Details for: ITK

Gene ID: 3702

Symbol: ITK

Ensembl ID: ENSG00000113263

Description: IL2 inducible T cell kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 44.5530
    Cell Significance Index: -6.9300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 28.1892
    Cell Significance Index: -7.1500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 25.5011
    Cell Significance Index: -10.3600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.5963
    Cell Significance Index: -6.9000
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.5335
    Cell Significance Index: 35.4300
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 2.6429
    Cell Significance Index: 7.0800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.3963
    Cell Significance Index: -7.3600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.3741
    Cell Significance Index: -6.3600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.0835
    Cell Significance Index: -4.5600
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.5454
    Cell Significance Index: 4.7100
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.4342
    Cell Significance Index: 14.8700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.2081
    Cell Significance Index: 35.4800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9032
    Cell Significance Index: 40.9400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6965
    Cell Significance Index: 132.5400
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.5385
    Cell Significance Index: 4.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5260
    Cell Significance Index: 52.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4538
    Cell Significance Index: 409.7900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2325
    Cell Significance Index: 37.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1986
    Cell Significance Index: 21.6000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.1632
    Cell Significance Index: 0.8900
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.1459
    Cell Significance Index: 1.0500
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.1338
    Cell Significance Index: 1.1400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0839
    Cell Significance Index: 5.8000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0355
    Cell Significance Index: 0.7600
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.0113
    Cell Significance Index: 0.1100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0097
    Cell Significance Index: 0.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0094
    Cell Significance Index: 0.3300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0028
    Cell Significance Index: 0.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0014
    Cell Significance Index: -0.5100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0017
    Cell Significance Index: -3.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0023
    Cell Significance Index: -0.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0031
    Cell Significance Index: -5.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0035
    Cell Significance Index: -5.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0043
    Cell Significance Index: -1.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0048
    Cell Significance Index: -6.5100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0080
    Cell Significance Index: -0.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0084
    Cell Significance Index: -6.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0093
    Cell Significance Index: -1.6700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0096
    Cell Significance Index: -0.0900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0096
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0104
    Cell Significance Index: -7.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0116
    Cell Significance Index: -2.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0136
    Cell Significance Index: -7.6900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0136
    Cell Significance Index: -7.4500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0141
    Cell Significance Index: -1.6600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0149
    Cell Significance Index: -10.9000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0152
    Cell Significance Index: -9.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0153
    Cell Significance Index: -6.7500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0166
    Cell Significance Index: -0.3600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0174
    Cell Significance Index: -0.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0177
    Cell Significance Index: -8.0500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0228
    Cell Significance Index: -0.3900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0246
    Cell Significance Index: -0.3400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0252
    Cell Significance Index: -1.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0367
    Cell Significance Index: -7.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0379
    Cell Significance Index: -6.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0427
    Cell Significance Index: -5.4800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0434
    Cell Significance Index: -1.3900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0447
    Cell Significance Index: -0.6400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0495
    Cell Significance Index: -7.1900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0524
    Cell Significance Index: -0.8900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0527
    Cell Significance Index: -2.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0534
    Cell Significance Index: -7.3400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0540
    Cell Significance Index: -1.1200
  • Cell Name: lung resident memory CD8-positive, alpha-beta T cell (CL4033039)
    Fold Change: -0.0543
    Cell Significance Index: -0.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0551
    Cell Significance Index: -6.7700
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0559
    Cell Significance Index: -0.5800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0592
    Cell Significance Index: -6.9000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0615
    Cell Significance Index: -0.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0629
    Cell Significance Index: -4.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0667
    Cell Significance Index: -7.6400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0680
    Cell Significance Index: -7.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0716
    Cell Significance Index: -9.2500
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0739
    Cell Significance Index: -0.7100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0779
    Cell Significance Index: -0.9200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0809
    Cell Significance Index: -8.2600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0836
    Cell Significance Index: -1.2600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0860
    Cell Significance Index: -6.6000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0936
    Cell Significance Index: -4.7300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0963
    Cell Significance Index: -6.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0985
    Cell Significance Index: -4.6300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1034
    Cell Significance Index: -0.9800
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.1052
    Cell Significance Index: -0.9500
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1173
    Cell Significance Index: -0.9900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1191
    Cell Significance Index: -3.1900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1215
    Cell Significance Index: -3.2500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1236
    Cell Significance Index: -9.2100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1291
    Cell Significance Index: -5.7100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1354
    Cell Significance Index: -3.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1367
    Cell Significance Index: -7.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1415
    Cell Significance Index: -8.7000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1416
    Cell Significance Index: -1.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1498
    Cell Significance Index: -7.7800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1500
    Cell Significance Index: -5.6800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1506
    Cell Significance Index: -4.2100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1511
    Cell Significance Index: -9.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1529
    Cell Significance Index: -7.1300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1543
    Cell Significance Index: -8.1000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1681
    Cell Significance Index: -5.8900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1708
    Cell Significance Index: -7.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Tyrosine Kinase Activity:** ITK possesses non-membrane spanning protein tyrosine kinase activity, which allows it to phosphorylate and activate downstream signaling pathways. 2. **IL-2 Inducibility:** ITK is specifically induced by IL-2, a cytokine that promotes T cell proliferation, differentiation, and survival. 3. **T Cell Receptor Signaling:** ITK is required for the activation of T cells through the T cell receptor (TCR) signaling pathway, which is essential for the recognition of antigens and the initiation of an immune response. 4. **Cellular Localization:** ITK is primarily localized to the plasma membrane and cytosol, where it interacts with other signaling molecules to regulate T cell activation and function. **Pathways and Functions:** 1. **Activation of Phospholipase C Activity:** ITK phosphorylates and activates phospholipase C, which generates second messenger molecules such as diacylglycerol (DAG) and inositol trisphosphate (IP3). These molecules regulate various cellular processes, including calcium mobilization and cell proliferation. 2. **Adaptive Immune Response:** ITK is essential for the development and function of alpha-beta T cells, which are critical components of the adaptive immune system. ITK regulates T cell activation, proliferation, and differentiation, and is required for the production of cytokines and other immune molecules. 3. **Gamma-Delta T Cell Activation:** ITK is also required for the activation of gamma-delta T cells, which are a subset of T cells that recognize non-peptide antigens. 4. **NK Cell Differentiation:** ITK is involved in the differentiation and function of natural killer (NK) cells, which are a critical component of the innate immune system. **Clinical Significance:** 1. **Immunodeficiency Disorders:** Mutations in the ITK gene have been associated with immunodeficiency disorders, including severe combined immunodeficiency (SCID) and X-linked lymphoproliferative disease (XLP). 2. **Cancer:** ITK has been implicated in the development and progression of various cancers, including T cell lymphomas and leukemias. 3. **Autoimmune Diseases:** ITK has been shown to play a role in the development of autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. 4. **Vaccine Development:** ITK has been identified as a potential target for the development of vaccines against infectious diseases, including HIV and tuberculosis. In conclusion, ITK is a critical regulator of T cell activation and immune response, and its dysregulation has been implicated in various immunodeficiency disorders, cancers, and autoimmune diseases. Further research on ITK is necessary to fully understand its role in the immune system and to develop effective therapeutic strategies for the treatment of immune-related diseases.

Genular Protein ID: 1989981007

Symbol: ITK_HUMAN

Name: Tyrosine-protein kinase ITK/TSK

UniProtKB Accession Codes:

Q08881 B2R752 Q32ML7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CORUM 1 CPTAC 2 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EC 2 EMBL 7 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 16 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 36 PDBsum 36 PIR 1 PRINTS 2 PRO 1 PROSITE 7 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 3 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8504851

Title: A novel human tyrosine kinase gene inducible in T cells by interleukin 2.

PubMed ID: 8504851

DOI: 10.1016/0014-5793(93)81520-a

PubMed ID: 8364206

Title: Identification, cloning, and characterization of a novel human T-cell-specific tyrosine kinase located at the hematopoietin complex on chromosome 5q.

PubMed ID: 8364206

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12573241

Title: Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases.

PubMed ID: 12573241

DOI: 10.1016/s1570-9639(02)00524-1

PubMed ID: 9312162

Title: Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity.

PubMed ID: 9312162

DOI: 10.1074/jbc.272.40.25401

PubMed ID: 9701039

Title: CD2-mediated activation of the Tec-family tyrosine kinase ITK is controlled by proline-rich stretch-4 of the CD2 cytoplasmic tail.

PubMed ID: 9701039

DOI: 10.1093/intimm/10.7.1009

PubMed ID: 10795735

Title: Tec kinases: a family with multiple roles in immunity.

PubMed ID: 10795735

DOI: 10.1016/s1074-7613(00)80189-2

PubMed ID: 12186560

Title: Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav.

PubMed ID: 12186560

DOI: 10.1021/bi025554o

PubMed ID: 12682224

Title: Inducible T cell tyrosine kinase regulates actin-dependent cytoskeletal events induced by the T cell antigen receptor.

PubMed ID: 12682224

DOI: 10.4049/jimmunol.170.8.3971

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 15308100

Title: Cyclophilin A regulates TCR signal strength in CD4+ T cells via a proline-directed conformational switch in Itk.

PubMed ID: 15308100

DOI: 10.1016/j.immuni.2004.07.005

PubMed ID: 15661896

Title: Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton.

PubMed ID: 15661896

DOI: 10.4049/jimmunol.174.3.1385

PubMed ID: 17060314

Title: Tec kinase Itk forms membrane clusters specifically in the vicinity of recruiting receptors.

PubMed ID: 17060314

DOI: 10.1074/jbc.m609180200

PubMed ID: 19807924

Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

PubMed ID: 19807924

DOI: 10.1186/1471-2172-10-53

PubMed ID: 19523959

Title: SH2-dependent autophosphorylation within the Tec family kinase Itk.

PubMed ID: 19523959

DOI: 10.1016/j.jmb.2009.06.023

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20596523

Title: Development and validation of a method for profiling post-translational modification activities using protein microarrays.

PubMed ID: 20596523

DOI: 10.1371/journal.pone.0011332

PubMed ID: 21725281

Title: Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells.

PubMed ID: 21725281

DOI: 10.1038/emboj.2011.213

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 19425169

Title: Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation.

PubMed ID: 19425169

DOI: 10.1172/jci37901

Sequence Information:

  • Length: 620
  • Mass: 71831
  • Checksum: DAE396BD2309319D
  • Sequence:
    • MNNFILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKASLAY FEDRHGKKRT LKGSIELSRI 
KCVEIVKSDI SIPCHYKYPF QVVHDNYLLY VFAPDRESRQ RWVLALKEET RNNNSLVPKY 
HPNFWMDGKW RCCSQLEKLA TGCAQYDPTK NASKKPLPPT PEDNRRPLWE PEETVVIALY 
DYQTNDPQEL ALRRNEEYCL LDSSEIHWWR VQDRNGHEGY VPSSYLVEKS PNNLETYEWY 
NKSISRDKAE KLLLDTGKEG AFMVRDSRTA GTYTVSVFTK AVVSENNPCI KHYHIKETND 
NPKRYYVAEK YVFDSIPLLI NYHQHNGGGL VTRLRYPVCF GRQKAPVTAG LRYGKWVIDP 
SELTFVQEIG SGQFGLVHLG YWLNKDKVAI KTIREGAMSE EDFIEEAEVM MKLSHPKLVQ 
LYGVCLEQAP ICLVFEFMEH GCLSDYLRTQ RGLFAAETLL GMCLDVCEGM AYLEEACVIH 
RDLAARNCLV GENQVIKVSD FGMTRFVLDD QYTSSTGTKF PVKWASPEVF SFSRYSSKSD 
VWSFGVLMWE VFSEGKIPYE NRSNSEVVED ISTGFRLYKP RLASTHVYQI MNHCWKERPE 
DRPAFSRLLR QLAEIAESGL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.