Gene KIF22 - ENSG00000079616 | NCBI Gene ID: 3835

Details for: KIF22

Gene ID: 3835

Symbol: KIF22

Ensembl ID: ENSG00000079616

Description: kinesin family member 22

Associated with

Adaptive immune system
(R-HSA-1280218)
Copi-dependent golgi-to-er retrograde traffic
(R-HSA-6811434)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Golgi-to-er retrograde transport
(R-HSA-8856688)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Intra-golgi and retrograde golgi-to-er traffic
(R-HSA-6811442)
Kinesins
(R-HSA-983189)
Membrane trafficking
(R-HSA-199991)
Mhc class ii antigen presentation
(R-HSA-2132295)
Vesicle-mediated transport
(R-HSA-5653656)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Chromatin
(GO:0000785)
Cytosol
(GO:0005829)
Dna binding
(GO:0003677)
Dna repair
(GO:0006281)
Kinesin complex
(GO:0005871)
Kinetochore
(GO:0000776)
Metaphase chromosome alignment
(GO:0051310)
Microtubule
(GO:0005874)
Microtubule-based movement
(GO:0007018)
Microtubule binding
(GO:0008017)
Microtubule motor activity
(GO:0003777)
Mitotic cell cycle
(GO:0000278)
Mitotic metaphase chromosome alignment
(GO:0007080)
Mitotic spindle
(GO:0072686)
Nuclear speck
(GO:0016607)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Sister chromatid cohesion
(GO:0007062)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.77
Marker Score: 4809
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 1.72
Marker Score: 1616
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 1.67
Marker Score: 8801
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.6
Marker Score: 3378
Cell Name: pneumocyte (CL0000322)
Fold Change: 1.58
Marker Score: 2545.5
Cell Name: oogonial cell (CL0000024)
Fold Change: 1.57
Marker Score: 2253
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 1.57
Marker Score: 10214
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.49
Marker Score: 1868.5
Cell Name: epithelial cell (CL0000066)
Fold Change: 1.48
Marker Score: 2347
Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167663
Cell Name: proerythroblast (CL0000547)
Fold Change: 1.45
Marker Score: 981.5
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 1.44
Marker Score: 1507
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.42
Marker Score: 5576
Cell Name: male germ cell (CL0000015)
Fold Change: 1.4
Marker Score: 402
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1.39
Marker Score: 2355
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 1.37
Marker Score: 1073
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1.31
Marker Score: 2745
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.28
Marker Score: 3791
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1.25
Marker Score: 1000
Cell Name: neural crest cell (CL0011012)
Fold Change: 1.23
Marker Score: 1311
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.23
Marker Score: 1296
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.19
Marker Score: 4217
Cell Name: Unknown (CL0000548)
Fold Change: 1.16
Marker Score: 846
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.12
Marker Score: 1125
Cell Name: plasmablast (CL0000980)
Fold Change: 1.09
Marker Score: 1448
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 1.07
Marker Score: 801
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 1.05
Marker Score: 7807
Cell Name: promyelocyte (CL0000836)
Fold Change: 1.03
Marker Score: 509
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.01
Marker Score: 15858
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 1.01
Marker Score: 636
Cell Name: serous secreting cell (CL0000313)
Fold Change: 1.01
Marker Score: 402
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71667
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47890
Cell Name: tracheobronchial serous cell (CL0019001)
Fold Change: 0.99
Marker Score: 361
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30387
Cell Name: blood cell (CL0000081)
Fold Change: 0.96
Marker Score: 11164
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2393
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 0.93
Marker Score: 8093
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.93
Marker Score: 479.5
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.93
Marker Score: 557
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 0.93
Marker Score: 1311
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.92
Marker Score: 2289
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.92
Marker Score: 434
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.92
Marker Score: 504.5
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.91
Marker Score: 5206
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.91
Marker Score: 336
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.91
Marker Score: 3725
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2706
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.89
Marker Score: 904
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.89
Marker Score: 2421
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.89
Marker Score: 884
Cell Name: stromal cell (CL0000499)
Fold Change: 0.88
Marker Score: 1036
Cell Name: oocyte (CL0000023)
Fold Change: 0.88
Marker Score: 218
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5287
Cell Name: kidney cell (CL1000497)
Fold Change: 0.87
Marker Score: 580
Cell Name: ionocyte (CL0005006)
Fold Change: 0.87
Marker Score: 263
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.85
Marker Score: 307
Cell Name: club cell (CL0000158)
Fold Change: 0.85
Marker Score: 991.5
Cell Name: stem cell (CL0000034)
Fold Change: 0.85
Marker Score: 2013
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.85
Marker Score: 2655
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 0.84
Marker Score: 291
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.82
Marker Score: 334
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.81
Marker Score: 1196
Cell Name: erythroblast (CL0000765)
Fold Change: 0.81
Marker Score: 505
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.81
Marker Score: 323
Cell Name: Unknown (CL0002371)
Fold Change: 0.8
Marker Score: 854
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.8
Marker Score: 1634.5
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.8
Marker Score: 187
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1263
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.78
Marker Score: 593
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.77
Marker Score: 378
Cell Name: peptic cell (CL0000155)
Fold Change: 0.77
Marker Score: 324
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.77
Marker Score: 2069
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.77
Marker Score: 397.5
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.77
Marker Score: 319
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.76
Marker Score: 400
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.76
Marker Score: 481
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.76
Marker Score: 770
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.76
Marker Score: 339
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.76
Marker Score: 1436
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.75
Marker Score: 709
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.75
Marker Score: 1772
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.75
Marker Score: 438
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.75
Marker Score: 260
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.74
Marker Score: 662
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.74
Marker Score: 1453
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.74
Marker Score: 4396
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.74
Marker Score: 2545.5
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.74
Marker Score: 2841
Cell Name: lactocyte (CL0002325)
Fold Change: 0.74
Marker Score: 11814
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 469
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.73
Marker Score: 420
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.72
Marker Score: 2665
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.72
Marker Score: 475.5
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.72
Marker Score: 372
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.71
Marker Score: 9418.5
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.71
Marker Score: 170
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 0.71
Marker Score: 196
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.71
Marker Score: 471
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.71
Marker Score: 143

Hover over a box to see details here...

**Key characteristics:** - KIF22 is a large protein (110 kDa) that belongs to the kinesin family of motor proteins. - It is a microtubule-associated protein that is involved in the regulation of organelle transport. - KIF22 is a key regulator of the sorting of proteins and organelles to the cell membrane. - It is also involved in the regulation of cell cycle progression and apoptosis. **Pathways and functions:** - KIF22 is involved in the adaptive immune system, where it helps to sort and transport immune complexes to their appropriate destinations. - It is also involved in the regulation of platelet production and the maintenance of platelet function. - It plays a role in the development and maintenance of the intestinal epithelium. **Clinical significance:** - Mutations in KIF22 have been linked to several human diseases, including cancer and cardiovascular disease. - Understanding the role of KIF22 in human health and disease is important for the development of new diagnostic and therapeutic strategies. **Additional information:** - KIF22 is a highly conserved protein that is found in organisms from yeast to humans. - It is a ubiquitin-dependent kinase that is phosphorylated by various signaling molecules, including PI3K and MAPK. - It is a key regulator of the cell cycle, and its activity is regulated by a variety of factors, including growth factors, cytokines, and cell signaling molecules.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Kinesin-like protein KIF22
B7Z9T5_HUMAN

Genular Protein ID: 3507800771

Symbol: KIF22_HUMAN

Name: Kinesin-like protein KIF22

UniProtKB Accession Codes:

Q14807 B2R5M0 B7Z265 O60845 O94814 Q53F58 Q9BT46

Database IDs:

Citations:

PubMed ID: 8599929

Title: Kid, a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindle.

PubMed ID: 8599929

DOI: 10.1002/j.1460-2075.1996.tb00378.x

PubMed ID: 9790757

Title: Human genes for KNSL4 and MAZ are located close to one another on chromosome 16p11.2.

PubMed ID: 9790757

DOI: 10.1006/geno.1998.5452

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10493829

Title: Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.

PubMed ID: 10493829

DOI: 10.1006/geno.1999.5927

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11146551

Title: SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis.

PubMed ID: 11146551

DOI: 10.1038/sj.onc.1204002

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18485706

Title: The spindle protein CHICA mediates localization of the chromokinesin Kid to the mitotic spindle.

PubMed ID: 18485706

DOI: 10.1016/j.cub.2008.04.041

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22152677

Title: Whole-exome sequencing identifies mutations of KIF22 in spondyloepimetaphyseal dysplasia with joint laxity, leptodactylic type.

PubMed ID: 22152677

DOI: 10.1016/j.ajhg.2011.10.015

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25743205

Title: Chromokinesin Kid and kinetochore kinesin CENP-E differentially support chromosome congression without end-on attachment to microtubules.

PubMed ID: 25743205

DOI: 10.1038/ncomms7447

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 22152678

Title: Recurrent dominant mutations affecting two adjacent residues in the motor domain of the monomeric kinesin KIF22 result in skeletal dysplasia and joint laxity.

PubMed ID: 22152678

DOI: 10.1016/j.ajhg.2011.10.016

Sequence Information:

Length: 665
Mass: 73262
Checksum: C6C0AC96741DD387
Sequence:

MAAGGSTQQR RREMAAASAA AISGAGRCRL SKIGATRRPP PARVRVAVRL RPFVDGTAGA 
SDPPCVRGMD SCSLEIANWR NHQETLKYQF DAFYGERSTQ QDIYAGSVQP ILRHLLEGQN 
ASVLAYGPTG AGKTHTMLGS PEQPGVIPRA LMDLLQLTRE EGAEGRPWAL SVTMSYLEIY 
QEKVLDLLDP ASGDLVIRED CRGNILIPGL SQKPISSFAD FERHFLPASR NRTVGATRLN 
QRSSRSHAVL LVKVDQRERL APFRQREGKL YLIDLAGSED NRRTGNKGLR LKESGAINTS 
LFVLGKVVDA LNQGLPRVPY RDSKLTRLLQ DSLGGSAHSI LIANIAPERR FYLDTVSALN 
FAARSKEVIN RPFTNESLQP HALGPVKLSQ KELLGPPEAK RARGPEEEEI GSPEPMAAPA 
SASQKLSPLQ KLSSMDPAML ERLLSLDRLL ASQGSQGAPL LSTPKRERMV LMKTVEEKDL 
EIERLKTKQK ELEAKMLAQK AEEKENHCPT MLRPLSHRTV TGAKPLKKAV VMPLQLIQEQ 
AASPNAEIHI LKNKGRKRKL ESLDALEPEE KAEDCWELQI SPELLAHGRQ KILDLLNEGS 
ARDLRSLQRI GPKKAQLIVG WRELHGPFSQ VEDLERVEGI TGKQMESFLK ANILGLAAGQ 
RCGAS

Genular Protein ID: 571460784

Symbol: B7Z9T5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z9T5

Database IDs:

Sequence Information:

Length: 597
Mass: 66337
Checksum: FA2908A945DED2EF
Sequence:

MDSCSLEIAN WRNHQETLKY QFDAFYGERS TQQDIYAGSV QPILRHLLEG QNASVLAYGP 
TGAGKTHTML GSPEQPGVIP RALMDLLQLT REEGAEGRPW ALSVTMSYLE IYQEKVLDLL 
DPASGDLVIR EDCRGNILIP GLSQKPISSF ADFERHFLPA SRNRTVGATR LNQRSSRSHA 
VLLVKVDQRE RLAPFRQREG KLYLIDLAGS EDNRRTGNKG LRLKESGAIN TSLFVLGKVV 
DALNQGLPRV PYRDSKLTRL LQDSLGGSAH SILIANIAPE RRFYLDTVSA LNFAARSKEV 
INWPFTNESL QPHALGPVKL SQKELLGPPE AKRARGPEEE EIGSPEPMAA PASASQKLSP 
LQKLSSMDPA MLERLLSLDR LLASQGSQGA PLLSTPKRER MVLMKTVEEK DLEIERLKTK 
QKELEAKMLA QKAEEKENHC PTMLRPLSHR TVTGAKPLKK AVVMPLQLIQ EQAASPNAEI 
HILKNKGRKR KLESLDALEP EEKAEDCWEL QISPELLAHG RQKILDLLNE GSARDLRSLQ 
RIGPKKAQLI VGWRELHGPF SQVEDLERVE GITGKQMESF LKANILGLAA GQRCGAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: KIF22

Associated with

Cells (max top 100)

Other Information

Kid, a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindle. PubMed ID: 8599929

Human genes for KNSL4 and MAZ are located close to one another on chromosome 16p11.2. PubMed ID: 9790757

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. PubMed ID: 10493829

The sequence and analysis of duplication-rich human chromosome 16. PubMed ID: 15616553

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis. PubMed ID: 11146551

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

The spindle protein CHICA mediates localization of the chromokinesin Kid to the mitotic spindle. PubMed ID: 18485706

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Whole-exome sequencing identifies mutations of KIF22 in spondyloepimetaphyseal dysplasia with joint laxity, leptodactylic type. PubMed ID: 22152677

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Chromokinesin Kid and kinetochore kinesin CENP-E differentially support chromosome congression without end-on attachment to microtubules. PubMed ID: 25743205

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Recurrent dominant mutations affecting two adjacent residues in the motor domain of the monomeric kinesin KIF22 result in skeletal dysplasia and joint laxity. PubMed ID: 22152678