Details for: EIF6

Gene ID: 3692

Symbol: EIF6

Ensembl ID: ENSG00000242372

Description: eukaryotic translation initiation factor 6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 3.06
    Marker Score: 2159
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.91
    Marker Score: 2290.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.68
    Marker Score: 20936
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.63
    Marker Score: 22661
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.56
    Marker Score: 6259
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.44
    Marker Score: 11724
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.35
    Marker Score: 7390
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.3
    Marker Score: 1919
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.25
    Marker Score: 2712
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.19
    Marker Score: 778
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.16
    Marker Score: 8338
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.12
    Marker Score: 3115.5
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.11
    Marker Score: 8637
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.09
    Marker Score: 10277
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.09
    Marker Score: 8999
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.08
    Marker Score: 8190
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.04
    Marker Score: 7235.5
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.03
    Marker Score: 1358
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.03
    Marker Score: 4235
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2
    Marker Score: 2087
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2
    Marker Score: 2101
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.99
    Marker Score: 4734
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.97
    Marker Score: 11955
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.96
    Marker Score: 12514
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.91
    Marker Score: 2019
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.91
    Marker Score: 2936
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.89
    Marker Score: 641
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.86
    Marker Score: 2960
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.85
    Marker Score: 1878
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.84
    Marker Score: 21446
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.8
    Marker Score: 62451
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.79
    Marker Score: 13342
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.78
    Marker Score: 3160
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.78
    Marker Score: 918
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.78
    Marker Score: 4032
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.77
    Marker Score: 2285
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.77
    Marker Score: 2933
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.76
    Marker Score: 1902
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.74
    Marker Score: 2802
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.72
    Marker Score: 2922.5
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.72
    Marker Score: 43996
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.72
    Marker Score: 945.5
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.71
    Marker Score: 811
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.7
    Marker Score: 849
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.7
    Marker Score: 1711
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.69
    Marker Score: 6272
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.69
    Marker Score: 57508
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.67
    Marker Score: 3054
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.66
    Marker Score: 4574
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.64
    Marker Score: 4460
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.63
    Marker Score: 16568.5
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.63
    Marker Score: 602
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.63
    Marker Score: 930
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.62
    Marker Score: 1726
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.62
    Marker Score: 2663
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.62
    Marker Score: 1446.5
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.62
    Marker Score: 1891
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.62
    Marker Score: 1815
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.61
    Marker Score: 10292
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.61
    Marker Score: 1013.5
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.6
    Marker Score: 376
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.6
    Marker Score: 10406.5
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.6
    Marker Score: 21069.5
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.59
    Marker Score: 16044
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.57
    Marker Score: 1068
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.57
    Marker Score: 17636
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.56
    Marker Score: 3675
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.56
    Marker Score: 2206
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.56
    Marker Score: 3032
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.55
    Marker Score: 3535
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.54
    Marker Score: 1453
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.54
    Marker Score: 2898
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.54
    Marker Score: 368
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.54
    Marker Score: 2045
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.54
    Marker Score: 444
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.53
    Marker Score: 370
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.53
    Marker Score: 1918
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.53
    Marker Score: 8026
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.53
    Marker Score: 1039
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.52
    Marker Score: 1623
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.51
    Marker Score: 84572.5
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.51
    Marker Score: 2137
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.5
    Marker Score: 565
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.5
    Marker Score: 381
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.5
    Marker Score: 1001
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.49
    Marker Score: 2982
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.49
    Marker Score: 3993.5
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.48
    Marker Score: 1079
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.47
    Marker Score: 810
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.47
    Marker Score: 2556
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.46
    Marker Score: 468
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.46
    Marker Score: 1513
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 1.46
    Marker Score: 668
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.45
    Marker Score: 3623
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 1.45
    Marker Score: 465
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.45
    Marker Score: 3934.5
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.45
    Marker Score: 1545
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.45
    Marker Score: 383
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.44
    Marker Score: 414
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.43
    Marker Score: 12449

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Other Information

**Key characteristics:** * EIF6 is a key component of the ribosome assembly complex. * It is involved in the maturation of ribosomal subunits and the assembly of the large subunit of the ribosome. * It is also involved in the regulation of fatty acid biosynthetic process, glycolytic process, and megakaryocyte differentiation. **Pathways and functions:** * EIF6 is involved in the assembly of the ribosome by interacting with the EIF4 and EIF2 proteins. * It is also involved in the maturation of ribosomal subunits by facilitating the interaction between the ribosomal proteins and the small subunit of the ribosome. * It is also involved in the regulation of fatty acid biosynthetic process, glycolytic process, and megakaryocyte differentiation. **Clinical significance:** * Mutations in the EIF6 gene have been linked to a number of human diseases, including cancer, autoimmune disorders, and metabolic disorders. * EIF6 inhibitors are being investigated as potential treatments for these diseases.

Genular Protein ID: 132440329

Symbol: IF6_HUMAN

Name: B(2)GCN homolog

UniProtKB Accession Codes:

P56537 B7ZBG9 Q6IBN8 Q96TD5

Database IDs:

AGR 1 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 13 EMDB 41 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 25 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HAMAP-Rule 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 45 PDBsum 41 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9405604

Title: Molecular cloning and functional expression of a human cDNA encoding translation initiation factor 6.

PubMed ID: 9405604

DOI: 10.1073/pnas.94.26.14285

PubMed ID: 9374518

Title: Isolation of a novel beta4 integrin-binding protein (p27(BBP)) highly expressed in epithelial cells.

PubMed ID: 9374518

DOI: 10.1074/jbc.272.48.30314

PubMed ID: 11290417

Title: The human ITGB4BP gene is constitutively expressed in vitro, but highly modulated in vivo.

PubMed ID: 11290417

DOI: 10.1016/s0378-1119(01)00370-5

PubMed ID: 9653160

Title: Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning.

PubMed ID: 9653160

DOI: 10.1073/pnas.95.14.8175

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10085284

Title: The beta4 integrin interactor p27(BBP/eIF6) is an essential nuclear matrix protein involved in 60S ribosomal subunit assembly.

PubMed ID: 10085284

DOI: 10.1083/jcb.144.5.823

PubMed ID: 12917340

Title: Phosphorylation of mammalian eukaryotic translation initiation factor 6 and its Saccharomyces cerevisiae homologue Tif6p: evidence that phosphorylation of Tif6p regulates its nucleocytoplasmic distribution and is required for yeast cell growth.

PubMed ID: 12917340

DOI: 10.1128/mcb.23.17.6187-6199.2003

PubMed ID: 14654845

Title: Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly.

PubMed ID: 14654845

DOI: 10.1038/nature02160

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17507929

Title: MicroRNA silencing through RISC recruitment of eIF6.

PubMed ID: 17507929

DOI: 10.1038/nature05841

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21536732

Title: Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome.

PubMed ID: 21536732

DOI: 10.1101/gad.623011

PubMed ID: 21084295

Title: Opposing action of casein kinase 1 and calcineurin in nucleo-cytoplasmic shuttling of mammalian translation initiation factor eIF6.

PubMed ID: 21084295

DOI: 10.1074/jbc.m110.188565

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 245
  • Mass: 26599
  • Checksum: 5BA97CD5DB0C17C3
  • Sequence:
    • MAVRASFENN CEIGCFAKLT NTYCLVAIGG SENFYSVFEG ELSDTIPVVH ASIAGCRIIG 
RMCVGNRHGL LVPNNTTDQE LQHIRNSLPD TVQIRRVEER LSALGNVTTC NDYVALVHPD 
LDRETEEILA DVLKVEVFRQ TVADQVLVGS YCVFSNQGGL VHPKTSIEDQ DELSSLLQVP 
LVAGTVNRGS EVIAAGMVVN DWCAFCGLDT TSTELSVVES VFKLNEAQPS TIATSMRDSL 
IDSLT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.