Details for: EIF6

Gene ID: 3692

Symbol: EIF6

Ensembl ID: ENSG00000242372

Description: eukaryotic translation initiation factor 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 292.9695
    Cell Significance Index: -45.5700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 147.7665
    Cell Significance Index: -37.4800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 121.4718
    Cell Significance Index: -50.0400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 111.2846
    Cell Significance Index: -52.5400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 109.8565
    Cell Significance Index: -44.6300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 99.1280
    Cell Significance Index: -50.9900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 78.4326
    Cell Significance Index: -52.6300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 47.6673
    Cell Significance Index: -45.5100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 41.4046
    Cell Significance Index: -51.0500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.4742
    Cell Significance Index: -53.1700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.5390
    Cell Significance Index: -32.3700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.4335
    Cell Significance Index: -27.9500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 4.5515
    Cell Significance Index: 530.4300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.4641
    Cell Significance Index: -9.7700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 4.4212
    Cell Significance Index: 35.3000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.7167
    Cell Significance Index: 25.0200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.6469
    Cell Significance Index: 137.5000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 2.2000
    Cell Significance Index: 18.9100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.0295
    Cell Significance Index: 151.2600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.8949
    Cell Significance Index: 244.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.6990
    Cell Significance Index: 306.2900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.6101
    Cell Significance Index: 43.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.6019
    Cell Significance Index: 75.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3660
    Cell Significance Index: 167.9600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.3011
    Cell Significance Index: 92.0200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.2995
    Cell Significance Index: 83.8400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.2909
    Cell Significance Index: 570.7500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2600
    Cell Significance Index: 688.1100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.2592
    Cell Significance Index: 14.3100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.2206
    Cell Significance Index: 13.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1929
    Cell Significance Index: 54.0700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1845
    Cell Significance Index: 192.6400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.1654
    Cell Significance Index: 30.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1146
    Cell Significance Index: 51.9700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0974
    Cell Significance Index: 150.7000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.0787
    Cell Significance Index: 31.6800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.0353
    Cell Significance Index: 21.6700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.0192
    Cell Significance Index: 53.0900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.9328
    Cell Significance Index: 21.5500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9326
    Cell Significance Index: 109.9800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.8693
    Cell Significance Index: 13.0300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8449
    Cell Significance Index: 29.3600
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.6140
    Cell Significance Index: 3.8000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5965
    Cell Significance Index: 17.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5915
    Cell Significance Index: 75.8300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.5868
    Cell Significance Index: 10.3700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.4496
    Cell Significance Index: 8.3100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.3859
    Cell Significance Index: 2.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.3327
    Cell Significance Index: 95.7400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2822
    Cell Significance Index: 53.7100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2672
    Cell Significance Index: 7.1600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2655
    Cell Significance Index: 239.7100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2522
    Cell Significance Index: 43.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2104
    Cell Significance Index: 6.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1554
    Cell Significance Index: 4.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1535
    Cell Significance Index: 8.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1437
    Cell Significance Index: 5.0500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1382
    Cell Significance Index: 13.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0894
    Cell Significance Index: 17.9400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0731
    Cell Significance Index: 55.3000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0223
    Cell Significance Index: 16.3200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0161
    Cell Significance Index: 0.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0120
    Cell Significance Index: -7.4700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0169
    Cell Significance Index: -11.6700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0171
    Cell Significance Index: -12.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0213
    Cell Significance Index: -2.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0250
    Cell Significance Index: -46.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0256
    Cell Significance Index: -5.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0346
    Cell Significance Index: -63.8800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0414
    Cell Significance Index: -63.8100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0475
    Cell Significance Index: -64.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0478
    Cell Significance Index: -3.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0497
    Cell Significance Index: -17.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0630
    Cell Significance Index: -35.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0700
    Cell Significance Index: -44.4500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0904
    Cell Significance Index: -4.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0938
    Cell Significance Index: -10.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1137
    Cell Significance Index: -51.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1178
    Cell Significance Index: -24.8100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1335
    Cell Significance Index: -3.4100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1454
    Cell Significance Index: -5.9600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1887
    Cell Significance Index: -1.1400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2302
    Cell Significance Index: -2.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3152
    Cell Significance Index: -8.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3207
    Cell Significance Index: -46.6200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3222
    Cell Significance Index: -36.7800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3401
    Cell Significance Index: -4.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3739
    Cell Significance Index: -29.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4616
    Cell Significance Index: -10.0000
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.4939
    Cell Significance Index: -3.2200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5166
    Cell Significance Index: -13.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5200
    Cell Significance Index: -54.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5971
    Cell Significance Index: -45.8200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6090
    Cell Significance Index: -37.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6865
    Cell Significance Index: -38.5200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7285
    Cell Significance Index: -18.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7296
    Cell Significance Index: -44.7300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.7830
    Cell Significance Index: -22.5600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8112
    Cell Significance Index: -54.5500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8148
    Cell Significance Index: -24.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EIF6 is a highly conserved protein that belongs to the eukaryotic translation initiation factor family. It is composed of two subunits, EIF6-A and EIF6-B, which interact with the small ribosomal subunit to facilitate the assembly of the large subunit precursor of the preribosome. EIF6 is also involved in the regulation of fatty acid biosynthesis, glycolysis, and reactive oxygen species metabolism, highlighting its role in energy production and cellular redox balance. **Pathways and Functions:** EIF6 is involved in several critical cellular pathways, including: 1. **Translation initiation**: EIF6 plays a crucial role in the assembly of the large subunit precursor of the preribosome, which is essential for the initiation of protein synthesis. 2. **Ribosome biogenesis**: EIF6 is required for the maturation of 5.8S rRNA and LSU-rrRNA, which are essential components of the ribosome. 3. **Regulation of fatty acid biosynthesis**: EIF6 modulates the activity of key enzymes involved in fatty acid synthesis, such as acetyl-CoA carboxylase and fatty acid synthase. 4. **Regulation of glycolysis**: EIF6 influences the activity of enzymes involved in glycolysis, including pyruvate kinase and phosphofructokinase-1. 5. **Regulation of reactive oxygen species metabolism**: EIF6 modulates the activity of enzymes involved in the regulation of ROS production, such as NADPH oxidase and glutathione peroxidase. EIF6's involvement in these pathways highlights its role in maintaining cellular homeostasis and regulating key cellular processes. **Clinical Significance:** EIF6's dysregulation has been implicated in various diseases, including: 1. **Cancer**: EIF6 overexpression has been observed in several types of cancer, including breast, lung, and colon cancer. 2. **Neurological disorders**: EIF6 mutations have been associated with neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Immunological disorders**: EIF6 dysregulation has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 4. **Metabolic disorders**: EIF6 overexpression has been observed in metabolic disorders, such as obesity and type 2 diabetes. In conclusion, EIF6 is a crucial gene that plays a pivotal role in regulating protein synthesis, cell growth, and differentiation. Its dysregulation has been implicated in various diseases, highlighting the importance of EIF6 in maintaining cellular homeostasis. Further research is needed to fully elucidate the mechanisms underlying EIF6's role in disease and to explore its potential as a therapeutic target.

Genular Protein ID: 132440329

Symbol: IF6_HUMAN

Name: B(2)GCN homolog

UniProtKB Accession Codes:

P56537 B7ZBG9 Q6IBN8 Q96TD5

Database IDs:

AGR 1 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 13 EMDB 44 Ensembl 4 ExpressionAtlas 1 GO 25 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 44 PDBsum 44 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9405604

Title: Molecular cloning and functional expression of a human cDNA encoding translation initiation factor 6.

PubMed ID: 9405604

DOI: 10.1073/pnas.94.26.14285

PubMed ID: 9374518

Title: Isolation of a novel beta4 integrin-binding protein (p27(BBP)) highly expressed in epithelial cells.

PubMed ID: 9374518

DOI: 10.1074/jbc.272.48.30314

PubMed ID: 11290417

Title: The human ITGB4BP gene is constitutively expressed in vitro, but highly modulated in vivo.

PubMed ID: 11290417

DOI: 10.1016/s0378-1119(01)00370-5

PubMed ID: 9653160

Title: Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning.

PubMed ID: 9653160

DOI: 10.1073/pnas.95.14.8175

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10085284

Title: The beta4 integrin interactor p27(BBP/eIF6) is an essential nuclear matrix protein involved in 60S ribosomal subunit assembly.

PubMed ID: 10085284

DOI: 10.1083/jcb.144.5.823

PubMed ID: 12917340

Title: Phosphorylation of mammalian eukaryotic translation initiation factor 6 and its Saccharomyces cerevisiae homologue Tif6p: evidence that phosphorylation of Tif6p regulates its nucleocytoplasmic distribution and is required for yeast cell growth.

PubMed ID: 12917340

DOI: 10.1128/mcb.23.17.6187-6199.2003

PubMed ID: 14654845

Title: Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly.

PubMed ID: 14654845

DOI: 10.1038/nature02160

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17507929

Title: MicroRNA silencing through RISC recruitment of eIF6.

PubMed ID: 17507929

DOI: 10.1038/nature05841

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21536732

Title: Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome.

PubMed ID: 21536732

DOI: 10.1101/gad.623011

PubMed ID: 21084295

Title: Opposing action of casein kinase 1 and calcineurin in nucleo-cytoplasmic shuttling of mammalian translation initiation factor eIF6.

PubMed ID: 21084295

DOI: 10.1074/jbc.m110.188565

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 245
  • Mass: 26599
  • Checksum: 5BA97CD5DB0C17C3
  • Sequence:
    • MAVRASFENN CEIGCFAKLT NTYCLVAIGG SENFYSVFEG ELSDTIPVVH ASIAGCRIIG 
RMCVGNRHGL LVPNNTTDQE LQHIRNSLPD TVQIRRVEER LSALGNVTTC NDYVALVHPD 
LDRETEEILA DVLKVEVFRQ TVADQVLVGS YCVFSNQGGL VHPKTSIEDQ DELSSLLQVP 
LVAGTVNRGS EVIAAGMVVN DWCAFCGLDT TSTELSVVES VFKLNEAQPS TIATSMRDSL 
IDSLT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.