Details for: KIF22
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 77.7864
Cell Significance Index: -19.7300 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 61.0757
Cell Significance Index: -25.1600 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 52.9960
Cell Significance Index: -21.5300 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 49.4998
Cell Significance Index: -23.3700 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 46.9298
Cell Significance Index: -24.1400 - Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 42.3028
Cell Significance Index: -6.5800 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 34.7977
Cell Significance Index: -23.3500 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 22.6658
Cell Significance Index: -21.6400 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 17.3891
Cell Significance Index: -21.4400 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 6.7753
Cell Significance Index: -18.1500 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 5.9477
Cell Significance Index: -23.4700 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 5.4893
Cell Significance Index: -16.8600 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 3.1847
Cell Significance Index: -6.9700 - Cell Name: germ cell (CL0000586)
Fold Change: 2.2971
Cell Significance Index: 17.3500 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.7174
Cell Significance Index: 18.6700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.1819
Cell Significance Index: 53.5700 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.1494
Cell Significance Index: 135.5500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.1008
Cell Significance Index: 179.0400 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 1.0120
Cell Significance Index: 27.0700 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.8288
Cell Significance Index: 28.8000 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.8022
Cell Significance Index: 21.8400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.6996
Cell Significance Index: 81.5300 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.6784
Cell Significance Index: 18.9600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.6419
Cell Significance Index: 29.9300 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.5465
Cell Significance Index: 11.4400 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4945
Cell Significance Index: 34.2000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.4905
Cell Significance Index: 25.4800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.4400
Cell Significance Index: 87.3200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.4202
Cell Significance Index: 57.7100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.3923
Cell Significance Index: 29.2400 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.3800
Cell Significance Index: 12.1700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.3687
Cell Significance Index: 45.3400 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.3641
Cell Significance Index: 46.6800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3255
Cell Significance Index: 61.9400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3212
Cell Significance Index: 142.0100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2989
Cell Significance Index: 29.5700 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2544
Cell Significance Index: 138.9600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.2443
Cell Significance Index: 17.2800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2387
Cell Significance Index: 43.0300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.2223
Cell Significance Index: 44.6000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.2201
Cell Significance Index: 12.3500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2184
Cell Significance Index: 197.1700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2135
Cell Significance Index: 6.1500 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.2088
Cell Significance Index: 6.1500 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.1944
Cell Significance Index: 5.1100 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.1805
Cell Significance Index: 2.0500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1753
Cell Significance Index: 8.2400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1391
Cell Significance Index: 49.8800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.1321
Cell Significance Index: 6.9400 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.1248
Cell Significance Index: 16.1300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.1001
Cell Significance Index: 6.3100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0827
Cell Significance Index: 62.5900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0728
Cell Significance Index: 12.4300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0487
Cell Significance Index: 1.3000 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0451
Cell Significance Index: 2.9100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0176
Cell Significance Index: 33.1300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0102
Cell Significance Index: 6.5000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0020
Cell Significance Index: -3.6400 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0038
Cell Significance Index: -0.0800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0043
Cell Significance Index: -3.1300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0053
Cell Significance Index: -0.4100 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0063
Cell Significance Index: -9.7500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0083
Cell Significance Index: -0.1800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0128
Cell Significance Index: -17.3800 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0186
Cell Significance Index: -1.9000 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0293
Cell Significance Index: -0.4900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0303
Cell Significance Index: -22.4400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0336
Cell Significance Index: -18.9700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0337
Cell Significance Index: -15.2800 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0462
Cell Significance Index: -1.1800 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0638
Cell Significance Index: -18.3700 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0691
Cell Significance Index: -10.0400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1253
Cell Significance Index: -26.3900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1279
Cell Significance Index: -14.6500 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1337
Cell Significance Index: -6.9700 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.1593
Cell Significance Index: -2.7300 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1605
Cell Significance Index: -2.1900 - Cell Name: kidney cell (CL1000497)
Fold Change: -0.1628
Cell Significance Index: -1.3000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1648
Cell Significance Index: -5.7900 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.1715
Cell Significance Index: -2.5700 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1917
Cell Significance Index: -11.7800 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2128
Cell Significance Index: -16.8500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2142
Cell Significance Index: -22.3000 - Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.2267
Cell Significance Index: -3.1800 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2397
Cell Significance Index: -16.1200 - Cell Name: peg cell (CL4033014)
Fold Change: -0.2584
Cell Significance Index: -5.9700 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.2835
Cell Significance Index: -3.3800 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.2892
Cell Significance Index: -4.2700 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.3116
Cell Significance Index: -5.7600 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3402
Cell Significance Index: -15.0500 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.3551
Cell Significance Index: -3.2700 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.3565
Cell Significance Index: -10.4700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3918
Cell Significance Index: -24.0200 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3959
Cell Significance Index: -11.3500 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.4322
Cell Significance Index: -11.5800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.4331
Cell Significance Index: -16.4000 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.4655
Cell Significance Index: -11.9700 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.4705
Cell Significance Index: -11.4800 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.5014
Cell Significance Index: -7.9600 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.5083
Cell Significance Index: -18.6600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3507800771
Symbol: KIF22_HUMAN
Name: Kinesin-like protein KIF22
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8599929
Title: Kid, a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindle.
PubMed ID: 8599929
PubMed ID: 9790757
Title: Human genes for KNSL4 and MAZ are located close to one another on chromosome 16p11.2.
PubMed ID: 9790757
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 10493829
Title: Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.
PubMed ID: 10493829
PubMed ID: 15616553
Title: The sequence and analysis of duplication-rich human chromosome 16.
PubMed ID: 15616553
DOI: 10.1038/nature03187
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11146551
Title: SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis.
PubMed ID: 11146551
PubMed ID: 17525332
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
PubMed ID: 17525332
PubMed ID: 18485706
Title: The spindle protein CHICA mediates localization of the chromokinesin Kid to the mitotic spindle.
PubMed ID: 18485706
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 22152677
Title: Whole-exome sequencing identifies mutations of KIF22 in spondyloepimetaphyseal dysplasia with joint laxity, leptodactylic type.
PubMed ID: 22152677
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25743205
Title: Chromokinesin Kid and kinetochore kinesin CENP-E differentially support chromosome congression without end-on attachment to microtubules.
PubMed ID: 25743205
DOI: 10.1038/ncomms7447
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 22152678
Title: Recurrent dominant mutations affecting two adjacent residues in the motor domain of the monomeric kinesin KIF22 result in skeletal dysplasia and joint laxity.
PubMed ID: 22152678
Sequence Information:
- Length: 665
- Mass: 73262
- Checksum: C6C0AC96741DD387
- Sequence:
MAAGGSTQQR RREMAAASAA AISGAGRCRL SKIGATRRPP PARVRVAVRL RPFVDGTAGA SDPPCVRGMD SCSLEIANWR NHQETLKYQF DAFYGERSTQ QDIYAGSVQP ILRHLLEGQN ASVLAYGPTG AGKTHTMLGS PEQPGVIPRA LMDLLQLTRE EGAEGRPWAL SVTMSYLEIY QEKVLDLLDP ASGDLVIRED CRGNILIPGL SQKPISSFAD FERHFLPASR NRTVGATRLN QRSSRSHAVL LVKVDQRERL APFRQREGKL YLIDLAGSED NRRTGNKGLR LKESGAINTS LFVLGKVVDA LNQGLPRVPY RDSKLTRLLQ DSLGGSAHSI LIANIAPERR FYLDTVSALN FAARSKEVIN RPFTNESLQP HALGPVKLSQ KELLGPPEAK RARGPEEEEI GSPEPMAAPA SASQKLSPLQ KLSSMDPAML ERLLSLDRLL ASQGSQGAPL LSTPKRERMV LMKTVEEKDL EIERLKTKQK ELEAKMLAQK AEEKENHCPT MLRPLSHRTV TGAKPLKKAV VMPLQLIQEQ AASPNAEIHI LKNKGRKRKL ESLDALEPEE KAEDCWELQI SPELLAHGRQ KILDLLNEGS ARDLRSLQRI GPKKAQLIVG WRELHGPFSQ VEDLERVEGI TGKQMESFLK ANILGLAAGQ RCGAS
Genular Protein ID: 571460784
Symbol: B7Z9T5_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 597
- Mass: 66337
- Checksum: FA2908A945DED2EF
- Sequence:
MDSCSLEIAN WRNHQETLKY QFDAFYGERS TQQDIYAGSV QPILRHLLEG QNASVLAYGP TGAGKTHTML GSPEQPGVIP RALMDLLQLT REEGAEGRPW ALSVTMSYLE IYQEKVLDLL DPASGDLVIR EDCRGNILIP GLSQKPISSF ADFERHFLPA SRNRTVGATR LNQRSSRSHA VLLVKVDQRE RLAPFRQREG KLYLIDLAGS EDNRRTGNKG LRLKESGAIN TSLFVLGKVV DALNQGLPRV PYRDSKLTRL LQDSLGGSAH SILIANIAPE RRFYLDTVSA LNFAARSKEV INWPFTNESL QPHALGPVKL SQKELLGPPE AKRARGPEEE EIGSPEPMAA PASASQKLSP LQKLSSMDPA MLERLLSLDR LLASQGSQGA PLLSTPKRER MVLMKTVEEK DLEIERLKTK QKELEAKMLA QKAEEKENHC PTMLRPLSHR TVTGAKPLKK AVVMPLQLIQ EQAASPNAEI HILKNKGRKR KLESLDALEP EEKAEDCWEL QISPELLAHG RQKILDLLNE GSARDLRSLQ RIGPKKAQLI VGWRELHGPF SQVEDLERVE GITGKQMESF LKANILGLAA GQRCGAS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.