Gene KCNJ15 - ENSG00000157551 | NCBI Gene ID: 3772

Details for: KCNJ15

Gene ID: 3772

Symbol: KCNJ15

Ensembl ID: ENSG00000157551

Description: potassium inwardly rectifying channel subfamily J member 15

Associated with

Activation of gabab receptors
(R-HSA-991365)
Activation of g protein gated potassium channels
(R-HSA-1296041)
Gaba b receptor activation
(R-HSA-977444)
Gaba receptor activation
(R-HSA-977443)
G protein gated potassium channels
(R-HSA-1296059)
Inhibition of voltage gated ca2+ channels via gbeta/gamma subunits
(R-HSA-997272)
Inwardly rectifying k+ channels
(R-HSA-1296065)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Potassium channels
(R-HSA-1296071)
Transmission across chemical synapses
(R-HSA-112315)
Inward rectifier potassium channel activity
(GO:0005242)
Monoatomic ion channel complex
(GO:0034702)
Plasma membrane
(GO:0005886)
Potassium ion import across plasma membrane
(GO:1990573)
Potassium ion transport
(GO:0006813)
Protein binding
(GO:0005515)
Regulation of monoatomic ion transmembrane transport
(GO:0034765)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: type II pneumocyte (CL0002063)
Fold Change: 2.59
Marker Score: 16873
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 2.58
Marker Score: 10750
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 2.31
Marker Score: 5819
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 2.25
Marker Score: 7981
Cell Name: renal principal cell (CL0005009)
Fold Change: 2.24
Marker Score: 1727
Cell Name: pneumocyte (CL0000322)
Fold Change: 1.67
Marker Score: 2684
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 1.6
Marker Score: 1249
Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.58
Marker Score: 1364
Cell Name: lactocyte (CL0002325)
Fold Change: 1.58
Marker Score: 25333
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.55
Marker Score: 3643
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.41
Marker Score: 1999
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.37
Marker Score: 868
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 1.31
Marker Score: 257
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.3
Marker Score: 2647
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.19
Marker Score: 1753
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 1.15
Marker Score: 9756.5
Cell Name: retina horizontal cell (CL0000745)
Fold Change: 1.15
Marker Score: 1098
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.07
Marker Score: 250
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.06
Marker Score: 1198
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.02
Marker Score: 1939
Cell Name: kidney cell (CL1000497)
Fold Change: 1.02
Marker Score: 682
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71816
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48041
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.97
Marker Score: 1007
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5311
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2736
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.9
Marker Score: 4729
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5289
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.87
Marker Score: 1670.5
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.82
Marker Score: 870
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.8
Marker Score: 862
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.79
Marker Score: 12322
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1264
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.78
Marker Score: 157
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.78
Marker Score: 594
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 707
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.76
Marker Score: 728
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 395
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.75
Marker Score: 496
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 0.75
Marker Score: 198
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.74
Marker Score: 232
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.72
Marker Score: 232
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.71
Marker Score: 1174
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.71
Marker Score: 2015.5
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 178
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.66
Marker Score: 296
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 0.61
Marker Score: 4542
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.59
Marker Score: 1001
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.58
Marker Score: 918
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.57
Marker Score: 397
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.57
Marker Score: 238
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.56
Marker Score: 148
Cell Name: preosteoblast (CL0007010)
Fold Change: 0.56
Marker Score: 158
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.55
Marker Score: 492
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.55
Marker Score: 289
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.54
Marker Score: 327
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.54
Marker Score: 1220
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.53
Marker Score: 194
Cell Name: podocyte (CL0000653)
Fold Change: 0.53
Marker Score: 195
Cell Name: neutrophil (CL0000775)
Fold Change: 0.53
Marker Score: 320
Cell Name: mucous neck cell (CL0000651)
Fold Change: 0.52
Marker Score: 1170
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.49
Marker Score: 497
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.48
Marker Score: 225
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.46
Marker Score: 2965
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.46
Marker Score: 309
Cell Name: malignant cell (CL0001064)
Fold Change: 0.46
Marker Score: 6187
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.45
Marker Score: 118
Cell Name: secretory cell (CL0000151)
Fold Change: 0.42
Marker Score: 761
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.42
Marker Score: 181
Cell Name: osteoblast (CL0000062)
Fold Change: 0.4
Marker Score: 216
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.4
Marker Score: 332
Cell Name: ionocyte (CL0005006)
Fold Change: 0.39
Marker Score: 118
Cell Name: club cell (CL0000158)
Fold Change: 0.36
Marker Score: 426
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 0.35
Marker Score: 188
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.35
Marker Score: 3031
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.35
Marker Score: 19395
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.34
Marker Score: 365
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.33
Marker Score: 159
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.31
Marker Score: 315
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.28
Marker Score: 684
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.27
Marker Score: 939
Cell Name: leukocyte (CL0000738)
Fold Change: 0.27
Marker Score: 153
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 0.27
Marker Score: 321
Cell Name: basal cell (CL0000646)
Fold Change: 0.26
Marker Score: 340
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.26
Marker Score: 145
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.26
Marker Score: 90
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.25
Marker Score: 147
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.25
Marker Score: 612
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.24
Marker Score: 129
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.24
Marker Score: 239
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.24
Marker Score: 216
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 0.24
Marker Score: 676
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.23
Marker Score: 353
Cell Name: monocyte (CL0000576)
Fold Change: 0.22
Marker Score: 291
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.22
Marker Score: 98
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.22
Marker Score: 148
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 0.21
Marker Score: 83

Hover over a box to see details here...

## Summary KCNJ15 is a potassium inwardly rectifying channel subfamily J member 15. It is a protein that is expressed in a variety of cell types, including type II pneumocyte, epithelial cell of lower respiratory tract, kidney collecting duct principal cell, epithelial cell of proximal tubule, renal principal cell, pneumocyte, thyroid follicular cell, taste receptor cell, lactocyte, and kidney proximal straight tubule epithelial cell. ## Key characteristics * KCNJ15 is a potassium channel that is responsible for maintaining the resting membrane potential of cells. * It is a member of the inwardly rectifying potassium channel subfamily J, which are characterized by a single transmembrane domain. * KCNJ15 is a ligand-gated potassium channel, which means that its activity is regulated by the binding of a ligand. * When KCNJ15 is activated, it opens, allowing potassium ions to flow into the cell. * This helps to maintain the resting membrane potential of cells and allows them to function properly. ## Pathways and functions KCNJ15 is involved in a variety of cellular processes, including: * **Activation of gabab receptors:** KCNJ15 is a key regulator of GABAergic signaling. When GABA binds to its receptors, it activates KCNJ15, which then opens and allows potassium ions to flow into the cell. This depolarizes the cell and inhibits the activity of downstream targets of GABA, such as NMDA receptors. * **Activation of g protein-gated potassium channels:** KCNJ15 can also activate g protein-gated potassium channels, which are a type of ion channel that is activated by the binding of a protein called G protein. When KCNJ15 is activated by G protein, it opens and allows potassium ions to flow into the cell. This depolarizes the cell and inhibits the activity of downstream targets of G protein, such as muscarinic cholinergic receptors. * **Gaba b receptor activation:** KCNJ15 is also a ligand-gated channel for GABA b receptors, which are a type of G protein-coupled receptor. When GABA b receptors bind to G proteins, they activate KCNJ15, which then opens and allows potassium ions to flow into the cell. This depolarizes the cell and inhibits the activity of downstream targets of GABA b receptors, such as NMDA receptors. ## Clinical significance KCNJ15 is a promising target for the treatment of a variety of diseases, including epilepsy, schizophrenia, and anxiety. Mutations in KCNJ15 have been linked to a number of neurological disorders, including autism, schizophrenia, and epilepsy. By understanding the role of KCNJ15 in cellular processes, researchers can develop new therapies for these diseases. For example, it is possible that drugs that block KCNJ15 could be used to treat epilepsy.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

ATP-sensitive inward rectifier potassium channel 15

Genular Protein ID: 171740982

Symbol: KCJ15_HUMAN

Name: ATP-sensitive inward rectifier potassium channel 15

UniProtKB Accession Codes:

Q99712 D3DSH5 O00564 Q96L28 Q99446

Database IDs:

Citations:

PubMed ID: 9299242

Title: A new inward rectifier potassium channel gene (KCNJ15) localized on chromosome 21 in the Down syndrome chromosome region 1 (DCR1).

PubMed ID: 9299242

DOI: 10.1006/geno.1997.4865

PubMed ID: 8995301

Title: Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3).

PubMed ID: 8995301

DOI: 10.1074/jbc.272.1.586

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9647694

Title: CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins.

PubMed ID: 9647694

DOI: 10.1006/mcne.1998.0679

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

Length: 375
Mass: 42577
Checksum: CECCB4EDF827B24D
Sequence:

MDAIHIGMSS TPLVKHTAGA GLKANRPRVM SKSGHSNVRI DKVDGIYLLY LQDLWTTVID 
MKWRYKLTLF AATFVMTWFL FGVIYYAIAF IHGDLEPGEP ISNHTPCIMK VDSLTGAFLF 
SLESQTTIGY GVRSITEECP HAIFLLVAQL VITTLIEIFI TGTFLAKIAR PKKRAETIKF 
SHCAVITKQN GKLCLVIQVA NMRKSLLIQC QLSGKLLQTH VTKEGERILL NQATVKFHVD 
SSSESPFLIL PMTFYHVLDE TSPLRDLTPQ NLKEKEFELV VLLNATVEST SAVCQSRTSY 
IPEEIYWGFE FVPVVSLSKN GKYVADFSQF EQIRKSPDCT FYCADSEKQQ LEEKYRQEDQ 
RERELRTLLL QQSNV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: KCNJ15

Associated with

Cells (max top 100)

Other Information

A new inward rectifier potassium channel gene (KCNJ15) localized on chromosome 21 in the Down syndrome chromosome region 1 (DCR1). PubMed ID: 9299242

Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3). PubMed ID: 8995301

The DNA sequence of human chromosome 21. PubMed ID: 10830953

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins. PubMed ID: 9647694