JAK1 | ENSG00000162434 | NCBI 3716

Details for: JAK1

Gene ID: 3716

Symbol: JAK1

Ensembl ID: ENSG00000162434

Description: Janus kinase 1

Associated with

Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Evasion by rsv of host interferon responses
(R-HSA-9833109)
Ifng signaling activates mapks
(R-HSA-9732724)
Il-6-type cytokine receptor ligand interactions
(R-HSA-6788467)
Immune system
(R-HSA-168256)
Inactivation of csf3 (g-csf) signaling
(R-HSA-9705462)
Infectious disease
(R-HSA-5663205)
Interferon alpha/beta signaling
(R-HSA-909733)
Interferon gamma signaling
(R-HSA-877300)
Interferon signaling
(R-HSA-913531)
Interleukin-2 family signaling
(R-HSA-451927)
Interleukin-2 signaling
(R-HSA-9020558)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-HSA-512988)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Interleukin-6 family signaling
(R-HSA-6783589)
Interleukin-6 signaling
(R-HSA-1059683)
Interleukin-7 signaling
(R-HSA-1266695)
Interleukin-9 signaling
(R-HSA-8985947)
Interleukin-10 signaling
(R-HSA-6783783)
Interleukin-12 family signaling
(R-HSA-447115)
Interleukin-12 signaling
(R-HSA-9020591)
Interleukin-15 signaling
(R-HSA-8983432)
Interleukin-20 family signaling
(R-HSA-8854691)
Interleukin-21 signaling
(R-HSA-9020958)
Interleukin-27 signaling
(R-HSA-9020956)
Interleukin-35 signalling
(R-HSA-8984722)
Interleukin receptor shc signaling
(R-HSA-912526)
Isg15 antiviral mechanism
(R-HSA-1169408)
Mapk1 (erk2) activation
(R-HSA-112411)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk3 (erk1) activation
(R-HSA-110056)
Mapk family signaling cascades
(R-HSA-5683057)
Other interleukin signaling
(R-HSA-449836)
Potential therapeutics for sars
(R-HSA-9679191)
Raf-independent mapk1/3 activation
(R-HSA-112409)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of ifna/ifnb signaling
(R-HSA-912694)
Regulation of ifng signaling
(R-HSA-877312)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Rsv-host interactions
(R-HSA-9833110)
Sars-cov-2 activates/modulates innate and adaptive immune responses
(R-HSA-9705671)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Signaling by csf3 (g-csf)
(R-HSA-9674555)
Signaling by interleukins
(R-HSA-449147)
Signal transduction
(R-HSA-162582)
Viral infection pathways
(R-HSA-9824446)
Atp binding
(GO:0005524)
Ccr5 chemokine receptor binding
(GO:0031730)
Cell differentiation
(GO:0030154)
Cell surface receptor signaling pathway via jak-stat
(GO:0007259)
Cellular response to virus
(GO:0098586)
Cytokine-mediated signaling pathway
(GO:0019221)
Growth hormone receptor binding
(GO:0005131)
Growth hormone receptor signaling pathway via jak-stat
(GO:0060397)
Interleukin-2-mediated signaling pathway
(GO:0038110)
Interleukin-4-mediated signaling pathway
(GO:0035771)
Interleukin-6-mediated signaling pathway
(GO:0070102)
Interleukin-7-mediated signaling pathway
(GO:0038111)
Interleukin-9-mediated signaling pathway
(GO:0038113)
Interleukin-10-mediated signaling pathway
(GO:0140105)
Interleukin-11-mediated signaling pathway
(GO:0038154)
Interleukin-15-mediated signaling pathway
(GO:0035723)
Intracellular signal transduction
(GO:0035556)
Metal ion binding
(GO:0046872)
Non-membrane spanning protein tyrosine kinase activity
(GO:0004715)
Positive regulation of homotypic cell-cell adhesion
(GO:0034112)
Positive regulation of protein localization to nucleus
(GO:1900182)
Positive regulation of sprouting angiogenesis
(GO:1903672)
Protein binding
(GO:0005515)
Protein localization to cell-cell junction
(GO:0150105)
Protein phosphatase binding
(GO:0019903)
Protein phosphorylation
(GO:0006468)
Protein tyrosine kinase activity
(GO:0004713)
Response to antibiotic
(GO:0046677)
T-helper 17 cell lineage commitment
(GO:0072540)
Type iii interferon-mediated signaling pathway
(GO:0038196)
Type ii interferon-mediated signaling pathway
(GO:0060333)
Type i interferon-mediated signaling pathway
(GO:0060337)
Ubiquitin protein ligase binding
(GO:0031625)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 675.2377
Cell Significance Index: -105.0300
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 398.5517
Cell Significance Index: -101.0900
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 260.4700
Cell Significance Index: -107.3000
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 236.3036
Cell Significance Index: -96.0000
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 234.3247
Cell Significance Index: -110.6300
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 211.4174
Cell Significance Index: -108.7500
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 165.2703
Cell Significance Index: -110.9000
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 102.1113
Cell Significance Index: -97.4900
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 87.2213
Cell Significance Index: -107.5400
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 34.3374
Cell Significance Index: -91.9900
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 32.9062
Cell Significance Index: -101.0700
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 27.4959
Cell Significance Index: -108.5000
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 23.0468
Cell Significance Index: -50.4400
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 3.2289
Cell Significance Index: 168.1900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 3.1906
Cell Significance Index: 1144.4100
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 2.8850
Cell Significance Index: 47.5400
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 2.7808
Cell Significance Index: 71.4800
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 2.4515
Cell Significance Index: 137.5700
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 2.1640
Cell Significance Index: 166.0700
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.0576
Cell Significance Index: 242.6500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.0020
Cell Significance Index: 274.9300
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.8799
Cell Significance Index: 53.8900
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.7735
Cell Significance Index: 355.7700
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.5971
Cell Significance Index: 173.7200
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.5799
Cell Significance Index: 284.8100
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.5340
Cell Significance Index: 188.6300
Cell Name: odontoblast (CL0000060)
Fold Change: 1.4265
Cell Significance Index: 182.8700
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 1.3438
Cell Significance Index: 67.9100
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.3293
Cell Significance Index: 263.8100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.3229
Cell Significance Index: 62.1800
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.1807
Cell Significance Index: 192.0400
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.0440
Cell Significance Index: 722.0800
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.0284
Cell Significance Index: 928.5800
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.0059
Cell Significance Index: 60.3900
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.9779
Cell Significance Index: 43.2600
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.9252
Cell Significance Index: 505.2700
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.9132
Cell Significance Index: 1719.5400
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.7834
Cell Significance Index: 29.6700
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.7032
Cell Significance Index: 446.6200
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.6494
Cell Significance Index: 48.4000
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.6472
Cell Significance Index: 39.7800
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.5586
Cell Significance Index: 246.9500
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.4920
Cell Significance Index: 223.3100
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.4739
Cell Significance Index: 12.9000
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.2405
Cell Significance Index: 370.3100
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.2331
Cell Significance Index: 39.8100
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1405
Cell Significance Index: 191.0500
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1387
Cell Significance Index: 255.8400
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.1100
Cell Significance Index: 7.0900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0463
Cell Significance Index: 2.1000
Cell Name: lactocyte (CL0002325)
Fold Change: 0.0052
Cell Significance Index: 0.6700
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.0034
Cell Significance Index: 0.1000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0437
Cell Significance Index: -33.0500
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0548
Cell Significance Index: -40.2000
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: -0.0606
Cell Significance Index: -11.5400
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0657
Cell Significance Index: -48.6500
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0676
Cell Significance Index: -1.3200
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0754
Cell Significance Index: -47.0600
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1306
Cell Significance Index: -9.2400
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1445
Cell Significance Index: -16.5000
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1533
Cell Significance Index: -86.4500
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1748
Cell Significance Index: -17.8500
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2887
Cell Significance Index: -19.4100
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2982
Cell Significance Index: -62.8000
Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.3205
Cell Significance Index: -31.7000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.3209
Cell Significance Index: -46.6400
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.3224
Cell Significance Index: -92.7600
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.3338
Cell Significance Index: -6.1700
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3756
Cell Significance Index: -39.1100
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.4283
Cell Significance Index: -19.9700
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.4370
Cell Significance Index: -12.5900
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.4750
Cell Significance Index: -2.8700
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.5577
Cell Significance Index: -63.8900
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.6114
Cell Significance Index: -31.7600
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.6480
Cell Significance Index: -18.1100
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.6565
Cell Significance Index: -76.5100
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.8068
Cell Significance Index: -19.3500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.9954
Cell Significance Index: -52.2600
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.1398
Cell Significance Index: -24.2800
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -1.1861
Cell Significance Index: -19.8500
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.2047
Cell Significance Index: -95.4100
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -1.3133
Cell Significance Index: -14.9200
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.3904
Cell Significance Index: -18.9700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -1.3951
Cell Significance Index: -96.4800
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.4047
Cell Significance Index: -88.5400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.5785
Cell Significance Index: -96.7800
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.7213
Cell Significance Index: -55.1300
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -1.7780
Cell Significance Index: -47.5600
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -1.7841
Cell Significance Index: -62.6900
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -1.7845
Cell Significance Index: -31.5400
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -1.7885
Cell Significance Index: -16.4700
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -1.8616
Cell Significance Index: -26.7800
Cell Name: granulosa cell (CL0000501)
Fold Change: -1.8654
Cell Significance Index: -49.0500
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -1.9028
Cell Significance Index: -54.3000
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -2.0033
Cell Significance Index: -53.4900
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -2.0738
Cell Significance Index: -25.8600
Cell Name: peg cell (CL4033014)
Fold Change: -2.1129
Cell Significance Index: -48.8200
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -2.1312
Cell Significance Index: -45.5600
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -2.1827
Cell Significance Index: -37.4100
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -2.2096
Cell Significance Index: -37.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** JAK1 is a non-receptor tyrosine kinase that is activated by the binding of cytokines to their respective receptors. This activation triggers a series of downstream signaling events, including the phosphorylation and activation of STAT proteins, which translocate to the nucleus to regulate gene expression. JAK1 is highly expressed in various immune cells, including T cells, B cells, and natural killer cells, and is involved in the regulation of multiple cytokine signaling pathways. **Pathways and Functions:** JAK1 is a central component of the JAK/STAT signaling pathway, which is involved in the regulation of immune responses to viral infections, cytokine signaling, and cell differentiation. Some of the key pathways and functions of JAK1 include: 1. **Antiviral Mechanism:** JAK1 mediates the antiviral effects of interferons (IFNs) by activating STAT proteins, which induce the expression of IFN-stimulated genes. 2. **Cytokine Signaling:** JAK1 is involved in the signaling of various cytokines, including IFNs, interleukins (IL-2, IL-4, IL-6, etc.), and interferons (IFN-α/β/γ). 3. **Cell Differentiation:** JAK1 regulates the differentiation of immune cells, including T cells and B cells, by modulating the expression of genes involved in cell fate decisions. 4. **Immune System Regulation:** JAK1 is involved in the regulation of immune responses to viral infections, including respiratory syncytial virus (RSV) and SARS-CoV-2. **Clinical Significance:** Dysregulation of JAK1 has been implicated in various immune-related disorders, including: 1. **Autoimmune Diseases:** JAK1 is involved in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis, lupus, and multiple sclerosis. 2. **Cancer:** JAK1 is overexpressed in certain types of cancer, including leukemia and lymphoma, and is involved in the regulation of tumor growth and survival. 3. **Viral Infections:** JAK1 is involved in the regulation of immune responses to viral infections, including RSV and SARS-CoV-2. 4. **Therapeutic Targeting:** JAK1 is a potential therapeutic target for the treatment of immune-related disorders, including autoimmune diseases and cancer. In conclusion, JAK1 is a crucial component of the immune system, involved in the regulation of various immune responses, including viral infections, cytokine signaling, and cell differentiation. Dysregulation of JAK1 has been implicated in numerous immune-related disorders, and its therapeutic targeting holds promise for the treatment of these diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 2658596508

Symbol: JAK1_HUMAN

Name: Tyrosine-protein kinase JAK1

UniProtKB Accession Codes:

P23458 Q59GQ2 Q9UD26

Database IDs:

Citations:

PubMed ID: 1848670

Title: Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase.

PubMed ID: 1848670

DOI: 10.1128/mcb.11.4.2057-2065.1991

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8247543

Title: A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.

PubMed ID: 8247543

PubMed ID: 7896447

Title: Receptor tyrosine kinases expressed in metastatic colon cancer.

PubMed ID: 7896447

DOI: 10.1002/ijc.2910600611

PubMed ID: 8232552

Title: The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction.

PubMed ID: 8232552

DOI: 10.1038/366129a0

PubMed ID: 7615558

Title: The Jak kinases differentially associate with the alpha and beta (accessory factor) chains of the interferon gamma receptor to form a functional receptor unit capable of activating STAT transcription factors.

PubMed ID: 7615558

DOI: 10.1074/jbc.270.29.17528

PubMed ID: 7657660

Title: Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor.

PubMed ID: 7657660

DOI: 10.1074/jbc.270.35.20775

PubMed ID: 7759950

Title: Soluble and membrane-anchored forms of the human IFN-alpha/beta receptor.

PubMed ID: 7759950

DOI: 10.1002/jlb.57.5.712

PubMed ID: 12200137

Title: IL-2 receptor signaling through the Shb adapter protein in T and NK cells.

PubMed ID: 12200137

DOI: 10.1016/s0006-291x(02)02016-8

PubMed ID: 11909529

Title: The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3.

PubMed ID: 11909529

DOI: 10.1016/s0960-9822(02)00697-8

PubMed ID: 12133952

Title: Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors.

PubMed ID: 12133952

DOI: 10.4049/jimmunol.169.3.1302

PubMed ID: 15194700

Title: Characterization of the signaling capacities of the novel gp130-like cytokine receptor.

PubMed ID: 15194700

DOI: 10.1074/jbc.m401122200

PubMed ID: 15277531

Title: Jamip1 (marlin-1) defines a family of proteins interacting with Janus kinases and microtubules.

PubMed ID: 15277531

DOI: 10.1074/jbc.m401915200

PubMed ID: 16239216

Title: JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation: cross-talk with IGF1 receptor.

PubMed ID: 16239216

DOI: 10.1074/jbc.c500358200

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26027934

Title: Downregulation of the ubiquitin ligase RNF125 underlies resistance of melanoma cells to BRAF inhibitors via JAK1 deregulation.

PubMed ID: 26027934

DOI: 10.1016/j.celrep.2015.04.049

PubMed ID: 28111307

Title: JAK1 gain-of-function causes an autosomal dominant immune dysregulatory and hypereosinophilic syndrome.

PubMed ID: 28111307

DOI: 10.1016/j.jaci.2016.12.957

PubMed ID: 19361440

Title: Dissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains.

PubMed ID: 19361440

DOI: 10.1016/j.jmb.2009.01.041

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 32750333

Title: Complex Autoinflammatory Syndrome Unveils Fundamental Principles of JAK1 Kinase Transcriptional and Biochemical Function.

PubMed ID: 32750333

DOI: 10.1016/j.immuni.2020.07.006

Sequence Information:

Length: 1154
Mass: 133277
Checksum: A2C4BE27851ACABB
Sequence:

MQYLNIKEDC NAMAFCAKMR SSKKTEVNLE APEPGVEVIF YLSDREPLRL GSGEYTAEEL 
CIRAAQACRI SPLCHNLFAL YDENTKLWYA PNRTITVDDK MSLRLHYRMR FYFTNWHGTN 
DNEQSVWRHS PKKQKNGYEK KKIPDATPLL DASSLEYLFA QGQYDLVKCL APIRDPKTEQ 
DGHDIENECL GMAVLAISHY AMMKKMQLPE LPKDISYKRY IPETLNKSIR QRNLLTRMRI 
NNVFKDFLKE FNNKTICDSS VSTHDLKVKY LATLETLTKH YGAEIFETSM LLISSENEMN 
WFHSNDGGNV LYYEVMVTGN LGIQWRHKPN VVSVEKEKNK LKRKKLENKH KKDEEKNKIR 
EEWNNFSYFP EITHIVIKES VVSINKQDNK KMELKLSSHE EALSFVSLVD GYFRLTADAH 
HYLCTDVAPP LIVHNIQNGC HGPICTEYAI NKLRQEGSEE GMYVLRWSCT DFDNILMTVT 
CFEKSEQVQG AQKQFKNFQI EVQKGRYSLH GSDRSFPSLG DLMSHLKKQI LRTDNISFML 
KRCCQPKPRE ISNLLVATKK AQEWQPVYPM SQLSFDRILK KDLVQGEHLG RGTRTHIYSG 
TLMDYKDDEG TSEEKKIKVI LKVLDPSHRD ISLAFFEAAS MMRQVSHKHI VYLYGVCVRD 
VENIMVEEFV EGGPLDLFMH RKSDVLTTPW KFKVAKQLAS ALSYLEDKDL VHGNVCTKNL 
LLAREGIDSE CGPFIKLSDP GIPITVLSRQ ECIERIPWIA PECVEDSKNL SVAADKWSFG 
TTLWEICYNG EIPLKDKTLI EKERFYESRC RPVTPSCKEL ADLMTRCMNY DPNQRPFFRA 
IMRDINKLEE QNPDIVSEKK PATEVDPTHF EKRFLKRIRD LGEGHFGKVE LCRYDPEGDN 
TGEQVAVKSL KPESGGNHIA DLKKEIEILR NLYHENIVKY KGICTEDGGN GIKLIMEFLP 
SGSLKEYLPK NKNKINLKQQ LKYAVQICKG MDYLGSRQYV HRDLAARNVL VESEHQVKIG 
DFGLTKAIET DKEYYTVKDD RDSPVFWYAP ECLMQSKFYI ASDVWSFGVT LHELLTYCDS 
DSSPMALFLK MIGPTHGQMT VTRLVNTLKE GKRLPCPPNC PDEVYQLMRK CWEFQPSNRT 
SFQNLIEGFE ALLK

Genular Protein ID: 2093571797

Symbol: Q6P669_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6P669

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 351
Mass: 40931
Checksum: 9763318A8CBF7B3E
Sequence:

MQYLNIKEDC NAMAFCAKMR SSKKTEVNLE APEPGVEVIF YLSDREPLRL GSGEYTAEEL 
CIRAAQACRI SPLCHNLFAL YDENTKLWYA PNRTITVDDK MSLRLHYRMR FYFTNWHGTN 
DNEQSVWRHS PKKQKNGYEK KKIPDATPLL DASSLEYLFA QGQYDLVKCL APIRDPKTEQ 
DGHDIENECL GMAVLAISHY AMMKKMQLPE LPKDISYKRY IPETLNKSIR QRNLLTRMRI 
NNVFKDFLKE FNNKTICDSS VSTHDLKVKY LATLETLTKH YGAEIFETSM LLISSENEMN 
WFHSNDGGNV LYYEVMVTGN LGIQWRHKPN VVSVEKEKNK LKKKKKKKKK K

Genular Protein ID: 2730941922

Symbol: A0A8V8TPQ9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8V8TPQ9

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

Length: 1153
Mass: 133149
Checksum: 05C2FB9813191268
Sequence:

MQYLNIKEDC NAMAFCAKMR SSKKTEVNLE APEPGVEVIF YLSDREPLRL GSGEYTAEEL 
CIRAAQACRI SPLCHNLFAL YDENTKLWYA PNRTITVDDK MSLRLHYRMR FYFTNWHGTN 
DNEQSVWRHS PKKQKNGYEK KKIPDATPLL DASSLEYLFA QGQYDLVKCL APIRDPKTEQ 
DGHDIENECL GMAVLAISHY AMMKKMQLPE LPKDISYKRY IPETLNKSIR QRNLLTRMRI 
NNVFKDFLKE FNNKTICDSS VSTHDLKVKY LATLETLTKH YGAEIFETSM LLISSENEMN 
WFHSNDGGNV LYYEVMVTGN LGIQWRHKPN VVSVEKEKNK LKRKKLENKH KKDEEKNKIR 
EEWNNFSYFP EITHIVIKES VVSINKQDNK KMELKLSSHE EALSFVSLVD GYFRLTADAH 
HYLCTDVAPP LIVHNIQNGC HGPICTEYAI NKLRQEGSEE GMYVLRWSCT DFDNILMTVT 
CFEKSEVQGA QKQFKNFQIE VQKGRYSLHG SDRSFPSLGD LMSHLKKQIL RTDNISFMLK 
RCCQPKPREI SNLLVATKKA QEWQPVYPMS QLSFDRILKK DLVQGEHLGR GTRTHIYSGT 
LMDYKDDEGT SEEKKIKVIL KVLDPSHRDI SLAFFEAASM MRQVSHKHIV YLYGVCVRDV 
ENIMVEEFVE GGPLDLFMHR KSDVLTTPWK FKVAKQLASA LSYLEDKDLV HGNVCTKNLL 
LAREGIDSEC GPFIKLSDPG IPITVLSRQE CIERIPWIAP ECVEDSKNLS VAADKWSFGT 
TLWEICYNGE IPLKDKTLIE KERFYESRCR PVTPSCKELA DLMTRCMNYD PNQRPFFRAI 
MRDINKLEEQ NPDIVSEKKP ATEVDPTHFE KRFLKRIRDL GEGHFGKVEL CRYDPEGDNT 
GEQVAVKSLK PESGGNHIAD LKKEIEILRN LYHENIVKYK GICTEDGGNG IKLIMEFLPS 
GSLKEYLPKN KNKINLKQQL KYAVQICKGM DYLGSRQYVH RDLAARNVLV ESEHQVKIGD 
FGLTKAIETD KEYYTVKDDR DSPVFWYAPE CLMQSKFYIA SDVWSFGVTL HELLTYCDSD 
SSPMALFLKM IGPTHGQMTV TRLVNTLKEG KRLPCPPNCP DEVYQLMRKC WEFQPSNRTS 
FQNLIEGFEA LLK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: JAK1

Associated with

Cells (max top 100)

Other Information

Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase. PubMed ID: 1848670

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes. PubMed ID: 8247543

Receptor tyrosine kinases expressed in metastatic colon cancer. PubMed ID: 7896447

The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction. PubMed ID: 8232552

The Jak kinases differentially associate with the alpha and beta (accessory factor) chains of the interferon gamma receptor to form a functional receptor unit capable of activating STAT transcription factors. PubMed ID: 7615558

Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor. PubMed ID: 7657660

Soluble and membrane-anchored forms of the human IFN-alpha/beta receptor. PubMed ID: 7759950

IL-2 receptor signaling through the Shb adapter protein in T and NK cells. PubMed ID: 12200137

The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3. PubMed ID: 11909529

Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors. PubMed ID: 12133952

Characterization of the signaling capacities of the novel gp130-like cytokine receptor. PubMed ID: 15194700

Jamip1 (marlin-1) defines a family of proteins interacting with Janus kinases and microtubules. PubMed ID: 15277531

JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation: cross-talk with IGF1 receptor. PubMed ID: 16239216

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Downregulation of the ubiquitin ligase RNF125 underlies resistance of melanoma cells to BRAF inhibitors via JAK1 deregulation. PubMed ID: 26027934

JAK1 gain-of-function causes an autosomal dominant immune dysregulatory and hypereosinophilic syndrome. PubMed ID: 28111307

Dissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains. PubMed ID: 19361440

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846

Complex Autoinflammatory Syndrome Unveils Fundamental Principles of JAK1 Kinase Transcriptional and Biochemical Function. PubMed ID: 32750333

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

Database document:

PubMed ID: 1848670

PubMed ID: 16710414

PubMed ID: 15489334

PubMed ID: 8247543

PubMed ID: 7896447

PubMed ID: 8232552

PubMed ID: 7615558

PubMed ID: 7657660

PubMed ID: 7759950

PubMed ID: 12200137

PubMed ID: 11909529

PubMed ID: 12133952

PubMed ID: 15194700

PubMed ID: 15277531

PubMed ID: 16239216

PubMed ID: 19369195

PubMed ID: 21269460

PubMed ID: 24275569

PubMed ID: 26027934

PubMed ID: 28111307

PubMed ID: 19361440

PubMed ID: 17344846

PubMed ID: 32750333

PubMed ID: 15489334

PubMed ID: 11237011

PubMed ID: 15496913

PubMed ID: 16710414