Details for: IPO5
Gene ID: 3843
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: IPO5
Ensembl ID: ENSG00000065150
Description: importin 5
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 10.49rCSI 32.81%PRS 29.46
-
CSI 7.81rCSI 10.38%PRS 44.77
-
CSI 6.06rCSI 8.74%PRS 50.41
-
CSI 5.81rCSI 7.19%PRS 36.52
-
CSI 5.78rCSI 8.84%PRS 56.5
-
CSI 5.49rCSI 6.45%PRS 44.28
-
CSI 5.01rCSI 6.85%PRS 37.52
-
CSI 4.89rCSI 4.42%PRS 37.2
-
CSI 4.65rCSI 3.23%PRS 48.3
-
CSI 4.63rCSI 8.32%PRS 34.5
-
CSI 4.61rCSI 9.56%PRS 38.68
-
CSI 4.48rCSI 3.45%PRS 38.93
-
CSI 4.17rCSI 6.63%PRS 34.34
-
CSI 4.11rCSI 3.09%PRS 43.4
-
CSI 4.08rCSI 6.26%PRS 46.87
-
CSI 3.93rCSI 8.95%PRS 39.36
-
CSI 3.89rCSI 24.32%PRS 33.68
-
CSI 3.74rCSI 3%PRS 61.67
-
CSI 3.71rCSI 3.78%PRS 52.76
-
CSI 3.59rCSI 3.4%PRS 41.64
-
CSI 3.43rCSI 5.17%PRS 42.02
-
CSI 3.37rCSI 4.68%PRS 40.12
-
CSI 3.32rCSI 8.06%PRS 25.55
-
CSI 3.19rCSI 14%PRS 60.04
-
CSI 3.13rCSI 7.02%PRS 26.92
-
CSI 3.12rCSI 4.59%PRS 37.03
-
CSI 3.06rCSI 2.47%PRS 40.88
-
CSI 2.94rCSI 6.51%PRS 37.78
-
CSI 2.85rCSI 2.11%PRS 34.73
-
CSI 2.83rCSI 2.24%PRS 29.29
-
CSI 2.75rCSI 2.13%PRS 40.59
-
CSI 2.69rCSI 4.52%PRS 26.32
-
CSI 2.68rCSI 3.15%PRS 55.15
-
CSI 2.68rCSI 6.8%PRS 31.93
-
CSI 2.66rCSI 2.3%PRS 44.1
-
CSI 2.63rCSI 3.73%PRS 37.7
-
CSI 2.61rCSI 11.28%PRS 57.09
-
CSI 2.6rCSI 2.19%PRS 57.3
-
CSI 2.58rCSI 2.76%PRS 38.32
-
CSI 2.52rCSI 1.68%PRS 44.5
-
CSI 2.43rCSI 1.84%PRS 52.07
-
CSI 2.42rCSI 4.62%PRS 56.95
-
CSI 2.23rCSI 1.76%PRS 46.43
-
CSI 2.23rCSI 5.66%PRS 37.13
-
CSI 2.17rCSI 5.1%PRS 49.98
-
CSI 2.17rCSI 3.31%PRS 37.39
-
CSI 2.16rCSI 3.32%PRS 43.57
-
CSI 2.14rCSI 3.47%PRS 39.18
-
CSI 2.14rCSI 6.32%PRS 44.64
-
CSI 2.13rCSI 2.22%PRS 40.98
-
CSI 2.11rCSI 1.82%PRS 49.67
-
CSI 2.11rCSI 1.61%PRS 51.01
-
CSI 2.1rCSI 4.17%PRS 40.16
-
CSI 2.08rCSI 3.59%PRS 31.95
-
CSI 2.07rCSI 1.49%PRS 52.59
-
CSI 2.07rCSI 2.13%PRS 57.66
-
CSI 2.05rCSI 2.15%PRS 42.81
-
CSI 2.03rCSI 3.22%PRS 50.34
-
CSI 2.02rCSI 2.54%PRS 53.52
-
CSI 1.98rCSI 3.02%PRS 49.07
-
CSI 1.98rCSI 2.17%PRS 44.15
-
CSI 1.98rCSI 2.94%PRS 43.53
-
CSI 1.98rCSI 3.54%PRS 38.92
-
CSI 1.95rCSI 3.91%PRS 31.22
-
CSI 1.95rCSI 3.11%PRS 43.67
-
CSI 1.94rCSI 1.79%PRS 41.44
-
CSI 1.91rCSI 1.7%PRS 39.67
-
CSI 1.83rCSI 2.45%PRS 48.44
-
CSI 1.83rCSI 1.69%PRS 60.52
-
CSI 1.8rCSI 1.67%PRS 40.23
-
CSI 1.75rCSI 1.45%PRS 41.23
-
CSI 1.74rCSI 2.57%PRS 44.96
-
CSI 1.74rCSI 1.17%PRS 49.84
-
CSI 1.73rCSI 2.11%PRS 47.63
-
CSI 1.72rCSI 1.43%PRS 38.94
-
CSI 1.71rCSI 1.5%PRS 45.09
-
CSI 1.7rCSI 3.9%PRS 39.85
-
CSI 1.69rCSI 4.89%PRS 32.73
-
CSI 1.65rCSI 8.88%PRS 55.6
-
CSI 1.64rCSI 3.73%PRS 34.65
-
CSI 1.61rCSI 1.56%PRS 31.81
-
CSI 1.59rCSI 47.65%PRS 65.49
-
CSI 1.58rCSI 2.71%PRS 49.47
-
CSI 1.57rCSI 2.76%PRS 33.46
-
CSI 1.57rCSI 4.47%PRS 40.57
-
CSI 1.57rCSI 5.88%PRS 34.4
-
CSI 1.56rCSI 2%PRS 44.95
-
CSI 1.56rCSI 1.98%PRS 45.3
-
CSI 1.54rCSI 1.78%PRS 35.39
-
CSI 1.53rCSI 1.35%PRS 30.63
-
CSI 1.53rCSI 1.07%PRS 52.78
-
CSI 1.49rCSI 3.69%PRS 38.55
-
CSI 1.48rCSI 6.03%PRS 38.67
-
CSI 1.47rCSI 1.42%PRS 41.01
-
CSI 1.46rCSI 6.47%PRS 38.93
-
CSI 1.45rCSI 1.22%PRS 45.49
-
CSI 1.44rCSI 2.3%PRS 34.89
-
CSI 1.43rCSI 1.95%PRS 44.94
-
CSI 1.43rCSI 1.16%PRS 41.38
-
CSI 1.41rCSI 6.96%PRS 51.55
-
CSI 0.1rCSI 2.6%PRS 63.2%
-
CSI 0.1rCSI 1.1%PRS 29.5%
-
CSI 0.2rCSI 5.2%PRS 25.7%
-
CSI 0.2rCSI 3.1%PRS 74.2%
-
CSI 0.2rCSI 5.7%PRS 26.6%
-
CSI 0.3rCSI 2.5%PRS 68.1%
-
CSI 0.4rCSI 6.7%PRS 75.2%
-
CSI 0.4rCSI 2.4%PRS 71.7%
-
CSI 0.4rCSI 2.2%PRS 51.4%
-
CSI 0.4rCSI 2.3%PRS 51.4%
-
CSI 0.4rCSI 3.9%PRS 82.0%
-
CSI 0.4rCSI 1.1%PRS 37.5%
-
CSI 0.4rCSI 1.1%PRS 53.8%
-
CSI 0.5rCSI 1.4%PRS 42.9%
-
CSI 0.6rCSI 2.2%PRS 27.2%
-
CSI 0.6rCSI 1.7%PRS 63.7%
-
CSI 0.6rCSI 1.4%PRS 57.6%
-
CSI 0.6rCSI 2.1%PRS 30.2%
-
CSI 0.6rCSI 0.9%PRS 32.7%
-
CSI 0.6rCSI 2.5%PRS 60.1%
-
CSI 0.7rCSI 2.3%PRS 25.3%
-
CSI 0.7rCSI 7.2%PRS 57.4%
-
CSI 0.7rCSI 2.5%PRS 35.0%
-
CSI 0.7rCSI 1.3%PRS 31.2%
-
CSI 0.7rCSI 1.5%PRS 31.5%
-
CSI 0.7rCSI 1.1%PRS 41.4%
-
CSI 0.7rCSI 2.8%PRS 56.0%
-
CSI 0.7rCSI 3.8%PRS 79.4%
-
CSI 0.7rCSI 2.5%PRS 56.2%
-
CSI 0.7rCSI 2.1%PRS 55.1%
-
CSI 0.7rCSI 4.3%PRS 27.5%
-
CSI 0.7rCSI 1.3%PRS 61.0%
-
CSI 0.8rCSI 1.1%PRS 51.1%
-
CSI 0.8rCSI 1.0%PRS 27.2%
-
CSI 0.8rCSI 2.2%PRS 49.2%
-
CSI 0.9rCSI 1.4%PRS 32.1%
-
CSI 0.9rCSI 4.1%PRS 42.3%
-
CSI 0.9rCSI 1.5%PRS 32.1%
-
CSI 0.9rCSI 1.9%PRS 36.0%
-
CSI 0.9rCSI 1.1%PRS 31.4%
-
CSI 0.9rCSI 1.8%PRS 42.2%
-
CSI 0.9rCSI 1.7%PRS 25.4%
-
CSI 0.9rCSI 1.1%PRS 26.2%
-
CSI 1.0rCSI 2.7%PRS 55.9%
-
CSI 1.0rCSI 0.9%PRS 47.3%
-
CSI 1.0rCSI 1.3%PRS 49.6%
-
CSI 1.0rCSI 1.8%PRS 56.2%
-
CSI 1.0rCSI 1.3%PRS 24.9%
-
CSI 1.0rCSI 1.2%PRS 38.6%
-
CSI 1.1rCSI 3.3%PRS 27.4%
-
CSI 1.1rCSI 3.5%PRS 43.8%
-
CSI 1.1rCSI 1.4%PRS 42.1%
-
CSI 1.1rCSI 2.5%PRS 33.2%
-
CSI 1.1rCSI 1.3%PRS 63.1%
-
CSI 1.1rCSI 5.8%PRS 64.3%
-
CSI 1.1rCSI 2.9%PRS 49.4%
-
CSI 1.1rCSI 1.3%PRS 51.2%
-
CSI 1.2rCSI 1.6%PRS 34.7%
-
CSI 1.2rCSI 2.8%PRS 56.9%
-
CSI 1.2rCSI 1.8%PRS 40.9%
-
CSI 1.2rCSI 1.8%PRS 38.5%
-
CSI 1.2rCSI 2.0%PRS 28.3%
-
CSI 1.3rCSI 2.2%PRS 48.6%
-
CSI 1.3rCSI 3.1%PRS 50.7%
-
CSI 1.3rCSI 2.3%PRS 34.8%
-
CSI 1.3rCSI 1.3%PRS 40.2%
-
CSI 1.3rCSI 1.6%PRS 42.9%
-
CSI 1.3rCSI 2.5%PRS 63.6%
-
CSI 1.3rCSI 5.1%PRS 49.7%
-
CSI 1.3rCSI 1.4%PRS 38.0%
-
CSI 1.3rCSI 1.9%PRS 54.1%
-
CSI 1.4rCSI 3.9%PRS 59.1%
-
CSI 1.4rCSI 2.0%PRS 43.2%
-
CSI 1.4rCSI 2.0%PRS 43.1%
-
CSI 1.4rCSI 1.4%PRS 35.1%
-
CSI 1.4rCSI 3.5%PRS 48.2%
-
CSI 1.4rCSI 1.8%PRS 38.5%
-
CSI 1.4rCSI 1.2%PRS 48.9%
-
CSI 1.4rCSI 1.0%PRS 42.1%
-
CSI 1.4rCSI 7.0%PRS 51.6%
-
CSI 1.4rCSI 1.2%PRS 41.4%
-
CSI 1.4rCSI 2.0%PRS 44.9%
-
CSI 1.4rCSI 2.3%PRS 34.9%
-
CSI 1.5rCSI 1.2%PRS 45.5%
-
CSI 1.5rCSI 6.5%PRS 38.9%
-
CSI 1.5rCSI 1.4%PRS 41.0%
-
CSI 1.5rCSI 6.0%PRS 38.7%
-
CSI 1.5rCSI 3.7%PRS 38.6%
-
CSI 1.5rCSI 1.1%PRS 52.8%
-
CSI 1.5rCSI 1.4%PRS 30.6%
-
CSI 1.5rCSI 1.8%PRS 35.4%
-
CSI 1.6rCSI 2.0%PRS 45.3%
-
CSI 1.6rCSI 2.0%PRS 45.0%
-
CSI 1.6rCSI 5.9%PRS 34.4%
-
CSI 1.6rCSI 4.5%PRS 40.6%
-
CSI 1.6rCSI 2.8%PRS 33.5%
-
CSI 1.6rCSI 2.7%PRS 49.5%
-
CSI 1.6rCSI 47.7%PRS 65.5%
-
CSI 1.6rCSI 1.6%PRS 31.8%
-
CSI 1.6rCSI 3.7%PRS 34.7%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1028072514
Symbol: IPO5_HUMAN
Name: Importin-5
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9114010
Title: Cloning and characterization of human karyopherin beta3.
PubMed ID: 9114010
PubMed ID: 9271386
Title: Ran-binding protein 5 (RanBP5) is related to the nuclear transport factor importin-beta but interacts differently with RanBP1.
PubMed ID: 9271386
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15057823
Title: The DNA sequence and analysis of human chromosome 13.
PubMed ID: 15057823
DOI: 10.1038/nature02379
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9687515
Title: Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells.
PubMed ID: 9687515
PubMed ID: 11682607
Title: Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin.
PubMed ID: 11682607
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16704975
Title: Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1.
PubMed ID: 16704975
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22730302
Title: NMDAR signaling facilitates the IPO5-mediated nuclear import of CPEB3.
PubMed ID: 22730302
DOI: 10.1093/nar/gks598
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23541588
Title: Structural basis for cell-cycle-dependent nuclear import mediated by the karyopherin Kap121p.
PubMed ID: 23541588
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 29475951
Title: Soluble syntaxin 3 functions as a transcriptional regulator.
PubMed ID: 29475951
Sequence Information:
- Length: 1097
- Mass: 123630
- Checksum: 1864AD23513F2DE1
- Sequence:
MAAAAAEQQQ FYLLLGNLLS PDNVVRKQAE ETYENIPGQS KITFLLQAIR NTTAAEEARQ MAAVLLRRLL SSAFDEVYPA LPSDVQTAIK SELLMIIQME TQSSMRKKVC DIAAELARNL IDEDGNNQWP EGLKFLFDSV SSQNVGLREA ALHIFWNFPG IFGNQQQHYL DVIKRMLVQC MQDQEHPSIR TLSARATAAF ILANEHNVAL FKHFADLLPG FLQAVNDSCY QNDDSVLKSL VEIADTVPKY LRPHLEATLQ LSLKLCGDTS LNNMQRQLAL EVIVTLSETA AAMLRKHTNI VAQTIPQMLA MMVDLEEDED WANADELEDD DFDSNAVAGE SALDRMACGL GGKLVLPMIK EHIMQMLQNP DWKYRHAGLM ALSAIGEGCH QQMEGILNEI VNFVLLFLQD PHPRVRYAAC NAVGQMATDF APGFQKKFHE KVIAALLQTM EDQGNQRVQA HAAAALINFT EDCPKSLLIP YLDNLVKHLH SIMVLKLQEL IQKGTKLVLE QVVTSIASVA DTAEEKFVPY YDLFMPSLKH IVENAVQKEL RLLRGKTIEC ISLIGLAVGK EKFMQDASDV MQLLLKTQTD FNDMEDDDPQ ISYMISAWAR MCKILGKEFQ QYLPVVMGPL MKTASIKPEV ALLDTQDMEN MSDDDGWEFV NLGDQQSFGI KTAGLEEKST ACQMLVCYAK ELKEGFVEYT EQVVKLMVPL LKFYFHDGVR VAAAESMPLL LECARVRGPE YLTQMWHFMC DALIKAIGTE PDSDVLSEIM HSFAKCIEVM GDGCLNNEHF EELGGILKAK LEEHFKNQEL RQVKRQDEDY DEQVEESLQD EDDNDVYILT KVSDILHSIF SSYKEKVLPW FEQLLPLIVN LICPHRPWPD RQWGLCIFDD VIEHCSPASF KYAEYFLRPM LQYVCDNSPE VRQAAAYGLG VMAQYGGDNY RPFCTEALPL LVRVIQSADS KTKENVNATE NCISAVGKIM KFKPDCVNVE EVLPHWLSWL PLHEDKEEAV QTFNYLCDLI ESNHPIVLGP NNTNLPKIFS IIAEGEMHEA IKHEDPCAKR LANVVRQVQT SGGLWTECIA QLSPEQQAAI QELLNSA
Genular Protein ID: 1010574661
Symbol: Q9BVS9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 310
- Mass: 35485
- Checksum: 11E949E78124B71F
- Sequence:
EHFEELGGIL KAKLEEHFKN QELRQVKRQD EDYDEQVEES LQDEDDNDVY ILTKVSDILH SIFSSYKEKV LPWFEQLLPL IVNLICPHRP WPDRQWGLCI FDDVIEHCSP ASFKYAEYFL RPMLQYVCDN SPEVRQAAAY GLGVMAQYGG DNYRPFCTEA LPLLVRVIQS ADSKTKENVN ATENCISAVG KIMKFKPDCV NVEEVLPHWL SWLPLHEDKE EAVQTFNYLC DLIESNHPIV LGPNNTNLPK IFSIIAEGEM HEAIKHEDPC AKRLANVVRQ VQTSGGLWTE CIAQLSPEQQ AAIQELLNSA
Genular Protein ID: 1826202725
Symbol: B3KWG6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
Sequence Information:
- Length: 718
- Mass: 81230
- Checksum: F99C8CB7F98A1760
- Sequence:
MALSAIGEGC HQQMEGILNE IVNFVLLFLQ DPHPRVRYAA CNAVGQMATD FAPGFQKKFH EKVIAALLQT MEDQGNQRVQ AHAAAALINF TEDCPKSLLI PYLDNLVKHL HSIMVLKLQE LIQKGTKLVL EQVVTSIASV ADTAEEKFVP YYDLFMPSLK HIVENAVQKE LRLLRGKTIE CISLIGLAVG KEKFMQDASD VMQLLLKTQT DFNDMEDDDP QISYMISAWA RMCKILGKEF QQYLPVVMGP LMKTASIKPE VALLDTQDME NMSDDDGWEF VNLGDQQSFG IKTAGLEEKS TACQMLVCYA KELKEGFVEY TEQVVKLMVP LLKFYFHDGV RVAAAESMPL LLECARVRGP EYLTQMWHFM CDALIKAIGT EPDSDVLSEI MHSFAKCIEV MGDGCLNNEH FEELGGILKA KLEEHFKNQE LRQVKRQDED YDEQVEESLQ DEDDNDVYIL TKVSDILHSI FSSYKEKVLP WFEQLLPLIV NLICPHRPWP DRQWGLCIFD DVIEHCSPAS FKYAEYFLRP MLQYVCDNSP EVRQAAAYGL GVMAQYGGDN YRPFCTEALP LLVRVIQSAD SKTKENVNAT ENCISAVGKI MKFKPDCVNV EEVLPHWLSW LPLHEDKEEA VQTFNYLCDL IESNHPIVLG PNNTNLPKIF SIIAEGEMHE AIKHEDPCAK RLANVVRQVQ TSGGLWTECI AQLSPEQQAA IQELLNSA