Details for: ITGAE

Gene ID: 3682

Symbol: ITGAE

Ensembl ID: ENSG00000083457

Description: integrin subunit alpha E

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.02
    Marker Score: 20502
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.01
    Marker Score: 5957
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.99
    Marker Score: 982
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.98
    Marker Score: 2377
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.89
    Marker Score: 2682
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.84
    Marker Score: 2047
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.71
    Marker Score: 4022
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.7
    Marker Score: 4634
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.66
    Marker Score: 6793
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.65
    Marker Score: 1659
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.58
    Marker Score: 2758
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.57
    Marker Score: 3306
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.54
    Marker Score: 338
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.53
    Marker Score: 20149
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.47
    Marker Score: 1382
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166718
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.45
    Marker Score: 883
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.44
    Marker Score: 830
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.43
    Marker Score: 1529
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 1.43
    Marker Score: 1143
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.41
    Marker Score: 519.5
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.41
    Marker Score: 5209
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.4
    Marker Score: 3481
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.36
    Marker Score: 1344
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.35
    Marker Score: 1993
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.35
    Marker Score: 2813
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.34
    Marker Score: 46549
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.33
    Marker Score: 1410
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.33
    Marker Score: 1764
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.32
    Marker Score: 796
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.28
    Marker Score: 11066
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.28
    Marker Score: 806
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.27
    Marker Score: 450
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.26
    Marker Score: 283
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.24
    Marker Score: 16602.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.22
    Marker Score: 9543
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.22
    Marker Score: 392
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.22
    Marker Score: 884
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.22
    Marker Score: 2070.5
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.21
    Marker Score: 7733
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.19
    Marker Score: 412
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.18
    Marker Score: 13670
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.16
    Marker Score: 596
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.15
    Marker Score: 766
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.13
    Marker Score: 11237
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.13
    Marker Score: 4376
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.12
    Marker Score: 813
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.12
    Marker Score: 422
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.11
    Marker Score: 942
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.11
    Marker Score: 387
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.1
    Marker Score: 4743
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.1
    Marker Score: 1148
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.09
    Marker Score: 576
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.09
    Marker Score: 1678.5
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.08
    Marker Score: 681
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.08
    Marker Score: 714
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.06
    Marker Score: 253
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.05
    Marker Score: 796
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.05
    Marker Score: 2396
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.05
    Marker Score: 251
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.04
    Marker Score: 514
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.04
    Marker Score: 507
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.02
    Marker Score: 252
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.02
    Marker Score: 56792
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.01
    Marker Score: 2409
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.01
    Marker Score: 642
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.01
    Marker Score: 1134
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.01
    Marker Score: 6128
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1
    Marker Score: 1614
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1
    Marker Score: 837
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 1
    Marker Score: 734
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1
    Marker Score: 758
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1
    Marker Score: 227
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71585
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.99
    Marker Score: 233
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47809
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.98
    Marker Score: 926
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30371
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.98
    Marker Score: 259
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.97
    Marker Score: 989
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.97
    Marker Score: 516
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.96
    Marker Score: 861
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.96
    Marker Score: 2516
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.96
    Marker Score: 271
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.96
    Marker Score: 969
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.96
    Marker Score: 1373
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.95
    Marker Score: 192
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.94
    Marker Score: 842
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.94
    Marker Score: 445.5
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.94
    Marker Score: 642
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.94
    Marker Score: 394
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2379
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.94
    Marker Score: 290
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.93
    Marker Score: 889
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 478
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.93
    Marker Score: 628
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.92
    Marker Score: 375
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.92
    Marker Score: 628
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.92
    Marker Score: 252

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Other Information

**Key characteristics:** * ITGAE is a transmembrane protein with a single extracellular domain and a single transmembrane domain. * It is expressed in high abundance on epithelial cells, where it is involved in cell-cell adhesion and tissue organization. * It is also expressed on endothelial cells, where it is involved in cell-matrix adhesion. * It is expressed on immune cells, including lymphocytes and epithelial cells. * ITGAE is a key molecule in cell adhesion and migration. **Pathways and functions:** * ITGAE is involved in cell-cell adhesion by binding to its ligand, VLA-4 (vascular cell adhesion molecule-4). * It is also involved in cell-matrix adhesion by binding to extracellular matrix proteins, such as collagen and fibronectin. * ITGAE is involved in cell adhesion mediated by integrins by binding to integrins on adjacent cells. * ITGAE is a key molecule in the integrin-mediated signaling pathway, which is involved in cell migration, proliferation, and survival. * ITGAE is also involved in the regulation of inflammation and tissue remodeling. **Clinical significance:** * Mutations in ITGAE are associated with a number of human diseases, including cancer, autoimmune disorders, and vascular diseases. * Targeting ITGAE has been investigated as a therapeutic strategy for these diseases. **Additional notes:** * ITGAE is a highly conserved protein, with a similar sequence found in mammals, birds, and reptiles. * ITGAE is a relatively new protein, with the gene encoding ITGAE first described in humans in 1994.

Genular Protein ID: 4007503996

Symbol: ITAE_HUMAN

Name: Integrin alpha-E

UniProtKB Accession Codes:

P38570 Q17RS6 Q9NZU9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 1 CPTC 1 CTD 1 ChEBI 12 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8119947

Title: Molecular cloning of the human mucosal lymphocyte integrin alpha E subunit. Unusual structure and restricted RNA distribution.

PubMed ID: 8119947

DOI: 10.1016/s0021-9258(17)37563-4

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10673275

Title: The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion.

PubMed ID: 10673275

DOI: 10.1101/gr.10.2.165

PubMed ID: 1542691

Title: A family of beta 7 integrins on human mucosal lymphocytes.

PubMed ID: 1542691

DOI: 10.1073/pnas.89.5.1924

PubMed ID: 10837471

Title: The role of alpha and beta chains in ligand recognition by beta 7 integrins.

PubMed ID: 10837471

DOI: 10.1074/jbc.m001228200

Sequence Information:

  • Length: 1179
  • Mass: 130159
  • Checksum: 6645F8FFF9A0F045
  • Sequence:
    • MWLFHTLLCI ASLALLAAFN VDVARPWLTP KGGAPFVLSS LLHQDPSTNQ TWLLVTSPRT 
KRTPGPLHRC SLVQDEILCH PVEHVPIPKG RHRGVTVVRS HHGVLICIQV LVRRPHSLSS 
ELTGTCSLLG PDLRPQAQAN FFDLENLLDP DARVDTGDCY SNKEGGGEDD VNTARQRRAL 
EKEEEEDKEE EEDEEEEEAG TEIAIILDGS GSIDPPDFQR AKDFISNMMR NFYEKCFECN 
FALVQYGGVI QTEFDLRDSQ DVMASLARVQ NITQVGSVTK TASAMQHVLD SIFTSSHGSR 
RKASKVMVVL TDGGIFEDPL NLTTVINSPK MQGVERFAIG VGEEFKSART ARELNLIASD 
PDETHAFKVT NYMALDGLLS KLRYNIISME GTVGDALHYQ LAQIGFSAQI LDERQVLLGA 
VGAFDWSGGA LLYDTRSRRG RFLNQTAAAA ADAEAAQYSY LGYAVAVLHK TCSLSYIAGA 
PRYKHHGAVF ELQKEGREAS FLPVLEGEQM GSYFGSELCP VDIDMDGSTD FLLVAAPFYH 
VHGEEGRVYV YRLSEQDGSF SLARILSGHP GFTNARFGFA MAAMGDLSQD KLTDVAIGAP 
LEGFGADDGA SFGSVYIYNG HWDGLSASPS QRIRASTVAP GLQYFGMSMA GGFDISGDGL 
ADITVGTLGQ AVVFRSRPVV RLKVSMAFTP SALPIGFNGV VNVRLCFEIS SVTTASESGL 
REALLNFTLD VDVGKQRRRL QCSDVRSCLG CLREWSSGSQ LCEDLLLMPT EGELCEEDCF 
SNASVKVSYQ LQTPEGQTDH PQPILDRYTE PFAIFQLPYE KACKNKLFCV AELQLATTVS 
QQELVVGLTK ELTLNINLTN SGEDSYMTSM ALNYPRNLQL KRMQKPPSPN IQCDDPQPVA 
SVLIMNCRIG HPVLKRSSAH VSVVWQLEEN AFPNRTADIT VTVTNSNERR SLANETHTLQ 
FRHGFVAVLS KPSIMYVNTG QGLSHHKEFL FHVHGENLFG AEYQLQICVP TKLRGLQVVA 
VKKLTRTQAS TVCTWSQERA CAYSSVQHVE EWHSVSCVIA SDKENVTVAA EISWDHSEEL 
LKDVTELQIL GEISFNKSLY EGLNAENHRT KITVVFLKDE KYHSLPIIIK GSVGGLLVLI 
VILVILFKCG FFKRKYQQLN LESIRKAQLK SENLLEEEN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.