -36.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0872
    Cell Significance Index: -8.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0917
    Cell Significance Index: -10.6900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1040
    Cell Significance Index: -29.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1054
    Cell Significance Index: -4.6600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1198
    Cell Significance Index: -3.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1454
    Cell Significance Index: -21.1300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1540
    Cell Significance Index: -8.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1716
    Cell Significance Index: -36.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1751
    Cell Significance Index: -13.4400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1888
    Cell Significance Index: -7.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1908
    Cell Significance Index: -11.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1962
    Cell Significance Index: -22.4800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2117
    Cell Significance Index: -1.6900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2317
    Cell Significance Index: -13.0000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2716
    Cell Significance Index: -5.0200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2886
    Cell Significance Index: -6.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3007
    Cell Significance Index: -20.2200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3088
    Cell Significance Index: -32.1500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3268
    Cell Significance Index: -25.8800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3761
    Cell Significance Index: -12.0500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3868
    Cell Significance Index: -8.3800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4005
    Cell Significance Index: -8.5300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4950
    Cell Significance Index: -13.2400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4974
    Cell Significance Index: -14.6500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5273
    Cell Significance Index: -15.1200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.5346
    Cell Significance Index: -5.6800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5502
    Cell Significance Index: -33.7300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5753
    Cell Significance Index: -8.6200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.5890
    Cell Significance Index: -4.5400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5913
    Cell Significance Index: -15.2000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.6094
    Cell Significance Index: -14.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ITGAE is a member of the integrin alpha subfamily, which consists of nine distinct alpha subunits. The alpha E subunit is characterized by its high degree of sequence homology with other alpha subunits, particularly alpha 4 and alpha 5. This homology is thought to be responsible for the functional similarities between these subunits. ITGAE is primarily expressed on immune cells, including B cells, T cells, and dendritic cells, and is also found on non-immune cells, such as enteric smooth muscle cells. **Pathways and Functions:** ITGAE plays a critical role in regulating cell-cell adhesion and signaling through its interaction with the beta 2, 3, or 7 subunits. The alpha E subunit is involved in the regulation of various cellular processes, including: 1. **Cell-cell adhesion:** ITGAE mediates the adhesion of immune cells to other cells, such as endothelial cells, and to the extracellular matrix. 2. **Cell migration:** ITGAE is involved in the migration of immune cells, such as T cells and dendritic cells, to lymphoid organs and to sites of inflammation. 3. **Signaling:** ITGAE regulates the activation of downstream signaling pathways, including the PI3K/AKT and MAPK/ERK pathways, which are involved in cell survival, proliferation, and differentiation. 4. **Immune cell interactions:** ITGAE mediates the interaction between immune cells, such as T cells and dendritic cells, and is involved in the regulation of immune cell activation and function. **Clinical Significance:** Dysregulation of ITGAE has been implicated in several immune-related disorders, including: 1. **Rheumatoid arthritis:** ITGAE has been shown to be overexpressed in rheumatoid synovial fibroblasts and is involved in the regulation of joint inflammation. 2. **Multiple sclerosis:** ITGAE has been implicated in the pathogenesis of multiple sclerosis, where it is thought to contribute to the disruption of the blood-brain barrier. 3. **Inflammatory bowel disease:** ITGAE has been shown to be overexpressed in inflammatory bowel disease, where it is involved in the regulation of intestinal inflammation. In conclusion, ITGAE plays a critical role in regulating cell-cell adhesion, migration, and signaling, and its dysregulation has been implicated in several immune-related disorders. Further research is needed to fully elucidate the role of ITGAE in immune function and to develop therapeutic strategies targeting this gene.

Genular Protein ID: 4007503996

Symbol: ITAE_HUMAN

Name: Integrin alpha-E

UniProtKB Accession Codes:

P38570 Q17RS6 Q9NZU9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 1 CPTC 1 CTD 1 ChEBI 12 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 1 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8119947

Title: Molecular cloning of the human mucosal lymphocyte integrin alpha E subunit. Unusual structure and restricted RNA distribution.

PubMed ID: 8119947

DOI: 10.1016/s0021-9258(17)37563-4

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10673275

Title: The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion.

PubMed ID: 10673275

DOI: 10.1101/gr.10.2.165

PubMed ID: 1542691

Title: A family of beta 7 integrins on human mucosal lymphocytes.

PubMed ID: 1542691

DOI: 10.1073/pnas.89.5.1924

PubMed ID: 10837471

Title: The role of alpha and beta chains in ligand recognition by beta 7 integrins.

PubMed ID: 10837471

DOI: 10.1074/jbc.m001228200

Sequence Information:

  • Length: 1179
  • Mass: 130159
  • Checksum: 6645F8FFF9A0F045
  • Sequence:
    • MWLFHTLLCI ASLALLAAFN VDVARPWLTP KGGAPFVLSS LLHQDPSTNQ TWLLVTSPRT 
KRTPGPLHRC SLVQDEILCH PVEHVPIPKG RHRGVTVVRS HHGVLICIQV LVRRPHSLSS 
ELTGTCSLLG PDLRPQAQAN FFDLENLLDP DARVDTGDCY SNKEGGGEDD VNTARQRRAL 
EKEEEEDKEE EEDEEEEEAG TEIAIILDGS GSIDPPDFQR AKDFISNMMR NFYEKCFECN 
FALVQYGGVI QTEFDLRDSQ DVMASLARVQ NITQVGSVTK TASAMQHVLD SIFTSSHGSR 
RKASKVMVVL TDGGIFEDPL NLTTVINSPK MQGVERFAIG VGEEFKSART ARELNLIASD 
PDETHAFKVT NYMALDGLLS KLRYNIISME GTVGDALHYQ LAQIGFSAQI LDERQVLLGA 
VGAFDWSGGA LLYDTRSRRG RFLNQTAAAA ADAEAAQYSY LGYAVAVLHK TCSLSYIAGA 
PRYKHHGAVF ELQKEGREAS FLPVLEGEQM GSYFGSELCP VDIDMDGSTD FLLVAAPFYH 
VHGEEGRVYV YRLSEQDGSF SLARILSGHP GFTNARFGFA MAAMGDLSQD KLTDVAIGAP 
LEGFGADDGA SFGSVYIYNG HWDGLSASPS QRIRASTVAP GLQYFGMSMA GGFDISGDGL 
ADITVGTLGQ AVVFRSRPVV RLKVSMAFTP SALPIGFNGV VNVRLCFEIS SVTTASESGL 
REALLNFTLD VDVGKQRRRL QCSDVRSCLG CLREWSSGSQ LCEDLLLMPT EGELCEEDCF 
SNASVKVSYQ LQTPEGQTDH PQPILDRYTE PFAIFQLPYE KACKNKLFCV AELQLATTVS 
QQELVVGLTK ELTLNINLTN SGEDSYMTSM ALNYPRNLQL KRMQKPPSPN IQCDDPQPVA 
SVLIMNCRIG HPVLKRSSAH VSVVWQLEEN AFPNRTADIT VTVTNSNERR SLANETHTLQ 
FRHGFVAVLS KPSIMYVNTG QGLSHHKEFL FHVHGENLFG AEYQLQICVP TKLRGLQVVA 
VKKLTRTQAS TVCTWSQERA CAYSSVQHVE EWHSVSCVIA SDKENVTVAA EISWDHSEEL 
LKDVTELQIL GEISFNKSLY EGLNAENHRT KITVVFLKDE KYHSLPIIIK GSVGGLLVLI 
VILVILFKCG FFKRKYQQLN LESIRKAQLK SENLLEEEN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.