Details for: ITK

Gene ID: 3702

Symbol: ITK

Ensembl ID: ENSG00000113263

Description: IL2 inducible T cell kinase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.28
    Marker Score: 1141
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.14
    Marker Score: 113396
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.93
    Marker Score: 597
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.83
    Marker Score: 555
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.82
    Marker Score: 5100
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.69
    Marker Score: 1222
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1157
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.58
    Marker Score: 15674
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.56
    Marker Score: 1459
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.55
    Marker Score: 3034
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.52
    Marker Score: 6512
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169865
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.45
    Marker Score: 1064
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.41
    Marker Score: 1401
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.36
    Marker Score: 818.5
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.36
    Marker Score: 1068
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.34
    Marker Score: 3272
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.34
    Marker Score: 4220
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.3
    Marker Score: 411.5
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.3
    Marker Score: 761
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 843
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.24
    Marker Score: 1087.5
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.24
    Marker Score: 2122
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.22
    Marker Score: 1321
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.22
    Marker Score: 1726
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.22
    Marker Score: 2172
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.17
    Marker Score: 718
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 480
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4793
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.13
    Marker Score: 947
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 1.1
    Marker Score: 2479
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.09
    Marker Score: 628
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.06
    Marker Score: 1025
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.06
    Marker Score: 1457
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.04
    Marker Score: 662.5
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.03
    Marker Score: 1138
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1
    Marker Score: 350
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71799
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48024
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.99
    Marker Score: 825
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.99
    Marker Score: 2730
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.99
    Marker Score: 6311
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.98
    Marker Score: 424
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.98
    Marker Score: 11379
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.97
    Marker Score: 703
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.96
    Marker Score: 15083
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.96
    Marker Score: 1813
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.96
    Marker Score: 483
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.94
    Marker Score: 426
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5274
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 369
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2733
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.89
    Marker Score: 572
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5279
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.87
    Marker Score: 400
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.87
    Marker Score: 311
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.86
    Marker Score: 626
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.86
    Marker Score: 1260
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.85
    Marker Score: 274
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 610.5
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.78
    Marker Score: 335
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.77
    Marker Score: 2250
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1251
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.76
    Marker Score: 795
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 692
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.72
    Marker Score: 1706
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.72
    Marker Score: 547
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 455
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.7
    Marker Score: 186
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.68
    Marker Score: 607
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.67
    Marker Score: 568
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.66
    Marker Score: 586
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.64
    Marker Score: 352
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.63
    Marker Score: 820
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.62
    Marker Score: 678
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.62
    Marker Score: 1013
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.59
    Marker Score: 185
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.58
    Marker Score: 325
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.52
    Marker Score: 117
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.49
    Marker Score: 403
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.49
    Marker Score: 227
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.48
    Marker Score: 167
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.48
    Marker Score: 156
  • Cell Name: T follicular regulatory cell (CL0009113)
    Fold Change: 0.48
    Marker Score: 130
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.48
    Marker Score: 227
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.47
    Marker Score: 185
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.46
    Marker Score: 119
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.45
    Marker Score: 100
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.45
    Marker Score: 305
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.45
    Marker Score: 143

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Other Information

## Summary The ITK gene encodes a protein called ITK, an ITK family kinase that plays a crucial role in the activation of the adaptive immune response. It is highly expressed in various cell types, including thymocytes, T cells, and immune cells. ## Key characteristics * ITK is a protein kinase that is activated by various cytokines and growth factors. * It is a key regulator of the adaptive immune response, as it is involved in the activation of T cells and the production of cytokines. * ITK is also involved in the regulation of inflammation and cell growth. ## Pathways and functions ITK is involved in a variety of pathways and functions, including: * Activation of phospholipase c activity * Adaptive immune response * Adaptive immune system * Activation of Fc epsilon receptor (fceri) signaling * Generation of second messenger molecules * Immune system * Innate immune system * Regulation of inflammation ## Clinical significance Mutations in the ITK gene have been linked to a number of human diseases, including cancer, autoimmune disorders, and inflammatory diseases. For example, mutations in ITK have been shown to be responsible for the development of leukemia, lymphoma, and other types of cancer. ITK inhibitors are currently being investigated as potential treatments for cancer and other diseases that are characterized by abnormal immune responses.

Genular Protein ID: 1989981007

Symbol: ITK_HUMAN

Name: Tyrosine-protein kinase ITK/TSK

UniProtKB Accession Codes:

Q08881 B2R752 Q32ML7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CORUM 1 CPTAC 2 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EC 2 EMBL 7 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 15 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 44 PDBsum 36 PIR 1 PRINTS 2 PRO 1 PROSITE 7 PROSITE-ProRule 6 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 3 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8504851

Title: A novel human tyrosine kinase gene inducible in T cells by interleukin 2.

PubMed ID: 8504851

DOI: 10.1016/0014-5793(93)81520-a

PubMed ID: 8364206

Title: Identification, cloning, and characterization of a novel human T-cell-specific tyrosine kinase located at the hematopoietin complex on chromosome 5q.

PubMed ID: 8364206

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12573241

Title: Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases.

PubMed ID: 12573241

DOI: 10.1016/s1570-9639(02)00524-1

PubMed ID: 9312162

Title: Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity.

PubMed ID: 9312162

DOI: 10.1074/jbc.272.40.25401

PubMed ID: 9701039

Title: CD2-mediated activation of the Tec-family tyrosine kinase ITK is controlled by proline-rich stretch-4 of the CD2 cytoplasmic tail.

PubMed ID: 9701039

DOI: 10.1093/intimm/10.7.1009

PubMed ID: 10795735

Title: Tec kinases: a family with multiple roles in immunity.

PubMed ID: 10795735

DOI: 10.1016/s1074-7613(00)80189-2

PubMed ID: 12186560

Title: Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav.

PubMed ID: 12186560

DOI: 10.1021/bi025554o

PubMed ID: 12682224

Title: Inducible T cell tyrosine kinase regulates actin-dependent cytoskeletal events induced by the T cell antigen receptor.

PubMed ID: 12682224

DOI: 10.4049/jimmunol.170.8.3971

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 15308100

Title: Cyclophilin A regulates TCR signal strength in CD4+ T cells via a proline-directed conformational switch in Itk.

PubMed ID: 15308100

DOI: 10.1016/j.immuni.2004.07.005

PubMed ID: 15661896

Title: Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton.

PubMed ID: 15661896

DOI: 10.4049/jimmunol.174.3.1385

PubMed ID: 17060314

Title: Tec kinase Itk forms membrane clusters specifically in the vicinity of recruiting receptors.

PubMed ID: 17060314

DOI: 10.1074/jbc.m609180200

PubMed ID: 19807924

Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

PubMed ID: 19807924

DOI: 10.1186/1471-2172-10-53

PubMed ID: 19523959

Title: SH2-dependent autophosphorylation within the Tec family kinase Itk.

PubMed ID: 19523959

DOI: 10.1016/j.jmb.2009.06.023

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20596523

Title: Development and validation of a method for profiling post-translational modification activities using protein microarrays.

PubMed ID: 20596523

DOI: 10.1371/journal.pone.0011332

PubMed ID: 21725281

Title: Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells.

PubMed ID: 21725281

DOI: 10.1038/emboj.2011.213

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 19425169

Title: Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation.

PubMed ID: 19425169

DOI: 10.1172/jci37901

Sequence Information:

  • Length: 620
  • Mass: 71831
  • Checksum: DAE396BD2309319D
  • Sequence:
    • MNNFILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKASLAY FEDRHGKKRT LKGSIELSRI 
KCVEIVKSDI SIPCHYKYPF QVVHDNYLLY VFAPDRESRQ RWVLALKEET RNNNSLVPKY 
HPNFWMDGKW RCCSQLEKLA TGCAQYDPTK NASKKPLPPT PEDNRRPLWE PEETVVIALY 
DYQTNDPQEL ALRRNEEYCL LDSSEIHWWR VQDRNGHEGY VPSSYLVEKS PNNLETYEWY 
NKSISRDKAE KLLLDTGKEG AFMVRDSRTA GTYTVSVFTK AVVSENNPCI KHYHIKETND 
NPKRYYVAEK YVFDSIPLLI NYHQHNGGGL VTRLRYPVCF GRQKAPVTAG LRYGKWVIDP 
SELTFVQEIG SGQFGLVHLG YWLNKDKVAI KTIREGAMSE EDFIEEAEVM MKLSHPKLVQ 
LYGVCLEQAP ICLVFEFMEH GCLSDYLRTQ RGLFAAETLL GMCLDVCEGM AYLEEACVIH 
RDLAARNCLV GENQVIKVSD FGMTRFVLDD QYTSSTGTKF PVKWASPEVF SFSRYSSKSD 
VWSFGVLMWE VFSEGKIPYE NRSNSEVVED ISTGFRLYKP RLASTHVYQI MNHCWKERPE 
DRPAFSRLLR QLAEIAESGL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.