Details for: KCNJ15

Gene ID: 3772

Symbol: KCNJ15

Ensembl ID: ENSG00000157551

Description: potassium inwardly rectifying channel subfamily J member 15

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 17.8991
    Cell Significance Index: -4.5400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 8.8960
    Cell Significance Index: -4.2000
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 8.6599
    Cell Significance Index: 92.0100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.9227
    Cell Significance Index: 31.3200
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.8814
    Cell Significance Index: 21.8700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.5984
    Cell Significance Index: 44.6700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.5261
    Cell Significance Index: -3.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4544
    Cell Significance Index: 75.5500
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 1.3565
    Cell Significance Index: 1.7600
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.3323
    Cell Significance Index: 8.2200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.2347
    Cell Significance Index: 10.9600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.1531
    Cell Significance Index: -4.5500
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.0343
    Cell Significance Index: 2.2800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.8050
    Cell Significance Index: 14.2300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6343
    Cell Significance Index: 44.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4977
    Cell Significance Index: 89.7200
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.4753
    Cell Significance Index: 1.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4684
    Cell Significance Index: 12.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4538
    Cell Significance Index: 55.8000
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.4186
    Cell Significance Index: 3.2000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.3037
    Cell Significance Index: 4.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2345
    Cell Significance Index: 103.6800
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.2289
    Cell Significance Index: 1.9300
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.2047
    Cell Significance Index: 2.1200
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.1573
    Cell Significance Index: 0.5400
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.1354
    Cell Significance Index: 0.5100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1235
    Cell Significance Index: 1.9100
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.1084
    Cell Significance Index: 1.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1021
    Cell Significance Index: 77.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1011
    Cell Significance Index: 1.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0725
    Cell Significance Index: 3.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0664
    Cell Significance Index: 41.4800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0647
    Cell Significance Index: 1.7300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0527
    Cell Significance Index: 0.4900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0514
    Cell Significance Index: 0.9500
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.0464
    Cell Significance Index: 0.5000
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.0294
    Cell Significance Index: 0.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0244
    Cell Significance Index: 2.8000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0238
    Cell Significance Index: 0.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0207
    Cell Significance Index: 2.6600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0188
    Cell Significance Index: 2.1900
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.0151
    Cell Significance Index: 0.1600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.0092
    Cell Significance Index: 0.7300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0042
    Cell Significance Index: 1.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0009
    Cell Significance Index: 1.7500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0019
    Cell Significance Index: -3.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0022
    Cell Significance Index: -3.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0023
    Cell Significance Index: -1.6800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0025
    Cell Significance Index: -1.8200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0036
    Cell Significance Index: -4.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0041
    Cell Significance Index: -2.3200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0042
    Cell Significance Index: -0.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0042
    Cell Significance Index: -0.7100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0043
    Cell Significance Index: -0.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0050
    Cell Significance Index: -3.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0054
    Cell Significance Index: -1.0700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0056
    Cell Significance Index: -0.0400
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0064
    Cell Significance Index: -0.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0069
    Cell Significance Index: -3.7500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0076
    Cell Significance Index: -2.7400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0077
    Cell Significance Index: -1.5500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0077
    Cell Significance Index: -0.8800
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0085
    Cell Significance Index: -0.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0099
    Cell Significance Index: -4.4800
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0165
    Cell Significance Index: -0.1500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0182
    Cell Significance Index: -0.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0214
    Cell Significance Index: -3.1100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0260
    Cell Significance Index: -3.3600
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0276
    Cell Significance Index: -0.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0336
    Cell Significance Index: -4.6200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0357
    Cell Significance Index: -4.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0360
    Cell Significance Index: -0.9600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0391
    Cell Significance Index: -0.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0419
    Cell Significance Index: -4.3600
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.0430
    Cell Significance Index: -0.3900
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: -0.0467
    Cell Significance Index: -0.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0517
    Cell Significance Index: -3.8600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0589
    Cell Significance Index: -3.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0590
    Cell Significance Index: -4.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0613
    Cell Significance Index: -2.8800
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.0630
    Cell Significance Index: -0.3000
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0642
    Cell Significance Index: -0.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0719
    Cell Significance Index: -4.4200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0734
    Cell Significance Index: -0.9500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0771
    Cell Significance Index: -2.2700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0779
    Cell Significance Index: -2.7300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0783
    Cell Significance Index: -3.9600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0895
    Cell Significance Index: -3.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0904
    Cell Significance Index: -5.0700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0907
    Cell Significance Index: -2.9700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0913
    Cell Significance Index: -3.3500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0924
    Cell Significance Index: -3.7900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0943
    Cell Significance Index: -0.5700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0954
    Cell Significance Index: -5.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0995
    Cell Significance Index: -4.4000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1001
    Cell Significance Index: -2.5000
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1056
    Cell Significance Index: -1.4600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1078
    Cell Significance Index: -2.6100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1151
    Cell Significance Index: -3.3000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1158
    Cell Significance Index: -2.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** KCNJ15 is a member of the inwardly rectifying potassium channel subfamily J, which is characterized by its high permeability to potassium ions and its inward rectifying properties. This channel is activated by the binding of GABA (gamma-aminobutyric acid) to its receptors, leading to the influx of potassium ions into the cell. KCNJ15 also interacts with Gβγ subunits, which inhibit the activity of voltage-gated Ca2+ channels, thereby regulating calcium influx into the cell. Furthermore, KCNJ15 is involved in the regulation of monoatomic ion transport across cell membranes, including the transport of potassium ions. **Pathways and Functions** KCNJ15 is involved in several key pathways and functions, including: 1. **Activation of GABA receptors**: KCNJ15 is activated by the binding of GABA to its receptors, leading to the influx of potassium ions into the cell. 2. **Inhibition of voltage-gated Ca2+ channels**: KCNJ15 interacts with Gβγ subunits, which inhibit the activity of voltage-gated Ca2+ channels, thereby regulating calcium influx into the cell. 3. **Regulation of monoatomic ion transport**: KCNJ15 is involved in the regulation of monoatomic ion transport across cell membranes, including the transport of potassium ions. 4. **Neurotransmitter receptors and postsynaptic signal transmission**: KCNJ15 plays a crucial role in neurotransmitter receptors and postsynaptic signal transmission, particularly in the regulation of GABA receptors. 5. **Inwardly rectifying K+ channels**: KCNJ15 is a key component of inwardly rectifying K+ channels, which allow potassium ions to flow into the cell. **Clinical Significance** Dysregulation of KCNJ15 has been implicated in various diseases and disorders, including: 1. **Respiratory diseases**: KCNJ15 is significantly expressed in type II pneumocytes, and mutations in this gene have been linked to respiratory diseases such as cystic fibrosis. 2. **Renal diseases**: KCNJ15 is expressed in renal cells, and dysregulation of this gene has been implicated in renal diseases such as chronic kidney disease. 3. **Neurological disorders**: KCNJ15 is involved in neurotransmitter receptors and postsynaptic signal transmission, and dysregulation of this gene has been linked to neurological disorders such as epilepsy and anxiety disorders. 4. **Thyroid diseases**: KCNJ15 is expressed in thyroid follicular cells, and dysregulation of this gene has been implicated in thyroid diseases such as hypothyroidism. In conclusion, KCNJ15 is a critical gene that encodes for a key component of various ion channels involved in maintaining cellular homeostasis. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of further research into the role of KCNJ15 in human health and disease.

Genular Protein ID: 171740982

Symbol: KCJ15_HUMAN

Name: ATP-sensitive inward rectifier potassium channel 15

UniProtKB Accession Codes:

Q99712 D3DSH5 O00564 Q96L28 Q99446

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 7 Ensembl 7 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 15 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9299242

Title: A new inward rectifier potassium channel gene (KCNJ15) localized on chromosome 21 in the Down syndrome chromosome region 1 (DCR1).

PubMed ID: 9299242

DOI: 10.1006/geno.1997.4865

PubMed ID: 8995301

Title: Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3).

PubMed ID: 8995301

DOI: 10.1074/jbc.272.1.586

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9647694

Title: CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins.

PubMed ID: 9647694

DOI: 10.1006/mcne.1998.0679

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 375
  • Mass: 42577
  • Checksum: CECCB4EDF827B24D
  • Sequence:
    • MDAIHIGMSS TPLVKHTAGA GLKANRPRVM SKSGHSNVRI DKVDGIYLLY LQDLWTTVID 
MKWRYKLTLF AATFVMTWFL FGVIYYAIAF IHGDLEPGEP ISNHTPCIMK VDSLTGAFLF 
SLESQTTIGY GVRSITEECP HAIFLLVAQL VITTLIEIFI TGTFLAKIAR PKKRAETIKF 
SHCAVITKQN GKLCLVIQVA NMRKSLLIQC QLSGKLLQTH VTKEGERILL NQATVKFHVD 
SSSESPFLIL PMTFYHVLDE TSPLRDLTPQ NLKEKEFELV VLLNATVEST SAVCQSRTSY 
IPEEIYWGFE FVPVVSLSKN GKYVADFSQF EQIRKSPDCT FYCADSEKQQ LEEKYRQEDQ 
RERELRTLLL QQSNV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.