Details for: KCNJ15

Gene ID: 3772

Symbol: KCNJ15

Ensembl ID: ENSG00000157551

Description: potassium inwardly rectifying channel subfamily J member 15

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.59
    Marker Score: 16,873
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.58
    Marker Score: 10,750
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.31
    Marker Score: 5,819
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.25
    Marker Score: 7,981
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.24
    Marker Score: 1,727
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.67
    Marker Score: 2,684
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.6
    Marker Score: 1,249
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.58
    Marker Score: 1,364
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.58
    Marker Score: 25,333
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.55
    Marker Score: 3,643
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.41
    Marker Score: 1,999
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 868
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.31
    Marker Score: 257
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.3
    Marker Score: 2,647
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.19
    Marker Score: 1,753
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 1.15
    Marker Score: 9,757
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 1.15
    Marker Score: 1,098
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.07
    Marker Score: 250
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.06
    Marker Score: 1,198
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.02
    Marker Score: 1,939
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.02
    Marker Score: 682
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,816
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,041
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.97
    Marker Score: 1,007
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,311
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,736
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.9
    Marker Score: 4,729
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,289
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.87
    Marker Score: 1,671
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.82
    Marker Score: 870
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.8
    Marker Score: 862
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.79
    Marker Score: 12,322
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,264
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.78
    Marker Score: 157
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 594
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.76
    Marker Score: 728
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 496
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.75
    Marker Score: 198
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.74
    Marker Score: 232
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.72
    Marker Score: 232
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.71
    Marker Score: 1,174
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.71
    Marker Score: 2,016
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.66
    Marker Score: 296
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.61
    Marker Score: 4,542
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.59
    Marker Score: 1,001
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.58
    Marker Score: 918
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.57
    Marker Score: 397
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 238
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.56
    Marker Score: 158
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.55
    Marker Score: 492
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.55
    Marker Score: 289
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.54
    Marker Score: 327
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.54
    Marker Score: 1,220
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.53
    Marker Score: 194
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.53
    Marker Score: 195
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.53
    Marker Score: 320
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.52
    Marker Score: 1,170
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.49
    Marker Score: 497
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.48
    Marker Score: 225
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.46
    Marker Score: 2,965
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.46
    Marker Score: 309
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.46
    Marker Score: 6,187
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.45
    Marker Score: 118
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.42
    Marker Score: 761
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.42
    Marker Score: 181
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.4
    Marker Score: 216
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.4
    Marker Score: 332
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.39
    Marker Score: 118
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.36
    Marker Score: 426
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.35
    Marker Score: 188
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.35
    Marker Score: 3,031
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.35
    Marker Score: 19,395
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.34
    Marker Score: 365
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.33
    Marker Score: 159
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.31
    Marker Score: 315
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.28
    Marker Score: 684
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.27
    Marker Score: 939
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.27
    Marker Score: 153
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.27
    Marker Score: 321
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.26
    Marker Score: 340
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.26
    Marker Score: 145
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.25
    Marker Score: 147
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.25
    Marker Score: 612
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.24
    Marker Score: 129
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.24
    Marker Score: 239
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.24
    Marker Score: 216
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.24
    Marker Score: 676
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.23
    Marker Score: 353
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.22
    Marker Score: 291
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.22
    Marker Score: 98
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.22
    Marker Score: 148
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.21
    Marker Score: 83

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** KCNJ15 is a member of the inwardly rectifying potassium channel subfamily J, which is characterized by its high permeability to potassium ions and its inward rectifying properties. This channel is activated by the binding of GABA (gamma-aminobutyric acid) to its receptors, leading to the influx of potassium ions into the cell. KCNJ15 also interacts with Gβγ subunits, which inhibit the activity of voltage-gated Ca2+ channels, thereby regulating calcium influx into the cell. Furthermore, KCNJ15 is involved in the regulation of monoatomic ion transport across cell membranes, including the transport of potassium ions. **Pathways and Functions** KCNJ15 is involved in several key pathways and functions, including: 1. **Activation of GABA receptors**: KCNJ15 is activated by the binding of GABA to its receptors, leading to the influx of potassium ions into the cell. 2. **Inhibition of voltage-gated Ca2+ channels**: KCNJ15 interacts with Gβγ subunits, which inhibit the activity of voltage-gated Ca2+ channels, thereby regulating calcium influx into the cell. 3. **Regulation of monoatomic ion transport**: KCNJ15 is involved in the regulation of monoatomic ion transport across cell membranes, including the transport of potassium ions. 4. **Neurotransmitter receptors and postsynaptic signal transmission**: KCNJ15 plays a crucial role in neurotransmitter receptors and postsynaptic signal transmission, particularly in the regulation of GABA receptors. 5. **Inwardly rectifying K+ channels**: KCNJ15 is a key component of inwardly rectifying K+ channels, which allow potassium ions to flow into the cell. **Clinical Significance** Dysregulation of KCNJ15 has been implicated in various diseases and disorders, including: 1. **Respiratory diseases**: KCNJ15 is significantly expressed in type II pneumocytes, and mutations in this gene have been linked to respiratory diseases such as cystic fibrosis. 2. **Renal diseases**: KCNJ15 is expressed in renal cells, and dysregulation of this gene has been implicated in renal diseases such as chronic kidney disease. 3. **Neurological disorders**: KCNJ15 is involved in neurotransmitter receptors and postsynaptic signal transmission, and dysregulation of this gene has been linked to neurological disorders such as epilepsy and anxiety disorders. 4. **Thyroid diseases**: KCNJ15 is expressed in thyroid follicular cells, and dysregulation of this gene has been implicated in thyroid diseases such as hypothyroidism. In conclusion, KCNJ15 is a critical gene that encodes for a key component of various ion channels involved in maintaining cellular homeostasis. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of further research into the role of KCNJ15 in human health and disease.

Genular Protein ID: 171740982

Symbol: KCJ15_HUMAN

Name: ATP-sensitive inward rectifier potassium channel 15

UniProtKB Accession Codes:

Q99712 D3DSH5 O00564 Q96L28 Q99446

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 7 Ensembl 7 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 15 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9299242

Title: A new inward rectifier potassium channel gene (KCNJ15) localized on chromosome 21 in the Down syndrome chromosome region 1 (DCR1).

PubMed ID: 9299242

DOI: 10.1006/geno.1997.4865

PubMed ID: 8995301

Title: Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3).

PubMed ID: 8995301

DOI: 10.1074/jbc.272.1.586

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9647694

Title: CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins.

PubMed ID: 9647694

DOI: 10.1006/mcne.1998.0679

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 375
  • Mass: 42577
  • Checksum: CECCB4EDF827B24D
  • Sequence:
    • MDAIHIGMSS TPLVKHTAGA GLKANRPRVM SKSGHSNVRI DKVDGIYLLY LQDLWTTVID 
MKWRYKLTLF AATFVMTWFL FGVIYYAIAF IHGDLEPGEP ISNHTPCIMK VDSLTGAFLF 
SLESQTTIGY GVRSITEECP HAIFLLVAQL VITTLIEIFI TGTFLAKIAR PKKRAETIKF 
SHCAVITKQN GKLCLVIQVA NMRKSLLIQC QLSGKLLQTH VTKEGERILL NQATVKFHVD 
SSSESPFLIL PMTFYHVLDE TSPLRDLTPQ NLKEKEFELV VLLNATVEST SAVCQSRTSY 
IPEEIYWGFE FVPVVSLSKN GKYVADFSQF EQIRKSPDCT FYCADSEKQQ LEEKYRQEDQ 
RERELRTLLL QQSNV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.